MXPA04004220A - Derivados de quinazolina como agentes antitumorales. - Google Patents

Derivados de quinazolina como agentes antitumorales.

Info

Publication number
MXPA04004220A
MXPA04004220A MXPA04004220A MXPA04004220A MXPA04004220A MX PA04004220 A MXPA04004220 A MX PA04004220A MX PA04004220 A MXPA04004220 A MX PA04004220A MX PA04004220 A MXPA04004220 A MX PA04004220A MX PA04004220 A MXPA04004220 A MX PA04004220A
Authority
MX
Mexico
Prior art keywords
quinazoline derivatives
antitumor agents
tumours
medicament
inhibition
Prior art date
Application number
MXPA04004220A
Other languages
English (en)
Inventor
Francois Andre Hennequ Laurent
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA04004220A publication Critical patent/MXPA04004220A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion concierne a derivados de quinazolina de la formula (I); en donde cada uno de Q1, Q2, Z, R1, R2, R3, L y m tienen cualquiera de los significados definidos en la descripcion; procesos para su preparacion , composiciones farmaceuticas que los contienen y su uso en la manufactura de un medicamento para usarse en la prevencion o tratamiento de tumores que son sensibles a la inhibicion de tirosincinasas del receptor erbB.
MXPA04004220A 2001-11-03 2002-10-31 Derivados de quinazolina como agentes antitumorales. MXPA04004220A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0126433.2A GB0126433D0 (en) 2001-11-03 2001-11-03 Compounds
PCT/GB2002/004932 WO2003040109A2 (en) 2001-11-03 2002-10-31 Quinazoline derivatives as antitumor agents

Publications (1)

Publication Number Publication Date
MXPA04004220A true MXPA04004220A (es) 2004-09-10

Family

ID=9925096

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004220A MXPA04004220A (es) 2001-11-03 2002-10-31 Derivados de quinazolina como agentes antitumorales.

Country Status (25)

Country Link
US (2) US20050054662A1 (es)
EP (1) EP1444211B1 (es)
JP (1) JP2005511603A (es)
KR (1) KR20050042058A (es)
CN (1) CN1764651A (es)
AR (1) AR037193A1 (es)
AT (1) ATE421507T1 (es)
BR (1) BR0213843A (es)
CA (1) CA2465100A1 (es)
CO (1) CO5580775A2 (es)
DE (1) DE60230995D1 (es)
ES (1) ES2319880T3 (es)
GB (1) GB0126433D0 (es)
HK (1) HK1065801A1 (es)
HU (1) HUP0401994A2 (es)
IL (1) IL161620A0 (es)
IS (1) IS7241A (es)
MX (1) MXPA04004220A (es)
NO (1) NO20042288L (es)
NZ (1) NZ532523A (es)
PL (1) PL369833A1 (es)
RU (1) RU2004116908A (es)
TW (1) TW200302221A (es)
WO (1) WO2003040109A2 (es)
ZA (2) ZA200403203B (es)

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JP2007505873A (ja) * 2003-09-16 2007-03-15 アストラゼネカ アクチボラグ チロシンキナーゼ阻害剤としてのキナゾリン誘導体
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
WO2005026157A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
SI1667991T1 (sl) * 2003-09-16 2008-10-31 Astrazeneca Ab Kinazolinski derivati kot inhibitorji tirozin kinaze
DE602004004811T2 (de) * 2003-09-19 2007-11-22 Astrazeneca Ab Chinazolinderivate
EP1670786A1 (en) * 2003-09-25 2006-06-21 Astrazeneca AB Quinazoline derivatives
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
WO2005075439A1 (en) * 2004-02-03 2005-08-18 Astrazeneca Ab Quinazoline derivatives
CN1993349A (zh) * 2004-06-04 2007-07-04 阿斯利康(瑞典)有限公司 作为erbb受体酪氨酸激酶的喹唑啉衍生物

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NZ532523A (en) 2007-02-23
CN1764651A (zh) 2006-04-26
IS7241A (is) 2004-04-30
HK1065801A1 (en) 2005-03-04
ATE421507T1 (de) 2009-02-15
NO20042288L (no) 2004-06-03
JP2005511603A (ja) 2005-04-28
CO5580775A2 (es) 2005-11-30
EP1444211A2 (en) 2004-08-11
TW200302221A (en) 2003-08-01
IL161620A0 (en) 2004-09-27
AR037193A1 (es) 2004-10-27
CA2465100A1 (en) 2003-05-15
DE60230995D1 (de) 2009-03-12
GB0126433D0 (en) 2002-01-02
EP1444211B1 (en) 2009-01-21
ZA200403203B (en) 2005-07-28
ES2319880T3 (es) 2009-05-14
US20070088044A1 (en) 2007-04-19
WO2003040109A3 (en) 2003-06-26
PL369833A1 (en) 2005-05-02
ZA200403200B (en) 2005-07-28
BR0213843A (pt) 2004-08-31
WO2003040109A2 (en) 2003-05-15
US20050054662A1 (en) 2005-03-10
RU2004116908A (ru) 2005-11-10
KR20050042058A (ko) 2005-05-04

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