IL161164A0 - Preparation of levofloxacin and forms thereof - Google Patents

Preparation of levofloxacin and forms thereof

Info

Publication number
IL161164A0
IL161164A0 IL16116402A IL16116402A IL161164A0 IL 161164 A0 IL161164 A0 IL 161164A0 IL 16116402 A IL16116402 A IL 16116402A IL 16116402 A IL16116402 A IL 16116402A IL 161164 A0 IL161164 A0 IL 161164A0
Authority
IL
Israel
Prior art keywords
levofloxacin
forms
preparation
methyl
benzoxazine
Prior art date
Application number
IL16116402A
Other languages
English (en)
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL161164(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of IL161164A0 publication Critical patent/IL161164A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IL16116402A 2001-10-03 2002-10-03 Preparation of levofloxacin and forms thereof IL161164A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32695801P 2001-10-03 2001-10-03
US33431601P 2001-11-29 2001-11-29
US35493902P 2002-02-11 2002-02-11
PCT/US2002/031850 WO2003028664A2 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and forms thereof

Publications (1)

Publication Number Publication Date
IL161164A0 true IL161164A0 (en) 2004-08-31

Family

ID=27406493

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16116402A IL161164A0 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and forms thereof

Country Status (11)

Country Link
US (2) US7629458B2 (de)
EP (3) EP1772457A3 (de)
JP (5) JP2005504818A (de)
AT (1) ATE341553T1 (de)
AU (2) AU2002341991A1 (de)
CA (1) CA2462023A1 (de)
DE (1) DE60215213T3 (de)
ES (1) ES2272781T5 (de)
IL (1) IL161164A0 (de)
PT (1) PT1451194E (de)
WO (2) WO2003028664A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504818A (ja) * 2001-10-03 2005-02-17 テバ ファーマシューティカル インダストリーズ リミティド レボフロキサシンおよびその形態の調製
US7425628B2 (en) 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
WO2003045329A2 (en) * 2001-11-29 2003-06-05 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
CN100412075C (zh) * 2004-06-22 2008-08-20 浙江医药股份有限公司新昌制药厂 左旋氧氟沙星和氧氟沙星的制备方法
EP1797101A4 (de) * 2004-09-17 2009-11-11 Matrix Lab Ltd Verbessertes verfahren zur herstellung von levofloxacin-hemihydrat
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070244318A1 (en) * 2004-11-08 2007-10-18 Rao Davuluri R Process for the Preparation of Levofloxacin Hemihydrate
JP2006273718A (ja) * 2005-03-28 2006-10-12 Shiono Chemical Co Ltd レボフロキサシン・１／２水和物の製法
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102146087B (zh) * 2010-02-10 2015-08-12 广东东阳光药业有限公司 一种制备高纯度左氧氟沙星半水合物的方法
NZ602126A (en) * 2010-02-25 2013-10-25 Santen Pharmaceutical Co Ltd Ophthalmic Solution for Treating Ocular Infection Comprising Levofloxacin or Salt Thereof or Solvate of the Same, Method for Treating Ocular Infection, Levofloxacin or Salt Thereof or Solvate of the Same, and Use Thereof
CN102558197A (zh) * 2012-01-11 2012-07-11 浙江医药股份有限公司新昌制药厂 左氧氟沙星-n-氧化物的制备方法
CN102850377B (zh) * 2012-09-04 2014-05-21 苏州弘森药业有限公司 一种盐酸左氧氟沙星的制备方法
PE20160945A1 (es) 2013-11-15 2016-09-26 Akebia Therapeutics Inc Formas solidas de acido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acetico, composiciones, y usos de las mismas
CN114507242B (zh) * 2022-01-26 2023-05-19 上虞京新药业有限公司 高光学纯度左氧氟沙星的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
NO166131C (no) 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
JPH0747592B2 (ja) 1985-06-20 1995-05-24 第一製薬株式会社 ピリドベンゾオキサジン誘導体
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
DE3543513A1 (de) 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
JPS62198685A (ja) 1986-02-26 1987-09-02 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
US4777253A (en) * 1986-04-25 1988-10-11 Abbott Laboratories Process for preparation of racemate and optically active ofloxacin and related derivatives
AU4376589A (en) 1988-11-07 1990-05-10 Gist-Brocades N.V. Optically active benzoxazines and benzothiazines
JP3105572B2 (ja) 1990-03-01 2000-11-06 第一製薬株式会社 水和物の選択的製法
TW208013B (de) 1990-03-01 1993-06-21 Daiichi Co Ltd
KR920003605B1 (ko) * 1990-03-27 1992-05-04 한국과학기술연구원 피페라지닐 퀴놀론 유도체의 제조방법
DE4019023A1 (de) 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DE4210941A1 (de) 1992-04-02 1993-10-07 Bayer Ag Neue 9-Fluor-7.oxo-7H-pyrido[1,2,3-d,e][1,4]benzoxacin-6-carbonsäuren und -ester
JPH0632776A (ja) 1992-07-14 1994-02-08 Mitsubishi Rayon Co Ltd Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリンの酸化防止法
KR0131914B1 (ko) * 1992-10-07 1998-04-17 조아퀸 가리데 센트멘나트 오플로옥사진, 레보플로옥사진과 이 유도체의 합성에 이용될 수 있는 벤조옥사진의 수득과정
ES2055656B1 (es) 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
KR0125115B1 (ko) † 1994-03-22 1997-12-05 김은영 (-)피페라진 벤즈옥사진 유도체의 제조방법
DE19729879C2 (de) 1997-07-11 1999-07-08 Mann Gerhard Chem Pharm Fab Lagerstabile ophthalmische Zusammensetzungen, umfassend Diclofenac und Ofloxacin
JPH11349589A (ja) 1997-12-24 1999-12-21 Sankyo Co Ltd 縮環キノリンカルボン酸誘導体
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
CN100537519C (zh) 1999-09-08 2009-09-09 第一三共株式会社 制备苯并嗪衍生物用中间体及其制备方法
JP2005504818A (ja) 2001-10-03 2005-02-17 テバ ファーマシューティカル インダストリーズ リミティド レボフロキサシンおよびその形態の調製
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
WO2003045329A2 (en) 2001-11-29 2003-06-05 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
AU2003285625A1 (en) * 2002-12-16 2004-07-09 Ranbaxy Laboratories Limited Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (ko) 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
EP1797101A4 (de) * 2004-09-17 2009-11-11 Matrix Lab Ltd Verbessertes verfahren zur herstellung von levofloxacin-hemihydrat
US20100029938A1 (en) 2006-12-22 2010-02-04 Farmaprojects, S. A. Process for the preparation of an antibacterial quinolone compound

Also Published As

Publication number Publication date
US20030130507A1 (en) 2003-07-10
JP2007131628A (ja) 2007-05-31
DE60215213D1 (de) 2006-11-16
EP1451194B1 (de) 2006-10-04
PT1451194E (pt) 2007-01-31
US20050222409A1 (en) 2005-10-06
US7629458B2 (en) 2009-12-08
ES2272781T3 (es) 2007-05-01
DE60215213T2 (de) 2007-08-30
ES2272781T5 (es) 2010-04-06
WO2003028664A3 (en) 2003-11-20
WO2003028665A3 (en) 2003-11-20
JP2008273956A (ja) 2008-11-13
ATE341553T1 (de) 2006-10-15
WO2003028664A2 (en) 2003-04-10
EP1772457A2 (de) 2007-04-11
EP1451194A4 (de) 2005-06-22
AU2002341991A1 (en) 2003-04-14
EP1772457A3 (de) 2007-07-04
CA2462023A1 (en) 2003-04-10
AU2002341990A1 (en) 2003-04-14
EP1451194B2 (de) 2009-12-16
JP2005504818A (ja) 2005-02-17
DE60215213T3 (de) 2010-07-01
WO2003028665A2 (en) 2003-04-10
JP2007169288A (ja) 2007-07-05
JP2006265261A (ja) 2006-10-05
EP1992629A1 (de) 2008-11-19
EP1451194A2 (de) 2004-09-01

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