IL160051A0 - Ecteinascidin derivatives and pharmaceutical compositions containing the same - Google Patents

Ecteinascidin derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL160051A0
IL160051A0 IL16005102A IL16005102A IL160051A0 IL 160051 A0 IL160051 A0 IL 160051A0 IL 16005102 A IL16005102 A IL 16005102A IL 16005102 A IL16005102 A IL 16005102A IL 160051 A0 IL160051 A0 IL 160051A0
Authority
IL
Israel
Prior art keywords
same
pharmaceutical compositions
compositions containing
ecteinascidin
derivatives
Prior art date
Application number
IL16005102A
Other languages
English (en)
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of IL160051A0 publication Critical patent/IL160051A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
IL16005102A 2001-08-07 2002-08-06 Ecteinascidin derivatives and pharmaceutical compositions containing the same IL160051A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119243.4A GB0119243D0 (en) 2001-08-07 2001-08-07 Antitumoral analogs of ET-743
PCT/GB2002/003592 WO2003014127A1 (en) 2001-08-07 2002-08-06 Antitumoral analogs

Publications (1)

Publication Number Publication Date
IL160051A0 true IL160051A0 (en) 2004-06-20

Family

ID=9919954

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16005102A IL160051A0 (en) 2001-08-07 2002-08-06 Ecteinascidin derivatives and pharmaceutical compositions containing the same
IL160051A IL160051A (en) 2001-08-07 2004-01-26 Ecteinascidin derivatives and pharmaceutical compositions containing the same as anti-cancer medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160051A IL160051A (en) 2001-08-07 2004-01-26 Ecteinascidin derivatives and pharmaceutical compositions containing the same as anti-cancer medicaments

Country Status (23)

Country Link
US (1) US7763615B2 (es)
EP (3) EP1806349A1 (es)
JP (2) JP4684552B2 (es)
KR (1) KR20040032150A (es)
CN (1) CN100334094C (es)
AT (1) ATE374777T1 (es)
AU (1) AU2002313540B2 (es)
CA (1) CA2455768C (es)
CY (1) CY1107830T1 (es)
DE (1) DE60222775T2 (es)
DK (1) DK1414828T3 (es)
ES (1) ES2294151T3 (es)
GB (1) GB0119243D0 (es)
HK (1) HK1065786A1 (es)
HU (1) HU229779B1 (es)
IL (2) IL160051A0 (es)
MX (1) MXPA04001240A (es)
NO (1) NO337476B1 (es)
NZ (1) NZ530837A (es)
PL (1) PL218295B1 (es)
PT (1) PT1414828E (es)
RU (1) RU2283842C2 (es)
WO (1) WO2003014127A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
CN101945872B (zh) * 2008-01-11 2014-07-23 阿尔巴尼分子研究公司 作为mch拮抗剂的(1-吖嗪酮)-取代的吡啶并吲哚
WO2011003021A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) * 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
EP2448585B1 (en) * 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
ES2534331T3 (es) * 2010-05-25 2015-04-21 Pharma Mar S.A. Proceso sintético para la producción de compuestos e intermedios de ecteinascidina
HUE049389T2 (hu) * 2010-11-12 2020-09-28 Pharma Mar Sa Kombinált terápia topoizomeráz inhibitorral
BR122015017254B1 (pt) 2010-11-26 2019-10-08 Nec Corporation Método de decodificação de vídeo e dispositivo de decodificação de vídeo
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
CN108271369A (zh) 2015-10-23 2018-07-10 法尔玛赞公司 用于制备色胺及其衍生物的新工艺
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
TWI824043B (zh) * 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
EP4025217A1 (en) 2019-09-03 2022-07-13 Pharma Mar, S.A. Lurbinectedin in the treatment of malignant mesothelioma
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
CR20220289A (es) 2019-11-21 2022-10-27 Pharma Mar Sa Métodos de tratamiento del cáncer de pulmón de células pequeñas con formulaciones de lurbinectedina
MA56827B2 (fr) 2019-11-21 2023-09-27 Pharma Mar Sa Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine
WO2021228414A1 (en) 2020-05-14 2021-11-18 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
CN115427081A (zh) 2020-04-21 2022-12-02 法马马有限公司 药物抗体共轭物
TW202144369A (zh) * 2020-04-26 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 海鞘素類衍生物及其製備方法與醫藥用途
WO2022048775A1 (en) 2020-09-04 2022-03-10 Pharma Mar, S.A. Combination of lurbinectedin and immune checkpoint inhibitor
WO2022101255A1 (en) 2020-11-10 2022-05-19 Pharma Mar, S.A. Lurbinectedin and irinotecan combinations
WO2023031960A1 (en) * 2021-08-31 2023-03-09 Natco Pharma Limited Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin
CA3237009A1 (en) 2021-11-08 2023-05-11 Luis Gonzaga PAZ-ARES RODRIGUEZ Lurbinectedin and atezolizumab combinations
CN115246846A (zh) * 2021-11-19 2022-10-28 江苏慧聚药业股份有限公司 卢比替定新晶型及其制备
CN115304619A (zh) * 2022-04-08 2022-11-08 上海皓元医药股份有限公司 一种卢比替定的晶型及其制备方法
CN114940682A (zh) * 2022-05-18 2022-08-26 博瑞制药(苏州)有限公司 芦比替定的晶型及其制备方法和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
EP0309477B1 (en) 1986-06-09 1991-11-06 The Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
SK285669B6 (sk) 1998-04-06 2007-06-07 The Board Of Trustees Of The University Of Illinois Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie
WO1999058125A1 (en) 1998-05-11 1999-11-18 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US6686470B2 (en) * 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
CZ304749B6 (cs) * 2000-04-12 2014-09-24 Pharma Mar, S. A. Ecteinascidin mající pět spojených kruhů s 1,4-můstkem, farmaceutický prostředek, použití a způsob
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
EP1414828A1 (en) 2004-05-06
PT1414828E (pt) 2007-12-27
CN100334094C (zh) 2007-08-29
NO337476B1 (no) 2016-04-18
MXPA04001240A (es) 2004-06-03
RU2283842C2 (ru) 2006-09-20
CA2455768A1 (en) 2003-02-20
HK1065786A1 (en) 2005-03-04
AU2002313540B2 (en) 2008-05-22
EP1414828B9 (en) 2008-02-20
GB0119243D0 (en) 2001-10-03
NZ530837A (en) 2005-07-29
HU229779B1 (en) 2014-07-28
CA2455768C (en) 2011-10-11
IL160051A (en) 2012-01-31
RU2004106617A (ru) 2005-04-10
US20060128711A1 (en) 2006-06-15
ES2294151T3 (es) 2008-04-01
KR20040032150A (ko) 2004-04-14
EP1806349A1 (en) 2007-07-11
JP4684552B2 (ja) 2011-05-18
US7763615B2 (en) 2010-07-27
CY1107830T1 (el) 2013-06-19
PL218295B1 (pl) 2014-11-28
JP2011026331A (ja) 2011-02-10
JP2005501093A (ja) 2005-01-13
DE60222775T2 (de) 2008-07-17
DE60222775D1 (de) 2007-11-15
EP2270018A1 (en) 2011-01-05
NO20040961L (no) 2004-03-05
WO2003014127A1 (en) 2003-02-20
PL367940A1 (en) 2005-03-07
ATE374777T1 (de) 2007-10-15
DK1414828T3 (da) 2008-02-04
CN1564822A (zh) 2005-01-12
HUP0401174A2 (hu) 2005-09-28
HUP0401174A3 (en) 2005-12-28
EP1414828B1 (en) 2007-10-03

Similar Documents

Publication Publication Date Title
IL160051A0 (en) Ecteinascidin derivatives and pharmaceutical compositions containing the same
PL304649A1 (en) Novel derivatives of taxane and pharmaceutical agents
IL161616A0 (en) Indazolypyrrolotriazine derivatives and pharmaceutical compositions containing the same
IL158523A0 (en) Epothilone derivatives and pharmaceutical compositions containing the same
IL157029A0 (en) Azaindoleoxoacetic piperazine derivatives and pharmaceutical compositions containing the same
TWI256389B (en) Novel hPPAR delta agonists and pharmaceutical compositions comprising the same
IL157131A0 (en) Nitrogen containing heterocyclic derivatives and pharmaceutical compositions containing the same
IL158044A0 (en) Cyclopropylindole derivatives and pharmaceutical compositions containing the same
IL158300A0 (en) Bisarylimidazol derivatives and pharmaceutical compositions containing the same
IL159086A0 (en) 3-aryl-5-aryl- [1, 2, 4] -oxadiazole derivatives and pharmaceutical compositions containing the same
IL159765A0 (en) Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same
EP1399414A4 (en) SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA
HUP0401567A3 (en) Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them
EP1420785A4 (en) SUBSTITUTED INDONO 1,2-C] ISOQUINOLINE DERIVATIVES AND METHODS OF USING THE SAME
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
IL151829A0 (en) Carbamate derivatives and pharmaceutical compositions containing the same
IL161429A0 (en) Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing the same
AU2002306269A1 (en) N-arylphenylacetamide derivatives and pharmaceutical composition containing the same
IL158041A0 (en) Benzimidazole derivatives and pharmaceutical compositions containing the same
IL156812A0 (en) Phthalazinone-piperidino derivatives and pharmaceutical compositions containing the same
IL161430A0 (en) Pharmaceutical compositions containing ecteinascidin 743
IL152094A0 (en) Ecteinascidin derivatives and pharmaceutical compositions containing the same
IL157740A0 (en) Heterocyclic derivatives and pharmaceutical compositions containing the same
IL157908A0 (en) Phthalazinone derivatives and pharmaceutical compositions containing the same
IL158671A0 (en) Benzyloxy derivatives and pharmaceutical compositions containing the same