HUP0401174A2 - Ekteinaszcidin-analógok, alkalmazásuk rák kezelésére alkalmas gyógyszerkészítmények előállítására és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Ekteinaszcidin-analógok, alkalmazásuk rák kezelésére alkalmas gyógyszerkészítmények előállítására és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401174A2 HUP0401174A2 HU0401174A HUP0401174A HUP0401174A2 HU P0401174 A2 HUP0401174 A2 HU P0401174A2 HU 0401174 A HU0401174 A HU 0401174A HU P0401174 A HUP0401174 A HU P0401174A HU P0401174 A2 HUP0401174 A2 HU P0401174A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- group
- compounds
- medicament
- cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical class C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
A találmány szerinti vegyületek (I) általános képletében R1, R2, R3,R4 és R5 jelentése egymástól fiiggetlenül H, OH, OR', SH, SR', SOR',SO2R', C(=O)R', C(=O)OR', NO2, NH2, NHR', N(R')2, NFC(O)R', CN,halogénatom, =O, adott esetben szubsztituált 1-25 szénatomosalkilcsoport, adott esetben szubsztituált 2-18 szénatomosalkenilcsoport, adott esetben szubsztituált 2-18 szénatomosalkinilcsoport, adott esetben szubsztituált arilcsoport vagy adottesetben szubsztituált heterociklusos csoport, X jelentése OR', CN,(=O) vagy H, R' jelentése az egyes előfordulási helyeken egymástólfiiggetlenül H, OH, NO2, NH2, SH, CN, halogénatom, =O, C(=O)H,C(=O)CH3, CO2H, adott esetben szubsztituált 1-25 szénatomosalkilcsoport, adott esetben szubsztituált 2-18 szénatomosalkenilcsoport, adott esetben szubsztituált 2-18 szénatomosalkinilcsoport vagy adott esetben szubsztituált arilcsoport, m értéke0, 1 vagy 2, n értéke 0, 1, 2, 3 vagy 4. A találmány kiterjed a fentivegyületeket tartalmazó gyógyszerkészítményekre és a vegyületekalkalmazására.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119243.4A GB0119243D0 (en) | 2001-08-07 | 2001-08-07 | Antitumoral analogs of ET-743 |
| PCT/GB2002/003592 WO2003014127A1 (en) | 2001-08-07 | 2002-08-06 | Antitumoral analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0401174A2 true HUP0401174A2 (hu) | 2005-09-28 |
| HUP0401174A3 HUP0401174A3 (en) | 2005-12-28 |
| HU229779B1 HU229779B1 (en) | 2014-07-28 |
Family
ID=9919954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401174A HU229779B1 (en) | 2001-08-07 | 2002-08-06 | Ecteinascidin analogues, their use in the preparation of a medicament for treatment of cancer and pharmaceutical compositions containing the compounds |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7763615B2 (hu) |
| EP (3) | EP1806349A1 (hu) |
| JP (2) | JP4684552B2 (hu) |
| KR (1) | KR20040032150A (hu) |
| CN (1) | CN100334094C (hu) |
| AT (1) | ATE374777T1 (hu) |
| AU (1) | AU2002313540B2 (hu) |
| CA (1) | CA2455768C (hu) |
| CY (1) | CY1107830T1 (hu) |
| DE (1) | DE60222775T2 (hu) |
| DK (1) | DK1414828T3 (hu) |
| ES (1) | ES2294151T3 (hu) |
| GB (1) | GB0119243D0 (hu) |
| HK (1) | HK1065786A1 (hu) |
| HU (1) | HU229779B1 (hu) |
| IL (2) | IL160051A0 (hu) |
| MX (1) | MXPA04001240A (hu) |
| NO (1) | NO337476B1 (hu) |
| NZ (1) | NZ530837A (hu) |
| PL (1) | PL218295B1 (hu) |
| PT (1) | PT1414828E (hu) |
| RU (1) | RU2283842C2 (hu) |
| WO (1) | WO2003014127A1 (hu) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| CN101945872B (zh) * | 2008-01-11 | 2014-07-23 | 阿尔巴尼分子研究公司 | 作为mch拮抗剂的(1-吖嗪酮)-取代的吡啶并吲哚 |
| WO2011003021A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) * | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8618299B2 (en) * | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) * | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| ES2534331T3 (es) * | 2010-05-25 | 2015-04-21 | Pharma Mar S.A. | Proceso sintético para la producción de compuestos e intermedios de ecteinascidina |
| HUE049389T2 (hu) * | 2010-11-12 | 2020-09-28 | Pharma Mar Sa | Kombinált terápia topoizomeráz inhibitorral |
| BR122015017254B1 (pt) | 2010-11-26 | 2019-10-08 | Nec Corporation | Método de decodificação de vídeo e dispositivo de decodificação de vídeo |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| TWI824043B (zh) * | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
| EP4025217A1 (en) | 2019-09-03 | 2022-07-13 | Pharma Mar, S.A. | Lurbinectedin in the treatment of malignant mesothelioma |
| CN112574234B (zh) * | 2019-09-27 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | 一种海鞘素衍生物的制备方法 |
| CR20220289A (es) | 2019-11-21 | 2022-10-27 | Pharma Mar Sa | Métodos de tratamiento del cáncer de pulmón de células pequeñas con formulaciones de lurbinectedina |
| MA56827B2 (fr) | 2019-11-21 | 2023-09-27 | Pharma Mar Sa | Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine |
| WO2021228414A1 (en) | 2020-05-14 | 2021-11-18 | Pharma Mar, S.A. | Methods of treating small cell lung cancer with lurbinectedin formulations |
| CN115427081A (zh) | 2020-04-21 | 2022-12-02 | 法马马有限公司 | 药物抗体共轭物 |
| TW202144369A (zh) * | 2020-04-26 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 海鞘素類衍生物及其製備方法與醫藥用途 |
| WO2022048775A1 (en) | 2020-09-04 | 2022-03-10 | Pharma Mar, S.A. | Combination of lurbinectedin and immune checkpoint inhibitor |
| WO2022101255A1 (en) | 2020-11-10 | 2022-05-19 | Pharma Mar, S.A. | Lurbinectedin and irinotecan combinations |
| WO2023031960A1 (en) * | 2021-08-31 | 2023-03-09 | Natco Pharma Limited | Novel crystalline polymorph of lurbinectedin and improved process for the preparation of lurbinectedin |
| CA3237009A1 (en) | 2021-11-08 | 2023-05-11 | Luis Gonzaga PAZ-ARES RODRIGUEZ | Lurbinectedin and atezolizumab combinations |
| CN115246846A (zh) * | 2021-11-19 | 2022-10-28 | 江苏慧聚药业股份有限公司 | 卢比替定新晶型及其制备 |
| CN115304619A (zh) * | 2022-04-08 | 2022-11-08 | 上海皓元医药股份有限公司 | 一种卢比替定的晶型及其制备方法 |
| CN114940682A (zh) * | 2022-05-18 | 2022-08-26 | 博瑞制药(苏州)有限公司 | 芦比替定的晶型及其制备方法和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| EP0309477B1 (en) | 1986-06-09 | 1991-11-06 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| SK285669B6 (sk) | 1998-04-06 | 2007-06-07 | The Board Of Trustees Of The University Of Illinois | Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie |
| WO1999058125A1 (en) | 1998-05-11 | 1999-11-18 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| US6686470B2 (en) * | 2000-01-19 | 2004-02-03 | The Trustees Of Columbia University In The City Of New York | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
| CZ304749B6 (cs) * | 2000-04-12 | 2014-09-24 | Pharma Mar, S. A. | Ecteinascidin mající pět spojených kruhů s 1,4-můstkem, farmaceutický prostředek, použití a způsob |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
2001
- 2001-08-07 GB GBGB0119243.4A patent/GB0119243D0/en not_active Ceased
-
2002
- 2002-08-06 MX MXPA04001240A patent/MXPA04001240A/es active IP Right Grant
- 2002-08-06 KR KR10-2004-7001924A patent/KR20040032150A/ko active Search and Examination
- 2002-08-06 AU AU2002313540A patent/AU2002313540B2/en active Active
- 2002-08-06 WO PCT/GB2002/003592 patent/WO2003014127A1/en active IP Right Grant
- 2002-08-06 RU RU2004106617/04A patent/RU2283842C2/ru active
- 2002-08-06 JP JP2003519076A patent/JP4684552B2/ja not_active Expired - Lifetime
- 2002-08-06 AT AT02753134T patent/ATE374777T1/de active
- 2002-08-06 EP EP07001308A patent/EP1806349A1/en not_active Ceased
- 2002-08-06 DK DK02753134T patent/DK1414828T3/da active
- 2002-08-06 PT PT02753134T patent/PT1414828E/pt unknown
- 2002-08-06 DE DE60222775T patent/DE60222775T2/de not_active Expired - Lifetime
- 2002-08-06 CN CNB028196511A patent/CN100334094C/zh not_active Expired - Lifetime
- 2002-08-06 ES ES02753134T patent/ES2294151T3/es not_active Expired - Lifetime
- 2002-08-06 EP EP02753134A patent/EP1414828B9/en not_active Expired - Lifetime
- 2002-08-06 CA CA2455768A patent/CA2455768C/en not_active Expired - Lifetime
- 2002-08-06 HU HU0401174A patent/HU229779B1/hu unknown
- 2002-08-06 PL PL367940A patent/PL218295B1/pl unknown
- 2002-08-06 IL IL16005102A patent/IL160051A0/xx unknown
- 2002-08-06 EP EP10180740A patent/EP2270018A1/en not_active Withdrawn
- 2002-08-06 US US10/485,536 patent/US7763615B2/en active Active
- 2002-08-06 NZ NZ530837A patent/NZ530837A/en not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160051A patent/IL160051A/en active IP Right Grant
- 2004-03-05 NO NO20040961A patent/NO337476B1/no not_active IP Right Cessation
- 2004-10-29 HK HK04108496A patent/HK1065786A1/xx not_active IP Right Cessation
-
2007
- 2007-12-12 CY CY20071101576T patent/CY1107830T1/el unknown
-
2010
- 2010-09-17 JP JP2010209928A patent/JP2011026331A/ja active Pending
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