HUP0402658A2 - Variolinszármazékok és ezeket tartalmazó daganatellenes gyógyászati készítmények - Google Patents

Variolinszármazékok és ezeket tartalmazó daganatellenes gyógyászati készítmények

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Publication number
HUP0402658A2
HUP0402658A2 HU0402658A HUP0402658A HUP0402658A2 HU P0402658 A2 HUP0402658 A2 HU P0402658A2 HU 0402658 A HU0402658 A HU 0402658A HU P0402658 A HUP0402658 A HU P0402658A HU P0402658 A2 HUP0402658 A2 HU P0402658A2
Authority
HU
Hungary
Prior art keywords
alkenyl
substituted
pharmaceutical compositions
compounds
antitumor agents
Prior art date
Application number
HU0402658A
Other languages
English (en)
Inventor
Modesto Remuinan
Juan Jose Gonzalez
Carlos Pozo
Andrés Francesch
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Regan James Anderson
Jonathan Charles Morris
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of HUP0402658A2 publication Critical patent/HUP0402658A2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgyát (5) általános képletű vegyületek képezik, ahol aképletben az X2, R1, R2, R3, R6, R7 és R12 szubsztituensek jelentéseegymástól függetlenül a következők közül választott: H, OH, OR', SH,SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, NHCOR', NHSO2R', CN,halogén, =O, C(=O)H, C(=O)R', CO2H, CO2R', karboxialkil-, 1-12szénatomos alkil-, 2-12 szénatomos alkenil-, 2-12 szénatomos alkenil-,szubsztituált vagy szubsztituálatlan aril-, szubsztituált vagyszubsztituálatlan aralkil- és szubsztituált vagy szubsztituálatlanheteroaromás csoport; ahol az R' csoportok jelentései egymástólfüggetlenül a következők közül választottak: H, OH, SH, NO2, NH2, CN,halogén, -O, C(=O)H, C(=O)CH3, CO2H, CO2CH3, 1-12 szénatomos alkil-,2-12 szénatomos alkenil-, 2-12 szénatomos alkinil-, aril-, aralkil- ésheteroaromás csoport; ahol az R1 és R2, R2 és R3, R3 és R12, R12 és R6vagy R6 és R7 szubsztituens párok összekapcsolódva egy karbociklusosvagy heterociklusos gyűrűrendszert képezhetnek. A találmány tárgyátképezik továbbá a fenti vegyületeket tartalmazó gyógyászatikészítmények és a vegyületek alkalmazása rákos megbetegedésekkezelésére használható gyógyászati készítmények előállítására. Ó
HU0402658A 2001-07-11 2002-07-11 Variolinszármazékok és ezeket tartalmazó daganatellenes gyógyászati készítmények HUP0402658A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116966.3A GB0116966D0 (en) 2001-07-11 2001-07-11 Anittumoral compounds
PCT/GB2002/003197 WO2003006457A1 (en) 2001-07-11 2002-07-11 Variolin derivatives and their use as antitumor agents

Publications (1)

Publication Number Publication Date
HUP0402658A2 true HUP0402658A2 (hu) 2005-04-28

Family

ID=9918335

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402658A HUP0402658A2 (hu) 2001-07-11 2002-07-11 Variolinszármazékok és ezeket tartalmazó daganatellenes gyógyászati készítmények

Country Status (20)

Country Link
US (2) US7495000B2 (hu)
EP (2) EP1867645B1 (hu)
JP (1) JP4369225B2 (hu)
KR (1) KR100929616B1 (hu)
CN (1) CN1553906B (hu)
AT (2) ATE396987T1 (hu)
AU (1) AU2002317329B2 (hu)
CA (1) CA2453418C (hu)
DE (2) DE60237652D1 (hu)
ES (2) ES2307768T3 (hu)
GB (1) GB0116966D0 (hu)
HK (1) HK1060354A1 (hu)
HU (1) HUP0402658A2 (hu)
IL (2) IL159792A0 (hu)
MX (1) MXPA04000355A (hu)
NO (1) NO328848B1 (hu)
NZ (1) NZ530556A (hu)
PL (1) PL366894A1 (hu)
RU (1) RU2302419C2 (hu)
WO (1) WO2003006457A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
US8501765B2 (en) * 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) * 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
JP4369225B2 (ja) 2009-11-18
ES2307768T3 (es) 2008-12-01
CA2453418C (en) 2011-05-17
KR20040023649A (ko) 2004-03-18
CN1553906A (zh) 2004-12-08
US20090197901A1 (en) 2009-08-06
JP2004536850A (ja) 2004-12-09
US20060235223A1 (en) 2006-10-19
US7495000B2 (en) 2009-02-24
EP1867645B1 (en) 2010-09-08
EP1404668B1 (en) 2008-05-28
NO20040113L (no) 2004-03-09
PL366894A1 (en) 2005-02-07
MXPA04000355A (es) 2005-03-07
NZ530556A (en) 2005-07-29
CA2453418A1 (en) 2003-01-23
US7772241B2 (en) 2010-08-10
DE60226869D1 (de) 2008-07-10
AU2002317329B2 (en) 2008-10-02
IL159792A (en) 2009-08-03
GB0116966D0 (en) 2001-09-05
ES2354991T3 (es) 2011-03-21
HK1060354A1 (en) 2004-08-06
EP1404668A1 (en) 2004-04-07
CN1553906B (zh) 2010-04-28
IL159792A0 (en) 2004-06-20
KR100929616B1 (ko) 2009-12-03
RU2302419C2 (ru) 2007-07-10
ATE480533T1 (de) 2010-09-15
NO328848B1 (no) 2010-05-31
EP1867645A1 (en) 2007-12-19
RU2004103857A (ru) 2005-06-20
DE60237652D1 (de) 2010-10-21
WO2003006457A1 (en) 2003-01-23
ATE396987T1 (de) 2008-06-15

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