HUP0401733A2 - Ciklikus aminszármazékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Ciklikus aminszármazékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0401733A2
HUP0401733A2 HU0401733A HUP0401733A HUP0401733A2 HU P0401733 A2 HUP0401733 A2 HU P0401733A2 HU 0401733 A HU0401733 A HU 0401733A HU P0401733 A HUP0401733 A HU P0401733A HU P0401733 A2 HUP0401733 A2 HU P0401733A2
Authority
HU
Hungary
Prior art keywords
group
substituted
general formula
unsubstituted
cyclic amine
Prior art date
Application number
HU0401733A
Other languages
English (en)
Inventor
Tatsuhiko Kodama
Masahiro Tamura
Toshiaki Oda
Yukiyoshi Yamazaki
Masahiro Nishikawa
Shunji Takemura
Takeshi Doi
Yoshinori Kyotani
Masao Ohkuchi
Original Assignee
Kowa Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/941,684 external-priority patent/US6395753B1/en
Priority claimed from US10/107,180 external-priority patent/US6605620B1/en
Application filed by Kowa Co., Ltd. filed Critical Kowa Co., Ltd.
Publication of HUP0401733A2 publication Critical patent/HUP0401733A2/hu
Publication of HUP0401733A3 publication Critical patent/HUP0401733A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

A találmány tárgya az (1) általános képletű ciklikus aminszármazékok -ahol a képletben R1, R2 és R3 jelentése egymástól függetlenülhidrogénatom, halogénatom vagy hidroxilcsoport, alkilcsoport,halogénatommal helyettesített alkilcsoport, alkoxicsoport, alkil-tio-csoport, karboxilcsoport, alkoxi-karbonil-csoport vagyalkanoilcsoport; W1 és W2 jelentése egymástól függetlenül nitrogénatomvagy CH-csoport; X jelentése oxigénatom, NR4 általános képletűcsoport, CONR4 általános képletű csoport vagy NR4CO általános képletűcsoport; R4 jelentése hidrogénatom, alkilcsoport, alkenilcsoport,alkinilcsoport, helyettesített vagy helyettesítetlen arilcsoport,helyettesített vagy helyettesítetlen heteroarilcsoport, helyettesítettvagy helyettesítetlen aralkilcsoport, vagy helyettesített vagyhelyettesítetlen hetero-aralkil-csoport; és l, m és a jelentése 0 vagy1, - vagy azok sói vagy hidrátjai. A találmány szerinti vegyületeksejtadhézió és sejtinfiltráció hatással rendelkeznek, ésantiasztmatikus, antiallergiás, antireumatikus,antiarterioszklerotikus, gyulladásgátló és a Sjogren-szindrómakezelésére alkalmas szerekként használhatók. Ó
HU0401733A 2001-08-30 2002-08-28 Cyclic amine-derivatives and pharmaceutical compositions containing them HUP0401733A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/941,684 US6395753B1 (en) 2001-08-30 2001-08-30 Cyclic amine compounds and pharmaceutical composition containing the same
US09/983,928 US6498169B1 (en) 2001-08-30 2001-10-26 Cyclic amine compounds and pharmaceutical composition containing the same
US10/107,180 US6605620B1 (en) 2001-08-30 2002-03-28 Cyclic amine compounds and pharmaceutical composition containing the same
US10/191,534 US6867221B2 (en) 2001-08-30 2002-07-10 Cyclic amine compounds and pharmaceutical composition containing the same
PCT/JP2002/008650 WO2003020703A1 (fr) 2001-08-30 2002-08-28 Compose d'amine cyclique

Publications (2)

Publication Number Publication Date
HUP0401733A2 true HUP0401733A2 (hu) 2004-12-28
HUP0401733A3 HUP0401733A3 (en) 2009-06-29

Family

ID=27493564

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401733A HUP0401733A3 (en) 2001-08-30 2002-08-28 Cyclic amine-derivatives and pharmaceutical compositions containing them

Country Status (10)

Country Link
US (1) US6867221B2 (hu)
EP (1) EP1422219A4 (hu)
CN (1) CN100406441C (hu)
AU (1) AU2002328576B8 (hu)
CA (1) CA2461963C (hu)
HU (1) HUP0401733A3 (hu)
NO (1) NO327074B1 (hu)
NZ (1) NZ531498A (hu)
TW (1) TWI254706B (hu)
WO (1) WO2003020703A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY134200A (en) * 2002-04-12 2007-11-30 Kowa Co Method for treating cancer
WO2004052859A1 (ja) * 2002-12-06 2004-06-24 Kowa Co., Ltd. エリスロポエチン産生促進剤
TWI344955B (en) 2003-03-14 2011-07-11 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
EP1674100A4 (en) * 2003-10-10 2010-04-14 Kowa Co INHIBITOR OF ANGIOGENESIS
CA2578168A1 (en) 2004-08-27 2006-03-02 Astellas Pharma Inc. 2-phenylpyridine derivative
PE20060598A1 (es) * 2004-09-13 2006-08-21 Ono Pharmaceutical Co Derivado heterociclo conteniendo nitrogeno como antagonista de quimiocina ccr5
WO2006082834A1 (ja) * 2005-02-02 2006-08-10 Kowa Co., Ltd. ケラチノサイト増殖に起因する疾患の予防・治療剤
EP1995246A4 (en) 2006-03-10 2010-11-17 Ono Pharmaceutical Co NITROGENATED HETEROCYCLIC DERIVATIVE AND MEDICAMENT WITH DERIVATIVE ACTIVE SUBSTANCE
US20100016358A1 (en) * 2006-10-13 2010-01-21 Kowa Co., Ltd. Gamma-globin inducer
US8071779B2 (en) 2006-12-18 2011-12-06 Inspire Pharmaceuticals, Inc. Cytoskeletal active rho kinase inhibitor compounds, composition and use
US20100022517A1 (en) * 2006-12-18 2010-01-28 Richards Lori A Ophthalmic formulation of rho kinase inhibitor compound
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JP5683489B2 (ja) 2009-01-12 2015-03-11 アレイ バイオファーマ、インコーポレイテッド ピペリジン含有化合物およびその用途
KR20140091036A (ko) 2011-11-03 2014-07-18 세라밴스 인코포레이티드 단편 [2-[4-(바이페닐-4-일)-1h-이미다조-2-일]피롤리딘-1-카르보닐메틸]아민을 포함하는 간상 c형 간염 바이러스 억제제
GB201708652D0 (en) 2017-05-31 2017-07-12 Mission Therapeutics Ltd Novel compounds and uses

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Also Published As

Publication number Publication date
HUP0401733A3 (en) 2009-06-29
CN1604893A (zh) 2005-04-06
US20040010147A1 (en) 2004-01-15
NO20040877L (no) 2004-02-25
CN100406441C (zh) 2008-07-30
AU2002328576B8 (en) 2008-05-15
CA2461963A1 (en) 2003-03-13
TWI254706B (en) 2006-05-11
NZ531498A (en) 2005-07-29
EP1422219A4 (en) 2005-08-17
EP1422219A1 (en) 2004-05-26
NO327074B1 (no) 2009-04-14
WO2003020703A1 (fr) 2003-03-13
US6867221B2 (en) 2005-03-15
AU2002328576B2 (en) 2008-04-03
CA2461963C (en) 2010-08-17

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