IL159792A0 - Variolin derivatives and pharmaceutical compositions containing the same - Google Patents

Variolin derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL159792A0
IL159792A0 IL15979202A IL15979202A IL159792A0 IL 159792 A0 IL159792 A0 IL 159792A0 IL 15979202 A IL15979202 A IL 15979202A IL 15979202 A IL15979202 A IL 15979202A IL 159792 A0 IL159792 A0 IL 159792A0
Authority
IL
Israel
Prior art keywords
same
pharmaceutical compositions
compositions containing
substituted
unsubstituted
Prior art date
Application number
IL15979202A
Other languages
English (en)
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of IL159792A0 publication Critical patent/IL159792A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15979202A 2001-07-11 2002-07-11 Variolin derivatives and pharmaceutical compositions containing the same IL159792A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116966.3A GB0116966D0 (en) 2001-07-11 2001-07-11 Anittumoral compounds
PCT/GB2002/003197 WO2003006457A1 (en) 2001-07-11 2002-07-11 Variolin derivatives and their use as antitumor agents

Publications (1)

Publication Number Publication Date
IL159792A0 true IL159792A0 (en) 2004-06-20

Family

ID=9918335

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15979202A IL159792A0 (en) 2001-07-11 2002-07-11 Variolin derivatives and pharmaceutical compositions containing the same
IL159792A IL159792A (en) 2001-07-11 2004-01-11 History of variolins and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159792A IL159792A (en) 2001-07-11 2004-01-11 History of variolins and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (2) US7495000B2 (xx)
EP (2) EP1867645B1 (xx)
JP (1) JP4369225B2 (xx)
KR (1) KR100929616B1 (xx)
CN (1) CN1553906B (xx)
AT (2) ATE396987T1 (xx)
AU (1) AU2002317329B2 (xx)
CA (1) CA2453418C (xx)
DE (2) DE60237652D1 (xx)
ES (2) ES2307768T3 (xx)
GB (1) GB0116966D0 (xx)
HK (1) HK1060354A1 (xx)
HU (1) HUP0402658A2 (xx)
IL (2) IL159792A0 (xx)
MX (1) MXPA04000355A (xx)
NO (1) NO328848B1 (xx)
NZ (1) NZ530556A (xx)
PL (1) PL366894A1 (xx)
RU (1) RU2302419C2 (xx)
WO (1) WO2003006457A1 (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
US8501765B2 (en) * 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) * 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
JP4369225B2 (ja) 2009-11-18
ES2307768T3 (es) 2008-12-01
CA2453418C (en) 2011-05-17
KR20040023649A (ko) 2004-03-18
CN1553906A (zh) 2004-12-08
US20090197901A1 (en) 2009-08-06
JP2004536850A (ja) 2004-12-09
US20060235223A1 (en) 2006-10-19
US7495000B2 (en) 2009-02-24
EP1867645B1 (en) 2010-09-08
EP1404668B1 (en) 2008-05-28
NO20040113L (no) 2004-03-09
PL366894A1 (en) 2005-02-07
MXPA04000355A (es) 2005-03-07
NZ530556A (en) 2005-07-29
CA2453418A1 (en) 2003-01-23
US7772241B2 (en) 2010-08-10
DE60226869D1 (de) 2008-07-10
AU2002317329B2 (en) 2008-10-02
IL159792A (en) 2009-08-03
GB0116966D0 (en) 2001-09-05
ES2354991T3 (es) 2011-03-21
HK1060354A1 (en) 2004-08-06
HUP0402658A2 (hu) 2005-04-28
EP1404668A1 (en) 2004-04-07
CN1553906B (zh) 2010-04-28
KR100929616B1 (ko) 2009-12-03
RU2302419C2 (ru) 2007-07-10
ATE480533T1 (de) 2010-09-15
NO328848B1 (no) 2010-05-31
EP1867645A1 (en) 2007-12-19
RU2004103857A (ru) 2005-06-20
DE60237652D1 (de) 2010-10-21
WO2003006457A1 (en) 2003-01-23
ATE396987T1 (de) 2008-06-15

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