DE60226869D1 - Variolinderivate und ihre verwendung als cytostatika - Google Patents

Variolinderivate und ihre verwendung als cytostatika

Info

Publication number
DE60226869D1
DE60226869D1 DE60226869T DE60226869T DE60226869D1 DE 60226869 D1 DE60226869 D1 DE 60226869D1 DE 60226869 T DE60226869 T DE 60226869T DE 60226869 T DE60226869 T DE 60226869T DE 60226869 D1 DE60226869 D1 DE 60226869D1
Authority
DE
Germany
Prior art keywords
substituted
derivatives
unsubstituted
variin
cytostatics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226869T
Other languages
English (en)
Inventor
Modesto Remuinan
Juan Jose Gonzalez
Pozo Carlos Del
Andres Francesch
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of DE60226869D1 publication Critical patent/DE60226869D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60226869T 2001-07-11 2002-07-11 Variolinderivate und ihre verwendung als cytostatika Expired - Lifetime DE60226869D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116966.3A GB0116966D0 (en) 2001-07-11 2001-07-11 Anittumoral compounds
PCT/GB2002/003197 WO2003006457A1 (en) 2001-07-11 2002-07-11 Variolin derivatives and their use as antitumor agents

Publications (1)

Publication Number Publication Date
DE60226869D1 true DE60226869D1 (de) 2008-07-10

Family

ID=9918335

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60226869T Expired - Lifetime DE60226869D1 (de) 2001-07-11 2002-07-11 Variolinderivate und ihre verwendung als cytostatika
DE60237652T Expired - Lifetime DE60237652D1 (de) 2001-07-11 2002-07-11 Variolinderivate und ihre Verwendung als Cytostatika

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60237652T Expired - Lifetime DE60237652D1 (de) 2001-07-11 2002-07-11 Variolinderivate und ihre Verwendung als Cytostatika

Country Status (20)

Country Link
US (2) US7495000B2 (de)
EP (2) EP1404668B1 (de)
JP (1) JP4369225B2 (de)
KR (1) KR100929616B1 (de)
CN (1) CN1553906B (de)
AT (2) ATE396987T1 (de)
AU (1) AU2002317329B2 (de)
CA (1) CA2453418C (de)
DE (2) DE60226869D1 (de)
ES (2) ES2354991T3 (de)
GB (1) GB0116966D0 (de)
HK (1) HK1060354A1 (de)
HU (1) HUP0402658A2 (de)
IL (2) IL159792A0 (de)
MX (1) MXPA04000355A (de)
NO (1) NO328848B1 (de)
NZ (1) NZ530556A (de)
PL (1) PL366894A1 (de)
RU (1) RU2302419C2 (de)
WO (1) WO2003006457A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1299388T3 (da) 2000-07-11 2009-08-31 Pharma Mar Sa Variolin-derivater som anti-cancermidler
GB0019117D0 (en) 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
DK2300475T3 (en) * 2008-06-11 2014-12-08 Genentech Inc Diazacarbazoler and methods of using
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1299388T3 (da) * 2000-07-11 2009-08-31 Pharma Mar Sa Variolin-derivater som anti-cancermidler
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
KR20040023649A (ko) 2004-03-18
EP1867645B1 (de) 2010-09-08
JP4369225B2 (ja) 2009-11-18
CN1553906A (zh) 2004-12-08
NO20040113L (no) 2004-03-09
RU2302419C2 (ru) 2007-07-10
EP1867645A1 (de) 2007-12-19
NO328848B1 (no) 2010-05-31
DE60237652D1 (de) 2010-10-21
CN1553906B (zh) 2010-04-28
JP2004536850A (ja) 2004-12-09
NZ530556A (en) 2005-07-29
US7495000B2 (en) 2009-02-24
PL366894A1 (en) 2005-02-07
AU2002317329B2 (en) 2008-10-02
EP1404668B1 (de) 2008-05-28
KR100929616B1 (ko) 2009-12-03
ATE396987T1 (de) 2008-06-15
IL159792A0 (en) 2004-06-20
HUP0402658A2 (hu) 2005-04-28
ES2354991T3 (es) 2011-03-21
US20060235223A1 (en) 2006-10-19
ES2307768T3 (es) 2008-12-01
RU2004103857A (ru) 2005-06-20
CA2453418C (en) 2011-05-17
IL159792A (en) 2009-08-03
MXPA04000355A (es) 2005-03-07
CA2453418A1 (en) 2003-01-23
GB0116966D0 (en) 2001-09-05
HK1060354A1 (en) 2004-08-06
WO2003006457A1 (en) 2003-01-23
US7772241B2 (en) 2010-08-10
EP1404668A1 (de) 2004-04-07
US20090197901A1 (en) 2009-08-06
ATE480533T1 (de) 2010-09-15

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