HK1060354A1 - Variolin derivatives and their use as antitumor agents - Google Patents

Variolin derivatives and their use as antitumor agents

Info

Publication number
HK1060354A1
HK1060354A1 HK04103219A HK04103219A HK1060354A1 HK 1060354 A1 HK1060354 A1 HK 1060354A1 HK 04103219 A HK04103219 A HK 04103219A HK 04103219 A HK04103219 A HK 04103219A HK 1060354 A1 HK1060354 A1 HK 1060354A1
Authority
HK
Hong Kong
Prior art keywords
substituted
antitumor agents
unsubstituted
groups
alkynyl
Prior art date
Application number
HK04103219A
Other languages
English (en)
Inventor
Remuinan Modesto
Gonzalez Juan Jose
Del Pozo Carlos
Francesch Andres
Cuevas Carmen
Munt Simon
Manzanares Ignacio
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of HK1060354A1 publication Critical patent/HK1060354A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK04103219A 2001-07-11 2004-05-07 Variolin derivatives and their use as antitumor agents HK1060354A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116966.3A GB0116966D0 (en) 2001-07-11 2001-07-11 Anittumoral compounds
PCT/GB2002/003197 WO2003006457A1 (en) 2001-07-11 2002-07-11 Variolin derivatives and their use as antitumor agents

Publications (1)

Publication Number Publication Date
HK1060354A1 true HK1060354A1 (en) 2004-08-06

Family

ID=9918335

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04103219A HK1060354A1 (en) 2001-07-11 2004-05-07 Variolin derivatives and their use as antitumor agents

Country Status (20)

Country Link
US (2) US7495000B2 (hu)
EP (2) EP1404668B1 (hu)
JP (1) JP4369225B2 (hu)
KR (1) KR100929616B1 (hu)
CN (1) CN1553906B (hu)
AT (2) ATE396987T1 (hu)
AU (1) AU2002317329B2 (hu)
CA (1) CA2453418C (hu)
DE (2) DE60226869D1 (hu)
ES (2) ES2354991T3 (hu)
GB (1) GB0116966D0 (hu)
HK (1) HK1060354A1 (hu)
HU (1) HUP0402658A2 (hu)
IL (2) IL159792A0 (hu)
MX (1) MXPA04000355A (hu)
NO (1) NO328848B1 (hu)
NZ (1) NZ530556A (hu)
PL (1) PL366894A1 (hu)
RU (1) RU2302419C2 (hu)
WO (1) WO2003006457A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1299388T3 (da) 2000-07-11 2009-08-31 Pharma Mar Sa Variolin-derivater som anti-cancermidler
GB0019117D0 (en) 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
DK2300475T3 (en) * 2008-06-11 2014-12-08 Genentech Inc Diazacarbazoler and methods of using
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1299388T3 (da) * 2000-07-11 2009-08-31 Pharma Mar Sa Variolin-derivater som anti-cancermidler
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
KR20040023649A (ko) 2004-03-18
EP1867645B1 (en) 2010-09-08
JP4369225B2 (ja) 2009-11-18
CN1553906A (zh) 2004-12-08
NO20040113L (no) 2004-03-09
RU2302419C2 (ru) 2007-07-10
EP1867645A1 (en) 2007-12-19
NO328848B1 (no) 2010-05-31
DE60237652D1 (de) 2010-10-21
CN1553906B (zh) 2010-04-28
JP2004536850A (ja) 2004-12-09
NZ530556A (en) 2005-07-29
US7495000B2 (en) 2009-02-24
PL366894A1 (en) 2005-02-07
AU2002317329B2 (en) 2008-10-02
EP1404668B1 (en) 2008-05-28
KR100929616B1 (ko) 2009-12-03
DE60226869D1 (de) 2008-07-10
ATE396987T1 (de) 2008-06-15
IL159792A0 (en) 2004-06-20
HUP0402658A2 (hu) 2005-04-28
ES2354991T3 (es) 2011-03-21
US20060235223A1 (en) 2006-10-19
ES2307768T3 (es) 2008-12-01
RU2004103857A (ru) 2005-06-20
CA2453418C (en) 2011-05-17
IL159792A (en) 2009-08-03
MXPA04000355A (es) 2005-03-07
CA2453418A1 (en) 2003-01-23
GB0116966D0 (en) 2001-09-05
WO2003006457A1 (en) 2003-01-23
US7772241B2 (en) 2010-08-10
EP1404668A1 (en) 2004-04-07
US20090197901A1 (en) 2009-08-06
ATE480533T1 (de) 2010-09-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120711