IL159674A0 - Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences - Google Patents
Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequencesInfo
- Publication number
- IL159674A0 IL159674A0 IL15967402A IL15967402A IL159674A0 IL 159674 A0 IL159674 A0 IL 159674A0 IL 15967402 A IL15967402 A IL 15967402A IL 15967402 A IL15967402 A IL 15967402A IL 159674 A0 IL159674 A0 IL 159674A0
- Authority
- IL
- Israel
- Prior art keywords
- dna sequences
- detecting
- methods
- gene transcription
- transcription regulatory
- Prior art date
Links
- 230000001105 regulatory effect Effects 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000013518 transcription Methods 0.000 title 1
- 230000035897 transcription Effects 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01202581A EP1273666A1 (en) | 2001-07-04 | 2001-07-04 | Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
US30319901P | 2001-07-05 | 2001-07-05 | |
PCT/NL2002/000390 WO2003004704A2 (en) | 2001-07-04 | 2002-06-14 | Method of selecting dna sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
US10/190,312 US7192741B2 (en) | 2001-07-04 | 2002-07-05 | DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159674A0 true IL159674A0 (en) | 2004-06-20 |
Family
ID=47915807
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15967402A IL159674A0 (en) | 2001-07-04 | 2002-06-14 | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
IL159674A IL159674A (en) | 2001-07-04 | 2004-01-01 | DNA sequences that have the ability to regulate transcription and methods for detecting and using these sequences |
IL193373A IL193373A (en) | 2001-07-04 | 2008-08-11 | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
IL193374A IL193374A (en) | 2001-07-04 | 2008-08-11 | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL159674A IL159674A (en) | 2001-07-04 | 2004-01-01 | DNA sequences that have the ability to regulate transcription and methods for detecting and using these sequences |
IL193373A IL193373A (en) | 2001-07-04 | 2008-08-11 | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
IL193374A IL193374A (en) | 2001-07-04 | 2008-08-11 | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
Country Status (22)
Country | Link |
---|---|
US (9) | US7192741B2 (no) |
EP (8) | EP1842919B1 (no) |
JP (3) | JP4500044B2 (no) |
KR (2) | KR100942117B1 (no) |
CN (1) | CN1266282C (no) |
AT (8) | ATE467682T1 (no) |
AU (3) | AU2002314629B2 (no) |
BR (1) | BRPI0210771B8 (no) |
CA (2) | CA2450020C (no) |
CY (1) | CY1107678T1 (no) |
DE (8) | DE60236331D1 (no) |
DK (8) | DK1806407T3 (no) |
ES (8) | ES2344074T3 (no) |
HK (1) | HK1068652A1 (no) |
IL (4) | IL159674A0 (no) |
MX (1) | MXPA03011801A (no) |
NO (1) | NO338477B1 (no) |
NZ (1) | NZ530218A (no) |
PT (1) | PT1600510E (no) |
SG (1) | SG143066A1 (no) |
WO (1) | WO2003004704A2 (no) |
ZA (1) | ZA200309599B (no) |
Families Citing this family (51)
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DE60236331D1 (de) | 2001-07-04 | 2010-06-17 | Chromagenics Bv | DNS-Sequenzen mit Anti-Repressor-Aktivität |
WO2003106674A2 (en) * | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
CA2489475C (en) * | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
DK1523496T3 (da) | 2002-07-18 | 2011-10-17 | Merus B V | Rekombinant fremstilling af blanding af antistoffer |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
ATE524559T1 (de) | 2002-12-18 | 2011-09-15 | Chromagenics Bv | Methode zur verbesserung der proteinproduktion |
DE60312039T2 (de) | 2002-12-20 | 2007-11-08 | Chromagenics B.V. | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
CN102174536B (zh) | 2003-10-02 | 2013-02-13 | 克鲁塞尔荷兰公司 | 用于重组腺病毒的包装细胞 |
WO2005059149A2 (en) * | 2003-12-12 | 2005-06-30 | Chromagenics B.V. | Improved protein production |
WO2005068622A2 (en) | 2004-01-20 | 2005-07-28 | Merus B.V. | Mixtures of binding proteins |
JP4805262B2 (ja) * | 2004-07-08 | 2011-11-02 | クロマジェニックス ベー ヴェー | 核酸の発現を改善するための新規配列 |
EP1786908B1 (en) * | 2004-08-18 | 2010-03-03 | Bayer CropScience AG | Plants with increased plastidic activity of r3 starch-phosphorylating enzyme |
EA010863B1 (ru) | 2004-11-08 | 2008-12-30 | Хромагеникс Б.В. | Отбор клеток-хозяев, экспрессирующих белок на высоких уровнях |
ES2384391T3 (es) * | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
JP5098014B2 (ja) * | 2004-11-18 | 2012-12-12 | 国立大学法人広島大学 | 遺伝子増幅により形成された反復配列から、発現抑制されているタンパク質を発現させる方法、キット、および形質転換体 |
US7968700B2 (en) | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
CN101627123A (zh) * | 2007-01-08 | 2010-01-13 | 米利波尔公司 | 消除基因扩增的高表达细胞系 |
CN102459607B (zh) | 2009-06-15 | 2014-08-06 | 萨拉基尼克有限公司 | 新的严格的可选择的标志物 |
US8566596B2 (en) | 2010-08-24 | 2013-10-22 | Cisco Technology, Inc. | Pre-association mechanism to provide detailed description of wireless services |
CN103180443B (zh) | 2010-09-01 | 2016-01-13 | 萨拉基尼克有限公司 | 用于增强基因表达的来自核糖体蛋白启动子的核酸片段 |
EP3594232A1 (en) | 2012-04-20 | 2020-01-15 | Merus N.V. | Methods and means for the production of ig-like molecules |
EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
EP3470431A1 (en) | 2012-09-27 | 2019-04-17 | Merus N.V. | Bispecific igg antibodies as t cell engagers |
US10417380B1 (en) | 2013-12-31 | 2019-09-17 | Mckesson Corporation | Systems and methods for determining and communicating a prescription benefit coverage denial to a prescriber |
US10489552B2 (en) | 2014-02-14 | 2019-11-26 | Mckesson Corporation | Systems and methods for determining and communicating patient incentive information to a prescriber |
KR20240042540A (ko) | 2014-02-28 | 2024-04-02 | 메뤼스 엔.페. | ErbB-2와 ErbB-3에 결합하는 항체 |
JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
US10157262B1 (en) | 2015-03-10 | 2018-12-18 | Mckesson Corporation | Systems and methods for determining patient financial responsibility for multiple prescription products |
RS57928B1 (sr) | 2015-07-10 | 2019-01-31 | Merus Nv | Antitela koja vezuju humani cd3 |
PL3365373T3 (pl) | 2015-10-23 | 2021-08-23 | Merus N.V. | Molekuły wiążące, które hamują wzrost nowotworu |
US11514137B1 (en) | 2016-03-30 | 2022-11-29 | Mckesson Corporation | Alternative therapy identification system |
US10999224B1 (en) | 2017-02-01 | 2021-05-04 | Mckesson Corporation | Method and apparatus for parsing an electronic message and constructing multiple differently prioritized messages therefrom |
CN110650752A (zh) | 2017-03-31 | 2020-01-03 | 美勒斯公司 | 用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体 |
SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
US10862832B1 (en) | 2018-07-24 | 2020-12-08 | Mckesson Corporation | Computing system and method for automatically reversing an action indicated by an electronic message |
US11043437B2 (en) | 2019-01-07 | 2021-06-22 | Applied Materials, Inc. | Transparent substrate with light blocking edge exclusion zone |
US11562437B1 (en) | 2019-06-26 | 2023-01-24 | Mckesson Corporation | Method, apparatus, and computer program product for providing estimated prescription costs |
US11636548B1 (en) | 2019-06-26 | 2023-04-25 | Mckesson Corporation | Method, apparatus, and computer program product for providing estimated prescription costs |
EP3772518A1 (en) | 2019-08-07 | 2021-02-10 | Merus N.V. | Modified human variable domains |
US20230104317A1 (en) * | 2020-01-31 | 2023-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and Methods to Identify Genetic Silencers and Applications Thereof |
US11610240B1 (en) | 2020-02-17 | 2023-03-21 | Mckesson Corporation | Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction |
AR122132A1 (es) | 2020-05-21 | 2022-08-17 | Merus Nv | Métodos y medios para producción de moléculas tipo ig |
US11587657B2 (en) | 2020-09-04 | 2023-02-21 | Mckesson Corporation | Method, apparatus, and computer program product for performing an alternative evaluation procedure in response to an electronic message |
CN113539357B (zh) * | 2021-06-10 | 2024-04-30 | 阿里巴巴达摩院(杭州)科技有限公司 | 基因检测方法、模型训练方法、装置、设备及系统 |
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EP1273666A1 (en) | 2001-07-04 | 2003-01-08 | Chromagenics B.V. | Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
CA2489475C (en) * | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
WO2003106674A2 (en) | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
ATE524559T1 (de) | 2002-12-18 | 2011-09-15 | Chromagenics Bv | Methode zur verbesserung der proteinproduktion |
DE60312039T2 (de) | 2002-12-20 | 2007-11-08 | Chromagenics B.V. | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
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2002
- 2002-06-14 DE DE60236331T patent/DE60236331D1/de not_active Expired - Lifetime
- 2002-06-14 EP EP06124491A patent/EP1842919B1/en not_active Expired - Lifetime
- 2002-06-14 EP EP05076209A patent/EP1600510B1/en not_active Expired - Lifetime
- 2002-06-14 BR BRPI0210771A patent/BRPI0210771B8/pt not_active IP Right Cessation
- 2002-06-14 ES ES06124491T patent/ES2344074T3/es not_active Expired - Lifetime
- 2002-06-14 DE DE60236334T patent/DE60236334D1/de not_active Expired - Lifetime
- 2002-06-14 EP EP06124481A patent/EP1845162B1/en not_active Expired - Lifetime
- 2002-06-14 EP EP06124475A patent/EP1829971B1/en not_active Expired - Lifetime
- 2002-06-14 EP EP02741531A patent/EP1404872B1/en not_active Expired - Lifetime
- 2002-06-14 DK DK06124470.3T patent/DK1806407T3/da active
- 2002-06-14 DE DE60237048T patent/DE60237048D1/de not_active Expired - Lifetime
- 2002-06-14 ES ES06124470T patent/ES2344070T3/es not_active Expired - Lifetime
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