ATE467682T1 - Dns-sequenzen mit anti-repressor aktivität - Google Patents

Dns-sequenzen mit anti-repressor aktivität

Info

Publication number
ATE467682T1
ATE467682T1 AT06124482T AT06124482T ATE467682T1 AT E467682 T1 ATE467682 T1 AT E467682T1 AT 06124482 T AT06124482 T AT 06124482T AT 06124482 T AT06124482 T AT 06124482T AT E467682 T1 ATE467682 T1 AT E467682T1
Authority
AT
Austria
Prior art keywords
regulatory sequences
repressor activity
sequences
dns
dns sequences
Prior art date
Application number
AT06124482T
Other languages
English (en)
Inventor
Arie Pieter Otte
Arhur Leo Kruckeberg
Original Assignee
Chromagenics Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202581A external-priority patent/EP1273666A1/de
Application filed by Chromagenics Bv filed Critical Chromagenics Bv
Application granted granted Critical
Publication of ATE467682T1 publication Critical patent/ATE467682T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT06124482T 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität ATE467682T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01202581A EP1273666A1 (de) 2001-07-04 2001-07-04 Verfahren zur Selektion einer transkription-modulatierenden DNA-Sequenz unter Verwendung einem Vektor mit einem transkriptions-repressions-aktivem Element
US30319901P 2001-07-05 2001-07-05
US10/190,312 US7192741B2 (en) 2001-07-04 2002-07-05 DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

Publications (1)

Publication Number Publication Date
ATE467682T1 true ATE467682T1 (de) 2010-05-15

Family

ID=47915807

Family Applications (8)

Application Number Title Priority Date Filing Date
AT06124470T ATE466941T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor-aktivität
AT06124475T ATE466942T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT05076209T ATE358183T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT06124482T ATE467682T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT06124481T ATE466944T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT06124465T ATE474053T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor-aktivität
AT02741531T ATE343004T1 (de) 2001-07-04 2002-06-14 Verfahren zur selektion einer transkription- modulatierenden dna-sequenz unter verwendung einem vektor mit einem transkriptions-repressions-aktivem element
AT06124491T ATE466943T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT06124470T ATE466941T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor-aktivität
AT06124475T ATE466942T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT05076209T ATE358183T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT06124481T ATE466944T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität
AT06124465T ATE474053T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor-aktivität
AT02741531T ATE343004T1 (de) 2001-07-04 2002-06-14 Verfahren zur selektion einer transkription- modulatierenden dna-sequenz unter verwendung einem vektor mit einem transkriptions-repressions-aktivem element
AT06124491T ATE466943T1 (de) 2001-07-04 2002-06-14 Dns-sequenzen mit anti-repressor aktivität

Country Status (21)

Country Link
US (9) US7192741B2 (de)
EP (8) EP1842919B1 (de)
JP (3) JP4500044B2 (de)
KR (2) KR100942117B1 (de)
CN (1) CN1266282C (de)
AT (8) ATE466941T1 (de)
AU (3) AU2002314629B2 (de)
BR (1) BRPI0210771B8 (de)
CA (2) CA2450020C (de)
CY (1) CY1107678T1 (de)
DE (8) DE60236379D1 (de)
DK (8) DK1806407T3 (de)
ES (8) ES2344072T3 (de)
IL (4) IL159674A0 (de)
MX (1) MXPA03011801A (de)
NO (1) NO338477B1 (de)
NZ (1) NZ530218A (de)
PT (1) PT1600510E (de)
SG (1) SG143066A1 (de)
WO (1) WO2003004704A2 (de)
ZA (1) ZA200309599B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE466941T1 (de) 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor-aktivität
NZ537073A (en) * 2002-06-14 2006-08-31 Chromagenics B A method for simultaneous production of multiple proteins; vectors and cells for use therein
EP1513936A2 (de) * 2002-06-14 2005-03-16 Chromagenics B.V. Verwendung von repression hemmende sequenzen in verfahren zur genexpression verbesserung
AU2003250074B2 (en) 2002-07-18 2010-09-09 Merus N.V. Recombinant production of mixtures of antibodies
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ATE524559T1 (de) 2002-12-18 2011-09-15 Chromagenics Bv Methode zur verbesserung der proteinproduktion
WO2004056986A2 (en) 2002-12-20 2004-07-08 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
EP2395017A3 (de) 2003-05-30 2012-12-19 Merus B.V. Entwurf und Verwendung von gepaarten unterschiedlichen Regionen von spezifisch bindenden Molekülen
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CA2538025C (en) 2003-10-02 2012-07-17 Crucell Holland B.V. Packaging cells for recombinant adenovirus
WO2005059149A2 (en) * 2003-12-12 2005-06-30 Chromagenics B.V. Improved protein production
JP5912211B2 (ja) 2004-01-20 2016-04-27 メルス ビー．ヴィー． 結合タンパク質の混合物
BRPI0512798A (pt) 2004-07-08 2008-04-08 Chromagenics Bv molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse
DK1786908T3 (da) * 2004-08-18 2010-06-07 Bayer Cropscience Ag Planter med forøget plastidisk aktivitet af stivelsesphosphorylerende R3-enzym
JP5291341B2 (ja) * 2004-11-08 2013-09-18 クロマジェニックス ベー ヴェー タンパク質を高レベルで発現する宿主細胞の選定
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
SI1809750T1 (sl) 2004-11-08 2012-08-31 Chromagenics Bv Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina
DE602005027738D1 (de) * 2004-11-18 2011-06-09 Univ Hiroshima Nat Univ Corp Verfahren und kit zur expression von protein unter regulation der expression von einer durch genamplifikation gebildeten wiederholungssequenz und transformant
EP1996705B1 (de) 2006-03-20 2011-08-31 ChromaGenics B.V. Die expression verstärkende dna-fragmente, deren verwendung und verfahren zum finden dieser
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
CN101627123A (zh) * 2007-01-08 2010-01-13 米利波尔公司 消除基因扩增的高表达细胞系
BRPI1013141A2 (pt) 2009-06-15 2015-10-06 Cellagenics B V novos marcadores selecionaveis rigorosos
US8566596B2 (en) 2010-08-24 2013-10-22 Cisco Technology, Inc. Pre-association mechanism to provide detailed description of wireless services
WO2012030218A1 (en) 2010-09-01 2012-03-08 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
CN120383672A (zh) 2012-04-20 2025-07-29 美勒斯公司 用于产生免疫球蛋白样分子的方法和手段
JP6514103B2 (ja) 2012-07-06 2019-05-15 ゲンマブ ビー．ブイ． 三重変異を有する二量体タンパク質
PT2900694T (pt) 2012-09-27 2018-11-13 Merus Nv Anticorpos de igg biespecíficos como ativadores de células t
US10417380B1 (en) 2013-12-31 2019-09-17 Mckesson Corporation Systems and methods for determining and communicating a prescription benefit coverage denial to a prescriber
US10489552B2 (en) 2014-02-14 2019-11-26 Mckesson Corporation Systems and methods for determining and communicating patient incentive information to a prescriber
IL301147A (en) 2014-02-28 2023-05-01 Merus Nv An antibody that binds to ErbB-2 and ErbB-3
EP3110846B1 (de) 2014-02-28 2020-08-19 Merus N.V. Egfr- und erbb3-bindende antikörper
US10157262B1 (en) 2015-03-10 2018-12-18 Mckesson Corporation Systems and methods for determining patient financial responsibility for multiple prescription products
HUE042039T2 (hu) 2015-07-10 2019-06-28 Merus Nv Humán CD3 kötõ antitest
HUE055222T2 (hu) 2015-10-23 2021-11-29 Merus Nv Megkötõ molekulák, amelyek gátolják a rák növekedését
US11514137B1 (en) 2016-03-30 2022-11-29 Mckesson Corporation Alternative therapy identification system
US10999224B1 (en) 2017-02-01 2021-05-04 Mckesson Corporation Method and apparatus for parsing an electronic message and constructing multiple differently prioritized messages therefrom
CN110650752A (zh) 2017-03-31 2020-01-03 美勒斯公司 用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体
EA201992522A1 (ru) 2017-05-17 2020-04-22 Мерус Н.В. КОМБИНАЦИЯ БИСПЕЦИФИЧЕСКОГО АНТИТЕЛА К ErbB-2/ErbB-3 С ЭНДОКРИННОЙ ТЕРАПИЕЙ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ
EP3665198B9 (de) 2017-08-09 2025-05-21 Merus N.V. Egfr- und cmet-bindende antikörper
US10862832B1 (en) 2018-07-24 2020-12-08 Mckesson Corporation Computing system and method for automatically reversing an action indicated by an electronic message
US11043437B2 (en) 2019-01-07 2021-06-22 Applied Materials, Inc. Transparent substrate with light blocking edge exclusion zone
US12469040B1 (en) 2019-06-26 2025-11-11 Mckesson Corporation Method, apparatus, and computer program product for providing real-time pricing information
US11562437B1 (en) 2019-06-26 2023-01-24 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
US11636548B1 (en) 2019-06-26 2023-04-25 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
EP3772518A1 (de) 2019-08-07 2021-02-10 Merus N.V. Modifizierte menschliche variable domänen
WO2021155369A1 (en) * 2020-01-31 2021-08-05 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods to identify genetic silencers and applications thereof
US12229834B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US11610240B1 (en) 2020-02-17 2023-03-21 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US12229833B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for reformatting an electronic prescription transaction
PH12022553147A1 (en) 2020-05-21 2024-03-04 Merus Nv Methods and means for the production of ig-like molecules
US11587657B2 (en) 2020-09-04 2023-02-21 Mckesson Corporation Method, apparatus, and computer program product for performing an alternative evaluation procedure in response to an electronic message
US12367954B1 (en) 2021-01-08 2025-07-22 Mckesson Corporation Method, apparatus, and computer program product for estimating a target quantitative measure based upon historical electronic messages
CN113539357B (zh) * 2021-06-10 2024-04-30 阿里巴巴达摩院(杭州)科技有限公司 基因检测方法、模型训练方法、装置、设备及系统
US12197972B1 (en) 2022-03-28 2025-01-14 Mckesson Corporation Method, apparatus, and computer program product for generating alternative evaluation messages

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US719271A (en) * 1902-01-13 1903-01-27 Solomon P Smith Furnace.
US5610053A (en) 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5972605A (en) * 1994-07-07 1999-10-26 Geron Corporation Assays for regulators of mammalian telomerase expression
WO1996030522A1 (en) * 1995-03-24 1996-10-03 Shionogi & Co., Ltd. Dna molecule relating to suppression of gene expression and novel protein
DE19539493A1 (de) * 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US6037525A (en) * 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
CA2333852C (en) 1998-07-21 2007-05-29 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
AU5450599A (en) 1998-08-14 2000-03-06 Stichting Voor De Technische Wetenschappen Method of detecting a dna sequence, a dna sequence, a method of making a dna construct and the use thereof
US6800457B2 (en) 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6521419B1 (en) 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
AU1128400A (en) 1998-10-22 2000-05-08 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
NZ517215A (en) * 1999-08-25 2004-01-30 Immunex Corp Compositions and methods for improved cell culture
AU2001238178A1 (en) 2000-02-11 2001-08-20 Millennium Pharmaceuticals, Inc. Seven-transmembrane proteins/g-protein coupled receptors
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
AU2001290067B2 (en) 2000-09-20 2007-04-05 Emd Millipore Corporation Artificial ubiquitous chromatin opening elements (UCOE)
ATE466941T1 (de) 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor-aktivität
EP1273666A1 (de) 2001-07-04 2003-01-08 Chromagenics B.V. Verfahren zur Selektion einer transkription-modulatierenden DNA-Sequenz unter Verwendung einem Vektor mit einem transkriptions-repressions-aktivem Element
EP1513936A2 (de) 2002-06-14 2005-03-16 Chromagenics B.V. Verwendung von repression hemmende sequenzen in verfahren zur genexpression verbesserung
NZ537073A (en) * 2002-06-14 2006-08-31 Chromagenics B A method for simultaneous production of multiple proteins; vectors and cells for use therein
ATE524559T1 (de) 2002-12-18 2011-09-15 Chromagenics Bv Methode zur verbesserung der proteinproduktion
WO2004056986A2 (en) 2002-12-20 2004-07-08 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors

Also Published As

Publication number Publication date
ZA200309599B (en) 2006-05-31
IL193373A (en) 2010-12-30
SG143066A1 (en) 2008-06-27
DE60236333D1 (de) 2010-06-17
ATE343004T1 (de) 2006-11-15
IL193374A (en) 2010-12-30
JP4500044B2 (ja) 2010-07-14
EP1829971B1 (de) 2010-05-05
DK1806407T3 (da) 2010-08-16
US7749733B2 (en) 2010-07-06
ES2344074T3 (es) 2010-08-17
US7662591B2 (en) 2010-02-16
EP1806407A2 (de) 2007-07-11
NO20040011L (no) 2004-03-03
DE60236331D1 (de) 2010-06-17
US20070037256A1 (en) 2007-02-15
MXPA03011801A (es) 2005-03-07
DK1829971T3 (da) 2010-08-16
ES2344072T3 (es) 2010-08-17
BRPI0210771B1 (pt) 2015-12-22
EP1806407A3 (de) 2008-06-04
US7736869B2 (en) 2010-06-15
EP1842919A1 (de) 2007-10-10
CA2450020C (en) 2013-08-13
EP1806407B1 (de) 2010-05-05
US20070031934A1 (en) 2007-02-08
US7659094B2 (en) 2010-02-09
DE60215502T2 (de) 2007-08-30
ES2344070T3 (es) 2010-08-17
KR100942117B1 (ko) 2010-02-12
US7192741B2 (en) 2007-03-20
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JP2004533262A (ja) 2004-11-04
ATE466943T1 (de) 2010-05-15
HK1068652A1 (en) 2005-04-29
KR100942116B1 (ko) 2010-02-12
EP1829972A3 (de) 2007-10-24
JP2010131024A (ja) 2010-06-17
US20070026499A1 (en) 2007-02-01
CA2812799C (en) 2016-01-26
NZ530218A (en) 2005-09-30
DE60236334D1 (de) 2010-06-17
EP1600510B1 (de) 2007-03-28
US7655441B2 (en) 2010-02-02
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US20070026498A1 (en) 2007-02-01
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EP1808488A3 (de) 2007-11-14
EP1829971A1 (de) 2007-09-05
ATE358183T1 (de) 2007-04-15
US20070031935A1 (en) 2007-02-08
BR0210771A (pt) 2004-07-13
CA2450020A1 (en) 2003-01-16
AU2007234619B2 (en) 2011-06-02
KR20090037960A (ko) 2009-04-16
CA2812799A1 (en) 2003-01-16
ES2344073T3 (es) 2010-08-17
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ES2285630T3 (es) 2007-11-16
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ATE474053T1 (de) 2010-07-15
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US20070128717A1 (en) 2007-06-07
ES2348174T3 (es) 2010-11-30
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US20070031936A1 (en) 2007-02-08
AU2002314629B2 (en) 2007-08-30
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EP1600510A3 (de) 2006-02-22
DE60219221D1 (de) 2007-05-10
DK1845162T3 (da) 2010-08-16
US7736868B2 (en) 2010-06-15
DK1842919T3 (da) 2010-08-16
EP1808488A2 (de) 2007-07-18
PT1600510E (pt) 2007-06-25
IL159674A (en) 2009-02-11
CN1266282C (zh) 2006-07-26
ES2344071T3 (es) 2010-08-17
EP1404872A2 (de) 2004-04-07
JP2010131025A (ja) 2010-06-17
DE60215502D1 (de) 2006-11-30
DE60236379D1 (de) 2010-06-24
EP1600510A2 (de) 2005-11-30
DK1829972T3 (da) 2010-09-13
ES2274045T3 (es) 2007-05-16
EP1829972B1 (de) 2010-05-12
JP5014444B2 (ja) 2012-08-29
EP1829971A3 (de) 2008-06-04
AU2011202193B2 (en) 2011-09-29
EP1808488B1 (de) 2010-07-14
CN1524128A (zh) 2004-08-25
ATE466944T1 (de) 2010-05-15
KR20090037485A (ko) 2009-04-15
ATE466942T1 (de) 2010-05-15
WO2003004704A2 (en) 2003-01-16
NO338477B1 (no) 2016-08-22
US20030199468A1 (en) 2003-10-23
EP1845162A1 (de) 2007-10-17
US7736870B2 (en) 2010-06-15
ATE466941T1 (de) 2010-05-15
AU2011202193A1 (en) 2011-06-02
JP5014443B2 (ja) 2012-08-29
WO2003004704A3 (en) 2003-10-16
IL159674A0 (en) 2004-06-20
US7951586B2 (en) 2011-05-31
BRPI0210771B8 (pt) 2021-05-25
US20070031933A1 (en) 2007-02-08

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