DE60237048D1 - DNS-Sequenzen mit Anti-Repressor-Aktivität - Google Patents

DNS-Sequenzen mit Anti-Repressor-Aktivität

Info

Publication number
DE60237048D1
DE60237048D1 DE60237048T DE60237048T DE60237048D1 DE 60237048 D1 DE60237048 D1 DE 60237048D1 DE 60237048 T DE60237048 T DE 60237048T DE 60237048 T DE60237048 T DE 60237048T DE 60237048 D1 DE60237048 D1 DE 60237048D1
Authority
DE
Germany
Prior art keywords
dna sequences
regulatory sequences
repressor activity
provides
screenings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237048T
Other languages
English (en)
Inventor
Arie Pieter Otte
Arthur Leo Kruckeberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromagenics BV
Original Assignee
Chromagenics BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202581A external-priority patent/EP1273666A1/de
Application filed by Chromagenics BV filed Critical Chromagenics BV
Application granted granted Critical
Publication of DE60237048D1 publication Critical patent/DE60237048D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
DE60237048T 2001-07-04 2002-06-14 DNS-Sequenzen mit Anti-Repressor-Aktivität Expired - Lifetime DE60237048D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01202581A EP1273666A1 (de) 2001-07-04 2001-07-04 Verfahren zur Selektion einer transkription-modulatierenden DNA-Sequenz unter Verwendung einem Vektor mit einem transkriptions-repressions-aktivem Element
US30319901P 2001-07-05 2001-07-05
US10/190,312 US7192741B2 (en) 2001-07-04 2002-07-05 DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

Publications (1)

Publication Number Publication Date
DE60237048D1 true DE60237048D1 (de) 2010-08-26

Family

ID=47915807

Family Applications (8)

Application Number Title Priority Date Filing Date
DE60236331T Expired - Lifetime DE60236331D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit Anti-Repressor-Aktivität
DE60215502T Expired - Lifetime DE60215502T2 (de) 2001-07-04 2002-06-14 Verfahren zur Selektion einer Transkription-Modulatierenden DNA-Sequenz unter Verwendung einem Vektor mit einem Transkriptions-Repressions-Aktivem Element
DE60236334T Expired - Lifetime DE60236334D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60236332T Expired - Lifetime DE60236332D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60237048T Expired - Lifetime DE60237048D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit Anti-Repressor-Aktivität
DE60236333T Expired - Lifetime DE60236333D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60219221T Expired - Lifetime DE60219221T2 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60236379T Expired - Lifetime DE60236379D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DE60236331T Expired - Lifetime DE60236331D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit Anti-Repressor-Aktivität
DE60215502T Expired - Lifetime DE60215502T2 (de) 2001-07-04 2002-06-14 Verfahren zur Selektion einer Transkription-Modulatierenden DNA-Sequenz unter Verwendung einem Vektor mit einem Transkriptions-Repressions-Aktivem Element
DE60236334T Expired - Lifetime DE60236334D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60236332T Expired - Lifetime DE60236332D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE60236333T Expired - Lifetime DE60236333D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60219221T Expired - Lifetime DE60219221T2 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität
DE60236379T Expired - Lifetime DE60236379D1 (de) 2001-07-04 2002-06-14 DNS-Sequenzen mit anti-repressor Aktivität

Country Status (22)

Country Link
US (9) US7192741B2 (de)
EP (8) EP1600510B1 (de)
JP (3) JP4500044B2 (de)
KR (2) KR100942117B1 (de)
CN (1) CN1266282C (de)
AT (8) ATE466943T1 (de)
AU (3) AU2002314629B2 (de)
BR (1) BRPI0210771B8 (de)
CA (2) CA2450020C (de)
CY (1) CY1107678T1 (de)
DE (8) DE60236331D1 (de)
DK (8) DK1829971T3 (de)
ES (8) ES2285630T3 (de)
HK (1) HK1068652A1 (de)
IL (4) IL159674A0 (de)
MX (1) MXPA03011801A (de)
NO (1) NO338477B1 (de)
NZ (1) NZ530218A (de)
PT (1) PT1600510E (de)
SG (1) SG143066A1 (de)
WO (1) WO2003004704A2 (de)
ZA (1) ZA200309599B (de)

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Also Published As

Publication number Publication date
US20070037256A1 (en) 2007-02-15
AU2002314629B2 (en) 2007-08-30
AU2007234619A1 (en) 2007-12-13
EP1600510B1 (de) 2007-03-28
US7192741B2 (en) 2007-03-20
EP1829972B1 (de) 2010-05-12
PT1600510E (pt) 2007-06-25
EP1829971A3 (de) 2008-06-04
US20070031934A1 (en) 2007-02-08
EP1806407B1 (de) 2010-05-05
EP1829971A1 (de) 2007-09-05
ATE474053T1 (de) 2010-07-15
KR20090037485A (ko) 2009-04-15
DK1808488T3 (da) 2010-10-18
JP4500044B2 (ja) 2010-07-14
NO338477B1 (no) 2016-08-22
CY1107678T1 (el) 2013-04-18
ES2285630T3 (es) 2007-11-16
DK1842919T3 (da) 2010-08-16
EP1842919B1 (de) 2010-05-05
DE60215502T2 (de) 2007-08-30
ATE466941T1 (de) 2010-05-15
EP1404872B1 (de) 2006-10-18
KR100942117B1 (ko) 2010-02-12
ES2274045T3 (es) 2007-05-16
US20070031936A1 (en) 2007-02-08
JP2010131024A (ja) 2010-06-17
ATE467682T1 (de) 2010-05-15
JP2004533262A (ja) 2004-11-04
NZ530218A (en) 2005-09-30
EP1808488A3 (de) 2007-11-14
CA2450020C (en) 2013-08-13
EP1829972A2 (de) 2007-09-05
HK1068652A1 (en) 2005-04-29
KR100942116B1 (ko) 2010-02-12
US7662591B2 (en) 2010-02-16
DK1845162T3 (da) 2010-08-16
ATE466942T1 (de) 2010-05-15
DE60236334D1 (de) 2010-06-17
US7659094B2 (en) 2010-02-09
AU2011202193B2 (en) 2011-09-29
DE60236333D1 (de) 2010-06-17
BR0210771A (pt) 2004-07-13
MXPA03011801A (es) 2005-03-07
ES2344074T3 (es) 2010-08-17
DK1404872T3 (da) 2007-02-19
BRPI0210771B1 (pt) 2015-12-22
ZA200309599B (en) 2006-05-31
EP1845162B1 (de) 2010-05-05
EP1808488A2 (de) 2007-07-18
US20070128717A1 (en) 2007-06-07
US20030199468A1 (en) 2003-10-23
ES2344072T3 (es) 2010-08-17
IL193373A (en) 2010-12-30
NO20040011L (no) 2004-03-03
DK1806407T3 (da) 2010-08-16
EP1829972A3 (de) 2007-10-24
ATE466943T1 (de) 2010-05-15
US7749733B2 (en) 2010-07-06
CA2812799C (en) 2016-01-26
EP1808488B1 (de) 2010-07-14
IL159674A0 (en) 2004-06-20
CN1524128A (zh) 2004-08-25
EP1600510A3 (de) 2006-02-22
JP5014443B2 (ja) 2012-08-29
US7736870B2 (en) 2010-06-15
ES2348174T3 (es) 2010-11-30
EP1842919A1 (de) 2007-10-10
DE60219221T2 (de) 2008-01-03
EP1404872A2 (de) 2004-04-07
EP1600510A2 (de) 2005-11-30
KR20090037960A (ko) 2009-04-16
DE60236379D1 (de) 2010-06-24
US20070026499A1 (en) 2007-02-01
JP5014444B2 (ja) 2012-08-29
US7736868B2 (en) 2010-06-15
US20070026498A1 (en) 2007-02-01
AU2011202193A1 (en) 2011-06-02
WO2003004704A2 (en) 2003-01-16
ES2344073T3 (es) 2010-08-17
IL159674A (en) 2009-02-11
US7655441B2 (en) 2010-02-02
US20070031935A1 (en) 2007-02-08
ES2344071T3 (es) 2010-08-17
CA2450020A1 (en) 2003-01-16
ATE343004T1 (de) 2006-11-15
EP1845162A1 (de) 2007-10-17
EP1806407A3 (de) 2008-06-04
DE60215502D1 (de) 2006-11-30
ATE358183T1 (de) 2007-04-15
SG143066A1 (en) 2008-06-27
US7736869B2 (en) 2010-06-15
EP1829971B1 (de) 2010-05-05
JP2010131025A (ja) 2010-06-17
IL193374A (en) 2010-12-30
DK1600510T3 (da) 2007-06-25
ATE466944T1 (de) 2010-05-15
US7951586B2 (en) 2011-05-31
ES2344070T3 (es) 2010-08-17
DE60236331D1 (de) 2010-06-17
US20070031933A1 (en) 2007-02-08
CA2812799A1 (en) 2003-01-16
DK1829972T3 (da) 2010-09-13
DE60219221D1 (de) 2007-05-10
CN1266282C (zh) 2006-07-26
EP1806407A2 (de) 2007-07-11
DE60236332D1 (de) 2010-06-17
WO2003004704A3 (en) 2003-10-16
AU2007234619B2 (en) 2011-06-02
DK1829971T3 (da) 2010-08-16
BRPI0210771B8 (pt) 2021-05-25

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