BR0210771A - Métodos para selecionar uma sequência de dna com uma qualidade moduladora da transcrição de gene, para identificar uma sequência de dna com uma qualidade repressora da transcrição de gene, para detectar a presença de uma sequência star e de um elemento star dentro de uma sequência de ácido nucleico, para determinar se uma sequência de ácido nucleico compreende uma sequência star, e, para produzir um produto de gene em uma célula, sequência de ácido nucleico isolada e/ou recombinante, sequência de dna, sequência star, coleção, construção de dna, uso de uma construção ou sequência de dna, e, biblioteca de ácidos nucleicos isolados e/ou recombinantes - Google Patents
Métodos para selecionar uma sequência de dna com uma qualidade moduladora da transcrição de gene, para identificar uma sequência de dna com uma qualidade repressora da transcrição de gene, para detectar a presença de uma sequência star e de um elemento star dentro de uma sequência de ácido nucleico, para determinar se uma sequência de ácido nucleico compreende uma sequência star, e, para produzir um produto de gene em uma célula, sequência de ácido nucleico isolada e/ou recombinante, sequência de dna, sequência star, coleção, construção de dna, uso de uma construção ou sequência de dna, e, biblioteca de ácidos nucleicos isolados e/ou recombinantesInfo
- Publication number
- BR0210771A BR0210771A BR0210771-6A BR0210771A BR0210771A BR 0210771 A BR0210771 A BR 0210771A BR 0210771 A BR0210771 A BR 0210771A BR 0210771 A BR0210771 A BR 0210771A
- Authority
- BR
- Brazil
- Prior art keywords
- sequence
- nucleic acid
- star
- dna
- acid sequence
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 11
- 150000007523 nucleic acids Chemical group 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000013518 transcription Methods 0.000 title abstract 4
- 230000035897 transcription Effects 0.000 title abstract 4
- 108020004414 DNA Proteins 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 230000001718 repressive effect Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01202581A EP1273666A1 (en) | 2001-07-04 | 2001-07-04 | Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
US30319901P | 2001-07-05 | 2001-07-05 | |
PCT/NL2002/000390 WO2003004704A2 (en) | 2001-07-04 | 2002-06-14 | Method of selecting dna sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
US10/190,312 US7192741B2 (en) | 2001-07-04 | 2002-07-05 | DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0210771A true BR0210771A (pt) | 2004-07-13 |
BRPI0210771B1 BRPI0210771B1 (pt) | 2015-12-22 |
BRPI0210771B8 BRPI0210771B8 (pt) | 2021-05-25 |
Family
ID=47915807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0210771A BRPI0210771B8 (pt) | 2001-07-04 | 2002-06-14 | construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna |
Country Status (22)
Country | Link |
---|---|
US (9) | US7192741B2 (pt) |
EP (8) | EP1600510B1 (pt) |
JP (3) | JP4500044B2 (pt) |
KR (2) | KR100942116B1 (pt) |
CN (1) | CN1266282C (pt) |
AT (8) | ATE466941T1 (pt) |
AU (3) | AU2002314629B2 (pt) |
BR (1) | BRPI0210771B8 (pt) |
CA (2) | CA2812799C (pt) |
CY (1) | CY1107678T1 (pt) |
DE (8) | DE60219221T2 (pt) |
DK (8) | DK1829972T3 (pt) |
ES (8) | ES2344074T3 (pt) |
HK (1) | HK1068652A1 (pt) |
IL (4) | IL159674A0 (pt) |
MX (1) | MXPA03011801A (pt) |
NO (1) | NO338477B1 (pt) |
NZ (1) | NZ530218A (pt) |
PT (1) | PT1600510E (pt) |
SG (1) | SG143066A1 (pt) |
WO (1) | WO2003004704A2 (pt) |
ZA (1) | ZA200309599B (pt) |
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BRPI0210771B8 (pt) | 2001-07-04 | 2021-05-25 | Chromagenics Bv | construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna |
DK1513937T3 (da) * | 2002-06-14 | 2011-05-16 | Chromagenics Bv | Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved |
WO2003106674A2 (en) * | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
CA2872136C (en) | 2002-07-18 | 2017-06-20 | Merus B.V. | Recombinant production of mixtures of antibodies |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
DK1573058T3 (da) | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
AU2003290453A1 (en) | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
CA2527694C (en) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
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WO2005059149A2 (en) * | 2003-12-12 | 2005-06-30 | Chromagenics B.V. | Improved protein production |
EP1737971B1 (en) | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
KR101188013B1 (ko) | 2004-07-08 | 2012-10-08 | 크로마제닉스 비.브이. | 핵산 발현의 개선을 위한 신규한 서열 |
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US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
BRPI0517380A (pt) * | 2004-11-08 | 2008-10-07 | Chromagenics Bv | molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse |
US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
EP1870470B1 (en) * | 2004-11-18 | 2011-04-06 | National University of Corporation Hiroshima University | Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification and transformant |
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BRPI0210771B8 (pt) | 2001-07-04 | 2021-05-25 | Chromagenics Bv | construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna |
EP1273666A1 (en) | 2001-07-04 | 2003-01-08 | Chromagenics B.V. | Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
DK1513937T3 (da) * | 2002-06-14 | 2011-05-16 | Chromagenics Bv | Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved |
WO2003106674A2 (en) | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
DK1573058T3 (da) | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
AU2003290453A1 (en) | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
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2002
- 2002-06-14 BR BRPI0210771A patent/BRPI0210771B8/pt not_active IP Right Cessation
- 2002-06-14 AT AT06124470T patent/ATE466941T1/de active
- 2002-06-14 EP EP05076209A patent/EP1600510B1/en not_active Expired - Lifetime
- 2002-06-14 EP EP02741531A patent/EP1404872B1/en not_active Expired - Lifetime
- 2002-06-14 EP EP06124465A patent/EP1808488B1/en not_active Expired - Lifetime
- 2002-06-14 DK DK06124482.8T patent/DK1829972T3/da active
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