IL158770A0 - N-formyl hydroxylamine compounds as inhibitors of pdf - Google Patents
N-formyl hydroxylamine compounds as inhibitors of pdfInfo
- Publication number
- IL158770A0 IL158770A0 IL15877002A IL15877002A IL158770A0 IL 158770 A0 IL158770 A0 IL 158770A0 IL 15877002 A IL15877002 A IL 15877002A IL 15877002 A IL15877002 A IL 15877002A IL 158770 A0 IL158770 A0 IL 158770A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- hydroxylamine compounds
- formyl hydroxylamine
- formyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841901P | 2001-06-15 | 2001-06-15 | |
| US36031302P | 2002-02-27 | 2002-02-27 | |
| PCT/EP2002/006604 WO2002102790A1 (en) | 2001-06-15 | 2002-06-14 | N-formyl hydroxylamine compounds as inhibitors of pdf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL158770A0 true IL158770A0 (en) | 2004-05-12 |
Family
ID=26970649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15877002A IL158770A0 (en) | 2001-06-15 | 2002-06-14 | N-formyl hydroxylamine compounds as inhibitors of pdf |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7148242B2 (ru) |
| EP (1) | EP1401828B1 (ru) |
| JP (1) | JP4361365B2 (ru) |
| KR (2) | KR20060014083A (ru) |
| CN (1) | CN1511152A (ru) |
| AR (1) | AR036053A1 (ru) |
| AT (1) | ATE323081T1 (ru) |
| AU (1) | AU2002321062B2 (ru) |
| BR (1) | BR0210377A (ru) |
| CA (1) | CA2448526A1 (ru) |
| CO (1) | CO5640131A2 (ru) |
| CY (1) | CY1105085T1 (ru) |
| CZ (1) | CZ20033388A3 (ru) |
| DE (1) | DE60210612T2 (ru) |
| DK (1) | DK1401828T3 (ru) |
| ES (1) | ES2262824T3 (ru) |
| HK (1) | HK1064370A1 (ru) |
| HU (1) | HUP0400208A3 (ru) |
| IL (1) | IL158770A0 (ru) |
| MX (1) | MXPA03011628A (ru) |
| MY (1) | MY138619A (ru) |
| NO (1) | NO327420B1 (ru) |
| NZ (1) | NZ529489A (ru) |
| PE (1) | PE20030100A1 (ru) |
| PL (1) | PL364476A1 (ru) |
| PT (1) | PT1401828E (ru) |
| RU (1) | RU2325386C2 (ru) |
| SI (1) | SI1401828T1 (ru) |
| SK (1) | SK15242003A3 (ru) |
| WO (1) | WO2002102790A1 (ru) |
| ZA (1) | ZA200308379B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102791A1 (en) * | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
| GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| MXPA05003089A (es) | 2002-09-19 | 2005-05-27 | Novartis Ag | Proceso para preparar intermediarios. |
| AU2004216178B2 (en) * | 2003-02-21 | 2008-07-03 | Novartis Ag | Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds |
| TW200427458A (en) * | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| WO2005000835A1 (en) * | 2003-06-26 | 2005-01-06 | Novartis Ag | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
| KR100527624B1 (ko) * | 2003-08-21 | 2005-11-22 | 한기종 | 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법 |
| CN1976703A (zh) * | 2004-06-30 | 2007-06-06 | 诺瓦提斯公司 | 通过使用外排泵抑制剂增加肽脱甲酰基酶抑制剂敏感性的方法 |
| EP1827449A4 (en) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | USE OF NOVEL ANTIBACTERIAL COMPOUNDS |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| KR20080014988A (ko) | 2005-06-07 | 2008-02-15 | 노파르티스 아게 | 펩티드 데포르밀라제 (ｐｄｆ) 억제제 4 |
| DE102005026231A1 (de) * | 2005-06-07 | 2006-12-14 | Origenis Ag | Peptid-Deformylase (PDF) Inhibitoren 3 |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| JP2009529008A (ja) * | 2006-03-03 | 2009-08-13 | ノバルティス アクチエンゲゼルシャフト | Ｎ−ホルミルヒドロキシルアミン化合物 |
| CN101328155B (zh) * | 2007-06-20 | 2010-11-03 | 上海医药工业研究院 | 噁唑烷衍生物及其制备方法和应用 |
| CN101434570B (zh) * | 2007-11-16 | 2011-02-02 | 上海医药工业研究院 | 吡咯烷衍生物及其制备方法和应用 |
| CN101584694B (zh) * | 2009-06-15 | 2011-01-12 | 华东师范大学 | 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法 |
| BR112012008147A2 (pt) * | 2009-09-04 | 2016-03-01 | Novartis Ag | compostos heteroarílicos como inibidores da quinase |
| US8518948B2 (en) * | 2010-03-10 | 2013-08-27 | Ingenium Pharmaceuticals Gmbh | Inhibitors of protein kinases |
| JP5825086B2 (ja) | 2011-12-19 | 2015-12-02 | 住友化学株式会社 | α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素 |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
| JP7001898B2 (ja) * | 2016-05-11 | 2022-01-20 | グアンドン・ヘボ・ファーマシューティカル・カンパニー・リミテッド | スピロ３員環、スピロ５員環系ペプチドデホルミラーゼ阻害剤および抗菌と抗腫瘍におけるその使用 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4311705A (en) | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4321383A (en) | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| US4303662A (en) | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| JPS6188884A (ja) | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| US4599361A (en) | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5128346A (en) | 1987-09-21 | 1992-07-07 | Abbott Laboratories | Derivatives of D-glutamic acid and D-aspartic acid |
| EP0334244A3 (en) | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Bradykinin antagonist peptides |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8827308D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8919251D0 (en) | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB8921326D0 (en) | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| US5268384A (en) | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| EP0489579B1 (en) | 1990-12-03 | 1995-03-29 | Celltech Therapeutics Limited | Peptidyl derivatives |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| AU2228292A (en) | 1991-06-14 | 1993-01-12 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
| US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JPH05125029A (ja) | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| RU2091373C1 (ru) | 1991-11-08 | 1997-09-27 | Санкио Компани Лимитед | Производные пиперазинкарбоновой кислоты, способы их получения и фармацевтическая композиция |
| DE69309047T2 (de) | 1992-04-07 | 1997-09-11 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
| GB9211706D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211707D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| CA2136108A1 (en) | 1993-03-18 | 1994-09-29 | Makoto Sakamoto | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| DE69419473T2 (de) | 1993-04-27 | 2000-03-16 | Celltech Therapeutics Ltd. | Peptidylderivate als inhibitoren von metalloproteinase |
| GB9308695D0 (en) | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9411598D0 (en) | 1994-06-09 | 1994-08-03 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9502858D0 (en) | 1995-02-14 | 1995-04-05 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| GB9504084D0 (en) | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
| FR2733750B1 (fr) | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| EP0939632B1 (en) | 1996-02-23 | 2005-10-05 | Eli Lilly And Company | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| GB9613547D0 (en) | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| CA2265671A1 (en) | 1997-07-10 | 1999-01-21 | Daniela Jabes | Matrix metalloproteinase inhibitors |
| WO1999039704A1 (en) * | 1998-02-07 | 1999-08-12 | British Biotech Pharmaceuticals Limited | Antibacterial agents |
-
2002
- 2002-06-13 AR ARP020102229A patent/AR036053A1/es not_active Application Discontinuation
- 2002-06-14 DE DE60210612T patent/DE60210612T2/de not_active Expired - Lifetime
- 2002-06-14 BR BR0210377-0A patent/BR0210377A/pt not_active IP Right Cessation
- 2002-06-14 DK DK02754681T patent/DK1401828T3/da active
- 2002-06-14 CZ CZ20033388A patent/CZ20033388A3/cs unknown
- 2002-06-14 RU RU2003137565/04A patent/RU2325386C2/ru not_active IP Right Cessation
- 2002-06-14 WO PCT/EP2002/006604 patent/WO2002102790A1/en active IP Right Grant
- 2002-06-14 PT PT02754681T patent/PT1401828E/pt unknown
- 2002-06-14 NZ NZ529489A patent/NZ529489A/en unknown
- 2002-06-14 IL IL15877002A patent/IL158770A0/xx unknown
- 2002-06-14 KR KR1020067002113A patent/KR20060014083A/ko not_active Application Discontinuation
- 2002-06-14 CA CA002448526A patent/CA2448526A1/en not_active Abandoned
- 2002-06-14 CN CNA028105966A patent/CN1511152A/zh active Pending
- 2002-06-14 JP JP2003506263A patent/JP4361365B2/ja not_active Expired - Fee Related
- 2002-06-14 MY MYPI20022243A patent/MY138619A/en unknown
- 2002-06-14 KR KR1020037016435A patent/KR100589544B1/ko not_active IP Right Cessation
- 2002-06-14 PE PE2002000516A patent/PE20030100A1/es not_active Application Discontinuation
- 2002-06-14 PL PL02364476A patent/PL364476A1/xx not_active Application Discontinuation
- 2002-06-14 US US10/171,706 patent/US7148242B2/en not_active Expired - Fee Related
- 2002-06-14 HU HU0400208A patent/HUP0400208A3/hu unknown
- 2002-06-14 MX MXPA03011628A patent/MXPA03011628A/es active IP Right Grant
- 2002-06-14 ES ES02754681T patent/ES2262824T3/es not_active Expired - Lifetime
- 2002-06-14 SK SK1524-2003A patent/SK15242003A3/sk not_active Application Discontinuation
- 2002-06-14 SI SI200230358T patent/SI1401828T1/sl unknown
- 2002-06-14 EP EP02754681A patent/EP1401828B1/en not_active Expired - Lifetime
- 2002-06-14 AU AU2002321062A patent/AU2002321062B2/en not_active Ceased
- 2002-06-14 AT AT02754681T patent/ATE323081T1/de not_active IP Right Cessation
-
2003
- 2003-10-28 ZA ZA200308379A patent/ZA200308379B/en unknown
- 2003-12-03 CO CO03106413A patent/CO5640131A2/es not_active Application Discontinuation
- 2003-12-12 NO NO20035571A patent/NO327420B1/no not_active IP Right Cessation
-
2004
- 2004-09-14 HK HK04107013A patent/HK1064370A1/xx not_active IP Right Cessation
-
2006
- 2006-07-12 CY CY20061100965T patent/CY1105085T1/el unknown
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