IL155945A0 - Biphenylcarboxamides useful as lipid lowering agents - Google Patents
Biphenylcarboxamides useful as lipid lowering agentsInfo
- Publication number
- IL155945A0 IL155945A0 IL15594501A IL15594501A IL155945A0 IL 155945 A0 IL155945 A0 IL 155945A0 IL 15594501 A IL15594501 A IL 15594501A IL 15594501 A IL15594501 A IL 15594501A IL 155945 A0 IL155945 A0 IL 155945A0
- Authority
- IL
- Israel
- Prior art keywords
- biphenylcarboxamides
- useful
- lowering agents
- lipid lowering
- lipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00204150 | 2000-11-21 | ||
PCT/EP2001/013316 WO2002042271A2 (fr) | 2000-11-21 | 2001-11-15 | Biphenylcarboxamides utiles comme hypolipidemiants |
Publications (1)
Publication Number | Publication Date |
---|---|
IL155945A0 true IL155945A0 (en) | 2003-12-23 |
Family
ID=8172315
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15594501A IL155945A0 (en) | 2000-11-21 | 2001-11-15 | Biphenylcarboxamides useful as lipid lowering agents |
IL155945A IL155945A (en) | 2000-11-21 | 2003-05-15 | Biphenylcarboxamides, preparations containing them and a process for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL155945A IL155945A (en) | 2000-11-21 | 2003-05-15 | Biphenylcarboxamides, preparations containing them and a process for their preparation |
Country Status (32)
Country | Link |
---|---|
US (5) | US7135586B2 (fr) |
EP (1) | EP1339685B1 (fr) |
JP (1) | JP4190283B2 (fr) |
KR (1) | KR20030051718A (fr) |
CN (1) | CN1289481C (fr) |
AR (1) | AR035072A1 (fr) |
AT (1) | ATE344243T1 (fr) |
AU (2) | AU1911502A (fr) |
BG (1) | BG107805A (fr) |
CA (1) | CA2427660C (fr) |
CZ (1) | CZ20031638A3 (fr) |
DE (1) | DE60124296T2 (fr) |
DK (1) | DK1339685T3 (fr) |
EA (1) | EA006101B1 (fr) |
EE (1) | EE200300234A (fr) |
ES (1) | ES2275759T3 (fr) |
GC (1) | GC0000312A (fr) |
HK (1) | HK1073310A1 (fr) |
HU (1) | HUP0400926A3 (fr) |
IL (2) | IL155945A0 (fr) |
JO (1) | JO2409B1 (fr) |
MX (1) | MXPA03004465A (fr) |
MY (1) | MY134167A (fr) |
NO (1) | NO20032272L (fr) |
NZ (1) | NZ526495A (fr) |
PA (1) | PA8532001A1 (fr) |
PL (1) | PL205290B1 (fr) |
PT (1) | PT1339685E (fr) |
SI (1) | SI1339685T1 (fr) |
SK (1) | SK7522003A3 (fr) |
WO (1) | WO2002042271A2 (fr) |
ZA (1) | ZA200303910B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
WO2002098839A1 (fr) * | 2001-06-01 | 2002-12-12 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamides et procede de preparation de ceux-ci |
CN1943786A (zh) | 2002-02-28 | 2007-04-11 | 日本烟草产业株式会社 | 酯化合物及其医药用途 |
BR0307607A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como inibidores de histona desacetilase |
ES2371632T3 (es) | 2002-03-13 | 2012-01-05 | Janssen Pharmaceutica N.V. | Nuevos inhibidores de desacetilasa de histona. |
UA79300C2 (en) * | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
MXPA05006679A (es) * | 2002-12-20 | 2005-08-16 | Pfizer Prod Inc | Inhibidores de la proteina de transferencia de trigliceridos microsomales. |
DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
WO2005021486A1 (fr) | 2003-08-29 | 2005-03-10 | Japan Tobacco Inc. | Derive d'ester et utilisation medicale de celui-ci |
FR2871463B1 (fr) * | 2004-06-11 | 2006-09-22 | Merck Sante Soc Par Actions Si | Derives a structure aroyl-o-piperidine, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en therapeutique |
CA2572833C (fr) | 2004-07-28 | 2013-04-09 | Janssen Pharmaceutica N.V. | Derives d'indolyl alkyl amine substitues utilises en tant que nouveaux inhibiteurs d'histone deacetylase |
US8101774B2 (en) | 2004-10-18 | 2012-01-24 | Japan Tobacco Inc. | Ester derivatives and medicinal use thereof |
EP1948629A1 (fr) | 2005-10-31 | 2008-07-30 | Janssen Pharmaceutica N.V. | Piperazines et piperidines substituees en tant que modulateurs du recepteur du neuropeptide y2 |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
JP5247470B2 (ja) | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
WO2009006185A1 (fr) * | 2007-07-03 | 2009-01-08 | Janssen Pharmaceutica, N.V. | Dérivés pipérazinylés utiles comme modulateurs du récepteur de neuropeptide y2 |
US10491357B2 (en) * | 2010-07-12 | 2019-11-26 | Entropic Communications Llc | Method and apparatus for using dynamic subchannels in a communications network |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910930A (en) | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
US3929801A (en) | 1973-11-20 | 1975-12-30 | Janssen Pharmaceutica Nv | 2-Benzimidazolinones |
US3929601A (en) * | 1974-03-26 | 1975-12-30 | Us Energy | Synthesis of pentafluorides |
DE2852203C3 (de) * | 1978-12-02 | 1982-03-11 | Ibm Deutschland Gmbh, 7000 Stuttgart | Lichtleiteinrichtung für eine mit Auflicht betriebene Abbildungsvorrichtung |
US4231576A (en) * | 1979-02-21 | 1980-11-04 | Perkins Sonnie J | Golf club head alignment apparatus |
US4329348A (en) | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4444764A (en) * | 1979-08-06 | 1984-04-24 | The Dow Chemical Company | Phosphorus esters of alkylcycloalkyl-5-pyrimidinols and control of corn rootworm and western spotted cucumber beetle with them |
US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
DE3124366A1 (de) | 1981-06-20 | 1982-12-30 | Hoechst Ag, 6000 Frankfurt | N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
DE3410498A1 (de) * | 1984-03-22 | 1985-10-03 | Hoechst Ag, 6230 Frankfurt | N-bicycloheptyl- und n-bicycloheptenyl-imidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate |
US4647576A (en) | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
US4847271A (en) | 1986-01-27 | 1989-07-11 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
US5041432A (en) | 1987-01-30 | 1991-08-20 | E. I. Du Pont De Nemours And Company | Steroid derivatives useful as hypocholesterolemics |
GB8716059D0 (en) * | 1987-07-08 | 1987-08-12 | Anderson Strathclyde Plc | Mining machine |
DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
US5064858A (en) * | 1988-08-17 | 1991-11-12 | Spectrum Pharmaceutical Corporation | Protected complex of procaine for the treatment of symptoms from narcotics addiction, tinnitus and Alzheimer's disease |
US5232833A (en) * | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
US5064856A (en) | 1989-07-31 | 1991-11-12 | Merck & Co., Inc. | Novel hmg-coa synthase inhibitors |
US5120729A (en) | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
DE4040203A1 (de) | 1990-12-15 | 1992-06-17 | Roehm Gmbh | Eingetruebte kunststoffelemente |
WO1992018113A1 (fr) * | 1991-04-18 | 1992-10-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Identification d'une nouvelle espece d'ehrlichia a partir d'un patient souffrant d'ehrlichiose |
DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
WO1993011782A1 (fr) | 1991-12-19 | 1993-06-24 | Southwest Foundation For Biomedical Research | Polypeptide inhibant la proteine de transfert aux esters de cholesteryl, anticorps contre le polypeptide synthetique et traitements prophylactiques et therapeutiques anti-atherosclerose |
SI9300097B (en) | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
CA2091102C (fr) | 1992-03-06 | 2009-05-26 | John R. Ii Wetterau | Proteine de transfert de triglycerides microsomaux |
ATE235474T1 (de) | 1992-04-20 | 2003-04-15 | Takeda Chemical Industries Ltd | 4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizide |
US5279454A (en) | 1992-04-24 | 1994-01-18 | Eastman Kodak Company | Straight through lateral constraint |
US5327875A (en) * | 1993-02-19 | 1994-07-12 | Hall S Franklin | Vapor enhanced carburetion system |
DE4319038A1 (de) | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
US5780248A (en) * | 1993-07-15 | 1998-07-14 | Ortho Diagnostic Systems, Inc. | Foil sealed cassette for agglutination reactions and liner therefor |
FI93396C (fi) | 1993-08-17 | 1995-03-27 | Petetronic Tmi P Kinnunen | Optinen menetelmä nesteen pinnankorkeuden mittaamiseksi |
WO1995005383A1 (fr) | 1993-08-19 | 1995-02-23 | Janssen Pharmaceutica N.V. | Derives de dihydrobenzopyrane vasoconstricteurs |
US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
AU678503B2 (en) | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
JP2925035B2 (ja) * | 1993-12-07 | 1999-07-26 | エス・ウント・エル・マシイネンバウ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ケーキを焼く方法およびその装置 |
JPH086412A (ja) * | 1994-06-20 | 1996-01-12 | Canon Inc | 加熱装置および画像形成装置 |
CA2200981A1 (fr) | 1994-10-04 | 1996-04-11 | Hisashi Takasugi | Derives d'uree et leur utilisation comme inhibiteurs de l'acat |
US5510379A (en) | 1994-12-19 | 1996-04-23 | Warner-Lambert Company | Sulfonate ACAT inhibitors |
US5536859A (en) | 1995-02-27 | 1996-07-16 | Amoco Corporation | Alpha-olefin catalyst and process |
GB9504066D0 (en) | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Phosphate derivatives of ureas and thioureas |
US5541199A (en) | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
WO1996040640A1 (fr) | 1995-06-07 | 1996-12-19 | Pfizer Inc. | DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B) |
DE69529849T2 (de) | 1995-06-07 | 2003-09-04 | Pfizer Inc., New York | Biphenyl-2-carbonsäure-tetrahydro-isochinolin-6-yl amid derivate, deren hestellung und deren verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und/oder der apolipoprotein b (apo b) sekretion |
US5696196A (en) * | 1995-09-15 | 1997-12-09 | Egyptian Lacquer Mfg. Co. | EMI/RFI-shielding coating |
US5827875A (en) | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
DE59708572D1 (de) | 1996-09-03 | 2002-11-28 | Siemens Ag | Anordnung und verfahren zur kryptographischen bearbeitung eines digitalen datenstroms, der eine beliebige anzahl von daten aufweist |
FR2756027B1 (fr) | 1996-11-15 | 1999-01-15 | Dimos | Crochet de securite |
BR9714364A (pt) * | 1996-11-27 | 2000-03-21 | Pfizer | Amidas inibidoras da secreção de apo b/mtp |
DE19649751C2 (de) | 1996-11-30 | 1999-12-30 | Cts Fahrzeug Dachsysteme Gmbh | Dachaufbau für Fahrzeuge, insbesondere Personenkraftwagen |
US5876070A (en) | 1996-12-11 | 1999-03-02 | Kennecott Holdings Corporation | Pipe flange connection for pressure retaining, abrasive/corrosive service |
GB9626045D0 (en) | 1996-12-14 | 1997-01-29 | Rover Group | A vehicle roll stabilising system |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
WO1998027979A1 (fr) | 1996-12-20 | 1998-07-02 | Bristol-Myers Squibb Company | Inhibiteurs heterocycliques de la proteine de transfert des triglycerides microsomiques et methode associee |
US5966677A (en) | 1997-02-28 | 1999-10-12 | Fiekowsky; Peter J. | High accuracy particle dimension measurement system |
GB9705206D0 (en) | 1997-03-13 | 1997-04-30 | Automotive Prod Italia | Drum brakes |
US5968950A (en) | 1997-06-23 | 1999-10-19 | Pfizer Inc | Apo B-secretion/MTP inhibitor hydrochloride salt |
US5988950A (en) * | 1997-11-18 | 1999-11-23 | Atlantic Richfield Company | Method and system for preventing upward migration of contaminants in soil |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
US5989950A (en) * | 1998-01-26 | 1999-11-23 | Texas Instruments - Acer Incorporated | Reduced mask CMOS salicided process |
US6173351B1 (en) | 1998-06-15 | 2001-01-09 | Sun Microsystems, Inc. | Multi-processor system bridge |
US6133217A (en) | 1998-08-28 | 2000-10-17 | Huntsman Petrochemical Corporation | Solubilization of low 2-phenyl alkylbenzene sulfonates |
US5985577A (en) * | 1998-10-14 | 1999-11-16 | The Trustees Of Columbia University In The City Of New York | Protein conjugates containing multimers of green fluorescent protein |
GB9826412D0 (en) | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
WO2000032532A1 (fr) | 1998-12-03 | 2000-06-08 | Lucio Alvaro | Procede de traitement thermique de materiaux inorganiques et organiques dans une serie de petites cuves et appareil pour le mettre en oeuvre |
JP2003501427A (ja) | 1999-06-02 | 2003-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アミノアルキル置換(ベンゾジオキサン、ベンゾフランもしくはベンゾピラン)誘導体 |
ES2231189T3 (es) | 1999-06-02 | 2005-05-16 | Janssen Pharmaceutica N.V. | Derivados de benzodioxano o benzopirano sustituidos con pirrolidinilo, piperidinilo u homopiperidinilo. |
AU2001262185A1 (en) | 2000-04-10 | 2001-10-23 | Novartis Ag | Substituted (hetero)aryl carboxamide derivatives as microsomal triglyceride transfer protein (mtp) and apolipoprotein b (apo b) secretion |
GB0013346D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
JO2352B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
CA2442141A1 (fr) | 2001-04-09 | 2002-10-17 | Eli Lilly And Company | Composes et compositions pharmaceutiques destines a inhiber la proteine mrp1 |
GB0423422D0 (en) * | 2004-10-21 | 2004-11-24 | Bard Inc C R | Medical device for fluid flow, and method of forming such device |
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