IL153680A0 - Aplidine derivatives and methods for the preparation thereof - Google Patents

Aplidine derivatives and methods for the preparation thereof

Info

Publication number
IL153680A0
IL153680A0 IL15368001A IL15368001A IL153680A0 IL 153680 A0 IL153680 A0 IL 153680A0 IL 15368001 A IL15368001 A IL 15368001A IL 15368001 A IL15368001 A IL 15368001A IL 153680 A0 IL153680 A0 IL 153680A0
Authority
IL
Israel
Prior art keywords
preparation
methods
aplidine
derivatives
aplidine derivatives
Prior art date
Application number
IL15368001A
Other languages
English (en)
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016148A external-priority patent/GB0016148D0/en
Priority claimed from GB0103750A external-priority patent/GB0103750D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of IL153680A0 publication Critical patent/IL153680A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL15368001A 2000-06-30 2001-07-02 Aplidine derivatives and methods for the preparation thereof IL153680A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016148A GB0016148D0 (en) 2000-06-30 2000-06-30 Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750A GB0103750D0 (en) 2001-02-15 2001-02-15 Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
PCT/GB2001/002901 WO2002002596A2 (en) 2000-06-30 2001-07-02 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

Publications (1)

Publication Number Publication Date
IL153680A0 true IL153680A0 (en) 2003-07-06

Family

ID=26244577

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15368001A IL153680A0 (en) 2000-06-30 2001-07-02 Aplidine derivatives and methods for the preparation thereof
IL153680A IL153680A (en) 2000-06-30 2002-12-26 History of Aplidin

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153680A IL153680A (en) 2000-06-30 2002-12-26 History of Aplidin

Country Status (25)

Country Link
US (2) US7348310B2 (ja)
EP (1) EP1294747B1 (ja)
JP (1) JP5289662B2 (ja)
KR (1) KR100866056B1 (ja)
CN (2) CN104650177A (ja)
AT (1) ATE393775T1 (ja)
AU (1) AU6769801A (ja)
BR (1) BRPI0112375B8 (ja)
CA (1) CA2414609C (ja)
CY (1) CY1108549T1 (ja)
CZ (1) CZ304204B6 (ja)
DE (1) DE60133817T2 (ja)
DK (1) DK1294747T3 (ja)
ES (1) ES2305083T3 (ja)
HK (1) HK1052940B (ja)
HU (1) HU228998B1 (ja)
IL (2) IL153680A0 (ja)
MX (1) MXPA03000202A (ja)
NO (1) NO334096B1 (ja)
NZ (1) NZ523367A (ja)
PL (1) PL208651B1 (ja)
PT (1) PT1294747E (ja)
SI (1) SI1294747T1 (ja)
UA (1) UA76718C2 (ja)
WO (1) WO2002002596A2 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
MXPA02004862A (es) * 1999-11-15 2003-01-28 Pharma Mar Sa Tratamiento de aplidina para canceres.
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
JP2003535048A (ja) 2000-04-07 2003-11-25 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア タマンダリンおよびジデムニン同族体およびそれらの作成および使用法
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
RU2003113210A (ru) 2000-10-12 2004-11-27 Фарма Мар, С.А. (Es) Лечение раковых заболеваний
SI1603584T1 (sl) 2003-03-12 2009-02-28 Dana Farber Cancer Inst Inc Aplidin za zdravljenje multiple mieloma
CN101579520A (zh) 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine
EP1613338A4 (en) 2003-03-21 2009-06-24 Madeleine M Joullie TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME
WO2007100385A2 (en) * 2005-10-31 2007-09-07 Genentech, Inc. Macrocyclic depsipeptide antibody-drug conjugates and methods
ME02450B (me) * 2006-02-28 2016-09-20 Pharma Mar Sa POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments
CN101965191A (zh) * 2008-03-07 2011-02-02 法马马有限公司 改善的抗癌治疗
WO2011020913A2 (en) 2009-08-21 2011-02-24 Pharma Mar, S.A. Cyclodepsipeptide antiviral compounds
JP2013537181A (ja) * 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
EP4114436A1 (en) 2020-03-02 2023-01-11 Pharma Mar S.A. Compounds for use in the treatment of coronavirus infection
PE20230302A1 (es) 2020-03-02 2023-02-13 Pharma Mar Sa Pld para su uso combinado en el tratamiento del coronavirus
US20230159594A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in viral infections
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
CN115594739A (zh) * 2021-06-28 2023-01-13 浙江珲达生物科技有限公司（Cn） 一种dehydrodidemnin B类化合物的制备方法
WO2024165764A1 (en) 2023-02-10 2024-08-15 Pharma Mar, S.A. Plitidepsin for use in the treatment of non-integrated dna viral infections

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
DE3161556D1 (en) 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) * 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
DE4120327A1 (de) * 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
US5462726A (en) * 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US6509316B2 (en) * 1995-03-07 2003-01-21 George Washington University Pharmaceutical compositions, methods, and kits for treatment and diagnosis of lung cancer
ES2102322B1 (es) * 1995-07-13 1998-03-01 Pharma Mar Sa Procedimiento de preparacion de didemnina a.
JP4172726B2 (ja) * 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6156724A (en) * 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
DE69723728T2 (de) * 1996-10-24 2004-06-03 The Board Of Trustees For The University Of Illinois, Urbana Totalsynthese des amino hip analogen von didemnin a
DE69735583T2 (de) * 1996-10-24 2007-04-05 The Board Of Trustees Of The University Of Illinois, Urbana Semisynthetisches verfahren zur herstellung von didemninanalogen
US6034058A (en) * 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
CA2288639A1 (en) * 1997-05-07 1998-11-12 Pharma Mar, S.A. Aplidine as an l-type calcium channel enhancer
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
PT1100589E (pt) * 1998-07-30 2005-05-31 Sigma Tau Ind Farmaceuti Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
JP2003500360A (ja) 1999-05-25 2003-01-07 ポイント セラピューティクス， インコーポレイテッド ボロプロリン化合物類を含む抗癌剤
MXPA02004862A (es) 1999-11-15 2003-01-28 Pharma Mar Sa Tratamiento de aplidina para canceres.
JP2003535048A (ja) * 2000-04-07 2003-11-25 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア タマンダリンおよびジデムニン同族体およびそれらの作成および使用法
US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
JP2004510824A (ja) 2000-10-12 2004-04-08 ファルマ・マール・ソシエダード・アノニマ ガンの治療
ATE411036T1 (de) 2001-10-19 2008-10-15 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
CN101579520A (zh) 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine

Also Published As

Publication number Publication date
DK1294747T3 (da) 2008-10-27
CY1108549T1 (el) 2014-04-09
AU6769801A (en) 2002-01-14
UA76718C2 (uk) 2006-09-15
HK1052940B (zh) 2008-10-24
NZ523367A (en) 2004-12-24
JP5289662B2 (ja) 2013-09-11
NO20026242D0 (no) 2002-12-27
KR20030013477A (ko) 2003-02-14
NO20026242L (no) 2003-02-27
KR100866056B1 (ko) 2008-10-30
CZ304204B6 (cs) 2014-01-02
CN1449408A (zh) 2003-10-15
PT1294747E (pt) 2008-08-08
BRPI0112375B8 (pt) 2021-05-25
PL360531A1 (en) 2004-09-06
US20080009435A1 (en) 2008-01-10
DE60133817D1 (de) 2008-06-12
BR0112375A (pt) 2003-06-24
CZ20024233A3 (cs) 2003-06-18
PL208651B1 (pl) 2011-05-31
CA2414609A1 (en) 2002-01-10
CA2414609C (en) 2012-04-24
SI1294747T1 (sl) 2008-12-31
HK1052940A1 (en) 2003-10-03
ATE393775T1 (de) 2008-05-15
BRPI0112375B1 (pt) 2020-12-01
CN104650177A (zh) 2015-05-27
MXPA03000202A (es) 2003-10-15
US7348310B2 (en) 2008-03-25
ES2305083T3 (es) 2008-11-01
NO334096B1 (no) 2013-12-09
US20040097413A1 (en) 2004-05-20
JP2004502702A (ja) 2004-01-29
DE60133817T2 (de) 2009-05-20
HUP0301387A3 (en) 2005-04-28
WO2002002596A3 (en) 2002-05-23
WO2002002596A2 (en) 2002-01-10
IL153680A (en) 2012-05-31
HUP0301387A2 (hu) 2003-08-28
US7678765B2 (en) 2010-03-16
HU228998B1 (en) 2013-07-29
EP1294747A2 (en) 2003-03-26
EP1294747B1 (en) 2008-04-30

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