HUP0301387A2 - Szintetikus módszerek aplidin és új tumorellenes származékok előállítására - Google Patents

Szintetikus módszerek aplidin és új tumorellenes származékok előállítására

Info

Publication number
HUP0301387A2
HUP0301387A2 HU0301387A HUP0301387A HUP0301387A2 HU P0301387 A2 HUP0301387 A2 HU P0301387A2 HU 0301387 A HU0301387 A HU 0301387A HU P0301387 A HUP0301387 A HU P0301387A HU P0301387 A2 HUP0301387 A2 HU P0301387A2
Authority
HU
Hungary
Prior art keywords
independently
organic group
aplidine
preparation
synthetic methods
Prior art date
Application number
HU0301387A
Other languages
English (en)
Inventor
Carmen Cuevas
Felix Cuevas
Pilar Gallego
Ignacio Manzanares
Simon Munt
Paloma Méndez
Concepción Polanco
Ignacio Rodriguez
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016148A external-priority patent/GB0016148D0/en
Priority claimed from GB0103750A external-priority patent/GB0103750D0/en
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of HUP0301387A2 publication Critical patent/HUP0301387A2/hu
Publication of HUP0301387A3 publication Critical patent/HUP0301387A3/hu
Publication of HU228998B1 publication Critical patent/HU228998B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A találmány (I) általános képletű vegyületekre és e vegyületekgyógyászatilag elfogadható sóira, valamint előállításukra vonatkozik.A képletben a szubsztituensek főbb jelentései a következők: Xjelentése egymástól függetlenül -C(R)2-, -O-, -S- vagy -NR-, ahol Rjelentése egymástól függetlenül H vagy egy szerves csoport; X2jelentése egymástól függetlenül, CR, O, S vagy N, ahol R jelentéseegymástól függetlenül H vagy egy szerves csoport; Y jelentése -(COR')nC0-, ahol a jelentése 0 vagy 1 és R' jelentése szerves csoport;X1 jelentése O vagy S; R1, R2 és R4 jelentése egymástól függetlenül Hvagy egy szerves csoport; vagy R1 és R2 X2-vel együtt egy adottesetben N-szubsztituált aa8 képletű prolincsoportot jelenthet, ahol R3jelentése egymástól függetlenül H vagy egy szerves csoport; vagy R1 ésR2 jelentése X2-vel együtt egy cikloalkilcsoport, arilcsoport vagyheterociklusos csoport; vagy R1, R2, X2, R4 és a nitrogént hordozó R4egy oxadiaza-spiroalkán-csoportot képez. A találmány szerintivegyületek főleg tumorok kezelésére használhatók. Ó
HU0301387A 2000-06-30 2001-07-02 Synthetic methods for preparation of aplidine and new antitumoral derivatives HU228998B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016148A GB0016148D0 (en) 2000-06-30 2000-06-30 Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750A GB0103750D0 (en) 2001-02-15 2001-02-15 Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
PCT/GB2001/002901 WO2002002596A2 (en) 2000-06-30 2001-07-02 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

Publications (3)

Publication Number Publication Date
HUP0301387A2 true HUP0301387A2 (hu) 2003-08-28
HUP0301387A3 HUP0301387A3 (en) 2005-04-28
HU228998B1 HU228998B1 (en) 2013-07-29

Family

ID=26244577

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301387A HU228998B1 (en) 2000-06-30 2001-07-02 Synthetic methods for preparation of aplidine and new antitumoral derivatives

Country Status (25)

Country Link
US (2) US7348310B2 (hu)
EP (1) EP1294747B1 (hu)
JP (1) JP5289662B2 (hu)
KR (1) KR100866056B1 (hu)
CN (2) CN104650177A (hu)
AT (1) ATE393775T1 (hu)
AU (1) AU6769801A (hu)
BR (1) BRPI0112375B8 (hu)
CA (1) CA2414609C (hu)
CY (1) CY1108549T1 (hu)
CZ (1) CZ304204B6 (hu)
DE (1) DE60133817T2 (hu)
DK (1) DK1294747T3 (hu)
ES (1) ES2305083T3 (hu)
HK (1) HK1052940B (hu)
HU (1) HU228998B1 (hu)
IL (2) IL153680A0 (hu)
MX (1) MXPA03000202A (hu)
NO (1) NO334096B1 (hu)
NZ (1) NZ523367A (hu)
PL (1) PL208651B1 (hu)
PT (1) PT1294747E (hu)
SI (1) SI1294747T1 (hu)
UA (1) UA76718C2 (hu)
WO (1) WO2002002596A2 (hu)

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GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
SK287762B6 (sk) * 1999-11-15 2011-09-05 Pharma Mar, S. A. Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
NZ521844A (en) 2000-04-07 2004-07-30 Univ Pennsylvania Tamandarin and didemnin analogs having deoxo-proline residue or dehydro-proline residue and methods of making and use thereof
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
CN1479622A (zh) 2000-10-12 2004-03-03 联合使用阿普里汀和肌肉保护剂来治疗癌症
JP4584245B2 (ja) 2003-03-12 2010-11-17 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 多発性骨髄腫治療用のアプリジン
JP2006519848A (ja) 2003-03-12 2006-08-31 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療
CA2519234A1 (en) 2003-03-21 2004-10-07 Madeleine M. Joullie Tamandarin analogs and fragments thereof and methods of making and using
WO2007100385A2 (en) * 2005-10-31 2007-09-07 Genentech, Inc. Macrocyclic depsipeptide antibody-drug conjugates and methods
HUE028055T2 (hu) 2006-02-28 2016-11-28 Pharma Mar Sa Myeloma multiplex feljavított kezelése
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments
JP2011513429A (ja) * 2008-03-07 2011-04-28 ファルマ・マール・ソシエダード・アノニマ 改善された抗癌治療法
WO2011020913A2 (en) 2009-08-21 2011-02-24 Pharma Mar, S.A. Cyclodepsipeptide antiviral compounds
EP2614089A1 (fr) * 2010-09-10 2013-07-17 Sanofi-Aventis Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
AU2021231197A1 (en) 2020-03-02 2022-10-06 Pharma Mar, S.A. Compounds for use in inflammatory conditions
EP4114436A1 (en) 2020-03-02 2023-01-11 Pharma Mar S.A. Compounds for use in the treatment of coronavirus infection
CA3169528A1 (en) 2020-03-02 2021-09-10 Pharma Mar, S.A.U. Pld for use in combination in the treatment of coronavirus
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
CN115594739A (zh) * 2021-06-28 2023-01-13 浙江珲达生物科技有限公司（Cn） 一种dehydrodidemnin B类化合物的制备方法

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US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
DE3161556D1 (en) 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
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IT1153974B (it) 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) * 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
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US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
NZ521844A (en) * 2000-04-07 2004-07-30 Univ Pennsylvania Tamandarin and didemnin analogs having deoxo-proline residue or dehydro-proline residue and methods of making and use thereof
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
JP2004510824A (ja) 2000-10-12 2004-04-08 ファルマ・マール・ソシエダード・アノニマ ガンの治療
WO2003033013A1 (en) 2001-10-19 2003-04-24 Pharma Mar, S.A. Use of aplidine for the treatment of pancreatic cancer
JP2006519848A (ja) 2003-03-12 2006-08-31 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療

Also Published As

Publication number Publication date
ATE393775T1 (de) 2008-05-15
US7348310B2 (en) 2008-03-25
SI1294747T1 (sl) 2008-12-31
NO20026242D0 (no) 2002-12-27
DK1294747T3 (da) 2008-10-27
UA76718C2 (uk) 2006-09-15
CZ20024233A3 (cs) 2003-06-18
HK1052940A1 (en) 2003-10-03
ES2305083T3 (es) 2008-11-01
IL153680A (en) 2012-05-31
WO2002002596A2 (en) 2002-01-10
PT1294747E (pt) 2008-08-08
DE60133817T2 (de) 2009-05-20
AU6769801A (en) 2002-01-14
NO20026242L (no) 2003-02-27
BR0112375A (pt) 2003-06-24
HU228998B1 (en) 2013-07-29
KR100866056B1 (ko) 2008-10-30
CA2414609C (en) 2012-04-24
JP5289662B2 (ja) 2013-09-11
DE60133817D1 (de) 2008-06-12
EP1294747B1 (en) 2008-04-30
JP2004502702A (ja) 2004-01-29
CY1108549T1 (el) 2014-04-09
HK1052940B (zh) 2008-10-24
CN104650177A (zh) 2015-05-27
CA2414609A1 (en) 2002-01-10
KR20030013477A (ko) 2003-02-14
PL360531A1 (en) 2004-09-06
BRPI0112375B8 (pt) 2021-05-25
BRPI0112375B1 (pt) 2020-12-01
EP1294747A2 (en) 2003-03-26
PL208651B1 (pl) 2011-05-31
CN1449408A (zh) 2003-10-15
MXPA03000202A (es) 2003-10-15
WO2002002596A3 (en) 2002-05-23
US20040097413A1 (en) 2004-05-20
US7678765B2 (en) 2010-03-16
CZ304204B6 (cs) 2014-01-02
NO334096B1 (no) 2013-12-09
HUP0301387A3 (en) 2005-04-28
NZ523367A (en) 2004-12-24
US20080009435A1 (en) 2008-01-10
IL153680A0 (en) 2003-07-06

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