WO2000063222A3 - Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments - Google Patents

Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments Download PDF

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Publication number
WO2000063222A3
WO2000063222A3 PCT/FR2000/000999 FR0000999W WO0063222A3 WO 2000063222 A3 WO2000063222 A3 WO 2000063222A3 FR 0000999 W FR0000999 W FR 0000999W WO 0063222 A3 WO0063222 A3 WO 0063222A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
medicaments
production
substituted aromatic
Prior art date
Application number
PCT/FR2000/000999
Other languages
English (en)
Other versions
WO2000063222A2 (fr
Inventor
Jacques Demassey
Michel Klich
Branislav Musicki
Original Assignee
Aventis Pharma Sa
Jacques Demassey
Michel Klich
Branislav Musicki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK1484-2001A priority Critical patent/SK14842001A3/sk
Priority to UA2001117895A priority patent/UA72919C2/uk
Application filed by Aventis Pharma Sa, Jacques Demassey, Michel Klich, Branislav Musicki filed Critical Aventis Pharma Sa
Priority to EP00920823A priority patent/EP1173455A2/fr
Priority to US09/980,728 priority patent/US6579902B1/en
Priority to APAP/P/2001/002312A priority patent/AP2001002312A0/en
Priority to NZ515108A priority patent/NZ515108A/xx
Priority to AU41256/00A priority patent/AU769514B2/en
Priority to IL14601800A priority patent/IL146018A0/xx
Priority to CA002363945A priority patent/CA2363945A1/fr
Priority to JP2000612312A priority patent/JP2002542253A/ja
Priority to PL00354192A priority patent/PL354192A1/xx
Priority to EA200101100A priority patent/EA004304B1/ru
Publication of WO2000063222A2 publication Critical patent/WO2000063222A2/fr
Publication of WO2000063222A3 publication Critical patent/WO2000063222A3/fr
Priority to NO20015058A priority patent/NO320703B1/no
Priority to HK02108190.9A priority patent/HK1046690B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Les composés de formule (I): R1: alkyle, alkényle ou alkynyle, O-alkyle, O-alkényle ou O-alkynyle éventuellement substitué, éventuellement interrompu; R2 hydrogène ou halogène; R3: hydrogène, alkyle ou halogène; R4: NHR' ou NHOR'' R' ou R'' identiques ou différents représentent hydrogène, alkyle, alkényle ou alkynyle, aryle; R5: hydrogène ou O-alkyle; R6: alkyle ou CH2-O-alkyle; R7: hydrogène ou alkyle ou bien R6 et R7 forment ensemble avec le carbone qui les porte un cycle ainsi que leurs sels d'addition avec les bases. Les composés de formule (I) présentent des propriétés antibiotiques.
PCT/FR2000/000999 1999-04-19 2000-04-18 Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments WO2000063222A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA002363945A CA2363945A1 (fr) 1999-04-19 2000-04-18 Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
IL14601800A IL146018A0 (en) 1999-04-19 2000-04-18 New aromatic amides substituted by a ribose, their preparation process and their use as medicaments
EP00920823A EP1173455A2 (fr) 1999-04-19 2000-04-18 Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
UA2001117895A UA72919C2 (uk) 1999-04-19 2000-04-18 Ароматичні аміди, заміщені рибозою, спосіб їх одержання та фармацевтична композиція
APAP/P/2001/002312A AP2001002312A0 (en) 1999-04-19 2000-04-18 New aromatic amides sustituted by a ribose, their preparation process and their use as medicaments.
NZ515108A NZ515108A (en) 1999-04-19 2000-04-18 Novel ribose-substituted aromatic amides, method for the production and use thereof as medicaments
JP2000612312A JP2002542253A (ja) 1999-04-19 2000-04-18 新規のリボース置換芳香族アミド、それらの製造方法及びそれらの薬剤としての使用
SK1484-2001A SK14842001A3 (sk) 1999-04-19 2000-04-18 Aromatické amidy substituované ribózou, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutické kompozície na ich báze
US09/980,728 US6579902B1 (en) 1999-04-19 2000-04-18 Ribose-substituted aromatic amides, method for the production and use thereof as medicaments
AU41256/00A AU769514B2 (en) 1999-04-19 2000-04-18 Novel ribose-substituted aromatic amides, method for the production and use thereof as medicaments
PL00354192A PL354192A1 (en) 1999-04-19 2000-04-18 Novel ribose-substituted aromatic amides, method for the production and use thereof as medicaments
EA200101100A EA004304B1 (ru) 1999-04-19 2000-04-18 Новые ароматические амиды, замещенные рибозой, способ их получения и их применение в качестве лекарств
NO20015058A NO320703B1 (no) 1999-04-19 2001-10-18 Nye ribose-substituerte aromatiske amider, fremgangsmate for deres fremstilling og farmasoytisk preparat inneholdende disse.
HK02108190.9A HK1046690B (zh) 1999-04-19 2002-11-12 核糖取代的新芳族酰胺、其製備方法及其作為藥劑的用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/04866 1999-04-19
FR9904866A FR2792320B1 (fr) 1999-04-19 1999-04-19 Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
WO2000063222A2 WO2000063222A2 (fr) 2000-10-26
WO2000063222A3 true WO2000063222A3 (fr) 2001-05-31

Family

ID=9544554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/000999 WO2000063222A2 (fr) 1999-04-19 2000-04-18 Nouveaux amides aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments

Country Status (24)

Country Link
US (1) US6579902B1 (fr)
EP (1) EP1173455A2 (fr)
JP (1) JP2002542253A (fr)
KR (1) KR100693258B1 (fr)
CN (1) CN1213055C (fr)
AP (1) AP2001002312A0 (fr)
AU (1) AU769514B2 (fr)
CA (1) CA2363945A1 (fr)
CZ (1) CZ20013708A3 (fr)
EA (1) EA004304B1 (fr)
FR (1) FR2792320B1 (fr)
HK (1) HK1046690B (fr)
HU (1) HUP0200778A3 (fr)
ID (1) ID30562A (fr)
IL (1) IL146018A0 (fr)
NO (1) NO320703B1 (fr)
NZ (1) NZ515108A (fr)
PL (1) PL354192A1 (fr)
SK (1) SK14842001A3 (fr)
TR (1) TR200103009T2 (fr)
UA (1) UA72919C2 (fr)
WO (1) WO2000063222A2 (fr)
YU (1) YU80301A (fr)
ZA (1) ZA200108627B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
KR100649357B1 (ko) * 2004-05-04 2006-11-24 제일약품주식회사 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물
US8212012B2 (en) * 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
CA2585091C (fr) * 2004-11-03 2016-07-19 University Of Kansas Analogues de novobiocine en tant qu'agents anticancereux
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
US7622451B2 (en) * 2004-11-03 2009-11-24 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
US8212011B2 (en) * 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
WO2010014617A1 (fr) * 2008-07-28 2010-02-04 University Of Kansas Schémas posologiques pour inhibiteurs des protéines de choc thermique 90
US20110082098A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
AU2019271126A1 (en) 2018-05-14 2020-12-10 Reata Pharmaceuticals, Inc. Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2052923A1 (fr) * 1969-06-02 1971-04-16 Upjohn Co
US3890297A (en) * 1973-03-29 1975-06-17 Upjohn Co Process for n-acylating novenamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2052923A1 (fr) * 1969-06-02 1971-04-16 Upjohn Co
US3890297A (en) * 1973-03-29 1975-06-17 Upjohn Co Process for n-acylating novenamine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BELL, WILLIAM ET AL: "Design, synthesis and evaluation of a novel series of spiroketals based o the structure of the antibacterial gyrase inhibitor novobiocin", J. CHEM. SOC., PERKIN TRANS. 1 (1997), (18), 2789-2801, XP002127248 *
CROW, FRANK W. ET AL: "Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2''-(O-Carbamyl)novobiocin, and novobiocin-2'',3''-carbonate", J. HETEROCYCL. CHEM. (1999), 36(2), 365-370, XP002127249 *

Also Published As

Publication number Publication date
HK1046690B (zh) 2006-03-10
WO2000063222A2 (fr) 2000-10-26
SK14842001A3 (sk) 2003-05-02
KR100693258B1 (ko) 2007-03-13
TR200103009T2 (tr) 2002-05-21
KR20020008155A (ko) 2002-01-29
ZA200108627B (en) 2002-10-21
UA72919C2 (uk) 2005-05-16
EP1173455A2 (fr) 2002-01-23
NO20015058L (no) 2001-12-17
ID30562A (id) 2001-12-20
EA004304B1 (ru) 2004-02-26
JP2002542253A (ja) 2002-12-10
CN1213055C (zh) 2005-08-03
EA200101100A1 (ru) 2002-04-25
NO320703B1 (no) 2006-01-16
NO20015058D0 (no) 2001-10-18
NZ515108A (en) 2004-01-30
PL354192A1 (en) 2003-12-29
YU80301A (sh) 2005-07-19
US6579902B1 (en) 2003-06-17
HUP0200778A2 (hu) 2002-07-29
HK1046690A1 (en) 2003-01-24
CA2363945A1 (fr) 2000-10-26
HUP0200778A3 (en) 2003-03-28
FR2792320B1 (fr) 2003-05-09
AP2001002312A0 (en) 2001-12-31
AU4125600A (en) 2000-11-02
FR2792320A1 (fr) 2000-10-20
AU769514B2 (en) 2004-01-29
CZ20013708A3 (cs) 2002-04-17
CN1357001A (zh) 2002-07-03
IL146018A0 (en) 2002-07-25

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