IL152315A - Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them - Google Patents

Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Info

Publication number
IL152315A
IL152315A IL152315A IL15231501A IL152315A IL 152315 A IL152315 A IL 152315A IL 152315 A IL152315 A IL 152315A IL 15231501 A IL15231501 A IL 15231501A IL 152315 A IL152315 A IL 152315A
Authority
IL
Israel
Prior art keywords
ctla4 mutant
mutant molecule
molecule
ctla4
cell
Prior art date
Application number
IL152315A
Other languages
English (en)
Hebrew (he)
Other versions
IL152315A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL152315A0 publication Critical patent/IL152315A0/xx
Publication of IL152315A publication Critical patent/IL152315A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL152315A 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them IL152315A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
IL152315A0 IL152315A0 (en) 2003-05-29
IL152315A true IL152315A (en) 2010-04-15

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
IL152315A IL152315A (en) 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Country Status (41)

Country Link
EP (3) EP3029062A1 (index.php)
JP (1) JP4328525B2 (index.php)
KR (2) KR100895134B1 (index.php)
CN (2) CN101255192A (index.php)
AR (1) AR031699A1 (index.php)
AT (1) ATE271066T1 (index.php)
AU (2) AU2001263466C1 (index.php)
BE (1) BE2011C041I2 (index.php)
BR (1) BRPI0111191B8 (index.php)
CA (1) CA2409748C (index.php)
CY (2) CY2011019I2 (index.php)
CZ (1) CZ304451B6 (index.php)
DE (2) DE60104282T2 (index.php)
DK (1) DK1248802T3 (index.php)
EC (1) ECSP024365A (index.php)
EE (2) EE05458B1 (index.php)
EG (1) EG24459A (index.php)
ES (2) ES2571852T3 (index.php)
FR (1) FR11C0053I2 (index.php)
GE (1) GEP20053658B (index.php)
HK (1) HK1048126B (index.php)
HU (2) HU228137B1 (index.php)
IL (1) IL152315A (index.php)
LT (1) LT5133B (index.php)
LU (1) LU91902I2 (index.php)
LV (1) LV12994B (index.php)
MX (1) MXPA02011534A (index.php)
MY (1) MY136113A (index.php)
NO (2) NO330797B1 (index.php)
PE (1) PE20011338A1 (index.php)
PL (1) PL206267B1 (index.php)
PT (1) PT1248802E (index.php)
RU (1) RU2283847C2 (index.php)
SI (1) SI1248802T1 (index.php)
SK (1) SK288131B6 (index.php)
TR (1) TR200402703T4 (index.php)
TW (2) TWI314933B (index.php)
UA (1) UA87432C2 (index.php)
UY (1) UY26723A1 (index.php)
WO (1) WO2001092337A2 (index.php)
ZA (1) ZA200208944B (index.php)

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US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
CZ303959B6 (cs) * 2000-07-03 2013-07-17 Bristol-Myers Squibb Company Solubilní CTLA4 fúzní molekula, farmaceutický prostredek s jejím obsahem a její pouzití
PL204899B1 (pl) 2001-05-23 2010-02-26 Bristol Myers Squibb Co Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4
AU2003243152A1 (en) * 2002-04-19 2003-11-03 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
US7541164B2 (en) 2002-12-23 2009-06-02 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CA2508925C (en) 2002-12-23 2012-08-28 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
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AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
BRPI0622251A2 (pt) * 2005-12-20 2011-07-19 Bristol-Myers Squibb Company método para obtenção de uma composição compreendendo uma população isolada de moléculas de ctla4-ig de um meio de cultura lìquido e para isolamento de uma composição compreendendo moléculas de ctla4-ig e composição
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KR20190064664A (ko) * 2008-10-02 2019-06-10 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Ｃｄ86 길항제 다중-표적 결합 단백질
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WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
HUE048925T2 (hu) * 2012-05-11 2020-09-28 Medimmune Ltd CTLA-4 variánsok
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
EP2866823A4 (en) * 2012-06-27 2016-03-02 Orban Biotech Llc CTLA4 FUSION PROTEINS FOR THE TREATMENT OF DIABETES
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CA2936104C (en) 2014-01-13 2022-04-19 Amgen Inc. Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
ES2980493T3 (es) 2014-06-04 2024-10-01 Amgen Inc Métodos de recolección en cultivos de células de mamífero
JP6698681B2 (ja) 2014-12-01 2020-05-27 アムジエン・インコーポレーテツド 糖タンパク質のグリカン含量のレベルを操作するためのプロセス
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CA2997947A1 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
CN108350416A (zh) 2015-11-09 2018-07-31 百时美施贵宝公司 操纵在cho细胞中产生的多肽的品质属性的方法
CN109715210B (zh) * 2016-09-19 2023-05-30 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
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TW202509053A (zh) 2019-12-06 2025-03-01 美商再生元醫藥公司 抗vegf蛋白組合物及其製備方法
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Also Published As

Publication number Publication date
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BE2011C041I2 (index.php) 2020-08-20
NO20025656L (no) 2002-11-25
AU2001263466B2 (en) 2006-04-27
SI1248802T1 (en) 2005-02-28
BRPI0111191B8 (pt) 2021-05-25
TR200402703T4 (tr) 2004-11-22
KR20030009502A (ko) 2003-01-29
GEP20053658B (en) 2005-11-10
FR11C0053I2 (fr) 2013-01-11
SK288131B6 (sk) 2013-10-02
UY26723A1 (es) 2001-12-28
CA2409748A1 (en) 2001-12-06
PE20011338A1 (es) 2002-01-13
KR100889887B1 (ko) 2009-03-24
EE200200659A (et) 2004-06-15
DE122011100063I1 (de) 2012-06-14
BRPI0111191B1 (pt) 2019-12-31
PL366231A1 (en) 2005-01-24
NO2011027I1 (no) 2012-01-09
AR031699A1 (es) 2003-10-01
CA2409748C (en) 2008-09-16
EP1248802B9 (en) 2005-05-11
WO2001092337A2 (en) 2001-12-06
EE05557B1 (et) 2012-08-15
BR0111191A (pt) 2004-07-06
CN1309735C (zh) 2007-04-11
CZ20023892A3 (cs) 2003-09-17
ECSP024365A (es) 2003-03-31
LT5133B (lt) 2004-05-25
DK1248802T3 (da) 2004-11-15
EP1536234A3 (en) 2009-06-03
DE60104282T2 (de) 2005-10-13
EE05458B1 (et) 2011-08-15
AU6346601A (en) 2001-12-11
UA87432C2 (uk) 2009-07-27
LT2002114A (en) 2003-12-29
DE60104282D1 (de) 2004-08-19
ATE271066T1 (de) 2004-07-15
HU228137B1 (en) 2012-12-28
EP1248802B1 (en) 2004-07-14
ES2571852T3 (es) 2016-05-27
NO330797B1 (no) 2011-07-18
HK1071931A1 (en) 2005-08-05
CN101255192A (zh) 2008-09-03
PT1248802E (pt) 2004-11-30
ES2225549T3 (es) 2005-03-16
IL152315A0 (en) 2003-05-29
FR11C0053I1 (index.php) 2012-01-13
AU2001263466C1 (en) 2006-10-26
CY2011019I1 (el) 2016-12-14
EP1536234B1 (en) 2016-03-16
JP2004511213A (ja) 2004-04-15
HK1048126B (en) 2005-03-04
RU2283847C2 (ru) 2006-09-20
NO20025656D0 (no) 2002-11-25
PL206267B1 (pl) 2010-07-30
KR100895134B1 (ko) 2009-05-04
MY136113A (en) 2008-08-29
NO2011027I2 (index.php) 2011-12-15
CY1117625T1 (el) 2017-04-26
EE201100050A (et) 2011-10-17
MXPA02011534A (es) 2004-08-12
HUS1300012I1 (hu) 2016-08-29
LV12994B (en) 2003-08-20
TWI314933B (en) 2009-09-21
ZA200208944B (en) 2004-02-13
EP1536234A2 (en) 2005-06-01
HUP0302201A3 (en) 2010-01-28
HUP0302201A2 (hu) 2003-10-28
EP3029062A1 (en) 2016-06-08
CZ304451B6 (cs) 2014-05-14
SK15702002A3 (sk) 2004-01-08
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
JP4328525B2 (ja) 2009-09-09
WO2001092337A3 (en) 2002-05-10
HK1048126A1 (en) 2003-03-21
TWI319405B (en) 2010-01-11
TW200906857A (en) 2009-02-16
EG24459A (en) 2009-07-16
CN1441810A (zh) 2003-09-10

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