IL152173A0 - Haemostatically active preparation containing vwf and method for the production thereof - Google Patents
Haemostatically active preparation containing vwf and method for the production thereofInfo
- Publication number
- IL152173A0 IL152173A0 IL15217301A IL15217301A IL152173A0 IL 152173 A0 IL152173 A0 IL 152173A0 IL 15217301 A IL15217301 A IL 15217301A IL 15217301 A IL15217301 A IL 15217301A IL 152173 A0 IL152173 A0 IL 152173A0
- Authority
- IL
- Israel
- Prior art keywords
- vwf
- fraction
- active
- production
- preparation containing
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 7
- 102100036537 von Willebrand factor Human genes 0.000 abstract 7
- 229960001134 von willebrand factor Drugs 0.000 abstract 7
- 241000700605 Viruses Species 0.000 abstract 2
- 238000011097 chromatography purification Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000005349 anion exchange Methods 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00108430A EP1148063A1 (de) | 2000-04-18 | 2000-04-18 | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
| PCT/EP2001/003819 WO2001079260A1 (de) | 2000-04-18 | 2001-04-04 | Haemostatisch aktives vwf enthaltendes präparat und verfahren zu seiner herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL152173A0 true IL152173A0 (en) | 2003-05-29 |
Family
ID=8168496
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15217301A IL152173A0 (en) | 2000-04-18 | 2001-04-04 | Haemostatically active preparation containing vwf and method for the production thereof |
| IL152173A IL152173A (en) | 2000-04-18 | 2002-10-08 | An active mosquito repellent containing VWF and a method for its preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL152173A IL152173A (en) | 2000-04-18 | 2002-10-08 | An active mosquito repellent containing VWF and a method for its preparation |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7166709B2 (cs) |
| EP (2) | EP1148063A1 (cs) |
| JP (1) | JP4976634B2 (cs) |
| KR (1) | KR100685448B1 (cs) |
| CN (1) | CN100448888C (cs) |
| AT (1) | ATE306494T1 (cs) |
| AU (2) | AU2001263835B2 (cs) |
| BR (1) | BR0110193A (cs) |
| CA (1) | CA2406626C (cs) |
| CZ (1) | CZ303932B6 (cs) |
| DE (1) | DE50107689D1 (cs) |
| DK (1) | DK1274721T3 (cs) |
| EA (1) | EA006209B1 (cs) |
| EE (1) | EE200200595A (cs) |
| ES (1) | ES2247117T3 (cs) |
| HU (1) | HU225992B1 (cs) |
| IL (2) | IL152173A0 (cs) |
| MX (1) | MXPA02010017A (cs) |
| NO (1) | NO324773B1 (cs) |
| RS (1) | RS50835B (cs) |
| SI (1) | SI1274721T1 (cs) |
| UA (1) | UA76714C2 (cs) |
| WO (1) | WO2001079260A1 (cs) |
| ZA (1) | ZA200208396B (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
| ITLU20070007A1 (it) * | 2007-05-07 | 2008-11-08 | Kedrion Spa | Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand. |
| FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
| SG187410A1 (en) | 2007-12-28 | 2013-02-28 | Baxter Int | Recombinant vwf formulations |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| PL2291523T3 (pl) | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
| EP2349314B1 (en) | 2008-10-21 | 2013-02-27 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
| IT1396528B1 (it) * | 2009-01-19 | 2012-12-14 | Kedrion Spa | Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). |
| JP5973997B2 (ja) * | 2010-06-01 | 2016-08-23 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 乾燥した安定な止血用組成物を作製するためのプロセス |
| RU2603103C2 (ru) * | 2010-09-20 | 2016-11-20 | Октафарма Аг | Способ получения фибриногена с использованием сильной анионообменной смолы и содержащий фибриноген продукт |
| SG191186A1 (en) | 2010-12-15 | 2013-07-31 | Baxter Int | Eluate collection using conductivity gradient |
| US10064406B2 (en) * | 2011-01-06 | 2018-09-04 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
| MX351340B (es) | 2012-03-13 | 2017-10-11 | Octapharma Ag | Proceso mejorado para la produccion de fibrinogeno y fibrinogeno producido por este. |
| JP2015515482A (ja) | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
| CN116284337A (zh) * | 2023-03-30 | 2023-06-23 | 同路生物制药有限公司 | 以冷沉淀peg沉淀及色谱层析法制备血友病因子的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
| FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| DE3878245D1 (de) | 1988-11-05 | 1993-03-18 | Octapharma Ag | Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie. |
| FR2673632A1 (fr) * | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| FR2681867B1 (fr) * | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
| DE4204694C3 (de) * | 1992-02-01 | 1995-10-12 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
| AU6653094A (en) * | 1992-12-16 | 1994-07-04 | Immuno Aktiengesellschaft | Process for preparing a virus-safe biological composition |
| DE4435392B4 (de) * | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
| DE4437544A1 (de) * | 1994-10-20 | 1996-04-25 | Behringwerke Ag | Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika |
| US6005077A (en) | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
| AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| AT404358B (de) * | 1997-02-04 | 1998-11-25 | Immuno Ag | Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial |
| US6531577B1 (en) * | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
| EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
-
2000
- 2000-04-18 EP EP00108430A patent/EP1148063A1/de not_active Withdrawn
-
2001
- 2001-04-04 SI SI200130460T patent/SI1274721T1/sl unknown
- 2001-04-04 CN CNB018082297A patent/CN100448888C/zh not_active Expired - Fee Related
- 2001-04-04 AU AU2001263835A patent/AU2001263835B2/en not_active Ceased
- 2001-04-04 BR BR0110193-5A patent/BR0110193A/pt not_active Application Discontinuation
- 2001-04-04 CA CA2406626A patent/CA2406626C/en not_active Expired - Fee Related
- 2001-04-04 CZ CZ20023454A patent/CZ303932B6/cs not_active IP Right Cessation
- 2001-04-04 AT AT01938084T patent/ATE306494T1/de active
- 2001-04-04 JP JP2001576857A patent/JP4976634B2/ja not_active Expired - Fee Related
- 2001-04-04 UA UA2002108257A patent/UA76714C2/uk unknown
- 2001-04-04 IL IL15217301A patent/IL152173A0/xx active IP Right Grant
- 2001-04-04 KR KR1020027013892A patent/KR100685448B1/ko not_active Expired - Fee Related
- 2001-04-04 US US10/257,375 patent/US7166709B2/en not_active Expired - Fee Related
- 2001-04-04 RS YUP-784/02A patent/RS50835B/sr unknown
- 2001-04-04 WO PCT/EP2001/003819 patent/WO2001079260A1/de not_active Ceased
- 2001-04-04 EP EP01938084A patent/EP1274721B1/de not_active Expired - Lifetime
- 2001-04-04 HU HU0301211A patent/HU225992B1/hu not_active IP Right Cessation
- 2001-04-04 ES ES01938084T patent/ES2247117T3/es not_active Expired - Lifetime
- 2001-04-04 MX MXPA02010017A patent/MXPA02010017A/es active IP Right Grant
- 2001-04-04 DE DE50107689T patent/DE50107689D1/de not_active Expired - Lifetime
- 2001-04-04 DK DK01938084T patent/DK1274721T3/da active
- 2001-04-04 EA EA200201104A patent/EA006209B1/ru not_active IP Right Cessation
- 2001-04-04 EE EEP200200595A patent/EE200200595A/xx unknown
- 2001-04-04 AU AU6383501A patent/AU6383501A/xx active Pending
-
2002
- 2002-10-08 IL IL152173A patent/IL152173A/en not_active IP Right Cessation
- 2002-10-17 ZA ZA200208396A patent/ZA200208396B/en unknown
- 2002-10-17 NO NO20025007A patent/NO324773B1/no not_active IP Right Cessation
-
2007
- 2007-01-04 US US11/649,357 patent/US7985846B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |