IL143104A - Method and apparatus for liposome production - Google Patents
Method and apparatus for liposome productionInfo
- Publication number
- IL143104A IL143104A IL14310499A IL14310499A IL143104A IL 143104 A IL143104 A IL 143104A IL 14310499 A IL14310499 A IL 14310499A IL 14310499 A IL14310499 A IL 14310499A IL 143104 A IL143104 A IL 143104A
- Authority
- IL
- Israel
- Prior art keywords
- liposome production
- liposomes
- therapeutic applications
- mixing system
- liposome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2215—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
- B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
- B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0468—Numerical pressure values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0472—Numerical temperature values
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10835598P | 1998-11-13 | 1998-11-13 | |
PCT/US1999/026738 WO2000029103A1 (fr) | 1998-11-13 | 1999-11-12 | Procede et dispositif de production de liposomes |
Publications (2)
Publication Number | Publication Date |
---|---|
IL143104A0 IL143104A0 (en) | 2002-04-21 |
IL143104A true IL143104A (en) | 2005-09-25 |
Family
ID=22321729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14310499A IL143104A (en) | 1998-11-13 | 1999-11-12 | Method and apparatus for liposome production |
Country Status (9)
Country | Link |
---|---|
US (3) | US6534018B1 (fr) |
EP (1) | EP1146959B1 (fr) |
JP (1) | JP2002529240A (fr) |
AT (1) | ATE397488T1 (fr) |
AU (1) | AU756196B2 (fr) |
CA (1) | CA2350430C (fr) |
DE (1) | DE69938875D1 (fr) |
IL (1) | IL143104A (fr) |
WO (1) | WO2000029103A1 (fr) |
Families Citing this family (68)
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US6855296B1 (en) * | 1998-11-13 | 2005-02-15 | Optime Therapeutics, Inc. | Method and apparatus for liposome production |
MXPA01007486A (es) * | 1999-01-25 | 2003-06-24 | Optime Therapeutics Inc | Formulaciones de liposomas. |
AU769357B2 (en) * | 1999-07-15 | 2004-01-22 | University Of British Columbia, The | Methods for preparation of lipid-encapsulated therapeutic agents |
US20020119188A1 (en) * | 2000-02-08 | 2002-08-29 | Susan Niemiec | Method of manufacturing liposomes |
DE60138934D1 (de) * | 2000-02-25 | 2009-07-23 | Hitachi Ltd | Mischvorrichtung für Analysenautomat |
EP1203614A1 (fr) * | 2000-11-03 | 2002-05-08 | Polymun Scientific Immunbiologische Forschung GmbH | Procédé et dispositif pour la préparation de vésicules de lipides |
CA2491164C (fr) * | 2002-06-28 | 2012-05-08 | Cory Giesbrecht | Appareil liposomal et procedes de fabrication |
US7879351B2 (en) | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
CA2504317C (fr) | 2002-10-29 | 2012-05-22 | Transave, Inc. | Liberation prolongee d'anti-infectieux |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
FR2854072B1 (fr) * | 2003-04-23 | 2006-08-04 | Centre Nat Rech Scient | Vecteur pour administration par voie orale |
JP4428385B2 (ja) * | 2004-03-23 | 2010-03-10 | 新東工業株式会社 | 鋳型造型装置およびそれに使用する金型装置 |
TW201204410A (en) * | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
DE102004018283A1 (de) * | 2004-04-15 | 2005-11-03 | Wacker-Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen |
US20080102111A1 (en) * | 2005-03-09 | 2008-05-01 | Hiromichi Imanaka | Anticancer Composition for Oral Use Comprising Liposome Containing Phytosterols and Prevention or Treatment for Cancer Using the Liposome |
AU2006274413B2 (en) | 2005-07-27 | 2013-01-10 | Arbutus Biopharma Corporation | Systems and methods for manufacturing liposomes |
EP3067047B1 (fr) | 2005-12-08 | 2022-04-20 | Insmed Incorporated | Compositions a base de lipide d'anti-infectieux pour traiter des infections pulmonaires |
US10631558B2 (en) | 2006-03-06 | 2020-04-28 | The Coca-Cola Company | Methods and apparatuses for making compositions comprising an acid and an acid degradable component and/or compositions comprising a plurality of selectable components |
US9146564B2 (en) | 2006-03-06 | 2015-09-29 | Deka Products Limited Partnership | Product dispensing system |
US11214476B2 (en) | 2006-03-06 | 2022-01-04 | Deka Products Limited Partnership | System and method for generating a drive signal |
US7740152B2 (en) | 2006-03-06 | 2010-06-22 | The Coca-Cola Company | Pump system with calibration curve |
US11906988B2 (en) | 2006-03-06 | 2024-02-20 | Deka Products Limited Partnership | Product dispensing system |
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US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
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US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
WO2009120247A2 (fr) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Compositions de nanoparticules de lipides et procédés de préparation et d’utilisation de celles-ci |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
JPWO2010041727A1 (ja) * | 2008-10-10 | 2012-03-08 | 株式会社リポソーム工学研究所 | リポソーム製造装置 |
JPWO2010044399A1 (ja) * | 2008-10-14 | 2012-03-15 | 株式会社リポソーム工学研究所 | 多機能リポソーム自動製造装置 |
AU2010208035B2 (en) | 2009-01-29 | 2016-06-23 | Arbutus Biopharma Corporation | Improved lipid formulation for the delivery of nucleic acids |
CN102421900B (zh) | 2009-03-12 | 2015-07-22 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因表达的脂质配制的组合物以及方法 |
CA2760706C (fr) | 2009-05-05 | 2019-08-06 | Alnylam Pharmaceuticals, Inc. | Procedes d'administration d'oligonucleotides en direction de cellules immunitaires |
JP5769701B2 (ja) | 2009-05-05 | 2015-08-26 | テクミラ ファーマシューティカルズ コーポレイションTekmira Pharmaceuticals Corporation | 脂質組成物 |
PL2440183T3 (pl) | 2009-06-10 | 2019-01-31 | Arbutus Biopharma Corporation | Ulepszona formulacja lipidowa |
EP2810643A3 (fr) | 2009-08-14 | 2015-03-11 | Alnylam Pharmaceuticals Inc. | Compositions formulées de lipides et procédés d'inhibition de l'expression d'un gène à partir du virus Ebola |
WO2011139911A2 (fr) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Arn simple brin à formulation lipidique |
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EP3581186A1 (fr) | 2012-11-29 | 2019-12-18 | Insmed Incorporated | Formulations de vancomycine stabilisées |
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EP2971013B1 (fr) * | 2013-03-15 | 2020-08-19 | The University Of British Columbia | Nanoparticules lipidiques pour la transfection et procédés associés |
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KR101713886B1 (ko) | 2013-12-19 | 2017-03-10 | 연세대학교 산학협력단 | PRK2를 표적으로 하는 C형 간염 바이러스 치료제 siRNA |
PT3142643T (pt) | 2014-05-15 | 2019-10-28 | Insmed Inc | Métodos para o tratamento de infeções mico bacterianas pulmonares não tuberculares |
JP6782171B2 (ja) | 2014-07-02 | 2020-11-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | メッセンジャーrnaのカプセル化 |
US10765817B2 (en) | 2014-08-13 | 2020-09-08 | Elwha, Llc | Methods, systems, and devices related to delivery of alcohol with an inhaler |
US10987048B2 (en) | 2014-08-13 | 2021-04-27 | Elwha Llc | Systems, methods, and devices to incentivize inhaler use |
US10245393B2 (en) | 2014-08-13 | 2019-04-02 | Elwha Llc | Methods, systems, and devices related to a supplemental inhaler |
JP6373749B2 (ja) | 2014-12-19 | 2018-08-15 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
CN113171694B (zh) * | 2015-03-19 | 2023-04-18 | 康涅狄格大学 | 用于连续制造脂质体药物制剂的系统和方法 |
US11571386B2 (en) | 2018-03-30 | 2023-02-07 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
WO2020061426A2 (fr) * | 2018-09-21 | 2020-03-26 | Acuitas Therapeutics, Inc. | Systèmes et procédés pour la fabrication de nanoparticules lipidiques et de liposomes |
EP3870352A2 (fr) * | 2018-10-26 | 2021-09-01 | University of Connecticut | Système et procédés de traitement continu pour des modifications internes et externes apportées à des nanoparticules |
US11154502B2 (en) * | 2019-01-24 | 2021-10-26 | CannaClear Inc. | Lecithin vesicles for oral delivery |
WO2022269097A1 (fr) | 2021-06-25 | 2022-12-29 | Alpine Antiviral Gmbh | Combinaisons d'arnsi ciblant les transcrits du sras-cov-2 et/ou du facteur hôte |
AU2022381525A1 (en) | 2021-11-03 | 2024-06-20 | Leon-Nanodrugs Gmbh | Apparatus and method for mixing small liquid volumes, and use of the apparatus |
IL313486A (en) | 2021-12-16 | 2024-08-01 | Acuitas Therapeutics Inc | Lipids for use in lipid nanoparticle formulations |
WO2024069012A1 (fr) | 2022-09-30 | 2024-04-04 | Leon-Nanodrugs Gmbh | Système de cassette pour procédé de mélange aseptique |
WO2024069014A1 (fr) | 2022-09-30 | 2024-04-04 | Leon-Nanodrugs Gmbh | Appareil et procédé pour actionner un dispositif de mélange statique |
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-
1999
- 1999-11-12 EP EP99972124A patent/EP1146959B1/fr not_active Expired - Lifetime
- 1999-11-12 JP JP2000582143A patent/JP2002529240A/ja not_active Withdrawn
- 1999-11-12 DE DE69938875T patent/DE69938875D1/de not_active Expired - Lifetime
- 1999-11-12 AT AT99972124T patent/ATE397488T1/de not_active IP Right Cessation
- 1999-11-12 WO PCT/US1999/026738 patent/WO2000029103A1/fr active IP Right Grant
- 1999-11-12 US US09/439,619 patent/US6534018B1/en not_active Expired - Lifetime
- 1999-11-12 AU AU14768/00A patent/AU756196B2/en not_active Expired
- 1999-11-12 CA CA002350430A patent/CA2350430C/fr not_active Expired - Lifetime
- 1999-11-12 IL IL14310499A patent/IL143104A/xx not_active IP Right Cessation
-
2002
- 2002-11-15 US US10/298,143 patent/US6855277B2/en not_active Expired - Lifetime
-
2005
- 2005-01-05 US US11/030,583 patent/US20050196435A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1146959A1 (fr) | 2001-10-24 |
EP1146959A4 (fr) | 2004-12-29 |
AU756196B2 (en) | 2003-01-09 |
US20030124033A1 (en) | 2003-07-03 |
WO2000029103A1 (fr) | 2000-05-25 |
US6534018B1 (en) | 2003-03-18 |
DE69938875D1 (fr) | 2008-07-17 |
EP1146959B1 (fr) | 2008-06-04 |
CA2350430A1 (fr) | 2000-05-25 |
IL143104A0 (en) | 2002-04-21 |
US20050196435A1 (en) | 2005-09-08 |
US6855277B2 (en) | 2005-02-15 |
JP2002529240A (ja) | 2002-09-10 |
CA2350430C (fr) | 2008-06-03 |
AU1476800A (en) | 2000-06-05 |
ATE397488T1 (de) | 2008-06-15 |
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Legal Events
Date | Code | Title | Description |
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KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |