IL143104A - Method and apparatus for liposome production - Google Patents

Method and apparatus for liposome production

Info

Publication number
IL143104A
IL143104A IL14310499A IL14310499A IL143104A IL 143104 A IL143104 A IL 143104A IL 14310499 A IL14310499 A IL 14310499A IL 14310499 A IL14310499 A IL 14310499A IL 143104 A IL143104 A IL 143104A
Authority
IL
Israel
Prior art keywords
liposome production
liposomes
therapeutic applications
mixing system
liposome
Prior art date
Application number
IL14310499A
Other languages
English (en)
Other versions
IL143104A0 (en
Original Assignee
Optime Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optime Therapeutics Inc filed Critical Optime Therapeutics Inc
Publication of IL143104A0 publication Critical patent/IL143104A0/xx
Publication of IL143104A publication Critical patent/IL143104A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/4105Methods of emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/411Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80Mixing plants; Combinations of mixers
    • B01F33/82Combinations of dissimilar mixers
    • B01F33/821Combinations of dissimilar mixers with consecutive receptacles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/21Measuring
    • B01F35/213Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/22Control or regulation
    • B01F35/221Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215Temperature
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80Forming a predetermined ratio of the substances to be mixed
    • B01F35/83Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
    • B01F35/831Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
    • B01F35/8311Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0468Numerical pressure values
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0472Numerical temperature values
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14310499A 1998-11-13 1999-11-12 Method and apparatus for liposome production IL143104A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10835598P 1998-11-13 1998-11-13
PCT/US1999/026738 WO2000029103A1 (en) 1998-11-13 1999-11-12 Method and apparatus for liposome production

Publications (2)

Publication Number Publication Date
IL143104A0 IL143104A0 (en) 2002-04-21
IL143104A true IL143104A (en) 2005-09-25

Family

ID=22321729

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14310499A IL143104A (en) 1998-11-13 1999-11-12 Method and apparatus for liposome production

Country Status (9)

Country Link
US (3) US6534018B1 (xx)
EP (1) EP1146959B1 (xx)
JP (1) JP2002529240A (xx)
AT (1) ATE397488T1 (xx)
AU (1) AU756196B2 (xx)
CA (1) CA2350430C (xx)
DE (1) DE69938875D1 (xx)
IL (1) IL143104A (xx)
WO (1) WO2000029103A1 (xx)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0943242A1 (en) * 1998-02-26 1999-09-22 Puratos N.V. Granulated bread improver for the preparation of bakery products
US6855296B1 (en) * 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
AU781703B2 (en) * 1999-01-25 2005-06-09 Blue Ridge Pharmaceuticals, Inc. Liposome formulations
DE60017406T2 (de) * 1999-07-15 2005-09-29 Inex Pharmaceuticals Corp., Burnaby Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
DE60138934D1 (de) * 2000-02-25 2009-07-23 Hitachi Ltd Mischvorrichtung für Analysenautomat
EP1203614A1 (de) * 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln
DK1519714T3 (da) * 2002-06-28 2011-01-31 Protiva Biotherapeutics Inc Fremgangsmåde og apparat til fremstilling af liposomer
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
ES2831305T3 (es) 2002-10-29 2021-06-08 Insmed Inc Liposomas que comprenden un aminoglucósido para el tratamiento de infecciones pulmonares
US7879351B2 (en) 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
FR2854072B1 (fr) * 2003-04-23 2006-08-04 Centre Nat Rech Scient Vecteur pour administration par voie orale
AU2005224247B2 (en) * 2004-03-23 2010-04-01 Sintokogio, Ltd. Casting mold forming apparatus and metal mold unit for use therein
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白(muc-1)疫苗
DE102004018283A1 (de) * 2004-04-15 2005-11-03 Wacker-Chemie Gmbh Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen
US20080102111A1 (en) * 2005-03-09 2008-05-01 Hiromichi Imanaka Anticancer Composition for Oral Use Comprising Liposome Containing Phytosterols and Prevention or Treatment for Cancer Using the Liposome
US9005654B2 (en) 2005-07-27 2015-04-14 Protiva Biotherapeutics, Inc. Systems and methods for manufacturing liposomes
EP3718532A1 (en) 2005-12-08 2020-10-07 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
US7740152B2 (en) 2006-03-06 2010-06-22 The Coca-Cola Company Pump system with calibration curve
US11906988B2 (en) 2006-03-06 2024-02-20 Deka Products Limited Partnership Product dispensing system
US9146564B2 (en) 2006-03-06 2015-09-29 Deka Products Limited Partnership Product dispensing system
US11214476B2 (en) 2006-03-06 2022-01-04 Deka Products Limited Partnership System and method for generating a drive signal
US10631558B2 (en) 2006-03-06 2020-04-28 The Coca-Cola Company Methods and apparatuses for making compositions comprising an acid and an acid degradable component and/or compositions comprising a plurality of selectable components
US8353619B2 (en) * 2006-08-01 2013-01-15 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) * 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
WO2009120247A2 (en) * 2007-12-27 2009-10-01 The Ohio State University Research Foundation Lipid nanoparticle compositions and methods of making and using the same
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JPWO2010041727A1 (ja) * 2008-10-10 2012-03-08 株式会社リポソーム工学研究所 リポソーム製造装置
WO2010044399A1 (ja) * 2008-10-14 2010-04-22 株式会社リポソーム工学研究所 多機能リポソーム自動製造装置
US20120101148A1 (en) 2009-01-29 2012-04-26 Alnylam Pharmaceuticals, Inc. lipid formulation
CN102421900B (zh) 2009-03-12 2015-07-22 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因表达的脂质配制的组合物以及方法
CA3042927C (en) 2009-05-05 2022-05-17 Arbutus Biopharma Corporation Lipid compositions for the delivery of therapeutic agents
JP5889783B2 (ja) 2009-05-05 2016-03-22 テクミラ ファーマシューティカルズ コーポレイションTekmira Pharmaceuticals Corporation 免疫細胞へオリゴヌクレオチドを送達する方法
EA028860B1 (ru) 2009-06-10 2018-01-31 Арбутус Биофарма Корпорэйшн Улучшенная липидная композиция
AP3574A (en) 2009-08-14 2016-02-08 Alnylam Pharmaceuticals Inc Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
US20130156845A1 (en) 2010-04-29 2013-06-20 Alnylam Pharmaceuticals, Inc. Lipid formulated single stranded rna
CN103370054A (zh) 2010-11-09 2013-10-23 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
AU2012330819B2 (en) 2011-11-04 2017-08-31 Nitto Denko Corporation Single use system for sterilely producing lipid-nucleic acid particles
EP2852391B1 (en) 2012-05-21 2021-11-17 Insmed Incorporated Systems for treating pulmonary infections
US9415109B2 (en) 2012-07-06 2016-08-16 Alnylam Pharmaceuticals, Inc. Stable non-aggregating nucleic acid lipid particle formulations
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
AU2013355258A1 (en) 2012-12-07 2015-06-11 Alnylam Pharmaceuticals, Inc. Improved nucleic acid lipid particle formulations
CA2906732C (en) 2013-03-15 2023-08-08 The University Of British Columbia Lipid nanoparticles for transfection and related methods
AU2014340568B2 (en) 2013-10-22 2017-02-02 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
KR101713886B1 (ko) 2013-12-19 2017-03-10 연세대학교 산학협력단 PRK2를 표적으로 하는 C형 간염 바이러스 치료제 siRNA
ES2755941T3 (es) 2014-05-15 2020-04-24 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas
CN114344275A (zh) * 2014-07-02 2022-04-15 川斯勒佰尔公司 信使rna的包封
US10765817B2 (en) 2014-08-13 2020-09-08 Elwha, Llc Methods, systems, and devices related to delivery of alcohol with an inhaler
US10987048B2 (en) 2014-08-13 2021-04-27 Elwha Llc Systems, methods, and devices to incentivize inhaler use
US10245393B2 (en) 2014-08-13 2019-04-02 Elwha Llc Methods, systems, and devices related to a supplemental inhaler
JP6373749B2 (ja) * 2014-12-19 2018-08-15 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
WO2020061426A2 (en) * 2018-09-21 2020-03-26 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
WO2020087064A2 (en) * 2018-10-26 2020-04-30 University Of Connecticut A continuous processing system and methods for internal and external modifications to nanoparticles
US11154502B2 (en) * 2019-01-24 2021-10-26 CannaClear Inc. Lecithin vesicles for oral delivery
WO2022269097A1 (en) 2021-06-25 2022-12-29 Alpine Antiviral Gmbh Sirna combinations targeting sars-cov-2 and/or host factor transcripts
CA3237294A1 (en) 2021-11-03 2023-05-11 Frank Stieneker Apparatus and method for mixing small liquid volumes, and use of the apparatus
WO2024069012A1 (en) 2022-09-30 2024-04-04 Leon-Nanodrugs Gmbh Cassette system for aseptic mixing process
WO2024069014A1 (en) 2022-09-30 2024-04-04 Leon-Nanodrugs Gmbh Apparatus and method for operating a static mixing device

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298194A (en) 1968-11-20 1972-11-29 Agfa Gevaert Improved method for encapsulating aqueous or hydrophilic material, the capsules obtained therewith and their application
JPS4945224B1 (xx) 1970-12-14 1974-12-03
DE2357212A1 (de) * 1973-11-16 1975-05-22 Henkel & Cie Gmbh Verfahren und vorrichtung zur kontinuierlichen herstellung von kolloidalen loesungen und emulsionen
US4108115A (en) * 1974-06-07 1978-08-22 Lucas Electrical Company, Limited Fuel injection systems for compression ignition engines
CH588887A5 (xx) 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
AU499635B2 (en) * 1976-02-20 1979-04-26 Thapa Chemical Industry Co Ltd Material mixing apparatus
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
DE3068743D1 (en) 1980-01-16 1984-08-30 Weder Hans G Process and dialysis-installation for the preparation of bilayer-vesicles and their use
US4452747A (en) * 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
DE3230289A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Herstellung von pharmazeutischen oder kosmetischen dispersionen
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS607932A (ja) 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4761288A (en) 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US4737276A (en) * 1984-12-21 1988-04-12 E. I. Du Pont De Nemours And Company Apparatus for manufacturing liposomes
US4752425A (en) 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US5628936A (en) 1987-03-13 1997-05-13 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US5474848A (en) 1987-03-13 1995-12-12 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4855090A (en) 1987-03-13 1989-08-08 Micro-Pak, Inc. Method of producing high aqueous volume multilamellar vesicles
US4853228A (en) 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US4935171A (en) * 1989-01-27 1990-06-19 Vestar, Inc. Method for vesicle formation
DE3916465A1 (de) * 1989-05-20 1990-11-22 Bayer Ag Herstellung kugelfoermiger dispersionen durch kristallisation von emulsionen
DE4031094A1 (de) 1990-10-02 1992-04-09 Basf Ag Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten
JP2729538B2 (ja) * 1991-02-13 1998-03-18 富士写真フイルム株式会社 マイクロカプセルの製造方法
US5474846A (en) * 1993-01-26 1995-12-12 Haldenby; George A. Uniform polymeric coated interior cylinder surface
EP0616801B1 (de) * 1993-03-24 1998-05-27 Novartis AG Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
CA2163860A1 (en) * 1993-06-30 1995-01-12 Chung C. Hsu Method for preparing liposomes
DE4432378A1 (de) * 1994-09-12 1996-03-14 Bayer Ag Injizierbare liposomale Arzneizubereitungen
JP3430787B2 (ja) * 1996-04-02 2003-07-28 ミノルタ株式会社 現像装置
JP4296341B2 (ja) * 2000-10-13 2009-07-15 独立行政法人産業技術総合研究所 リポソームの製造方法およびその装置
EP1203614A1 (de) * 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln

Also Published As

Publication number Publication date
CA2350430A1 (en) 2000-05-25
ATE397488T1 (de) 2008-06-15
AU1476800A (en) 2000-06-05
AU756196B2 (en) 2003-01-09
US20050196435A1 (en) 2005-09-08
US6855277B2 (en) 2005-02-15
US6534018B1 (en) 2003-03-18
DE69938875D1 (xx) 2008-07-17
EP1146959A1 (en) 2001-10-24
JP2002529240A (ja) 2002-09-10
EP1146959A4 (en) 2004-12-29
IL143104A0 (en) 2002-04-21
CA2350430C (en) 2008-06-03
US20030124033A1 (en) 2003-07-03
WO2000029103A1 (en) 2000-05-25
EP1146959B1 (en) 2008-06-04

Similar Documents

Publication Publication Date Title
IL143104A0 (en) Method and apparatus for liposome production
GB2326974B (en) Plasma producing method and apparatus including an inductively-coupled plasma source
AU5910796A (en) Method of producing L-lysine
AU7062496A (en) Process for the production of Bis(silyalkyl)-disulfanes
AU3496995A (en) Method for producing slabs of cementitious material
EP1334765A4 (en) METHOD FOR THE PRODUCTION OF LIPOSOMES AND DEVICE THEREFOR
AU3270599A (en) Method and apparatus for producing direct reduced iron with improved reducing gas utilization
HK1040642A1 (en) Method for controlling liposome size.
MY116593A (en) Process for the preparation of o-demethyltramadol enantiomers
AU6421698A (en) Method of production of low pollution fuel and production apparatus therefor
AU2442595A (en) Lightweight cement blocks and method of producing same
EP0990755A4 (en) KEY PANNER AND MANUFACTURING METHOD
AU3355595A (en) Photocatalyst, method for preparing the same, and production of hydrogen using the same
PL312350A1 (en) Method of obtaining flavanolignane preparations of enhanced liberation and resorption power, flavanolignane preparations of enhanced liberation and resorption power, and their application in production of pharmaceutic agents
AU4410697A (en) Production of moulded articles and apparatus for producing moulded articles
AU4166099A (en) Mixing-agitating machine and method of producing gypsum board using mixing-agitating machine
ATE116646T1 (de) Verfahren zur herstellung von hochreinem propylencarbonat und zur gleichzeitigen herstellung von passivierten elektroden.
AU1721899A (en) Industrial precursor for use in construction material production and method of producing same
GB8917138D0 (en) Process for the production of stable dispersions,the dispersions so produced,and the use thereof in the manufacture of polyurethanes
ZA995726B (en) Method of producing reduced iron and production facilities therefor.
MX9704836A (es) Proceso para la fabricaciom de acetonilbenzamidas.
AU6222796A (en) Process and apparatus for the magnetic treatment of substancs
DE59306616D1 (de) Doppelplatte und verfahren zu ihrer herstellung
PL322700A1 (en) Method of and apparatus for making cheeses in an intermittent and continuous production process
HU9602959D0 (en) Spider neurotoxins and method of producing the same

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees