ATE397488T1 - Vorrichtung zur herstellung von liposomen - Google Patents

Vorrichtung zur herstellung von liposomen

Info

Publication number
ATE397488T1
ATE397488T1 AT99972124T AT99972124T ATE397488T1 AT E397488 T1 ATE397488 T1 AT E397488T1 AT 99972124 T AT99972124 T AT 99972124T AT 99972124 T AT99972124 T AT 99972124T AT E397488 T1 ATE397488 T1 AT E397488T1
Authority
AT
Austria
Prior art keywords
producing liposomes
liposomes
producing
therapeutic applications
mixing system
Prior art date
Application number
AT99972124T
Other languages
English (en)
Inventor
Martin Baker
William Heriot
Original Assignee
Heriot William A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heriot William A filed Critical Heriot William A
Application granted granted Critical
Publication of ATE397488T1 publication Critical patent/ATE397488T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
    • B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
    • B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0468—Numerical pressure values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0472—Numerical temperature values
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99972124T 1998-11-13 1999-11-12 Vorrichtung zur herstellung von liposomen ATE397488T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10835598P 1998-11-13 1998-11-13

Publications (1)

Publication Number Publication Date
ATE397488T1 true ATE397488T1 (de) 2008-06-15

Family

ID=22321729

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99972124T ATE397488T1 (de) 1998-11-13 1999-11-12 Vorrichtung zur herstellung von liposomen

Country Status (9)

Country Link
US (3) US6534018B1 (de)
EP (1) EP1146959B1 (de)
JP (1) JP2002529240A (de)
AT (1) ATE397488T1 (de)
AU (1) AU756196B2 (de)
CA (1) CA2350430C (de)
DE (1) DE69938875D1 (de)
IL (1) IL143104A (de)
WO (1) WO2000029103A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0943242A1 (de) * 1998-02-26 1999-09-22 Puratos N.V. Granuliertes Brotvergesserungmittel sowie ihre Verwendung zur Herstellung von Teigwaren
US6855296B1 (en) * 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
WO2000042990A1 (en) * 1999-01-25 2000-07-27 Optime Therapeutics, Inc. Liposome formulations
CA2378430A1 (en) * 1999-07-15 2001-01-25 Inex Pharmaceuticals Corp. Methods and apparatus for preparation of lipid vesicles
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
DE60138934D1 (de) * 2000-02-25 2009-07-23 Hitachi Ltd Mischvorrichtung für Analysenautomat
EP1203614A1 (de) * 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln
US7901708B2 (en) * 2002-06-28 2011-03-08 Protiva Biotherapeutics, Inc. Liposomal apparatus and manufacturing methods
EP1581236B1 (de) 2002-10-29 2013-10-16 Insmed Incorporated Verzögerte freisetzung von anti-infektionsmitteln
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
FR2854072B1 (fr) * 2003-04-23 2006-08-04 Centre Nat Rech Scient Vecteur pour administration par voie orale
AU2005224247B2 (en) * 2004-03-23 2010-04-01 Sintokogio, Ltd. Casting mold forming apparatus and metal mold unit for use therein
TW201204410A (en) * 2004-04-01 2012-02-01 Oncothyreon Inc Mucinous glycoprotein (MUC-1) vaccine
DE102004018283A1 (de) * 2004-04-15 2005-11-03 Wacker-Chemie Gmbh Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen
JPWO2006095798A1 (ja) * 2005-03-09 2008-08-14 サンスター株式会社 フィトステロールを含んだリポソームを含有する抗癌用経口組成物、該リポソームによる癌の予防又は治療
US9005654B2 (en) 2005-07-27 2015-04-14 Protiva Biotherapeutics, Inc. Systems and methods for manufacturing liposomes
HUE029994T2 (en) 2005-12-08 2017-04-28 Insmed Inc Lipid-based compositions of antiinfectives for treating pulmonary infections
US9146564B2 (en) 2006-03-06 2015-09-29 Deka Products Limited Partnership Product dispensing system
US11906988B2 (en) 2006-03-06 2024-02-20 Deka Products Limited Partnership Product dispensing system
US7740152B2 (en) 2006-03-06 2010-06-22 The Coca-Cola Company Pump system with calibration curve
US11214476B2 (en) 2006-03-06 2022-01-04 Deka Products Limited Partnership System and method for generating a drive signal
US10631558B2 (en) 2006-03-06 2020-04-28 The Coca-Cola Company Methods and apparatuses for making compositions comprising an acid and an acid degradable component and/or compositions comprising a plurality of selectable components
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) * 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
CA2710983A1 (en) * 2007-12-27 2009-10-01 The Ohio State University Research Foundation Lipid nanoparticle compositions and methods of making and using the same
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US20110221082A1 (en) * 2008-10-10 2011-09-15 Hashimoto Electronic Industry Co., Ltd. Liposome manufacturing device
JPWO2010044399A1 (ja) * 2008-10-14 2012-03-15 株式会社リポソーム工学研究所 多機能リポソーム自動製造装置
EP3243504A1 (de) 2009-01-29 2017-11-15 Arbutus Biopharma Corporation Verbesserte lipidformulierung
AU2010223967B2 (en) 2009-03-12 2015-07-30 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
JP5889783B2 (ja) 2009-05-05 2016-03-22 テクミラ ファーマシューティカルズ コーポレイションＴｅｋｍｉｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 免疫細胞へオリゴヌクレオチドを送達する方法
KR20180094137A (ko) 2009-05-05 2018-08-22 알닐람 파마슈티칼스 인코포레이티드 지질 조성물
MX342785B (es) 2009-06-10 2016-10-12 Alnylam Pharmaceuticals Inc Formulacion mejorada de lipido.
US9029338B2 (en) 2009-08-14 2015-05-12 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
WO2011139911A2 (en) 2010-04-29 2011-11-10 Isis Pharmaceuticals, Inc. Lipid formulated single stranded rna
US9339513B2 (en) 2010-11-09 2016-05-17 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
CA2853685C (en) 2011-11-04 2019-09-03 Nitto Denko Corporation Single use system for sterilely producing lipid-nucleic acid particles
MX369828B (es) 2012-05-21 2019-11-22 Insmed Inc Sistemas para tratar infecciones pulmonares.
WO2014008334A1 (en) 2012-07-06 2014-01-09 Alnylam Pharmaceuticals, Inc. Stable non-aggregating nucleic acid lipid particle formulations
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
US9687448B2 (en) 2012-12-07 2017-06-27 Alnylam Pharmaceuticals, Inc. Nucleic acid lipid particle formulations
CA2906732C (en) 2013-03-15 2023-08-08 The University Of British Columbia Lipid nanoparticles for transfection and related methods
US9987227B2 (en) 2013-10-22 2018-06-05 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
KR101713886B1 (ko) 2013-12-19 2017-03-10 연세대학교 산학협력단 ＰＲＫ２를 표적으로 하는 Ｃ형 간염 바이러스 치료제 ｓｉＲＮＡ
SMT202000516T1 (it) 2014-05-15 2020-11-10 Insmed Inc Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
BR112016030852A2 (pt) * 2014-07-02 2018-01-16 Shire Human Genetic Therapies encapsulação de rna mensageiro
US10245393B2 (en) 2014-08-13 2019-04-02 Elwha Llc Methods, systems, and devices related to a supplemental inhaler
US10765817B2 (en) 2014-08-13 2020-09-08 Elwha, Llc Methods, systems, and devices related to delivery of alcohol with an inhaler
US10987048B2 (en) 2014-08-13 2021-04-27 Elwha Llc Systems, methods, and devices to incentivize inhaler use
JP6373749B2 (ja) * 2014-12-19 2018-08-15 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
WO2018089801A1 (en) * 2016-11-10 2018-05-17 Translate Bio, Inc. Improved process of preparing mrna-loaded lipid nanoparticles
EP3773505B1 (de) 2018-03-30 2026-04-29 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
WO2019213398A1 (en) 2018-05-02 2019-11-07 Insmed Incorporated Methods for the manufacture of liposomal drug formulations
IL281615B2 (en) * 2018-09-21 2026-01-01 Acuitas Therapeutics Inc Systems and methods for producing lipid nanoparticles and liposomes
JP7543259B2 (ja) 2018-10-18 2024-09-02 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
US12434208B2 (en) 2018-10-26 2025-10-07 University Of Connecticut Continuous processing system and methods for internal and external modifications to nanoparticles
US11154502B2 (en) * 2019-01-24 2021-10-26 CannaClear Inc. Lecithin vesicles for oral delivery
US12324800B2 (en) 2019-01-24 2025-06-10 CannaClear Inc. Lecithin vesicles
US12201724B2 (en) 2019-01-24 2025-01-21 CannaClear Inc. Lecithin vesicles for oral delivery
WO2022016070A1 (en) 2020-07-16 2022-01-20 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
WO2022269097A1 (en) 2021-06-25 2022-12-29 Alpine Antiviral Gmbh Sirna combinations targeting sars-cov-2 and/or host factor transcripts
KR20240116908A (ko) 2021-11-03 2024-07-30 레온-나노드럭스 게엠베하 소량의 액체를 혼합하기 위한 장치 및 방법, 및 장치의 사용
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CA3268291A1 (en) 2022-09-30 2024-04-04 Leon-Nanodrugs Gmbh CASSETTE SYSTEM FOR ASEPTIC MIXING PROCESS
CA3268281A1 (en) 2022-09-30 2024-04-04 Leon-Nanodrugs Gmbh APPARATUS AND METHOD FOR OPERATING A STATIC MIXING DEVICE
WO2025221360A1 (en) * 2024-02-15 2025-10-23 Recode Therapeutics, Inc. Systems and methods for generating lipid nanoparticles

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298194A (en) 1968-11-20 1972-11-29 Agfa Gevaert Improved method for encapsulating aqueous or hydrophilic material, the capsules obtained therewith and their application
JPS4945224B1 (de) 1970-12-14 1974-12-03
DE2357212A1 (de) * 1973-11-16 1975-05-22 Henkel & Cie Gmbh Verfahren und vorrichtung zur kontinuierlichen herstellung von kolloidalen loesungen und emulsionen
US4108115A (en) * 1974-06-07 1978-08-22 Lucas Electrical Company, Limited Fuel injection systems for compression ignition engines
CH588887A5 (de) 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
AU499635B2 (en) * 1976-02-20 1979-04-26 Thapa Chemical Industry Co Ltd Material mixing apparatus
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
EP0032578B1 (de) 1980-01-16 1984-07-25 Hans Georg Prof. Dr. Weder Verfahren und Dialysiereinrichtung zur Herstellung von Bilayer-Vesikeln und Verwendung der Bilayer-Vesikel
US4452747A (en) * 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
DE3230289A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Herstellung von pharmazeutischen oder kosmetischen dispersionen
US4551288A (en) 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS607932A (ja) 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4761288A (en) 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US4737276A (en) * 1984-12-21 1988-04-12 E. I. Du Pont De Nemours And Company Apparatus for manufacturing liposomes
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US5628936A (en) 1987-03-13 1997-05-13 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US5474848A (en) 1987-03-13 1995-12-12 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4855090A (en) 1987-03-13 1989-08-08 Micro-Pak, Inc. Method of producing high aqueous volume multilamellar vesicles
US4853228A (en) 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US4935171A (en) 1989-01-27 1990-06-19 Vestar, Inc. Method for vesicle formation
DE3916465A1 (de) * 1989-05-20 1990-11-22 Bayer Ag Herstellung kugelfoermiger dispersionen durch kristallisation von emulsionen
DE4031094A1 (de) * 1990-10-02 1992-04-09 Basf Ag Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten
JP2729538B2 (ja) 1991-02-13 1998-03-18 富士写真フイルム株式会社 マイクロカプセルの製造方法
US5474846A (en) * 1993-01-26 1995-12-12 Haldenby; George A. Uniform polymeric coated interior cylinder surface
ATE166573T1 (de) * 1993-03-24 1998-06-15 Ciba Geigy Ag Verfahren zur herstellung einer liposomendispersion im hochdruckbereich
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
WO1995001164A1 (en) * 1993-06-30 1995-01-12 Genentech, Inc. Method for preparing liposomes
DE4432378A1 (de) * 1994-09-12 1996-03-14 Bayer Ag Injizierbare liposomale Arzneizubereitungen
JP3430787B2 (ja) * 1996-04-02 2003-07-28 ミノルタ株式会社 現像装置
US20040099976A1 (en) * 2000-10-13 2004-05-27 Katsuto Otake Process for producing liposome and apparatus therefor
EP1203614A1 (de) * 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln

Also Published As

Publication number Publication date
EP1146959A1 (de) 2001-10-24
US20030124033A1 (en) 2003-07-03
WO2000029103A1 (en) 2000-05-25
US20050196435A1 (en) 2005-09-08
US6855277B2 (en) 2005-02-15
JP2002529240A (ja) 2002-09-10
EP1146959B1 (de) 2008-06-04
EP1146959A4 (de) 2004-12-29
US6534018B1 (en) 2003-03-18
CA2350430A1 (en) 2000-05-25
AU1476800A (en) 2000-06-05
IL143104A0 (en) 2002-04-21
IL143104A (en) 2005-09-25
DE69938875D1 (de) 2008-07-17
CA2350430C (en) 2008-06-03
AU756196B2 (en) 2003-01-09

Similar Documents

Publication Publication Date Title
ATE397488T1 (de) Vorrichtung zur herstellung von liposomen
DE69420604D1 (de) Vorrichtung zur Herstellung von Wasserstoff
DE69924682D1 (de) Vorrichtung zur Herstellung von Wasserstoff
DE69927548D1 (de) Vorrichtung zur Herstellung von Dünnfilmen
DE69716767D1 (de) Verfahren zur herstellung von tolterodin
ATE223383T1 (de) Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole
DE69309763D1 (de) Vorrichtung zur Herstellung von Rohren
DE60028492D1 (de) Vorrichtung zur Herstellung von Dünnfilmen
DE69824481D1 (de) Verfahren zur Herstellung von FET-Bauelementen mit flacher,maskenloser Grabenisolation
DE69434937D1 (de) Verfahren zur Herstellung von Leistungsbauteilen in MOS-Technologie
DE69624976D1 (de) Verfahren zur Herstellung von MOS-Leistungstransistoren
DE69424806D1 (de) Vorrichtung zur Herstellung von Stempeln
DE59810077D1 (de) Vorrichtung zur erzeugung von plasma
DE69531762D1 (de) Vorrichtung zur Erzeugung von Ozonwasser
DE60009210D1 (de) Vorrichtung zur Herstellung von Wasserstoff
DE69311582D1 (de) Vorrichtung zur herstellung von knochenzement
DE69916725D1 (de) Vorrichtung zur herstellung von zement
DE59705368D1 (de) Vorrichtung zur Herstellung von Kunststoff-Verbund-Rohren
DE69927602D1 (de) Verfahren zur herstellung von vitaminpulvern
ATE153073T1 (de) Verfahren zur herstellung von n- acetylneuraminsäure
DE69403550D1 (de) Vorrichtung zur Herstellung von gebohrten Nadelrohlingen
ATA138096A (de) Vorrichtung zur gewinnung von biogas
BG101894A (bg) 4-аминотетрахидробензизоксазолови или -изотиазолови съединения
DE59500727D1 (de) Vorrichtung zur Herstellung von Aufgussgetränken
DE59503886D1 (de) Vorrichtung zur herstellung von teigbändern

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties