IL139786A0 - Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c - Google Patents

Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c

Info

Publication number
IL139786A0
IL139786A0 IL13978699A IL13978699A IL139786A0 IL 139786 A0 IL139786 A0 IL 139786A0 IL 13978699 A IL13978699 A IL 13978699A IL 13978699 A IL13978699 A IL 13978699A IL 139786 A0 IL139786 A0 IL 139786A0
Authority
IL
Israel
Prior art keywords
ribavirin
ifn
peg
alpha
treatment
Prior art date
Application number
IL13978699A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8232086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL139786(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL139786A0 publication Critical patent/IL139786A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IL13978699A 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c IL139786A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110433 1998-06-08
PCT/EP1999/003746 WO1999064016A1 (en) 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c

Publications (1)

Publication Number Publication Date
IL139786A0 true IL139786A0 (en) 2002-02-10

Family

ID=8232086

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13978699A IL139786A0 (en) 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
IL139786A IL139786A (en) 1998-06-08 2000-11-20 Use of PEG-IFN-ALPHA and ribavirin in the preparation of a drug for the treatment of chronic hepatitis C.

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL139786A IL139786A (en) 1998-06-08 2000-11-20 Use of PEG-IFN-ALPHA and ribavirin in the preparation of a drug for the treatment of chronic hepatitis C.

Country Status (35)

Country Link
US (3) US20030053986A1 (de)
EP (1) EP1087778B1 (de)
JP (2) JP3839667B2 (de)
KR (2) KR20050055053A (de)
CN (1) CN1170543C (de)
AR (1) AR019855A1 (de)
AT (1) ATE307597T1 (de)
AU (1) AU767131B2 (de)
BR (1) BR9911076A (de)
CA (1) CA2334267C (de)
CL (1) CL2010000828A1 (de)
CO (1) CO5050297A1 (de)
CZ (1) CZ298681B6 (de)
DE (1) DE69927971T2 (de)
DK (1) DK1087778T3 (de)
ES (1) ES2251196T3 (de)
HK (1) HK1037981A1 (de)
HR (1) HRP20000808A2 (de)
HU (1) HU228218B1 (de)
ID (1) ID29285A (de)
IL (2) IL139786A0 (de)
MA (1) MA26641A1 (de)
MY (1) MY124091A (de)
NO (1) NO325598B1 (de)
NZ (1) NZ508249A (de)
PE (1) PE20000560A1 (de)
PL (1) PL192364B1 (de)
RS (1) RS50144B (de)
RU (1) RU2271217C2 (de)
SA (1) SA99200208B1 (de)
SI (1) SI1087778T1 (de)
TR (1) TR200003635T2 (de)
TW (1) TWI241913B (de)
WO (1) WO1999064016A1 (de)
ZA (1) ZA200006814B (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767131B2 (en) * 1998-06-08 2003-10-30 F. Hoffmann-La Roche Ag Use of PEG-IFN-alpha and ribavirin for the treatment of chronic hepatitis C
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20030036189A (ko) 2000-05-26 2003-05-09 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US7208167B2 (en) 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
MXPA03001145A (es) * 2000-08-07 2004-08-02 Sciclone Pharmaceuticals Inc Composicion farmaceutica para el tratamiento de la hepatitis c con timocina, interferon y ribavirin.
US7179791B2 (en) 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
KR100480429B1 (ko) * 2001-12-04 2005-04-06 선바이오(주) 인터페론-알파와 폴리에틸렌글리콜 유도체의 배합체
DE14169110T1 (de) 2002-06-28 2022-05-12 Centre National De La Recherche Scientifique -Cnrs- Modifizierte 2'- und 3'-Nukleosid-Prodrugs zur Behandlung von Flaviridae-Infektionen
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003248748A1 (en) * 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
EP2319853B1 (de) * 2002-12-12 2014-03-12 IDENIX Pharmaceuticals, Inc. Verfahren zur Herstellung von 2 -verzweigten Nucleosiden
RU2005123395A (ru) * 2002-12-23 2006-01-27 Айденикс (Кайман) Лимитед (Ky) Способ получения 3-нуклеозидных пролекарств
US7429572B2 (en) 2003-05-30 2008-09-30 Pharmasset, Inc. Modified fluorinated nucleoside analogues
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7892827B2 (en) 2004-11-26 2011-02-22 Pieris Ag Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
WO2007020195A2 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Peg-ifn alpha and ribavirin for hbv treatment
US9201979B2 (en) * 2005-09-14 2015-12-01 Millennial Media, Inc. Syndication of a behavioral profile associated with an availability condition using a monetization platform
US7781576B2 (en) * 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
EP2313430B1 (de) 2008-06-24 2018-05-02 Technische Universität München Muteine von hngal und verwandter proteine mit affinität für ein vorgegebenes zielmolekül
BRPI0918653A2 (pt) * 2008-09-17 2015-12-01 Boehringer Ingelheim Int combinação de inibidor de ns3 protese de hcv com interferon e ribavirina.
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP2376088B1 (de) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituierte-2-Amino-Purin-Nukleosid-Phosphoramidate
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
JP2012526149A (ja) 2009-05-08 2012-10-25 サイクローン・ファーマシューティカルズ・インコーポレイテッド ワクチン増強剤としてのαチモシンペプチド
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
WO2011015634A2 (en) 2009-08-05 2011-02-10 Pieris Ag Controlled release formulations of lipocalin muteins
EA201200650A1 (ru) 2009-10-30 2012-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин
BR112012013662B1 (pt) 2009-12-07 2022-08-02 Pieris Pharmaceuticals Gmbh Muteínas de lipocalina associada à gelatinase de neutrófilo humano (lcn2, hngal), seu uso e seus métodos de geração e produção, molécula de ácido nucleico, célula hospedeira, composição farmacêutica e kit de diagnóstico ou analítico
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
NZ603562A (en) 2010-06-08 2014-07-25 Pieris Ag Tear lipocalin muteins binding il-4 r alpha
DK2606061T3 (da) 2010-08-16 2017-11-06 Pieris Pharmaceuticals Gmbh Bindingsproteiner til hepcidin
EP2640740B1 (de) 2010-11-15 2017-03-15 Pieris Pharmaceuticals GmbH Muteine von menschlichem lipocalin 2 mit affinität für glypican-3 (gpc3)
AR084044A1 (es) 2010-11-30 2013-04-17 Pharmasset Inc Compuestos 2’-espiro-nucleosidos
EP2646552B1 (de) 2010-12-02 2017-07-05 Pieris Pharmaceuticals GmbH Muteine von menschlichem lipocalin 2 mit affinität für ctla-4
JP6073897B2 (ja) 2011-09-16 2017-02-01 ギリアド ファーマセット エルエルシー Hcvを処置するための方法
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
HUE042720T2 (hu) 2011-12-13 2019-07-29 Pieris Pharmaceuticals Gmbh Eljárás bizonyos rendellenességek megelõzésére vagy kezelésére IL-4 és/vagy IL-13 saját receptorához történõ kötõdésének gátlása révén
WO2013174783A1 (en) 2012-05-23 2013-11-28 Pieris Ag Lipocalin muteins with binding-affinity for glypican-3 (gpc-3) and use of lipocalin muteins for target-specific delivery to cells expressing gpc-3
US20140039923A1 (en) * 2012-08-03 2014-02-06 AxelaCare Health Solutions, Inc. Computer program, method, and system for receiving and managing patient data gathered during patient treatments
ES2771458T3 (es) 2013-01-31 2020-07-06 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
AU2014230460B2 (en) 2013-03-14 2018-04-05 Pieris Pharmaceuticals Gmbh Novel binding proteins for PCSK9
CA2891557A1 (en) 2013-03-26 2014-05-22 Pieris Ag Novel specific-binding polypeptides and uses thereof
PL3650014T3 (pl) 2013-08-27 2022-01-31 Gilead Pharmasset Llc Preparat złożony dwóch związków przeciwwirusowych
AU2015205530B8 (en) 2014-01-13 2019-09-19 Pieris Pharmaceuticals Gmbh Multi-specific polypeptide useful for localized tumor immunomodulation
DK3145945T3 (da) 2014-05-22 2020-09-28 Pieris Pharmaceuticals Gmbh Hidtil ukendte specifikt bindende polypeptider og anvendelser deraf
EP3250586B1 (de) 2015-01-28 2021-10-27 Pieris Pharmaceuticals GmbH Neuartige angiogenesespezifische proteine
TW201636364A (zh) 2015-02-18 2016-10-16 賽諾菲公司 對於螢光鐵載體及綠膿桿菌螯鐵蛋白具特異性之新穎蛋白
SG11201708339QA (en) 2015-05-04 2017-11-29 Pieris Pharmaceuticals Gmbh Proteins specific for cd137
CN114316067A (zh) 2015-05-04 2022-04-12 皮里斯制药有限公司 抗癌融合多肽
WO2016184875A1 (en) 2015-05-18 2016-11-24 Pieris Pharmaceuticals Gmbh Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3)
RU2754466C2 (ru) 2015-05-18 2021-09-02 ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ Слитый полипептид с противораковой активностью
EP3115371A1 (de) 2015-07-07 2017-01-11 Sanofi Fusionsmoleküle
MX2018000447A (es) 2015-07-15 2018-08-15 Pieris Pharmaceuticals Gmbh Novedosas proteinas especificas para lag-3.
SG10201911499TA (en) 2015-11-30 2020-01-30 Pieris Australia Pty Ltd Novel anti-angiogenic fusion polypeptides
TW201725212A (zh) 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
WO2018087108A1 (en) 2016-11-09 2018-05-17 Pieris Pharmaceuticals Gmbh Proteins specific for cd137
CN110402252A (zh) 2017-01-18 2019-11-01 皮里斯制药有限公司 对lag-3具有结合亲和力的脂质运载蛋白突变蛋白
KR20210040103A (ko) 2018-07-31 2021-04-12 피어이스 파마슈티컬즈 게엠베하 Cd137 및 pd-l1에 특이적인 신규한 융합 단백질
CA3124441A1 (en) 2019-02-26 2020-09-03 Pieris Pharmaceuticals Gmbh Novel fusion proteins specific for cd137 and gpc3
EP4161957A1 (de) 2020-06-05 2023-04-12 Pieris Pharmaceuticals GmbH Gegen 4-1bb gerichteter multimerer immunmodulator
KR20230165917A (ko) 2021-04-08 2023-12-05 피어이스 파마슈티컬즈 게엠베하 결합 조직 성장 인자(ctgf)에 특이적인 신규 리포칼린 뮤테인
WO2022243341A1 (en) 2021-05-18 2022-11-24 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding affinity for ox40
WO2024064713A1 (en) 2022-09-21 2024-03-28 Seagen Inc. Novel fusion protein specific for cd137 and cd228

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211771A (en) * 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US4609546A (en) * 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4681848A (en) * 1982-09-22 1987-07-21 Takeda Chemical Industries, Ltd. Novel peptide and use thereof
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
DE3719046A1 (de) * 1987-06-06 1988-12-15 Basf Ag Verwendung von salzen von sulfonamidcarbonsaeuren als korrosionsinhibitoren in waessrigen systemen
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5238915A (en) * 1991-02-08 1993-08-24 Wakunaga Seiyaku K.K. Aromatic composition and method for controlling aroma
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
DK0730470T3 (da) * 1993-11-10 2002-06-03 Enzon Inc Forbedrede interferonpolymerkonjugater
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
US5695760A (en) * 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
US6387365B1 (en) * 1995-05-19 2002-05-14 Schering Corporation Combination therapy for chronic hepatitis C infection
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
JP2000507917A (ja) * 1995-11-02 2000-06-27 シェーリング コーポレイション 持続的低用量サイトカイン注入治療
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US6172046B1 (en) * 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
AU767131B2 (en) * 1998-06-08 2003-10-30 F. Hoffmann-La Roche Ag Use of PEG-IFN-alpha and ribavirin for the treatment of chronic hepatitis C

Also Published As

Publication number Publication date
CA2334267A1 (en) 1999-12-16
NZ508249A (en) 2003-02-28
DE69927971D1 (de) 2005-12-01
MY124091A (en) 2006-06-30
JP2006160759A (ja) 2006-06-22
HUP0102033A3 (en) 2010-01-28
DE69927971T2 (de) 2006-07-27
HRP20000808A2 (en) 2001-10-31
EP1087778B1 (de) 2005-10-26
PE20000560A1 (es) 2000-07-05
HU228218B1 (en) 2013-02-28
SA99200208B1 (ar) 2006-08-15
HK1037981A1 (en) 2002-03-01
CN1305382A (zh) 2001-07-25
NO20006178L (no) 2000-12-05
RS50144B (sr) 2009-03-25
CO5050297A1 (es) 2001-06-27
CN1170543C (zh) 2004-10-13
JP2002517451A (ja) 2002-06-18
ATE307597T1 (de) 2005-11-15
CZ20004487A3 (en) 2001-06-13
WO1999064016A1 (en) 1999-12-16
HUP0102033A2 (hu) 2001-10-28
AU4503399A (en) 1999-12-30
EP1087778A1 (de) 2001-04-04
DK1087778T3 (da) 2005-12-19
NO325598B1 (no) 2008-06-23
ID29285A (id) 2001-08-16
AU767131B2 (en) 2003-10-30
PL344794A1 (en) 2001-11-19
YU77000A (sh) 2003-08-29
AR019855A1 (es) 2002-03-20
TR200003635T2 (tr) 2001-04-20
BR9911076A (pt) 2001-02-20
MA26641A1 (fr) 2004-12-20
ES2251196T3 (es) 2006-04-16
US20070196385A1 (en) 2007-08-23
IL139786A (en) 2007-10-31
US20050031589A1 (en) 2005-02-10
CZ298681B6 (cs) 2007-12-19
KR20050055053A (ko) 2005-06-10
KR20010052622A (ko) 2001-06-25
US20030053986A1 (en) 2003-03-20
PL192364B1 (pl) 2006-10-31
NO20006178D0 (no) 2000-12-05
CA2334267C (en) 2009-02-17
JP3839667B2 (ja) 2006-11-01
SI1087778T1 (sl) 2006-02-28
TWI241913B (en) 2005-10-21
ZA200006814B (en) 2002-05-03
RU2271217C2 (ru) 2006-03-10
CL2010000828A1 (es) 2011-02-11

Similar Documents

Publication Publication Date Title
IL139786A0 (en) Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
HUP9802324A3 (en) Use of ribavirin and interferon alpha for the treatment of hepatitis c
IL129352A0 (en) Benzimidazole-2- carbamates for the treatment of viral infections and cancer
PL344535A1 (en) Use of organophosphoric compounds for the therapeutic and preventative treatment of infections
EP1283702A4 (de) Medizinische verbandsanordnung und verfahren deren anwendung
HK1020259A1 (en) Composition for use in the treatment and prevention of hyperuricemia.
GB9805419D0 (en) Treatment of liquids
HUP0000963A3 (en) The use of levobupivacaine in paediatric surgery
GB9816234D0 (en) Compounds for use in the treatment of inflammation
IL141426A0 (en) Compositions and methods for the treatment of tumor
AU9279601A (en) Compounds and methods for use thereof in the treatment of cancer or viral infections
IL143212A0 (en) Compositions and methods for the treatment of tumor
IL143413A0 (en) Method for the activation of water and use thereof
ZA988519B (en) Use of IFN-alpha and amantadine for the treatment of chronic hepatitis C
GB9612990D0 (en) Compositions and methods for the treatment of chronic infections
EP1112250A4 (de) Therapeutische verbindungen und verfahren
EP1245236A4 (de) Prophylaktika und therapeutika zur behandung von chronischer hepatitis
GB2351904B (en) Herbal composition and use of the composition for treating viral infection of the liver
IL143795A0 (en) Use of 3-isoxazolidinones and hydroxylamic acids for the treatment of infections
GB9828564D0 (en) Materials and methods for the treatment and diagnosis of cancer
EP1150967A4 (de) Therapeutisch anwendbare verbindungen und methoden
IL132848A0 (en) Treatment of hepatic cirrhosis
HK1040922A1 (zh) 抑鬱癥的治療
BR7601412U (pt) Aparelho aplicável no tratamento de fluxo de graos em geral
GB9803671D0 (en) Catheter clamps and arrangements

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed