HK1037981A1 - Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis C. - Google Patents
Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis C.Info
- Publication number
- HK1037981A1 HK1037981A1 HK01108946A HK01108946A HK1037981A1 HK 1037981 A1 HK1037981 A1 HK 1037981A1 HK 01108946 A HK01108946 A HK 01108946A HK 01108946 A HK01108946 A HK 01108946A HK 1037981 A1 HK1037981 A1 HK 1037981A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ribavirin
- ifn
- peg
- alpha
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98110433 | 1998-06-08 | ||
PCT/EP1999/003746 WO1999064016A1 (en) | 1998-06-08 | 1999-05-29 | Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1037981A1 true HK1037981A1 (en) | 2002-03-01 |
Family
ID=8232086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK01108946A HK1037981A1 (en) | 1998-06-08 | 2001-12-20 | Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis C. |
Country Status (35)
Country | Link |
---|---|
US (3) | US20030053986A1 (xx) |
EP (1) | EP1087778B1 (xx) |
JP (2) | JP3839667B2 (xx) |
KR (2) | KR20010052622A (xx) |
CN (1) | CN1170543C (xx) |
AR (1) | AR019855A1 (xx) |
AT (1) | ATE307597T1 (xx) |
AU (1) | AU767131B2 (xx) |
BR (1) | BR9911076A (xx) |
CA (1) | CA2334267C (xx) |
CL (1) | CL2010000828A1 (xx) |
CO (1) | CO5050297A1 (xx) |
CZ (1) | CZ298681B6 (xx) |
DE (1) | DE69927971T2 (xx) |
DK (1) | DK1087778T3 (xx) |
ES (1) | ES2251196T3 (xx) |
HK (1) | HK1037981A1 (xx) |
HR (1) | HRP20000808A2 (xx) |
HU (1) | HU228218B1 (xx) |
ID (1) | ID29285A (xx) |
IL (2) | IL139786A0 (xx) |
MA (1) | MA26641A1 (xx) |
MY (1) | MY124091A (xx) |
NO (1) | NO325598B1 (xx) |
NZ (1) | NZ508249A (xx) |
PE (1) | PE20000560A1 (xx) |
PL (1) | PL192364B1 (xx) |
RS (1) | RS50144B (xx) |
RU (1) | RU2271217C2 (xx) |
SA (1) | SA99200208B1 (xx) |
SI (1) | SI1087778T1 (xx) |
TR (1) | TR200003635T2 (xx) |
TW (1) | TWI241913B (xx) |
WO (1) | WO1999064016A1 (xx) |
ZA (1) | ZA200006814B (xx) |
Families Citing this family (70)
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EP1087778B1 (en) * | 1998-06-08 | 2005-10-26 | F. Hoffmann-La Roche Ag | Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
CN1315862C (zh) | 2000-05-26 | 2007-05-16 | 艾登尼科斯(开曼)有限公司 | 处理黄病毒和瘟病毒的方法和组合物 |
US7208167B2 (en) | 2000-08-07 | 2007-04-24 | Sciclone Pharmaceuticals, Inc. | Treatment of hepatitis C with thymosin and peptide combination therapy |
MXPA03001145A (es) * | 2000-08-07 | 2004-08-02 | Sciclone Pharmaceuticals Inc | Composicion farmaceutica para el tratamiento de la hepatitis c con timocina, interferon y ribavirin. |
US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
KR100480429B1 (ko) * | 2001-12-04 | 2005-04-06 | 선바이오(주) | 인터페론-알파와 폴리에틸렌글리콜 유도체의 배합체 |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
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CN103319554A (zh) | 2002-06-28 | 2013-09-25 | 埃迪尼克斯医药公司 | 用于治疗黄病毒感染的修饰的2’和3’-核苷前药 |
EP1576138B1 (en) | 2002-11-15 | 2017-02-01 | Idenix Pharmaceuticals LLC. | 2'-methyl nucleosides in combination with interferon and flaviviridae mutation |
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BRPI0512360A (pt) * | 2004-06-23 | 2008-03-11 | Idenix Cayman Ltd | derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae |
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TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
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BR112012010110A2 (pt) | 2009-10-30 | 2019-09-24 | Boehringer Ingelheim Int | regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina |
RU2707126C2 (ru) | 2009-12-07 | 2019-11-22 | Пирис Аг | МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ |
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US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
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PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
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PL3038601T3 (pl) | 2013-08-27 | 2020-08-24 | Gilead Pharmasset Llc | Formulacja złożona dwóch związków przeciwwirusowych |
EP3094650A2 (en) | 2014-01-13 | 2016-11-23 | Pieris Pharmaceuticals GmbH | Multi-specific polypeptide useful for localized tumor immunomodulation |
US10774119B2 (en) | 2014-05-22 | 2020-09-15 | Pieris Pharmaceuticals Gmbh | Specific-binding polypeptides and uses thereof |
BR112017015773A2 (pt) | 2015-01-28 | 2018-03-27 | Pieris Pharmaceuticals Gmbh | muteína de lipocalina, muteína de hngal, molécula de ácido nucleico, célula hospedeira, método para produzir a muteína de hngal, composição farmacêutica, kit, uso da muteína de hngal, uso da muteína de hngal, método para ligar ang-2 em um indivíduo, método para inibir angiogênese em um indivíduo, método para tratar, prevenir ou melhorar uma doença e método para inibir ou reduzir angiogênese em um indivíduo |
TN2017000348A1 (en) | 2015-02-18 | 2019-01-16 | Sanofi Sa | Novel proteins specific for pyoverdine and pyochelin |
SG11201708334RA (en) | 2015-05-04 | 2017-11-29 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
RU2736312C2 (ru) | 2015-05-04 | 2020-11-13 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Белки, специфичные в отношении cd137 |
US10273275B2 (en) | 2015-05-18 | 2019-04-30 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof |
ES2938525T3 (es) | 2015-05-18 | 2023-04-12 | Pieris Pharmaceuticals Gmbh | Polipéptido de fusión anticanceroso |
EP3115371A1 (en) | 2015-07-07 | 2017-01-11 | Sanofi | Fusion molecules |
JP7108535B2 (ja) | 2015-07-15 | 2022-07-28 | ピエリス ファーマシューティカルズ ゲーエムベーハー | Lag-3に特異的な新規タンパク質 |
AU2016363668A1 (en) | 2015-11-30 | 2018-05-24 | Pieris Australia Pty Ltd. | Novel anti-angiogenic fusion polypeptides |
TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
WO2018087108A1 (en) | 2016-11-09 | 2018-05-17 | Pieris Pharmaceuticals Gmbh | Proteins specific for cd137 |
CN110402252A (zh) | 2017-01-18 | 2019-11-01 | 皮里斯制药有限公司 | 对lag-3具有结合亲和力的脂质运载蛋白突变蛋白 |
CA3100119A1 (en) | 2018-07-31 | 2020-02-06 | Pieris Pharmaceuticals Gmbh | Fusion protein specific for cd137 and pd-l1 |
US20220153864A1 (en) | 2019-02-26 | 2022-05-19 | Pieris Pharmaceuticals Gmbh | Novel Fusion Proteins Specific for CD137 and GPC3 |
WO2021245240A1 (en) | 2020-06-05 | 2021-12-09 | Pieris Pharmaceuticals Gmbh | Multimeric immunomodulator targeting 4-1bb |
JP2024515564A (ja) | 2021-04-08 | 2024-04-10 | ピエリス ファーマシューティカルズ ゲーエムベーハー | 結合組織増殖因子(ctgf)に特異的な新規リポカリンムテイン |
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WO2024064713A1 (en) | 2022-09-21 | 2024-03-28 | Seagen Inc. | Novel fusion protein specific for cd137 and cd228 |
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-
1999
- 1999-05-29 EP EP99927804A patent/EP1087778B1/en not_active Expired - Lifetime
- 1999-05-29 DK DK99927804T patent/DK1087778T3/da active
- 1999-05-29 NZ NZ508249A patent/NZ508249A/xx not_active IP Right Cessation
- 1999-05-29 RS YUP-770/00A patent/RS50144B/sr unknown
- 1999-05-29 IL IL13978699A patent/IL139786A0/xx active IP Right Grant
- 1999-05-29 CZ CZ20004487A patent/CZ298681B6/cs not_active IP Right Cessation
- 1999-05-29 AU AU45033/99A patent/AU767131B2/en not_active Expired
- 1999-05-29 BR BR9911076-8A patent/BR9911076A/pt not_active Application Discontinuation
- 1999-05-29 JP JP2000553084A patent/JP3839667B2/ja not_active Expired - Lifetime
- 1999-05-29 PL PL344794A patent/PL192364B1/pl unknown
- 1999-05-29 ID IDW20002551A patent/ID29285A/id unknown
- 1999-05-29 KR KR1020007013843A patent/KR20010052622A/ko active Search and Examination
- 1999-05-29 CN CNB998071706A patent/CN1170543C/zh not_active Expired - Lifetime
- 1999-05-29 HU HU0102033A patent/HU228218B1/hu unknown
- 1999-05-29 DE DE69927971T patent/DE69927971T2/de not_active Expired - Lifetime
- 1999-05-29 KR KR1020057009098A patent/KR20050055053A/ko not_active Application Discontinuation
- 1999-05-29 RU RU2003119460/14A patent/RU2271217C2/ru active
- 1999-05-29 AT AT99927804T patent/ATE307597T1/de active
- 1999-05-29 CA CA002334267A patent/CA2334267C/en not_active Expired - Lifetime
- 1999-05-29 ES ES99927804T patent/ES2251196T3/es not_active Expired - Lifetime
- 1999-05-29 TR TR2000/03635T patent/TR200003635T2/xx unknown
- 1999-05-29 WO PCT/EP1999/003746 patent/WO1999064016A1/en active IP Right Grant
- 1999-05-29 SI SI9930843T patent/SI1087778T1/sl unknown
- 1999-06-02 SA SA99200208A patent/SA99200208B1/ar unknown
- 1999-06-04 AR ARP990102664A patent/AR019855A1/es not_active Application Discontinuation
- 1999-06-04 CO CO99035303A patent/CO5050297A1/es unknown
- 1999-06-04 TW TW088109246A patent/TWI241913B/zh not_active IP Right Cessation
- 1999-06-04 PE PE1999000478A patent/PE20000560A1/es not_active Application Discontinuation
- 1999-06-07 MY MYPI99002297A patent/MY124091A/en unknown
- 1999-06-08 MA MA25613A patent/MA26641A1/fr unknown
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2000
- 2000-11-20 IL IL139786A patent/IL139786A/en not_active IP Right Cessation
- 2000-11-21 ZA ZA200006814A patent/ZA200006814B/en unknown
- 2000-11-24 HR HR20000808A patent/HRP20000808A2/hr not_active Application Discontinuation
- 2000-12-05 NO NO20006178A patent/NO325598B1/no not_active IP Right Cessation
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2001
- 2001-11-07 US US10/037,064 patent/US20030053986A1/en not_active Abandoned
- 2001-12-20 HK HK01108946A patent/HK1037981A1/xx not_active IP Right Cessation
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2004
- 2004-07-26 US US10/899,726 patent/US20050031589A1/en not_active Abandoned
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2006
- 2006-02-02 JP JP2006025756A patent/JP2006160759A/ja active Pending
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2007
- 2007-01-24 US US11/657,287 patent/US20070196385A1/en not_active Abandoned
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2010
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Date | Code | Title | Description |
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PE | Patent expired |
Effective date: 20190528 |