IL138404A - Process for the preparation of 1 - [[[5- (4-chlorophenyl) -2-furanyl] methylene] amino] - 3- (4-methyl-1-piperazinyl) butyl] -2,4 imidazolidinedione dihydrochloride - Google Patents

Process for the preparation of 1 - [[[5- (4-chlorophenyl) -2-furanyl] methylene] amino] - 3- (4-methyl-1-piperazinyl) butyl] -2,4 imidazolidinedione dihydrochloride

Info

Publication number
IL138404A
IL138404A IL13840499A IL13840499A IL138404A IL 138404 A IL138404 A IL 138404A IL 13840499 A IL13840499 A IL 13840499A IL 13840499 A IL13840499 A IL 13840499A IL 138404 A IL138404 A IL 138404A
Authority
IL
Israel
Prior art keywords
amino
methylene
furanyl
chlorophenyl
imidazolidinedione
Prior art date
Application number
IL13840499A
Other languages
English (en)
Hebrew (he)
Other versions
IL138404A0 (en
Original Assignee
Procter & Gamble
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble, Lonza Ag filed Critical Procter & Gamble
Publication of IL138404A0 publication Critical patent/IL138404A0/xx
Publication of IL138404A publication Critical patent/IL138404A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13840499A 1998-04-29 1999-04-27 Process for the preparation of 1 - [[[5- (4-chlorophenyl) -2-furanyl] methylene] amino] - 3- (4-methyl-1-piperazinyl) butyl] -2,4 imidazolidinedione dihydrochloride IL138404A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8349398P 1998-04-29 1998-04-29
PCT/US1999/009092 WO1999055700A1 (en) 1998-04-29 1999-04-27 Process for making 1,3-disubstituted-4-oxocyclic ureas

Publications (2)

Publication Number Publication Date
IL138404A0 IL138404A0 (en) 2001-10-31
IL138404A true IL138404A (en) 2004-07-25

Family

ID=22178700

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13840499A IL138404A (en) 1998-04-29 1999-04-27 Process for the preparation of 1 - [[[5- (4-chlorophenyl) -2-furanyl] methylene] amino] - 3- (4-methyl-1-piperazinyl) butyl] -2,4 imidazolidinedione dihydrochloride

Country Status (28)

Country Link
US (1) US6414151B1 (id)
EP (1) EP1075473B1 (id)
JP (1) JP4549531B2 (id)
KR (1) KR100400050B1 (id)
CN (1) CN1298403A (id)
AR (1) AR015044A1 (id)
AT (1) ATE366251T1 (id)
AU (1) AU751681B2 (id)
BR (1) BR9910074A (id)
CA (1) CA2330686C (id)
CO (1) CO5070625A1 (id)
CZ (1) CZ299163B6 (id)
DE (1) DE69936449T2 (id)
DK (1) DK1075473T3 (id)
ES (1) ES2288020T3 (id)
HU (1) HUP0102666A3 (id)
ID (1) ID27452A (id)
IL (1) IL138404A (id)
MY (1) MY133753A (id)
NO (1) NO20005424D0 (id)
PE (1) PE20000925A1 (id)
PL (1) PL197776B1 (id)
RU (1) RU2194706C2 (id)
SG (1) SG120901A1 (id)
SK (1) SK15842000A3 (id)
TR (1) TR200003137T2 (id)
WO (1) WO1999055700A1 (id)
ZA (1) ZA200004712B (id)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ506773A (en) * 1998-04-29 2004-03-26 Procter & Gamble Process for making 1, 3-disubstituted-4-oxocyclic ureas
CN100443473C (zh) * 2005-04-30 2008-12-17 中国药科大学 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法
US20120178762A1 (en) 2006-12-15 2012-07-12 Warner Chilcott Company, Llc Compositions of azimilide dihydrochloride
TW200840578A (en) * 2006-12-15 2008-10-16 Procter & Gamble Compositions of azimilide dihydrochloride
CN101735205B (zh) * 2009-12-17 2013-05-15 天津药物研究院 盐酸阿齐利特的晶型ⅴ及其制备方法和用途
CN101735202B (zh) * 2009-12-17 2012-05-30 天津药物研究院 盐酸阿齐利特的晶型ⅰ及其制备方法和用途
CN101735203B (zh) * 2009-12-17 2012-05-23 天津药物研究院 盐酸阿齐利特的晶型ⅱ及其制备方法和用途
US10028858B2 (en) 2011-07-11 2018-07-24 Medicines360 Intrauterine systems, IUD insertion devices, and related methods and kits therefor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919231A (en) 1974-06-17 1975-11-11 Morton Norwich Products Inc Series of 5-aryl-2-furamidines
US3906010A (en) 1974-06-17 1975-09-16 Morton Norwich Products Inc Series of 5-aryl-2-furamidines
US3946049A (en) 1975-04-03 1976-03-23 Morton-Norwich Products, Inc. 5-phenyl-2-furamidoximes
US4001222A (en) 1975-10-14 1977-01-04 Morton-Norwich Products, Inc. 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof
JPS5726653A (en) 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
IL82856A0 (en) 1986-06-26 1987-12-20 Norwich Eaton Pharma Pharmaceutical compositions containing 2-(5-phenyl-2-furanyl)imidazoles and certain such novel compounds
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
JP3031973B2 (ja) * 1990-08-16 2000-04-10 富士レビオ株式会社 フェニトイン誘導体
RU2221788C2 (ru) * 1991-08-14 2004-01-20 Проктер энд Гэмбл Фармасьютикалз Оксоциклические соединения мочевины, фармацевтическая композиция, способ лечения
RU2125568C1 (ru) 1991-08-14 1999-01-27 Проктер энд Гэмбл Фармасьютикалз, Инк. Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции
NZ506773A (en) * 1998-04-29 2004-03-26 Procter & Gamble Process for making 1, 3-disubstituted-4-oxocyclic ureas

Also Published As

Publication number Publication date
IL138404A0 (en) 2001-10-31
AU751681B2 (en) 2002-08-22
WO1999055700A1 (en) 1999-11-04
EP1075473A1 (en) 2001-02-14
DE69936449T2 (de) 2008-03-06
CO5070625A1 (es) 2001-08-28
DK1075473T3 (da) 2007-11-05
TR200003137T2 (tr) 2001-02-21
DE69936449D1 (de) 2007-08-16
CZ20003951A3 (cs) 2001-08-15
KR100400050B1 (ko) 2003-09-29
SK15842000A3 (sk) 2001-06-11
PL197776B1 (pl) 2008-04-30
CA2330686A1 (en) 1999-11-04
AR015044A1 (es) 2001-04-11
ZA200004712B (en) 2003-02-26
JP2002513021A (ja) 2002-05-08
BR9910074A (pt) 2000-12-26
MY133753A (en) 2007-11-30
CN1298403A (zh) 2001-06-06
PL343734A1 (en) 2001-09-10
PE20000925A1 (es) 2000-11-17
ES2288020T3 (es) 2007-12-16
HUP0102666A3 (en) 2002-05-28
KR20010043052A (ko) 2001-05-25
EP1075473B1 (en) 2007-07-04
SG120901A1 (en) 2006-04-26
HUP0102666A2 (hu) 2002-03-28
NO20005424L (no) 2000-10-27
CZ299163B6 (cs) 2008-05-07
US6414151B1 (en) 2002-07-02
ID27452A (id) 2001-04-12
RU2194706C2 (ru) 2002-12-20
JP4549531B2 (ja) 2010-09-22
NO20005424D0 (no) 2000-10-27
CA2330686C (en) 2006-09-26
ATE366251T1 (de) 2007-07-15
AU3573599A (en) 1999-11-16

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