IL135797A - Thrombin receptor antagonists and pharmaceutical compositions comprising them - Google Patents

Thrombin receptor antagonists and pharmaceutical compositions comprising them

Info

Publication number
IL135797A
IL135797A IL13579798A IL13579798A IL135797A IL 135797 A IL135797 A IL 135797A IL 13579798 A IL13579798 A IL 13579798A IL 13579798 A IL13579798 A IL 13579798A IL 135797 A IL135797 A IL 135797A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
receptor antagonists
thrombin receptor
thrombin
antagonists
Prior art date
Application number
IL13579798A
Other languages
English (en)
Other versions
IL135797A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL135797A0 publication Critical patent/IL135797A0/xx
Publication of IL135797A publication Critical patent/IL135797A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
IL13579798A 1997-11-25 1998-11-23 Thrombin receptor antagonists and pharmaceutical compositions comprising them IL135797A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25
PCT/US1998/024523 WO1999026943A1 (en) 1997-11-25 1998-11-23 Thrombin receptor antagonists

Publications (2)

Publication Number Publication Date
IL135797A0 IL135797A0 (en) 2001-05-20
IL135797A true IL135797A (en) 2003-09-17

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13579798A IL135797A (en) 1997-11-25 1998-11-23 Thrombin receptor antagonists and pharmaceutical compositions comprising them

Country Status (31)

Country Link
EP (1) EP1036072B1 (ko)
JP (2) JP3449620B2 (ko)
KR (1) KR100393492B1 (ko)
CN (2) CN101274929A (ko)
AR (1) AR017189A1 (ko)
AT (1) ATE266025T1 (ko)
AU (1) AU747204B2 (ko)
BR (1) BR9812793A (ko)
CA (1) CA2309352C (ko)
CO (1) CO4990946A1 (ko)
CZ (1) CZ298578B6 (ko)
DE (1) DE69823694T2 (ko)
DK (1) DK1036072T3 (ko)
ES (1) ES2219919T3 (ko)
HK (1) HK1031726A1 (ko)
HU (1) HUP0100607A3 (ko)
ID (1) ID24726A (ko)
IL (1) IL135797A (ko)
MY (1) MY140887A (ko)
NO (1) NO322022B1 (ko)
NZ (1) NZ504218A (ko)
PE (1) PE133799A1 (ko)
PL (1) PL195027B1 (ko)
PT (1) PT1036072E (ko)
RU (1) RU2204557C2 (ko)
SA (1) SA99190972B1 (ko)
SK (1) SK285153B6 (ko)
TR (1) TR200001480T2 (ko)
TW (1) TWI236476B (ko)
WO (1) WO1999026943A1 (ko)
ZA (1) ZA9810685B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) * 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
WO2001017968A1 (fr) 1999-09-02 2001-03-15 Shionogi & Co., Ltd. Inhibiteur d'integrase contenant des derives heterocycliques aromatiques
EP1764366A3 (en) * 2000-06-15 2007-10-03 Schering Corporation Thrombin receptor antagonists
EP2301930B1 (en) * 2000-06-15 2016-01-06 Merck Sharp & Dohme Corp. Derivatives of hexahydrobenzofuranone useful for the treatment of (inter alia) auto-immune or inflammatory disorders
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
KR100749794B1 (ko) 2001-04-19 2007-08-17 에자이 알앤드디 매니지먼트 가부시키가이샤 2-이미노피롤리딘 유도체
NZ535880A (en) * 2002-04-16 2007-11-30 Schering Corp Tricyclic thrombin receptor antagonists
CN100439336C (zh) 2003-02-19 2008-12-03 卫材R&D管理有限公司 制备环状苯甲脒衍生物的方法
WO2005108370A1 (ja) 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
ATE406366T1 (de) * 2004-05-28 2008-09-15 Schering Corp Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
US7488752B2 (en) * 2004-10-08 2009-02-10 Schering Corporation Thrombin receptor antagonists
US7605275B2 (en) * 2005-01-14 2009-10-20 Schering Corporation Exo- and diastereo- selective syntheses of himbacine analogs
CA2594807A1 (en) * 2005-01-14 2006-07-20 Schering Corporation An exo-selective synthesis of himbacine analogs
AR052870A1 (es) * 2005-01-14 2007-04-11 Schering Corp Sintesis de analogos de himbacina
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
WO2008042422A2 (en) 2006-10-04 2008-04-10 Schering Corporation Bicyclic and tricyclic derivatives as thrombin receptor antagonists
WO2011128421A1 (de) 2010-04-16 2011-10-20 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
PL2558462T3 (pl) 2010-04-16 2015-03-31 Sanofi Sa Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JP3449620B2 (ja) 2003-09-22
CN101274929A (zh) 2008-10-01
CO4990946A1 (es) 2000-12-26
CZ298578B6 (cs) 2007-11-14
HUP0100607A3 (en) 2002-06-28
ATE266025T1 (de) 2004-05-15
BR9812793A (pt) 2000-10-17
SK285153B6 (sk) 2006-07-07
TWI236476B (en) 2005-07-21
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04
AU747204B2 (en) 2002-05-09
PL341114A1 (en) 2001-03-26
SK7592000A3 (en) 2001-02-12
AR017189A1 (es) 2001-08-22
PL195027B1 (pl) 2007-08-31
NO322022B1 (no) 2006-08-07
MY140887A (en) 2010-01-29
TR200001480T2 (tr) 2000-09-21
KR100393492B1 (ko) 2003-08-02
KR20010032439A (ko) 2001-04-25
JP2003128670A (ja) 2003-05-08
SA99190972B1 (ar) 2006-07-30
CA2309352A1 (en) 1999-06-03
CZ20001856A3 (cs) 2000-10-11
CA2309352C (en) 2005-01-25
DE69823694T2 (de) 2005-04-21
PT1036072E (pt) 2004-08-31
DK1036072T3 (da) 2004-09-06
EP1036072B1 (en) 2004-05-06
ZA9810685B (en) 1999-12-23
DE69823694D1 (de) 2004-06-09
RU2204557C2 (ru) 2003-05-20
NO20002659D0 (no) 2000-05-24
CN1290265A (zh) 2001-04-04
HUP0100607A2 (hu) 2002-05-29
NZ504218A (en) 2002-04-26
NO20002659L (no) 2000-07-24
PE133799A1 (es) 2000-01-10
WO1999026943A1 (en) 1999-06-03
AU1415899A (en) 1999-06-15
EP1036072A1 (en) 2000-09-20
ES2219919T3 (es) 2004-12-01
IL135797A0 (en) 2001-05-20
ID24726A (id) 2000-08-03

Similar Documents

Publication Publication Date Title
HUP0103796A3 (en) Neuropeptide y5 receptor antagonists and medicaments containing them
IL135797A (en) Thrombin receptor antagonists and pharmaceutical compositions comprising them
HUP0201545A2 (en) Betha2-adrenergic receptor agonists and pharmaceutical compositions containing them
HUP0302969A3 (en) Npyy5 antagonists, pharmaceutical compositions containing them and their use
IL118325A0 (en) Integrin receptor antagonists and pharmaceutical compositions containing them
HUP0303081A3 (en) Thrombin receptor antagonists, pharmaceutical compositions containing them and their use
HUP0100266A3 (en) 1-amino-alkylcyclohexane nmda receptor antagonists, pharmaceutical compositions containing the compounds and their preparations
HUP0001309A3 (en) 1-phenyl-4-benzylpiperazines and pharmaceutical compositions containing them
GB9727053D0 (en) Pharmaceutical compositions
CY2569B1 (en) Pharmaceutical compositions
HUP0002324A3 (en) Benzimidazole derivatives and pharmaceutical compositions containing them
NZ329429A (en) Vitronectin receptor antagonists comprising fibrinogen receptor antagonists and medicaments thereof
HUP9802132A3 (en) Biphenyl-sulfonyl-cyanamides, their use and pharmaceutical compositions containing them
HUP0101701A3 (en) Substituted betha-alanines and pharmaceutical compositions comprising them
HUP0002929A3 (en) 2-acylaminopropanamines as tachykinin receptor antagonists and pharmaceutical compositions containing the same
GB9723985D0 (en) Pharmaceutical compositions
HUP0500079A3 (en) Chemokine receptor antagonists, their use and pharmaceutical compositions containing them
GB9726735D0 (en) Pharmaceutical compositions
HUP0002714A3 (en) Betha-amino and betha-azidocarboxylic acid derivatives, and pharmaceutical compositions containing them as endothelin receptor antagonists
GB9820014D0 (en) Receptor antagonists and uses thereof
IL125262A0 (en) Synthetic peptides and pharmaceutical compositions comprising them
HUP0001010A3 (en) Benzimidazole derivatives and pharmaceutical compositions containing them
HUP0003548A3 (en) 2-acylaminopropanamines as tachykinin receptor antagonists and pharmaceutical compositions containing the same
HUP0003612A3 (en) Quinoxalinediones and pharmaceutical compositions containing them
IL141899A0 (en) Pharmaceutical compositions comprising a chemokine receptor antagonist and a cyclosporin

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees