IL135055A - Pharmaceutical preparations that include plasma protein - Google Patents
Pharmaceutical preparations that include plasma proteinInfo
- Publication number
- IL135055A IL135055A IL13505598A IL13505598A IL135055A IL 135055 A IL135055 A IL 135055A IL 13505598 A IL13505598 A IL 13505598A IL 13505598 A IL13505598 A IL 13505598A IL 135055 A IL135055 A IL 135055A
- Authority
- IL
- Israel
- Prior art keywords
- protein fraction
- plasma protein
- active substance
- water
- products
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 36
- 102000004506 Blood Proteins Human genes 0.000 title claims abstract description 23
- 108010017384 Blood Proteins Proteins 0.000 title claims abstract description 23
- 239000013543 active substance Substances 0.000 claims abstract description 82
- 229940081857 plasma protein fraction Drugs 0.000 claims abstract description 69
- 108010058237 plasma protein fraction Proteins 0.000 claims abstract description 68
- 230000027455 binding Effects 0.000 claims abstract description 63
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000000203 mixture Substances 0.000 claims abstract description 46
- 239000007787 solid Substances 0.000 claims abstract description 38
- 230000002776 aggregation Effects 0.000 claims abstract description 36
- 238000004220 aggregation Methods 0.000 claims abstract description 36
- 238000009472 formulation Methods 0.000 claims abstract description 29
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 239000003381 stabilizer Substances 0.000 claims abstract description 17
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 239000000654 additive Substances 0.000 claims abstract description 13
- 230000000996 additive effect Effects 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 230000004845 protein aggregation Effects 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 121
- 229930012538 Paclitaxel Natural products 0.000 claims description 59
- 229960001592 paclitaxel Drugs 0.000 claims description 59
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 59
- 239000000047 product Substances 0.000 claims description 52
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 48
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 44
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 24
- 229930105110 Cyclosporin A Natural products 0.000 claims description 24
- 108010036949 Cyclosporine Proteins 0.000 claims description 24
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 22
- 108060003951 Immunoglobulin Proteins 0.000 claims description 21
- 102000014150 Interferons Human genes 0.000 claims description 21
- 108010050904 Interferons Proteins 0.000 claims description 21
- 102000007562 Serum Albumin Human genes 0.000 claims description 21
- 108010071390 Serum Albumin Proteins 0.000 claims description 21
- 102000018358 immunoglobulin Human genes 0.000 claims description 21
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims description 21
- 229960004134 propofol Drugs 0.000 claims description 21
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 20
- 102000003886 Glycoproteins Human genes 0.000 claims description 20
- 108090000288 Glycoproteins Proteins 0.000 claims description 20
- 102000015696 Interleukins Human genes 0.000 claims description 20
- 108010063738 Interleukins Proteins 0.000 claims description 20
- 229960003942 amphotericin b Drugs 0.000 claims description 20
- 229940079322 interferon Drugs 0.000 claims description 20
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 16
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 16
- 229940127093 camptothecin Drugs 0.000 claims description 16
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 16
- 108010074605 gamma-Globulins Proteins 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 15
- 229960000623 carbamazepine Drugs 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims description 12
- -1 taxonoids Substances 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 11
- 238000000108 ultra-filtration Methods 0.000 claims description 11
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 10
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 229960001265 ciclosporin Drugs 0.000 claims description 9
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229960002509 miconazole Drugs 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 7
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 7
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims description 7
- 229960002170 azathioprine Drugs 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 7
- 229960000311 ritonavir Drugs 0.000 claims description 7
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 7
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 claims description 6
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 6
- 239000003146 anticoagulant agent Substances 0.000 claims description 6
- 239000001961 anticonvulsive agent Substances 0.000 claims description 6
- 229960003627 gemfibrozil Drugs 0.000 claims description 6
- 229960001967 tacrolimus Drugs 0.000 claims description 6
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 6
- 229960001603 tamoxifen Drugs 0.000 claims description 6
- RBKASMJPSJDQKY-RBFSKHHSSA-N tirilazad Chemical compound O=C([C@@H]1[C@@]2(C)CC=C3[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)CN(CC1)CCN1C(N=1)=CC(N2CCCC2)=NC=1N1CCCC1 RBKASMJPSJDQKY-RBFSKHHSSA-N 0.000 claims description 6
- 229960005155 tirilazad Drugs 0.000 claims description 6
- FMHHVULEAZTJMA-UHFFFAOYSA-N trioxsalen Chemical compound CC1=CC(=O)OC2=C1C=C1C=C(C)OC1=C2C FMHHVULEAZTJMA-UHFFFAOYSA-N 0.000 claims description 6
- 229960000850 trioxysalen Drugs 0.000 claims description 6
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 5
- VMIYHDSEFNYJSL-UHFFFAOYSA-N Bromazepam Chemical compound C12=CC(Br)=CC=C2NC(=O)CN=C1C1=CC=CC=N1 VMIYHDSEFNYJSL-UHFFFAOYSA-N 0.000 claims description 5
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 claims description 5
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 5
- PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 claims description 5
- 229960001671 azapropazone Drugs 0.000 claims description 5
- WOIIIUDZSOLAIW-NSHDSACASA-N azapropazone Chemical compound C1=C(C)C=C2N3C(=O)[C@H](CC=C)C(=O)N3C(N(C)C)=NC2=C1 WOIIIUDZSOLAIW-NSHDSACASA-N 0.000 claims description 5
- 229960002729 bromazepam Drugs 0.000 claims description 5
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 5
- 229960003120 clonazepam Drugs 0.000 claims description 5
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 5
- 229960003529 diazepam Drugs 0.000 claims description 5
- DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 claims description 5
- 229960001912 dicoumarol Drugs 0.000 claims description 5
- HIZKPJUTKKJDGA-UHFFFAOYSA-N dicumarol Natural products O=C1OC2=CC=CC=C2C(=O)C1CC1C(=O)C2=CC=CC=C2OC1=O HIZKPJUTKKJDGA-UHFFFAOYSA-N 0.000 claims description 5
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 claims description 5
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 5
- 229960002768 dipyridamole Drugs 0.000 claims description 5
- UVTNFZQICZKOEM-UHFFFAOYSA-N disopyramide Chemical compound C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 UVTNFZQICZKOEM-UHFFFAOYSA-N 0.000 claims description 5
- 229960001066 disopyramide Drugs 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 229960002200 flunitrazepam Drugs 0.000 claims description 5
- 229960004125 ketoconazole Drugs 0.000 claims description 5
- 229960000916 niflumic acid Drugs 0.000 claims description 5
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 claims description 5
- 229960004535 oxazepam Drugs 0.000 claims description 5
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 claims description 5
- 229960002695 phenobarbital Drugs 0.000 claims description 5
- 229960002036 phenytoin Drugs 0.000 claims description 5
- 229960003387 progesterone Drugs 0.000 claims description 5
- 239000000186 progesterone Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 229960003329 sulfinpyrazone Drugs 0.000 claims description 5
- MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 claims description 5
- MDKGKXOCJGEUJW-UHFFFAOYSA-N suprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-UHFFFAOYSA-N 0.000 claims description 5
- 229960003604 testosterone Drugs 0.000 claims description 5
- 229960000604 valproic acid Drugs 0.000 claims description 5
- 229960005080 warfarin Drugs 0.000 claims description 5
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 claims description 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 4
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- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000012265 solid product Substances 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 150000005846 sugar alcohols Polymers 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 239000003098 androgen Substances 0.000 claims description 3
- 230000003288 anthiarrhythmic effect Effects 0.000 claims description 3
- 230000003556 anti-epileptic effect Effects 0.000 claims description 3
- 229940127219 anticoagulant drug Drugs 0.000 claims description 3
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- 239000002249 anxiolytic agent Substances 0.000 claims description 3
- 230000000949 anxiolytic effect Effects 0.000 claims description 3
- 239000003218 coronary vasodilator agent Substances 0.000 claims description 3
- 230000000147 hypnotic effect Effects 0.000 claims description 3
- 239000003504 photosensitizing agent Substances 0.000 claims description 3
- 239000000583 progesterone congener Substances 0.000 claims description 3
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- 239000003270 steroid hormone Substances 0.000 claims description 3
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- 229940088594 vitamin Drugs 0.000 claims description 3
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- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 238000007865 diluting Methods 0.000 claims description 2
- 239000012263 liquid product Substances 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 229940127557 pharmaceutical product Drugs 0.000 claims description 2
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 229960000648 digitoxin Drugs 0.000 claims 2
- 229940116731 Uricosuric agent Drugs 0.000 claims 1
- 229940030486 androgens Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940125681 anticonvulsant agent Drugs 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
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- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701554A HUP9701554D0 (en) | 1997-09-18 | 1997-09-18 | Pharmaceutical composition containing plazma proteins |
| PCT/HU1998/000086 WO1999013914A1 (en) | 1997-09-18 | 1998-09-17 | Pharmaceutical compositions containing plasma protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL135055A0 IL135055A0 (en) | 2001-05-20 |
| IL135055A true IL135055A (en) | 2004-09-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13505598A IL135055A (en) | 1997-09-18 | 1998-09-17 | Pharmaceutical preparations that include plasma protein |
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| US (5) | US6743826B1 (cs) |
| EP (1) | EP0981375B1 (cs) |
| JP (1) | JP2001508806A (cs) |
| KR (1) | KR100587962B1 (cs) |
| CN (1) | CN1189216C (cs) |
| AR (1) | AR017120A1 (cs) |
| AT (1) | ATE230611T1 (cs) |
| AU (1) | AU734695B2 (cs) |
| BG (1) | BG64749B1 (cs) |
| BR (1) | BR9812469A (cs) |
| CA (1) | CA2269923C (cs) |
| CZ (1) | CZ301326B6 (cs) |
| DE (1) | DE69810612T2 (cs) |
| DK (1) | DK0981375T3 (cs) |
| EA (1) | EA004700B1 (cs) |
| ES (1) | ES2187062T3 (cs) |
| HR (1) | HRP980499A2 (cs) |
| HU (1) | HUP9701554D0 (cs) |
| IL (1) | IL135055A (cs) |
| LT (1) | LT4736B (cs) |
| LV (1) | LV12493B (cs) |
| NO (1) | NO325294B1 (cs) |
| NZ (1) | NZ503302A (cs) |
| PL (1) | PL193067B1 (cs) |
| PT (1) | PT981375E (cs) |
| RO (1) | RO118695B1 (cs) |
| RS (1) | RS50102B (cs) |
| SI (1) | SI20189B (cs) |
| SK (1) | SK284683B6 (cs) |
| TR (1) | TR200001545T2 (cs) |
| TW (1) | TWI222365B (cs) |
| WO (1) | WO1999013914A1 (cs) |
| ZA (1) | ZA988585B (cs) |
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| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
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| AR100034A1 (es) | 2015-01-30 | 2016-09-07 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Una composición farmacéutica soluble en agua que comprende, al menos, una sustancia terapéuticamente activa y, al menos, una sustancia con capacidad para formar micelas |
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| RU2019131436A (ru) | 2017-03-09 | 2021-04-10 | Изун Фармасьютикалс Корп. | Стабилизированные композиции связанных с белком каннабиоидов |
| US11105747B2 (en) | 2017-03-20 | 2021-08-31 | Spectral Platforms, Inc. | Spectroscopic methods to detect and characterize microorganisms |
| MX2020000265A (es) | 2017-07-07 | 2020-07-22 | Epicentrx Inc | Composiciones para la administración parenteral de agentes terapéuticos. |
| AU2019232153B2 (en) * | 2018-03-09 | 2023-07-13 | Panoptes Pharma Ges.M.B.H. | Ophthalmic formulation |
| EP3811982A1 (en) * | 2019-10-25 | 2021-04-28 | Université de Strasbourg | Protein-based biomaterial with viscoelastic behaviour, process for obtaining it and uses thereof |
| CN111529506B (zh) * | 2020-05-18 | 2021-09-03 | 同济大学 | 一种两性霉素b白蛋白纳米制剂及其制备方法和应用 |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| KR102435211B1 (ko) * | 2021-06-29 | 2022-08-23 | (주)진셀바이오텍 | 알부민을 고효율로 생산하는 식물 세포주 및 이의 용도 |
| CN114544926A (zh) * | 2021-12-02 | 2022-05-27 | 浙江鑫科医疗科技有限公司 | 一种血清蛋白稳定剂 |
| CN115236216B (zh) * | 2022-06-07 | 2024-03-01 | 合肥和合医疗科技有限公司 | 高效液相色谱串联质谱检测全血中免疫抑制剂的试剂盒，其制备方法和检测方法 |
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| DE2653534C2 (de) * | 1975-12-22 | 1986-08-28 | Baxter Travenol Laboratories, Inc., Deerfield, Ill. | Feste Antihämophilen-Faktor-Präparation und Verfahren zu ihrer Herstellung |
| JPS58216126A (ja) * | 1982-06-11 | 1983-12-15 | Ono Pharmaceut Co Ltd | 可容化製剤 |
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1997
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1998
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- 1998-09-17 DK DK98946629T patent/DK0981375T3/da active
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- 1998-09-17 RO ROA200000315A patent/RO118695B1/ro unknown
- 1998-09-17 SI SI9820067A patent/SI20189B/sl active Search and Examination
- 1998-09-17 EP EP98946629A patent/EP0981375B1/en not_active Expired - Lifetime
- 1998-09-17 SK SK329-2000A patent/SK284683B6/sk not_active IP Right Cessation
- 1998-09-17 AT AT98946629T patent/ATE230611T1/de active
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- 1998-09-17 DE DE69810612T patent/DE69810612T2/de not_active Expired - Lifetime
- 1998-09-17 BR BR9812469-2A patent/BR9812469A/pt not_active Application Discontinuation
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- 1998-09-17 CA CA002269923A patent/CA2269923C/en not_active Expired - Lifetime
- 1998-09-17 EA EA200000331A patent/EA004700B1/ru not_active IP Right Cessation
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- 1998-09-17 CN CNB988092514A patent/CN1189216C/zh not_active Expired - Fee Related
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- 1998-09-17 WO PCT/HU1998/000086 patent/WO1999013914A1/en not_active Application Discontinuation
- 1998-09-17 CZ CZ20000952A patent/CZ301326B6/cs not_active IP Right Cessation
- 1998-09-17 RS YUP-166/00A patent/RS50102B/sr unknown
- 1998-09-18 ZA ZA9808585A patent/ZA988585B/xx unknown
- 1998-09-18 AR ARP980104659A patent/AR017120A1/es not_active Application Discontinuation
- 1998-09-18 TW TW087115619A patent/TWI222365B/zh not_active IP Right Cessation
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