IL133366A - 4-Phenylpiperidine compounds, process for their preparation and uses thereof - Google Patents
4-Phenylpiperidine compounds, process for their preparation and uses thereofInfo
- Publication number
- IL133366A IL133366A IL13336697A IL13336697A IL133366A IL 133366 A IL133366 A IL 133366A IL 13336697 A IL13336697 A IL 13336697A IL 13336697 A IL13336697 A IL 13336697A IL 133366 A IL133366 A IL 133366A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- preparation
- phenylpiperidine compounds
- halo
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/NL1997/000328 WO1998056787A1 (de) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidin-Derivate |
US08/872,023 US5874447A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds for treating depression |
Publications (2)
Publication Number | Publication Date |
---|---|
IL133366A0 IL133366A0 (en) | 2001-04-30 |
IL133366A true IL133366A (en) | 2005-11-20 |
Family
ID=26647319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13336697A IL133366A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds, process for their preparation and uses thereof |
Country Status (26)
Country | Link |
---|---|
US (4) | US5874447A (de) |
EP (2) | EP1078925A1 (de) |
JP (1) | JP2002503248A (de) |
KR (1) | KR100543614B1 (de) |
AT (1) | ATE200781T1 (de) |
AU (1) | AU3108097A (de) |
BG (1) | BG64315B1 (de) |
BR (1) | BR9714787A (de) |
CA (1) | CA2293247C (de) |
CZ (1) | CZ295301B6 (de) |
DE (2) | DE69704679T2 (de) |
DK (1) | DK0994872T3 (de) |
EE (2) | EE200200633A (de) |
ES (1) | ES2155995T3 (de) |
GR (1) | GR3035784T3 (de) |
HK (1) | HK1027352A1 (de) |
HU (1) | HUP0003141A3 (de) |
IL (1) | IL133366A (de) |
IS (2) | IS1927B (de) |
NO (3) | NO317371B1 (de) |
PL (1) | PL188450B1 (de) |
PT (1) | PT994872E (de) |
SI (1) | SI0994872T1 (de) |
SK (1) | SK283394B6 (de) |
TR (2) | TR199903025T2 (de) |
WO (1) | WO1998056787A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
CA2327450A1 (en) * | 1998-04-09 | 1999-10-21 | Victor Witold Jacewicz | Paroxetine maleate |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
GB9814316D0 (en) * | 1998-07-02 | 1998-09-02 | Smithkline Beecham Plc | Novel compounds |
AU724845B3 (en) * | 1998-07-02 | 2000-09-28 | Smithkline Beecham Plc | Novel compound |
US20010023252A1 (en) * | 1998-07-02 | 2001-09-20 | Smithkline Beecham Plc | Novel compound |
EP1102764A1 (de) * | 1998-08-08 | 2001-05-30 | Smithkline Beecham Plc | Salze von paroxetin |
GB9827431D0 (en) * | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
GB9828781D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
GB9828779D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
GB9828780D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
ES2159260B1 (es) * | 1999-06-22 | 2002-05-01 | Smithkline Beechan Plc | Nueva composicion de metanosulfonato de paroxetina |
AU5078700A (en) * | 1999-06-22 | 2001-01-09 | Smithkline Beecham Plc | Novel composition |
GB9914585D0 (en) * | 1999-06-22 | 1999-08-25 | Smithkline Beecham Plc | Novel process |
KR100759159B1 (ko) * | 1999-07-01 | 2007-09-14 | 이탈파마코 에스.피.에이. | 파록세틴과 사이클로덱스트린 또는 사이클로덱스트린유도체의 컴플렉스 |
GB9919052D0 (en) * | 1999-08-12 | 1999-10-13 | Smithkline Beecham Plc | Novel compound composition and process |
US6503927B1 (en) * | 1999-10-28 | 2003-01-07 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
SI1286965T1 (en) * | 2000-05-12 | 2004-04-30 | Synthon B.V. | Piperidine compounds and process for providing such |
CZ20023694A3 (cs) * | 2000-05-12 | 2003-05-14 | Synthon B. V. | Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů |
NZ523902A (en) * | 2000-08-28 | 2004-05-28 | Synthon Bv | Paroxetine compositions and processes for making the same |
WO2002022609A1 (fr) * | 2000-09-14 | 2002-03-21 | Asahi Glass Company, Limited | Procede de production de sel de paroxetine sensiblement exempt de solvant organique |
DE20100529U1 (de) * | 2001-01-11 | 2001-05-10 | Synthon Bv | Pharmazeutische Tablette umfassend Paroxetinmesylat |
US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
NL1017421C2 (nl) * | 2001-02-21 | 2002-01-15 | Synthon Bv | Werkwijze voor het vervaardigen van paroxetine. |
US20030032809A1 (en) * | 2001-04-25 | 2003-02-13 | Subhash P. Upadhyaya | Optimized procedures for the manufacture of paroxetine salts |
US6930186B2 (en) * | 2001-06-13 | 2005-08-16 | Teva Pharmacetical Industries Ltd. | Process for the preparation of paroxetine substantially free of alkoxy impurities |
IL159280A0 (en) * | 2001-06-14 | 2004-06-01 | Teva Pharma | A process for preparing paroxetine hcl which limits formation of pink colored compounds |
WO2003020717A1 (en) * | 2001-08-02 | 2003-03-13 | Spurcourt Limited | Paroxetine isethionate salt, process of preparation and use in the treatment of depression |
US20030181488A1 (en) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
AR039163A1 (es) * | 2002-03-28 | 2005-02-09 | Synthon Bv | Besilato de venlafaxina |
US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
PT1691811E (pt) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
US20060063737A1 (en) * | 2004-08-18 | 2006-03-23 | Holmdahl Lisa K | Liquid paroxetine compositions |
EP1791531A1 (de) * | 2004-08-20 | 2007-06-06 | Alpharma, Inc. | Paroxetinformulierungen |
BRPI0615973A2 (pt) * | 2005-07-29 | 2011-05-31 | Concert Pharmaceuticals Inc | novos derivados de benzo [d] [1,3] - dioxol |
US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
US20070112031A1 (en) * | 2005-11-14 | 2007-05-17 | Gant Thomas G | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
WO2009035652A1 (en) | 2007-09-13 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
JP6038128B2 (ja) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー |
KR101950057B1 (ko) * | 2012-01-31 | 2019-02-19 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 파록세틴 유도체 |
MX2014011971A (es) | 2012-04-04 | 2015-01-16 | Ivax Int Gmbh | Composiciones farmaceuticas para terapia de combinacion. |
HRP20221047T1 (hr) | 2014-08-28 | 2022-11-11 | Eisai R&D Management Co., Ltd. | Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju |
JP6792546B2 (ja) | 2015-02-25 | 2020-11-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体の苦味抑制方法 |
CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
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-
1997
- 1997-06-10 US US08/872,023 patent/US5874447A/en not_active Expired - Lifetime
- 1997-06-10 DE DE69704679T patent/DE69704679T2/de not_active Expired - Lifetime
- 1997-06-10 IL IL13336697A patent/IL133366A/xx not_active IP Right Cessation
- 1997-06-10 JP JP50212699A patent/JP2002503248A/ja not_active Ceased
- 1997-06-10 WO PCT/NL1997/000328 patent/WO1998056787A1/de active IP Right Grant
- 1997-06-10 EP EP00203910A patent/EP1078925A1/de not_active Withdrawn
- 1997-06-10 AT AT97926276T patent/ATE200781T1/de not_active IP Right Cessation
- 1997-06-10 EE EEP200200633A patent/EE200200633A/xx unknown
- 1997-06-10 TR TR1999/03025T patent/TR199903025T2/xx unknown
- 1997-06-10 KR KR1019997011625A patent/KR100543614B1/ko not_active IP Right Cessation
- 1997-06-10 TR TR2002/01156T patent/TR200201156T2/xx unknown
- 1997-06-10 DE DE29724281U patent/DE29724281U1/de not_active Expired - Lifetime
- 1997-06-10 EE EEP199900570A patent/EE03970B1/xx not_active IP Right Cessation
- 1997-06-10 CZ CZ19994295A patent/CZ295301B6/cs not_active IP Right Cessation
- 1997-06-10 PT PT97926276T patent/PT994872E/pt unknown
- 1997-06-10 SI SI9730138T patent/SI0994872T1/xx unknown
- 1997-06-10 DK DK97926276T patent/DK0994872T3/da active
- 1997-06-10 AU AU31080/97A patent/AU3108097A/en not_active Abandoned
- 1997-06-10 ES ES97926276T patent/ES2155995T3/es not_active Expired - Lifetime
- 1997-06-10 PL PL97336895A patent/PL188450B1/pl not_active IP Right Cessation
- 1997-06-10 BR BR9714787-7A patent/BR9714787A/pt unknown
- 1997-06-10 SK SK1619-99A patent/SK283394B6/sk unknown
- 1997-06-10 HU HU0003141A patent/HUP0003141A3/hu unknown
- 1997-06-10 CA CA002293247A patent/CA2293247C/en not_active Expired - Lifetime
- 1997-06-10 EP EP97926276A patent/EP0994872B9/de not_active Expired - Lifetime
-
1998
- 1998-11-30 US US09/200,743 patent/US7598271B1/en not_active Expired - Lifetime
-
1999
- 1999-11-08 NO NO19995455A patent/NO317371B1/no unknown
- 1999-11-16 IS IS5249A patent/IS1927B/is unknown
- 1999-12-10 BG BG103980A patent/BG64315B1/bg unknown
-
2000
- 2000-10-10 HK HK00106418A patent/HK1027352A1/xx not_active IP Right Cessation
-
2001
- 2001-04-26 GR GR20010400220T patent/GR3035784T3/el not_active IP Right Cessation
- 2001-05-16 US US09/855,710 patent/US6900327B2/en not_active Expired - Lifetime
-
2003
- 2003-08-25 NO NO20033765A patent/NO20033765D0/no not_active Application Discontinuation
- 2003-08-25 NO NO20033766A patent/NO20033766D0/no not_active Application Discontinuation
-
2004
- 2004-01-08 IS IS7098A patent/IS7098A/is unknown
-
2009
- 2009-01-23 US US12/358,997 patent/US20090326233A1/en not_active Abandoned
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