IL132532A - Intermediates for the preparation of substituted cephalosporins - Google Patents

Intermediates for the preparation of substituted cephalosporins

Info

Publication number
IL132532A
IL132532A IL13253296A IL13253296A IL132532A IL 132532 A IL132532 A IL 132532A IL 13253296 A IL13253296 A IL 13253296A IL 13253296 A IL13253296 A IL 13253296A IL 132532 A IL132532 A IL 132532A
Authority
IL
Israel
Prior art keywords
intermediates
preparation
substituted cephalosporins
cephalosporins
substituted
Prior art date
Application number
IL13253296A
Other languages
English (en)
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT79495A external-priority patent/AT402820B/de
Priority claimed from AT99295A external-priority patent/AT402821B/de
Priority claimed from AT69896A external-priority patent/AT403283B/de
Priority claimed from AT73396A external-priority patent/AT403284B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of IL132532A publication Critical patent/IL132532A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A01N3/02—Keeping cut flowers fresh chemically
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C05F11/10—Fertilisers containing plant vitamins or hormones
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/20—Liquid fertilisers
    • C05G5/23—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/40—Bio-organic fraction processing; Production of fertilisers from the organic fraction of waste or refuse
IL13253296A 1995-05-11 1996-05-10 Intermediates for the preparation of substituted cephalosporins IL132532A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT79495A AT402820B (de) 1995-05-11 1995-05-11 Organische verbindungen
AT99295A AT402821B (de) 1995-06-12 1995-06-12 Organische verbindungen
AT69896A AT403283B (de) 1996-04-17 1996-04-17 3-methylimino-3-cephemderivate
AT73396A AT403284B (de) 1996-04-23 1996-04-23 3-methylimino-3-cephemderivate

Publications (1)

Publication Number Publication Date
IL132532A true IL132532A (en) 2003-06-24

Family

ID=27421316

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11822196A IL118221A (en) 1995-05-11 1996-05-10 Transformed cephalosporins, the process for their preparation and the pharmaceutical preparations containing them
IL13253296A IL132532A (en) 1995-05-11 1996-05-10 Intermediates for the preparation of substituted cephalosporins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11822196A IL118221A (en) 1995-05-11 1996-05-10 Transformed cephalosporins, the process for their preparation and the pharmaceutical preparations containing them

Country Status (30)

Country Link
US (2) US6531465B1 (no)
EP (2) EP0824535B1 (no)
JP (2) JPH11506429A (no)
KR (1) KR100451336B1 (no)
CN (1) CN1142937C (no)
AR (1) AR001931A1 (no)
AT (2) ATE233268T1 (no)
AU (1) AU712814B2 (no)
BR (1) BR9608517A (no)
CA (1) CA2219656C (no)
CO (1) CO4750666A1 (no)
CY (1) CY2445B1 (no)
CZ (1) CZ352997A3 (no)
DE (2) DE69626389T2 (no)
DK (1) DK0824535T3 (no)
ES (1) ES2193246T3 (no)
HK (1) HK1008993A1 (no)
HU (1) HUP9801387A3 (no)
IL (2) IL118221A (no)
MX (1) MX9708696A (no)
NO (1) NO326126B1 (no)
NZ (1) NZ308518A (no)
PE (1) PE8398A1 (no)
PL (1) PL193133B1 (no)
PT (1) PT824535E (no)
RU (1) RU2183212C2 (no)
SK (1) SK284962B6 (no)
TW (1) TW452579B (no)
WO (1) WO1996035692A1 (no)
ZA (1) ZA963758B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405180B (de) * 1997-04-01 1999-06-25 Biochemie Gmbh Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung
DE69816057T2 (de) * 1997-04-01 2004-04-15 Biochemie Gesellschaft M.B.H. Antibakterielle substituierte 7-acylamino-3-(methylhydrazono)methyl-cephalosporine und zwischenprodukte
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
AT406772B (de) * 1998-03-23 2000-08-25 Biochemie Gmbh Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
UY26380A1 (es) 1999-10-08 2001-04-30 Smithkline Beecham Corp Inhibidores de fab i
KR100739830B1 (ko) * 2001-03-23 2007-07-13 주식회사 하원제약 세파로스포린 유도체의 제조방법
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
AR040545A1 (es) * 2002-07-15 2005-04-13 Sandoz Ag Cefalosporinas
PT1575951E (pt) 2002-12-06 2014-09-15 Debiopharm Int Sa Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
EP1828167B1 (en) 2004-06-04 2014-08-06 Debiopharm International SA Acrylamide derivatives as antibiotic agents
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP2125802A4 (en) * 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
EA028136B1 (ru) 2012-06-19 2017-10-31 Дибиофарм Интернешнл Са Пролекарственные производные (е)-n-метил-n-((3-метилбензофуран-2-ил)метил)-3-(7-оксо-5,6,7,8-тетрагидро-1,8-нафтиридин-3-ил)акриламида
BR122023021456A2 (pt) 2016-02-26 2024-02-20 Debiopharm International S.A. Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
CA3147354A1 (en) 2019-09-06 2021-03-11 Rosemarie Riedl Siderophore cephalosporin conjugates and uses thereof
CN110590814A (zh) * 2019-09-29 2019-12-20 天津力生制药股份有限公司 一种生产头孢唑林钠产生的二聚体杂质的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2333263A1 (de) * 1972-07-07 1974-01-24 Ciba Geigy Ag 7 beta-amino-3-oximinomethyl-cephem-4carbonsaeureverbindungen und verfahren zu ihrer herstellung
JPS5417030B2 (no) 1972-12-06 1979-06-27
DE2262500A1 (de) * 1972-12-20 1973-07-05 Lilly Co Eli 3-oxyiminomethylcephalosporinverbindungen
US4053469A (en) 1973-02-28 1977-10-11 Shionogi & Co., Ltd. Intermediates for the preparation of 7-acylamino-3-oxyiminomethyl-3-cephem-4-carboxylic acids
JPS49109391A (no) * 1973-02-28 1974-10-17
JPS49124091A (no) * 1973-03-30 1974-11-27
JPS5013389A (no) * 1973-06-08 1975-02-12
JPS5093989A (no) 1973-10-25 1975-07-26
JPS5076085A (no) * 1973-10-31 1975-06-21
JPS5083391A (no) * 1973-11-28 1975-07-05
JPS5715597B2 (no) * 1973-12-20 1982-03-31
JPS50131982A (no) * 1974-04-05 1975-10-18
US4101658A (en) 1975-06-04 1978-07-18 Shionogi & Co., Ltd. Antibacterial hydrazono cephalosporins
JPS5283865A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Cephalosporin derivatives
JPS5470294A (en) * 1977-11-09 1979-06-05 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates

Also Published As

Publication number Publication date
PL193133B1 (pl) 2007-01-31
TW452579B (en) 2001-09-01
IL118221A0 (en) 1996-09-12
DE69626389D1 (de) 2003-04-03
PE8398A1 (es) 1998-03-13
AU712814B2 (en) 1999-11-18
CZ352997A3 (cs) 1998-02-18
US6531465B1 (en) 2003-03-11
EP1221446B1 (en) 2005-04-06
JP2007023046A (ja) 2007-02-01
EP1221446A1 (en) 2002-07-10
KR100451336B1 (ko) 2005-01-17
PT824535E (pt) 2003-07-31
HK1008993A1 (en) 1999-05-21
PL323233A1 (en) 1998-03-16
BR9608517A (pt) 1999-06-08
ATE233268T1 (de) 2003-03-15
IL118221A (en) 2004-06-01
ZA963758B (en) 1997-11-10
CA2219656C (en) 2008-08-19
AR001931A1 (es) 1997-12-10
CN1186494A (zh) 1998-07-01
ATE292637T1 (de) 2005-04-15
NZ308518A (en) 2000-01-28
EP0824535A1 (en) 1998-02-25
HUP9801387A2 (hu) 1999-01-28
US7317101B2 (en) 2008-01-08
US20030191105A1 (en) 2003-10-09
WO1996035692A1 (en) 1996-11-14
SK284962B6 (sk) 2006-03-02
KR19990014669A (ko) 1999-02-25
NO975151L (no) 1997-11-10
DE69626389T2 (de) 2003-10-09
CN1142937C (zh) 2004-03-24
MX9708696A (es) 1998-08-30
HUP9801387A3 (en) 2000-12-28
NO975151D0 (no) 1997-11-10
JPH11506429A (ja) 1999-06-08
CO4750666A1 (es) 1999-03-31
CY2445B1 (en) 2004-11-12
EP0824535B1 (en) 2003-02-26
NO326126B1 (no) 2008-09-29
RU2183212C2 (ru) 2002-06-10
SK150397A3 (en) 1998-03-04
DE69634581T2 (de) 2006-02-09
CA2219656A1 (en) 1996-11-14
ES2193246T3 (es) 2003-11-01
DK0824535T3 (da) 2003-06-02
DE69634581D1 (de) 2005-05-12
AU5818496A (en) 1996-11-29

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