IL131812A0 - Salt of naphthyridine carboxylic acid derivative - Google Patents

Salt of naphthyridine carboxylic acid derivative

Info

Publication number
IL131812A0
IL131812A0 IL13181298A IL13181298A IL131812A0 IL 131812 A0 IL131812 A0 IL 131812A0 IL 13181298 A IL13181298 A IL 13181298A IL 13181298 A IL13181298 A IL 13181298A IL 131812 A0 IL131812 A0 IL 131812A0
Authority
IL
Israel
Prior art keywords
salt
carboxylic acid
acid derivative
naphthyridine carboxylic
naphthyridine
Prior art date
Application number
IL13181298A
Other languages
English (en)
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of IL131812A0 publication Critical patent/IL131812A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13181298A 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative IL131812A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970009840 1997-03-21
PCT/KR1998/000051 WO1998042705A1 (en) 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative

Publications (1)

Publication Number Publication Date
IL131812A0 true IL131812A0 (en) 2001-03-19

Family

ID=19500439

Family Applications (2)

Application Number Title Priority Date Filing Date
IL131812A IL131812A (en) 1997-03-21 1998-03-20 Acid 7 - (3 - Aminomethyl - 4 - Methoxyaiminopyrrolidine - 1 - il) - 1 - Cyclopropyl - 6 - Fluoro - 4,1 - Dihydro - 4 - Oxo - 8,1 - Naphthyridine - 3 - Carboxylic methanesulfonate hydrates
IL13181298A IL131812A0 (en) 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL131812A IL131812A (en) 1997-03-21 1998-03-20 Acid 7 - (3 - Aminomethyl - 4 - Methoxyaiminopyrrolidine - 1 - il) - 1 - Cyclopropyl - 6 - Fluoro - 4,1 - Dihydro - 4 - Oxo - 8,1 - Naphthyridine - 3 - Carboxylic methanesulfonate hydrates

Country Status (39)

Country Link
US (9) US7700617B2 (bg)
EP (2) EP1179533B1 (bg)
JP (3) JP3759962B2 (bg)
KR (1) KR100266499B1 (bg)
CN (1) CN1131229C (bg)
AP (1) AP1331A (bg)
AR (1) AR012125A1 (bg)
AT (2) ATE257836T1 (bg)
AU (1) AU726634B2 (bg)
BG (1) BG63972B1 (bg)
BR (1) BR9808290A (bg)
CA (1) CA2283671C (bg)
CZ (2) CZ288673B6 (bg)
DE (2) DE69814378T2 (bg)
DK (2) DK0981527T3 (bg)
DZ (1) DZ2448A1 (bg)
EA (1) EA001674B1 (bg)
ES (2) ES2198697T3 (bg)
HK (1) HK1026698A1 (bg)
HU (2) HU225412B1 (bg)
ID (1) ID22681A (bg)
IL (2) IL131812A (bg)
IN (1) IN188178B (bg)
IS (2) IS2093B (bg)
MA (1) MA24500A1 (bg)
MY (1) MY137653A (bg)
NO (1) NO312515B1 (bg)
NZ (1) NZ337748A (bg)
OA (1) OA11161A (bg)
PE (1) PE67999A1 (bg)
PL (1) PL191815B1 (bg)
PT (2) PT981527E (bg)
SA (1) SA98181055B1 (bg)
SI (2) SI0981527T1 (bg)
SK (1) SK284107B6 (bg)
TR (1) TR199902313T2 (bg)
UA (1) UA56218C2 (bg)
WO (1) WO1998042705A1 (bg)
ZA (1) ZA982335B (bg)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
JP2002539248A (ja) * 1999-03-19 2002-11-19 クノール・ゲー・エム・ベー・ハー 変形性関節症の治療
US6262071B1 (en) 1999-06-29 2001-07-17 Smithkline Beecham Corporation Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria
US6331550B1 (en) 1999-06-29 2001-12-18 Smithkline Beecham Corporation Methods of use of quinolone compounds against anaerobic pathogenic bacteria
US6803376B1 (en) 1999-06-29 2004-10-12 Smithkline Beecham Corporation Method of use of quinolone compounds against pneumococcal and haemophilus bacteria
CA2282066C (en) 1999-06-29 2010-09-07 Smithkline Beecham Corporation Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
GB9920917D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GR1003520B (el) * 1999-09-22 2001-01-22 Smithkline Beecham Plc Μεθοδος χρησης ενωσεων φλουοροκινολονης εναντια σε νοσοκομειακα αρνητικα κατα gramμ παθογενων βακτηριδιων
JP2001097891A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸器系病原菌に対するフルオロキノロン化合物の使用法
JP2001097864A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸管および尿路病原性細菌に対するフルオロキノリン化合物の使用方法
JP2001097863A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 嫌気性病原菌に対するフルオロキノロン化合物の使用法
EP1242079A4 (en) * 1999-09-22 2003-01-22 Smithkline Beecham Methods of anti-bacterial use of fluoroquinolonic compounds
GR1003521B (el) * 1999-09-23 2001-01-22 Smithkline Beecham Plc Μεθοδοι χρησεως ενωσεων φλουοροκινολονης εναντια κατα gram θετικων παθογονων βακτηριδιων
KR20010091379A (ko) * 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
JP2005500350A (ja) 2001-08-02 2005-01-06 エルジー ライフサイエンス リミテッド 4−アミノメチレン−ピロリジン−3−オンおよび/または4−アミノメチレン−ピロリジン−3−アルコキシイミノ誘導体のアミノ保護誘導体、および/またはジェミフロキサシンまたはその塩の製造方法
AU2002360218A1 (en) * 2001-11-30 2003-06-10 Lg Life Sciences Ltd. A METHOD OF TREATING BACTERIAL INFECTIONS USING GEMIFLOXACIN OR A SALT THEREOF AND A Beta -LACTAM ANTIBIOTIC
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
AR043880A1 (es) * 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
EP1891037A1 (en) * 2005-06-15 2008-02-27 Hetero Drugs Limited Gemifloxacin process and polymorphs
CN101500564B (zh) * 2006-03-07 2012-07-25 沃克哈特有限公司 苯并喹嗪-2-羧酸的前药
WO2010001408A2 (en) * 2008-06-06 2010-01-07 Matrix Laboratories Ltd. Novel polymorphic forms of gemifloxacin mesylate
WO2010146594A1 (en) * 2009-06-16 2010-12-23 Hetero Research Foundation Novel polymorphs of gemifloxacin mesylate
EP2491921A1 (en) * 2011-02-25 2012-08-29 Deva Holding Anonim Sirketi Conservation of anhydrous form of gemifloxacin
CA2865585C (en) * 2012-02-27 2019-12-10 Bristol-Myers Squibb Company N-(5s, 6s, 9r)-5-amino-6-(2,3-difluorophenyl)-6, 7, 8, 9-tetrahydro-5h-cyclohepta [b] pyridin-9-yl-4-(2-oxo-2, 3-dihydro-1h-imidazo [4, 5-b] pyridin-1-yl) piperidine-1-carboxylate, hemisulfate salt
CZ2016104A3 (cs) * 2016-02-24 2017-09-06 Zentiva, K.S. Krystalické modifikace solí methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}fenyl)amino](fenyl)methyliden}-2-oxo-2,3-dihydro-1H-indol-6-karboxylátu a způsoby jejich přípravy

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AR223983A1 (es) 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
ES8304117A1 (es) 1981-06-11 1983-02-16 Warner Lambert Co "un procedimiento para preparar sales de compuestos de naftiridina y quinoleina".
IN162769B (bg) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US4931446A (en) * 1988-03-23 1990-06-05 Abbott Laboratories Antimicrobial for in-vitro diagnostic kits
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
HU219403B (hu) 1989-08-16 2001-04-28 Pfizer Inc. Azabiciklo-csoporttal helyettesített kinolon- és naftiridon-karbonsavak és eljárás ezek előállítására
EP0541086A1 (en) 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
WO1993025545A1 (en) 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
US5776944A (en) * 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
WO1996012704A1 (fr) 1994-10-20 1996-05-02 Wakunaga Seiyaku Kabushiki Kaisha Nouveau derive de pyridone-carboxylate, ou sel de celui-ci, et antibacterien le contenant comme principe actif
KR100499366B1 (ko) 1995-01-30 2005-09-08 와쿠나가 세이야쿠 가부시키 가이샤 신규피리돈카르복실산유도체또는그염및그물질을유효성분으로하는항균제
WO1996039406A1 (en) 1995-06-06 1996-12-12 Pfizer Inc. NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT
US20020032216A1 (en) * 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
KR100286874B1 (ko) * 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
KR19980080504A (ko) 1998-11-25
CZ288715B6 (cs) 2001-08-15
DE69821147T2 (de) 2004-11-11
US7700617B2 (en) 2010-04-20
BG103750A (bg) 2000-06-30
IN188178B (bg) 2002-08-31
AP9901649A0 (en) 1999-09-30
BG63972B1 (bg) 2003-08-29
HK1026698A1 (en) 2000-12-22
ZA982335B (en) 1999-11-23
ID22681A (id) 1999-12-09
IS5181A (is) 1999-09-14
US20130065917A1 (en) 2013-03-14
AR012125A1 (es) 2000-09-27
EA199900855A1 (ru) 2000-04-24
JP2009051851A (ja) 2009-03-12
ATE257836T1 (de) 2004-01-15
PE67999A1 (es) 1999-09-30
IS2095B (is) 2006-04-12
PT981527E (pt) 2003-09-30
NO994595D0 (no) 1999-09-21
ES2213669T3 (es) 2004-09-01
EP0981527B1 (en) 2003-05-07
DK0981527T3 (da) 2003-09-01
NZ337748A (en) 2001-03-30
JP4781614B2 (ja) 2011-09-28
HU0600401D0 (en) 2006-07-28
EP0981527A1 (en) 2000-03-01
KR100266499B1 (ko) 2000-12-01
EP1179533B1 (en) 2004-01-14
JP2004002413A (ja) 2004-01-08
JP3759962B2 (ja) 2006-03-29
CZ328299A3 (cs) 2000-02-16
US20170253588A1 (en) 2017-09-07
PL335812A1 (en) 2000-05-22
ES2198697T3 (es) 2004-02-01
BR9808290A (pt) 2000-05-16
AU726634B2 (en) 2000-11-16
US20090182006A1 (en) 2009-07-16
AU6636698A (en) 1998-10-20
EA001674B1 (ru) 2001-06-25
IS2093B (is) 2006-04-12
MY137653A (en) 2009-02-27
US20140187576A1 (en) 2014-07-03
IS7952A (is) 2005-07-21
HU225412B1 (en) 2006-11-28
SK284107B6 (sk) 2004-09-08
SA98181055B1 (ar) 2006-10-11
EP1179533A2 (en) 2002-02-13
SI0981527T1 (en) 2003-10-31
JP2000510484A (ja) 2000-08-15
TR199902313T2 (xx) 1999-12-21
DE69814378T2 (de) 2004-02-26
HUP0000728A2 (hu) 2000-09-28
AP1331A (en) 2004-11-26
UA56218C2 (uk) 2003-05-15
IL131812A (en) 2006-04-10
HU227536B1 (en) 2011-08-29
WO1998042705A1 (en) 1998-10-01
HUP0600401A3 (en) 2010-05-28
US20100240694A1 (en) 2010-09-23
DZ2448A1 (fr) 2003-01-11
CA2283671A1 (en) 1998-10-01
SI1179533T1 (en) 2004-04-30
DE69821147D1 (de) 2004-02-19
NO994595L (no) 1999-09-21
DE69814378D1 (de) 2003-06-12
EP1179533A3 (en) 2002-03-20
US20080039488A1 (en) 2008-02-14
ATE239724T1 (de) 2003-05-15
CZ288673B6 (cs) 2001-08-15
PL191815B1 (pl) 2006-07-31
CN1251101A (zh) 2000-04-19
MA24500A1 (fr) 1998-10-01
SK123699A3 (en) 2000-08-14
US20150291585A1 (en) 2015-10-15
CN1131229C (zh) 2003-12-17
HUP0000728A3 (en) 2002-12-28
US20110312987A1 (en) 2011-12-22
OA11161A (en) 2003-04-25
NO312515B1 (no) 2002-05-21
US20160264569A1 (en) 2016-09-15
CA2283671C (en) 2003-09-16
DK1179533T3 (da) 2004-05-03
PT1179533E (pt) 2004-05-31

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