IL131327A - A pharmaceutical preparation containing liposomes that have undergone lyophilization that envelops an active ingredient that is soluble in water and the process for preparing this preparation - Google Patents
A pharmaceutical preparation containing liposomes that have undergone lyophilization that envelops an active ingredient that is soluble in water and the process for preparing this preparationInfo
- Publication number
- IL131327A IL131327A IL13132798A IL13132798A IL131327A IL 131327 A IL131327 A IL 131327A IL 13132798 A IL13132798 A IL 13132798A IL 13132798 A IL13132798 A IL 13132798A IL 131327 A IL131327 A IL 131327A
- Authority
- IL
- Israel
- Prior art keywords
- liposomes
- trehalose
- active principle
- water
- temperature
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000362A IT1289938B1 (it) | 1997-02-20 | 1997-02-20 | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
| PCT/EP1998/000817 WO1998036736A1 (en) | 1997-02-20 | 1998-02-12 | Pharmaceutical preparation comprising lyophilized liposomes encapsulating an active principle which is highly insoluble in water, and the process for preparing the said preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL131327A0 IL131327A0 (en) | 2001-01-28 |
| IL131327A true IL131327A (en) | 2004-07-25 |
Family
ID=11376097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13132798A IL131327A (en) | 1997-02-20 | 1998-02-12 | A pharmaceutical preparation containing liposomes that have undergone lyophilization that envelops an active ingredient that is soluble in water and the process for preparing this preparation |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6319517B1 (it) |
| EP (1) | EP0981332B1 (it) |
| JP (1) | JP4290767B2 (it) |
| KR (1) | KR100496802B1 (it) |
| CN (1) | CN1089581C (it) |
| AR (1) | AR011681A1 (it) |
| AT (1) | ATE285754T1 (it) |
| AU (1) | AU744115B2 (it) |
| BG (1) | BG64580B1 (it) |
| CA (1) | CA2288958C (it) |
| CZ (1) | CZ295998B6 (it) |
| DE (1) | DE69828394T2 (it) |
| EA (1) | EA001637B1 (it) |
| ES (1) | ES2235320T3 (it) |
| GE (1) | GEP20022734B (it) |
| HK (1) | HK1026148A1 (it) |
| HU (1) | HU225593B1 (it) |
| IL (1) | IL131327A (it) |
| IT (1) | IT1289938B1 (it) |
| PL (1) | PL190628B1 (it) |
| PT (1) | PT981332E (it) |
| SK (1) | SK282931B6 (it) |
| TR (1) | TR199902025T2 (it) |
| UA (1) | UA70296A (it) |
| WO (1) | WO1998036736A1 (it) |
| ZA (1) | ZA981352B (it) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60012932T2 (de) * | 1999-06-23 | 2005-08-18 | Cornell Research Foundation, Inc. | Entwässerung/rehydratisierung von markierten liposomen auf einer prüfeinrichtung |
| US6576460B1 (en) | 1999-10-28 | 2003-06-10 | Cornell Research Foundation, Inc. | Filtration-detection device and method of use |
| MXPA05007571A (es) * | 2003-01-17 | 2005-11-17 | Threshold Pharmaceuticals Inc | Tratamiento para hiperplasia protatica benigna utilizando agentes energoliticos. |
| JP2008535921A (ja) | 2005-04-12 | 2008-09-04 | エラン・ファルマ・インターナショナル・リミテッド | シクロスポリンを含むナノ粒子および放出調節された組成物 |
| WO2008036979A2 (en) * | 2006-09-22 | 2008-03-27 | Guilford F Timothy | Topical application of melatonin directly or in liposomes for the amelioration of itching and histamine and non-histamine related inflammatory skin changes |
| CN101049504B (zh) * | 2007-04-05 | 2010-05-19 | 广州立恩生物科技有限公司 | 一种脂质体药物载体及其制备方法 |
| US9446147B2 (en) | 2011-02-24 | 2016-09-20 | The Ohio State University | Membrane stabilizing compositions and methods |
| EP2768484B1 (en) | 2011-10-21 | 2019-07-24 | Jazz Pharmaceuticals Research LLC | Lyophilized liposomes |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| JP5957610B2 (ja) * | 2012-08-31 | 2016-07-27 | チュンアン ユニバーシティー インダストリー アカデミック コアポレイション ファウンデイション | 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法 |
| US10722465B1 (en) | 2017-12-08 | 2020-07-28 | Quicksilber Scientific, Inc. | Transparent colloidal vitamin supplement |
| US11344497B1 (en) | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
| KR102646145B1 (ko) | 2018-05-31 | 2024-03-11 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| BR112020026635A2 (pt) * | 2018-06-27 | 2021-04-20 | Breath Therapeutics Gmbh | composições inaláveis compreendendo imunosupressores macrocíclicos |
| BR112020026629A2 (pt) | 2018-06-27 | 2021-03-23 | Breath Therapeutics Gmbh | Composições farmacêuticas na forma liofilizada |
| JP7079984B2 (ja) | 2018-07-28 | 2022-06-03 | エクソコバイオ インコーポレイテッド | エキソソームの凍結乾燥方法 |
| KR102163806B1 (ko) | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| EA202092892A1 (ru) | 2018-12-04 | 2021-05-27 | Брес Терапьютикс Гмбх | Ингаляционные композиции, содержащие макроциклические иммуносупрессанты |
| US11291702B1 (en) | 2019-04-15 | 2022-04-05 | Quicksilver Scientific, Inc. | Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method |
| WO2020261158A1 (en) | 2019-06-25 | 2020-12-30 | Translatum Medicus Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
| CN111358955B (zh) * | 2020-04-01 | 2023-05-02 | 重庆理工大学 | 一种用于治疗脂质代谢疾病的炎症靶向的宾达利纳米粒、制备方法及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| FR2542749B1 (fr) * | 1983-03-18 | 1985-07-12 | Beghin Say Sa | Copolymere allyloligosaccharide-acrylique salifie, procede de preparation du copolymere et application comme super-absorbant |
| US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| US4963362A (en) * | 1987-08-07 | 1990-10-16 | Regents Of The University Of Minnesota | Freeze-dried liposome mixture containing cyclosporin |
| US5683714A (en) * | 1991-04-19 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Liposomal cyclosporin pharmaceutical formulation |
| US5817336A (en) * | 1993-04-02 | 1998-10-06 | Orion-Yhtyma Oy | Composition containing selegiline |
| GB9320668D0 (en) * | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| CA2153251C (en) * | 1993-11-05 | 1998-09-01 | David Samuel Collins | Liposome preparation and material encapsulation method |
-
1997
- 1997-02-20 IT IT97MI000362A patent/IT1289938B1/it active IP Right Grant
-
1998
- 1998-02-12 EA EA199900751A patent/EA001637B1/ru not_active IP Right Cessation
- 1998-02-12 UA UA99095150A patent/UA70296A/uk unknown
- 1998-02-12 HU HU0001464A patent/HU225593B1/hu not_active IP Right Cessation
- 1998-02-12 TR TR1999/02025T patent/TR199902025T2/xx unknown
- 1998-02-12 CA CA002288958A patent/CA2288958C/en not_active Expired - Fee Related
- 1998-02-12 JP JP53622898A patent/JP4290767B2/ja not_active Expired - Fee Related
- 1998-02-12 KR KR10-1999-7007538A patent/KR100496802B1/ko not_active IP Right Cessation
- 1998-02-12 EP EP98910659A patent/EP0981332B1/en not_active Expired - Lifetime
- 1998-02-12 IL IL13132798A patent/IL131327A/en not_active IP Right Cessation
- 1998-02-12 CN CN98802737A patent/CN1089581C/zh not_active Expired - Fee Related
- 1998-02-12 DE DE69828394T patent/DE69828394T2/de not_active Expired - Lifetime
- 1998-02-12 GE GEAP19984991A patent/GEP20022734B/en unknown
- 1998-02-12 CZ CZ19992925A patent/CZ295998B6/cs not_active IP Right Cessation
- 1998-02-12 AU AU64969/98A patent/AU744115B2/en not_active Ceased
- 1998-02-12 SK SK1110-99A patent/SK282931B6/sk not_active IP Right Cessation
- 1998-02-12 US US09/367,715 patent/US6319517B1/en not_active Expired - Lifetime
- 1998-02-12 ES ES98910659T patent/ES2235320T3/es not_active Expired - Lifetime
- 1998-02-12 WO PCT/EP1998/000817 patent/WO1998036736A1/en active IP Right Grant
- 1998-02-12 PL PL98335207A patent/PL190628B1/pl unknown
- 1998-02-12 PT PT98910659T patent/PT981332E/pt unknown
- 1998-02-12 AT AT98910659T patent/ATE285754T1/de active
- 1998-02-18 ZA ZA981352A patent/ZA981352B/xx unknown
- 1998-02-20 AR ARP980100754A patent/AR011681A1/es active IP Right Grant
-
1999
- 1999-09-16 BG BG103738A patent/BG64580B1/bg unknown
-
2000
- 2000-09-01 HK HK00105485A patent/HK1026148A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |