BG64580B1 - Фармацевтичен състав, съдържащ лиофилизирани липозоми, включващи трудно разтворимо във вода активно вещество и метод за получаването на този състав - Google Patents

Фармацевтичен състав, съдържащ лиофилизирани липозоми, включващи трудно разтворимо във вода активно вещество и метод за получаването на този състав Download PDF

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Publication number
BG64580B1
BG64580B1 BG103738A BG10373899A BG64580B1 BG 64580 B1 BG64580 B1 BG 64580B1 BG 103738 A BG103738 A BG 103738A BG 10373899 A BG10373899 A BG 10373899A BG 64580 B1 BG64580 B1 BG 64580B1
Authority
BG
Bulgaria
Prior art keywords
liposomes
trehalose
temperature
active substance
lyophilization
Prior art date
Application number
BG103738A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103738A (en
Inventor
Giovanni Cavallo
Leonardo Marchitto
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of BG103738A publication Critical patent/BG103738A/xx
Publication of BG64580B1 publication Critical patent/BG64580B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG103738A 1997-02-20 1999-09-16 Фармацевтичен състав, съдържащ лиофилизирани липозоми, включващи трудно разтворимо във вода активно вещество и метод за получаването на този състав BG64580B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000362A IT1289938B1 (it) 1997-02-20 1997-02-20 Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
PCT/EP1998/000817 WO1998036736A1 (en) 1997-02-20 1998-02-12 Pharmaceutical preparation comprising lyophilized liposomes encapsulating an active principle which is highly insoluble in water, and the process for preparing the said preparation

Publications (2)

Publication Number Publication Date
BG103738A BG103738A (en) 2000-05-31
BG64580B1 true BG64580B1 (bg) 2005-08-31

Family

ID=11376097

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103738A BG64580B1 (bg) 1997-02-20 1999-09-16 Фармацевтичен състав, съдържащ лиофилизирани липозоми, включващи трудно разтворимо във вода активно вещество и метод за получаването на този състав

Country Status (26)

Country Link
US (1) US6319517B1 (it)
EP (1) EP0981332B1 (it)
JP (1) JP4290767B2 (it)
KR (1) KR100496802B1 (it)
CN (1) CN1089581C (it)
AR (1) AR011681A1 (it)
AT (1) ATE285754T1 (it)
AU (1) AU744115B2 (it)
BG (1) BG64580B1 (it)
CA (1) CA2288958C (it)
CZ (1) CZ295998B6 (it)
DE (1) DE69828394T2 (it)
EA (1) EA001637B1 (it)
ES (1) ES2235320T3 (it)
GE (1) GEP20022734B (it)
HK (1) HK1026148A1 (it)
HU (1) HU225593B1 (it)
IL (1) IL131327A (it)
IT (1) IT1289938B1 (it)
PL (1) PL190628B1 (it)
PT (1) PT981332E (it)
SK (1) SK282931B6 (it)
TR (1) TR199902025T2 (it)
UA (1) UA70296C2 (it)
WO (1) WO1998036736A1 (it)
ZA (1) ZA981352B (it)

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AU762944B2 (en) * 1999-06-23 2003-07-10 Cornell Research Foundation Inc. Dehydration/rehydration of marked liposomes on a test device
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
EP1610778A4 (en) * 2003-01-17 2006-05-31 Threshold Pharmaceuticals Inc TREATMENT OF BENIGNER PROSTATE HYPERPLASIA
WO2006110802A1 (en) 2005-04-12 2006-10-19 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cyclosporine
WO2008036979A2 (en) * 2006-09-22 2008-03-27 Guilford F Timothy Topical application of melatonin directly or in liposomes for the amelioration of itching and histamine and non-histamine related inflammatory skin changes
CN101049504B (zh) * 2007-04-05 2010-05-19 广州立恩生物科技有限公司 一种脂质体药物载体及其制备方法
US9446147B2 (en) 2011-02-24 2016-09-20 The Ohio State University Membrane stabilizing compositions and methods
KR102024836B1 (ko) 2011-10-21 2019-09-24 셀라토 파마슈티칼즈, 인코포레이티드 동결건조된 리포좀
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
WO2014035206A2 (ko) * 2012-08-31 2014-03-06 중앙대학교 산학협력단 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법
US11344497B1 (en) 2017-12-08 2022-05-31 Quicksilver Scientific, Inc. Mitochondrial performance enhancement nanoemulsion
US10722465B1 (en) 2017-12-08 2020-07-28 Quicksilber Scientific, Inc. Transparent colloidal vitamin supplement
KR102646145B1 (ko) 2018-05-31 2024-03-11 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
EA202092893A1 (ru) 2018-06-27 2021-04-19 Брес Терапьютикс Гмбх Фармацевтические композиции в лиофилизированной форме
AU2019294975A1 (en) * 2018-06-27 2021-01-14 Breath Therapeutics Gmbh Inhalable compositions comprising macrocyclic immunosuppressants
CN112261871B (zh) * 2018-07-28 2022-05-17 韩国外泌体生技有限公司 用于使外排体冻干的方法
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
EA202092892A1 (ru) 2018-12-04 2021-05-27 Брес Терапьютикс Гмбх Ингаляционные композиции, содержащие макроциклические иммуносупрессанты
US11291702B1 (en) 2019-04-15 2022-04-05 Quicksilver Scientific, Inc. Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method
WO2020261158A1 (en) 2019-06-25 2020-12-30 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN111358955B (zh) * 2020-04-01 2023-05-02 重庆理工大学 一种用于治疗脂质代谢疾病的炎症靶向的宾达利纳米粒、制备方法及其应用
JP7508359B2 (ja) 2020-12-11 2024-07-01 株式会社東芝 脂質粒子の製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
FR2542749B1 (fr) * 1983-03-18 1985-07-12 Beghin Say Sa Copolymere allyloligosaccharide-acrylique salifie, procede de preparation du copolymere et application comme super-absorbant
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US5683714A (en) * 1991-04-19 1997-11-04 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin pharmaceutical formulation
US5817336A (en) * 1993-04-02 1998-10-06 Orion-Yhtyma Oy Composition containing selegiline
GB9320668D0 (en) * 1993-10-07 1993-11-24 Secr Defence Liposomes containing particulare materials
DK0678017T3 (da) * 1993-11-05 1998-10-19 Amgen Inc Liposomfremstilling og materialeindkapslingsfremgangsmåde

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes

Also Published As

Publication number Publication date
SK282931B6 (sk) 2003-01-09
AU744115B2 (en) 2002-02-14
HK1026148A1 (en) 2000-12-08
US6319517B1 (en) 2001-11-20
DE69828394D1 (de) 2005-02-03
ZA981352B (en) 1998-08-19
CZ295998B6 (cs) 2005-12-14
PT981332E (pt) 2005-05-31
IL131327A (en) 2004-07-25
UA70296A (uk) 2004-10-15
UA70296C2 (uk) 2004-10-15
ES2235320T3 (es) 2005-07-01
JP4290767B2 (ja) 2009-07-08
ITMI970362A1 (it) 1998-08-20
EP0981332A1 (en) 2000-03-01
EA001637B1 (ru) 2001-06-25
EA199900751A1 (ru) 2000-10-30
PL190628B1 (pl) 2005-12-30
EP0981332B1 (en) 2004-12-29
CN1248163A (zh) 2000-03-22
AR011681A1 (es) 2000-08-30
ATE285754T1 (de) 2005-01-15
AU6496998A (en) 1998-09-09
CA2288958A1 (en) 1998-08-27
KR100496802B1 (ko) 2005-06-22
CN1089581C (zh) 2002-08-28
BG103738A (en) 2000-05-31
JP2001519776A (ja) 2001-10-23
GEP20022734B (en) 2002-07-25
PL335207A1 (en) 2000-04-10
TR199902025T2 (xx) 1999-11-22
KR20000075479A (ko) 2000-12-15
SK111099A3 (en) 2000-05-16
HUP0001464A3 (en) 2001-12-28
HUP0001464A2 (hu) 2000-10-28
DE69828394T2 (de) 2005-12-08
CZ292599A3 (cs) 2000-01-12
WO1998036736A1 (en) 1998-08-27
IT1289938B1 (it) 1998-10-19
IL131327A0 (en) 2001-01-28
CA2288958C (en) 2007-08-21
HU225593B1 (en) 2007-05-02

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