IL130969A - שיטה לדירדור בררני של חלבון חלב בנוכחות חלבוני חלב אחרים - Google Patents
שיטה לדירדור בררני של חלבון חלב בנוכחות חלבוני חלב אחריםInfo
- Publication number
- IL130969A IL130969A IL13096998A IL13096998A IL130969A IL 130969 A IL130969 A IL 130969A IL 13096998 A IL13096998 A IL 13096998A IL 13096998 A IL13096998 A IL 13096998A IL 130969 A IL130969 A IL 130969A
- Authority
- IL
- Israel
- Prior art keywords
- casein
- protein
- caseinate
- milk
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 141
- 108010011756 Milk Proteins Proteins 0.000 title claims description 128
- 102000014171 Milk Proteins Human genes 0.000 title claims description 126
- 235000021239 milk protein Nutrition 0.000 title claims description 126
- 230000008684 selective degradation Effects 0.000 title description 7
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 403
- 235000021240 caseins Nutrition 0.000 claims abstract description 377
- 239000005018 casein Substances 0.000 claims abstract description 372
- 235000018102 proteins Nutrition 0.000 claims abstract description 231
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 231
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 229
- 102000035195 Peptidases Human genes 0.000 claims abstract description 147
- 108091005804 Peptidases Proteins 0.000 claims abstract description 147
- 230000007062 hydrolysis Effects 0.000 claims abstract description 127
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 127
- 229940071162 caseinate Drugs 0.000 claims abstract description 107
- 235000019833 protease Nutrition 0.000 claims abstract description 107
- 239000000470 constituent Substances 0.000 claims abstract description 92
- 239000007864 aqueous solution Substances 0.000 claims abstract description 23
- 210000002421 cell wall Anatomy 0.000 claims abstract description 11
- 108010007093 dispase Proteins 0.000 claims abstract description 7
- 108060005980 Collagenase Proteins 0.000 claims abstract description 5
- 102000029816 Collagenase Human genes 0.000 claims abstract description 5
- 229960002424 collagenase Drugs 0.000 claims abstract description 5
- 241000194036 Lactococcus Species 0.000 claims abstract 2
- 108010076119 Caseins Proteins 0.000 claims description 396
- 102000011632 Caseins Human genes 0.000 claims description 396
- 238000002360 preparation method Methods 0.000 claims description 164
- 108010046377 Whey Proteins Proteins 0.000 claims description 93
- 235000021119 whey protein Nutrition 0.000 claims description 79
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 77
- 229940098773 bovine serum albumin Drugs 0.000 claims description 77
- 230000000890 antigenic effect Effects 0.000 claims description 76
- 108700031875 bovine (152-168) serum albumin Proteins 0.000 claims description 64
- 238000000108 ultra-filtration Methods 0.000 claims description 52
- 239000008267 milk Substances 0.000 claims description 48
- 210000004080 milk Anatomy 0.000 claims description 48
- 102000007544 Whey Proteins Human genes 0.000 claims description 47
- 235000013336 milk Nutrition 0.000 claims description 46
- 235000013305 food Nutrition 0.000 claims description 34
- 238000000926 separation method Methods 0.000 claims description 32
- 108010079058 casein hydrolysate Proteins 0.000 claims description 29
- 230000008105 immune reaction Effects 0.000 claims description 16
- 239000005862 Whey Substances 0.000 claims description 14
- 206010012601 diabetes mellitus Diseases 0.000 claims description 10
- 208000009793 Milk Hypersensitivity Diseases 0.000 claims description 8
- 241000194034 Lactococcus lactis subsp. cremoris Species 0.000 claims description 6
- 235000014962 Streptococcus cremoris Nutrition 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 201000010859 Milk allergy Diseases 0.000 claims description 4
- 241000194105 Paenibacillus polymyxa Species 0.000 claims description 4
- 235000008452 baby food Nutrition 0.000 claims 6
- 238000011084 recovery Methods 0.000 claims 4
- 108010013295 Microbial collagenase Proteins 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 description 62
- 239000012634 fragment Substances 0.000 description 58
- 239000012528 membrane Substances 0.000 description 42
- 102000004190 Enzymes Human genes 0.000 description 41
- 108090000790 Enzymes Proteins 0.000 description 41
- 229940088598 enzyme Drugs 0.000 description 41
- 229940027941 immunoglobulin g Drugs 0.000 description 34
- 239000000413 hydrolysate Substances 0.000 description 32
- 238000002965 ELISA Methods 0.000 description 24
- 239000012466 permeate Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 24
- 230000001900 immune effect Effects 0.000 description 22
- 239000003531 protein hydrolysate Substances 0.000 description 22
- 239000012465 retentate Substances 0.000 description 22
- 239000004365 Protease Substances 0.000 description 18
- 230000000694 effects Effects 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- 239000007858 starting material Substances 0.000 description 18
- 108010073771 Soybean Proteins Proteins 0.000 description 14
- 230000015556 catabolic process Effects 0.000 description 14
- 238000006731 degradation reaction Methods 0.000 description 14
- 230000002163 immunogen Effects 0.000 description 14
- 229940080237 sodium caseinate Drugs 0.000 description 14
- 229940001941 soy protein Drugs 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 12
- 235000020247 cow milk Nutrition 0.000 description 12
- 238000010324 immunological assay Methods 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 238000004007 reversed phase HPLC Methods 0.000 description 12
- JDIIGWSSTNUWGK-UHFFFAOYSA-N 1h-imidazol-3-ium;chloride Chemical compound [Cl-].[NH2+]1C=CN=C1 JDIIGWSSTNUWGK-UHFFFAOYSA-N 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 10
- 235000013365 dairy product Nutrition 0.000 description 10
- 235000013350 formula milk Nutrition 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000000758 substrate Substances 0.000 description 10
- 235000021247 β-casein Nutrition 0.000 description 9
- 102000008192 Lactoglobulins Human genes 0.000 description 8
- 108010060630 Lactoglobulins Proteins 0.000 description 8
- 101710118538 Protease Proteins 0.000 description 8
- 230000002009 allergenic effect Effects 0.000 description 8
- 229940021722 caseins Drugs 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 230000037029 cross reaction Effects 0.000 description 8
- 230000003301 hydrolyzing effect Effects 0.000 description 8
- 239000013067 intermediate product Substances 0.000 description 8
- 235000004252 protein component Nutrition 0.000 description 8
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 8
- 244000063299 Bacillus subtilis Species 0.000 description 6
- 235000014469 Bacillus subtilis Nutrition 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 6
- 108010009736 Protein Hydrolysates Proteins 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 235000019658 bitter taste Nutrition 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 238000003776 cleavage reaction Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 235000019419 proteases Nutrition 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 230000007017 scission Effects 0.000 description 6
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 108090000746 Chymosin Proteins 0.000 description 4
- 102000018389 Exopeptidases Human genes 0.000 description 4
- 108010091443 Exopeptidases Proteins 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 241000194035 Lactococcus lactis Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 108010033276 Peptide Fragments Proteins 0.000 description 4
- 102000007079 Peptide Fragments Human genes 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 108090000631 Trypsin Proteins 0.000 description 4
- 102000004142 Trypsin Human genes 0.000 description 4
- 230000006978 adaptation Effects 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 235000011148 calcium chloride Nutrition 0.000 description 4
- 235000013351 cheese Nutrition 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 229940080701 chymosin Drugs 0.000 description 4
- 230000009260 cross reactivity Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- 230000007071 enzymatic hydrolysis Effects 0.000 description 4
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000000774 hypoallergenic effect Effects 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 235000019624 protein content Nutrition 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 102000004400 Aminopeptidases Human genes 0.000 description 2
- 108090000915 Aminopeptidases Proteins 0.000 description 2
- 108010032595 Antibody Binding Sites Proteins 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 2
- 241000228257 Aspergillus sp. Species 0.000 description 2
- 241000194108 Bacillus licheniformis Species 0.000 description 2
- 108050008461 Beta-lactoglobulin Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000222290 Cladosporium Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 241000193159 Hathewaya histolytica Species 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 102000005741 Metalloproteases Human genes 0.000 description 2
- 108010006035 Metalloproteases Proteins 0.000 description 2
- 241000235395 Mucor Species 0.000 description 2
- 102100033174 Neutrophil elastase Human genes 0.000 description 2
- 108010019160 Pancreatin Proteins 0.000 description 2
- 108090000526 Papain Proteins 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 101710135670 Putative Xaa-Pro dipeptidyl-peptidase Proteins 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 101710143531 Xaa-Pro dipeptidyl-peptidase Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000005349 anion exchange Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 239000003593 chromogenic compound Substances 0.000 description 2
- 229960002376 chymotrypsin Drugs 0.000 description 2
- 238000005352 clarification Methods 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 201000005356 cow milk allergy Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- -1 oc-lactalbumin Proteins 0.000 description 2
- 108090000155 pancreatic elastase II Proteins 0.000 description 2
- 229940055695 pancreatin Drugs 0.000 description 2
- 229940055729 papain Drugs 0.000 description 2
- 235000019834 papain Nutrition 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000012134 supernatant fraction Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000021249 α-casein Nutrition 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1005037A NL1005037C2 (nl) | 1997-01-17 | 1997-01-17 | Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten. |
| PCT/NL1998/000025 WO1998031239A1 (en) | 1997-01-17 | 1998-01-16 | Method for the selective degradation of milk protein in the presence of other milk proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL130969A0 IL130969A0 (en) | 2001-01-28 |
| IL130969A true IL130969A (he) | 2002-11-10 |
Family
ID=19764239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13096998A IL130969A (he) | 1997-01-17 | 1998-01-16 | שיטה לדירדור בררני של חלבון חלב בנוכחות חלבוני חלב אחרים |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6451552B1 (he) |
| EP (1) | EP0959690A1 (he) |
| JP (1) | JP2001516204A (he) |
| KR (1) | KR20000070231A (he) |
| AU (1) | AU734222B2 (he) |
| BR (1) | BR9806911A (he) |
| CA (1) | CA2277899A1 (he) |
| EE (1) | EE9900297A (he) |
| IL (1) | IL130969A (he) |
| NL (1) | NL1005037C2 (he) |
| NO (1) | NO993424L (he) |
| NZ (1) | NZ336810A (he) |
| WO (1) | WO1998031239A1 (he) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927603D0 (en) * | 1999-11-22 | 2000-01-19 | Nestle Sa | Use of a milk protein hydrolysate in the treatment of diabetes |
| WO2001043563A1 (de) * | 1999-12-17 | 2001-06-21 | N.V. Nutricia | Verwendung von modifizierten lebensmittelinhaltsstoffen zur vorbeugung der entwicklung eines diabetes mellitus (iddm) bei bestehendem epidemiologisch begründetem risiko |
| US20030224096A1 (en) * | 2002-06-04 | 2003-12-04 | Novozymes A/S | Whey protein hydrolysate |
| US7393659B2 (en) * | 2002-08-29 | 2008-07-01 | Abbott Laboratories | Analytical method for the determination of infant formula protein digestibility in vitro |
| CA2538507A1 (en) | 2003-08-30 | 2005-03-10 | Nestec S.A. | Acid soluble proteins from micellar casein |
| WO2005072056A2 (en) | 2004-01-28 | 2005-08-11 | Develogen Israel Ltd. | Hsp therapy in conjunction with a low antigenicity diet |
| EP2003989A1 (en) * | 2006-03-31 | 2008-12-24 | DSMIP Assets B.V. | Process for the hydrolysis of milk proteins |
| JP2008189637A (ja) * | 2007-02-08 | 2008-08-21 | Snow Brand Milk Prod Co Ltd | 自己免疫疾患予防剤 |
| EP2300606B1 (en) * | 2008-06-03 | 2011-12-28 | Novozymes A/S | Method for producing a casein hydrolysate |
| EP2258208A1 (en) * | 2009-06-02 | 2010-12-08 | University of Limerick | Protein Product With Modified Antigenicity |
| EP2489281A1 (en) * | 2011-02-17 | 2012-08-22 | University of Limerick | A casein hydrolysate |
| EP2583564A1 (en) * | 2011-10-21 | 2013-04-24 | Nestec S.A. | Use of whey protein micelles for improving insulin profile in diabetic patients |
| US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
| US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
| US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
| US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
| US9345727B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
| US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
| EP2845863A1 (en) * | 2013-09-10 | 2015-03-11 | Consejo Superior de Investigaciones Cientificas (CSIC) | Mathanococcus jannaschii protease and its use |
| MX2020007545A (es) | 2018-01-16 | 2020-09-09 | Frieslandcampina Nederland Bv | Leche de formula infantil hipoalergenica y metodos para prepararla. |
| CN114504051B (zh) * | 2022-03-10 | 2023-05-02 | 中国海洋大学 | 一种基于分子模拟的凝乳酶预处理高效降解酪蛋白抗原性的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK589785A (da) * | 1985-12-18 | 1987-06-19 | Samuelsson Ernst Gunnar | Peptidpraeparat, fremgangsmaade til fremstilling deraf samt anvendelse af peptidpraeparatet |
| DK595285D0 (da) | 1985-12-20 | 1985-12-20 | Nordisk Gentofte | Injicerbart og varmebehandet igg-praeparat og fremgangsmaade til fremstilling af samme |
| CA1333471C (en) * | 1988-04-29 | 1994-12-13 | Gustavo Bounous | Whey protein concentrate as food supplement |
| NL8901994A (nl) * | 1989-08-02 | 1991-03-01 | Dmv Campina Bv | Aminopeptidase. |
| EP0421309B2 (en) * | 1989-10-02 | 2001-08-16 | Novartis Nutrition AG | Protein hydrolysates |
| EP0522203A1 (en) * | 1991-05-16 | 1993-01-13 | Probicom Research B.V. | Protein from lactic acid bacteria |
| US5486461A (en) * | 1991-11-08 | 1996-01-23 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| AU4818393A (en) * | 1992-09-18 | 1994-04-12 | Unilever Plc | Production of desired proteins or polypeptides by culturing a transformed lactic acid bacterium |
| FI94089C (fi) * | 1992-12-10 | 1995-07-25 | Valio Oy | Menetelmä allergiaa aiheuttavien yhdisteiden poistamiseksi proteiinipitoisista koostumuksista |
| JP3112597B2 (ja) * | 1993-03-16 | 2000-11-27 | 雪印乳業株式会社 | 低アレルゲン性乳蛋白質の製造法 |
| US5405637A (en) * | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| JP3226695B2 (ja) * | 1994-01-12 | 2001-11-05 | 森永乳業株式会社 | 乳化性及び熱安定性に優れた乳清蛋白質分解物の製造法、並びに該乳清蛋白質分解物を使用した抗アレルギー性調製乳 |
| DE69532414T2 (de) * | 1994-10-26 | 2004-12-02 | Novozymes A/S | Verfahren für die herstellung eines milch-protein-hydrolysates |
| JP3364551B2 (ja) * | 1995-03-03 | 2003-01-08 | 天野エンザイム株式会社 | 低アレルゲン性乳蛋白質の製造法 |
-
1997
- 1997-01-17 NL NL1005037A patent/NL1005037C2/nl not_active IP Right Cessation
-
1998
- 1998-01-16 JP JP53416898A patent/JP2001516204A/ja active Pending
- 1998-01-16 CA CA002277899A patent/CA2277899A1/en not_active Abandoned
- 1998-01-16 WO PCT/NL1998/000025 patent/WO1998031239A1/en not_active Ceased
- 1998-01-16 IL IL13096998A patent/IL130969A/he not_active IP Right Cessation
- 1998-01-16 BR BR9806911-0A patent/BR9806911A/pt not_active Application Discontinuation
- 1998-01-16 EE EEP199900297A patent/EE9900297A/xx unknown
- 1998-01-16 KR KR1019997006458A patent/KR20000070231A/ko not_active Withdrawn
- 1998-01-16 US US09/341,785 patent/US6451552B1/en not_active Expired - Fee Related
- 1998-01-16 EP EP98900763A patent/EP0959690A1/en not_active Withdrawn
- 1998-01-16 NZ NZ336810A patent/NZ336810A/en unknown
- 1998-01-16 AU AU55780/98A patent/AU734222B2/en not_active Ceased
-
1999
- 1999-07-12 NO NO993424A patent/NO993424L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ336810A (en) | 2001-08-31 |
| IL130969A0 (en) | 2001-01-28 |
| CA2277899A1 (en) | 1998-07-23 |
| NO993424D0 (no) | 1999-07-12 |
| WO1998031239A1 (en) | 1998-07-23 |
| AU734222B2 (en) | 2001-06-07 |
| AU5578098A (en) | 1998-08-07 |
| EP0959690A1 (en) | 1999-12-01 |
| JP2001516204A (ja) | 2001-09-25 |
| BR9806911A (pt) | 2000-05-16 |
| NL1005037C2 (nl) | 1998-07-20 |
| NO993424L (no) | 1999-09-15 |
| US6451552B1 (en) | 2002-09-17 |
| KR20000070231A (ko) | 2000-11-25 |
| US20020061548A1 (en) | 2002-05-23 |
| EE9900297A (et) | 2000-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU734222B2 (en) | Method for the selective degradation of milk protein in the presence of other m ilk proteins | |
| Smacchi et al. | Bioactive peptides in dairy products: synthesis and interaction with proteolytic enzymes | |
| Matar et al. | The effect of milk fermentation by Lactobacillus helveticus on the release of peptides during in vitro digestion | |
| AU2016247052B2 (en) | Milk-based protein hydrolysates and infant formulae and nutritional compositions made thereof | |
| Parrot et al. | In vitro study on digestion of peptides in Emmental cheese: Analytical evaluation and influence on angiotensin I converting enzyme inhibitory peptides | |
| AU613684B2 (en) | A process for the preparation of a hypoallergenic whey protein hydrolyzate and food | |
| AU2007343749B2 (en) | Milk protein hydrolyzates with reduced immunogenic potential | |
| JP6748099B2 (ja) | 乳ベースタンパク質加水分解物及びそれから作製された組成物 | |
| JP2005528110A (ja) | トリペプチドに富むタンパク水解物 | |
| EP0671126B1 (en) | Low-phosphorus whey protein, process for producing the same, hydrolyzate of purified low-phosphorus whey protein, and process for producing the same | |
| WO1992013964A1 (en) | Protein preparations | |
| CN113226063A (zh) | 用来自土生隐球菌的β-半乳糖苷酶制备GOS制剂的方法、由此获得的GOS制剂及其用途 | |
| Wohlrab et al. | Purification and characterization of a dipeptidase from Lactobacillus delbrueckii subsp. bulgaricus | |
| CA2391063A1 (en) | Protein hydrolyzate, manufacuring method therefor, and foods and drinks containing the protein hydrolyzate | |
| LIN et al. | Debittering casein hydrolysates with octadecyl‐siloxane (C18) columns | |
| JP2008511317A (ja) | Ａｃｅ阻害乳漿加水分解物 | |
| Alting et al. | Selective hydrolysis of milk proteins to facilitate the elimination of the ABBOS epitope of bovine serum albumin and other immunoreactive epitopes | |
| JP3222638B2 (ja) | オリゴペプチド混合物及びその製造法 | |
| JPH055000A (ja) | 経口寛容誘導能を有する低アレルゲン性 酵素分解ペプチド組成物 | |
| JP2887302B2 (ja) | カゼインホスホオリゴペプチド混合物、その製造法、及び該混合物を含有する健康食品 | |
| JPH10271958A (ja) | 臭気の低減された蛋白質加水分解物の製造方法 | |
| JPH05344847A (ja) | 不快味のない低抗原性たん白質分解物 及びその製造方法 | |
| JPH05137515A (ja) | 不快味のない低抗原性たん白質分解物 及びその製造方法 | |
| Hussein | Enzymatic Modification of Buffalos and Cows Milk Proteins | |
| Mullally | Physicochemical and bioactive properties of whey protein hydrolysates produced using gastric and pancreatic proteinases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| RH1 | Patent not in force |