IL128567A - Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir - Google Patents

Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir

Info

Publication number
IL128567A
IL128567A IL12856797A IL12856797A IL128567A IL 128567 A IL128567 A IL 128567A IL 12856797 A IL12856797 A IL 12856797A IL 12856797 A IL12856797 A IL 12856797A IL 128567 A IL128567 A IL 128567A
Authority
IL
Israel
Prior art keywords
group
formula
aryl
compound
alkyl
Prior art date
Application number
IL12856797A
Other languages
English (en)
Hebrew (he)
Other versions
IL128567A0 (en
Original Assignee
Agouron Pharma
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Japan Tobacco Inc filed Critical Agouron Pharma
Publication of IL128567A0 publication Critical patent/IL128567A0/xx
Publication of IL128567A publication Critical patent/IL128567A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/287—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL12856797A 1996-09-05 1997-09-04 Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir IL128567A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70841196A 1996-09-05 1996-09-05
PCT/US1997/015468 WO1998009951A2 (en) 1996-09-05 1997-09-04 Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors

Publications (2)

Publication Number Publication Date
IL128567A0 IL128567A0 (en) 2000-01-31
IL128567A true IL128567A (en) 2004-03-28

Family

ID=24845703

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12856797A IL128567A (en) 1996-09-05 1997-09-04 Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir

Country Status (33)

Country Link
EP (2) EP0927165B1 (xx)
JP (3) JP4149000B2 (xx)
KR (1) KR100563289B1 (xx)
CN (2) CN1183117C (xx)
AP (2) AP2003002938A0 (xx)
AT (2) ATE254603T1 (xx)
AU (2) AU740369B2 (xx)
BG (2) BG64793B1 (xx)
BR (1) BR9713192A (xx)
CA (1) CA2264756A1 (xx)
CZ (2) CZ298175B6 (xx)
DE (2) DE69734689T2 (xx)
DK (2) DK1361216T3 (xx)
EA (1) EA002051B1 (xx)
EE (1) EE04465B1 (xx)
ES (2) ES2210573T3 (xx)
GE (1) GEP20022799B (xx)
HK (1) HK1062171A1 (xx)
HU (1) HUP0000028A3 (xx)
IL (1) IL128567A (xx)
IS (1) IS2030B (xx)
NO (1) NO313287B1 (xx)
NZ (1) NZ334909A (xx)
OA (1) OA10988A (xx)
PL (2) PL198408B1 (xx)
PT (1) PT927165E (xx)
SG (1) SG94780A1 (xx)
SI (2) SI1361216T1 (xx)
SK (2) SK284899B6 (xx)
TR (1) TR199900473T2 (xx)
UA (1) UA67727C2 (xx)
WO (1) WO1998009951A2 (xx)
YU (1) YU11599A (xx)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0641038A (ja) * 1992-07-17 1994-02-15 Mitsubishi Kasei Corp カルボン酸誘導体
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JPH07248183A (ja) * 1994-03-11 1995-09-26 Osaka Gas Co Ltd 浴室兼用衣類乾燥室
JP3298293B2 (ja) * 1994-03-14 2002-07-02 松下電器産業株式会社 厨芥処理機
WO1996028423A1 (fr) * 1995-03-15 1996-09-19 Sankyo Company, Limited Composes dipeptidiques de structure ahpba
AU717637B2 (en) * 1995-09-26 2000-03-30 Agouron Pharmaceuticals, Inc. Production of amide derivatives and intermediates therefor
WO1997011938A1 (fr) * 1995-09-26 1997-04-03 Japan Tobacco Inc. Procede de production de derives amides et de leurs intermediaires
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor
US5925767A (en) * 1996-02-24 1999-07-20 Basf Aktiengesellschaft Pyrazole-4-yl-hetaroyl derivatives as herbicides

Also Published As

Publication number Publication date
SK28299A3 (en) 1999-11-08
BG64793B1 (bg) 2006-04-28
SI0927165T1 (en) 2004-04-30
DK0927165T3 (da) 2004-03-15
CZ298174B6 (cs) 2007-07-11
DE69726298T2 (de) 2004-05-27
YU11599A (sh) 2000-03-21
KR20010029489A (ko) 2001-04-06
HUP0000028A3 (en) 2003-05-28
HK1062171A1 (en) 2004-10-21
NO991072L (no) 1999-03-04
BR9713192A (pt) 1999-12-21
BG103305A (en) 2000-01-31
NO991072D0 (no) 1999-03-04
SG94780A1 (en) 2003-03-18
SI1361216T1 (sl) 2006-02-28
EE04465B1 (et) 2005-04-15
GEP20022799B (en) 2002-09-25
OA10988A (en) 2001-11-01
AP2003002938A0 (en) 2003-12-31
ATE309990T1 (de) 2005-12-15
CN1232455A (zh) 1999-10-20
CN1183117C (zh) 2005-01-05
BG65237B1 (bg) 2007-09-28
DE69726298D1 (de) 2003-12-24
CN1537846A (zh) 2004-10-20
ATE254603T1 (de) 2003-12-15
IL128567A0 (en) 2000-01-31
AU740369B2 (en) 2001-11-01
EP1361216A1 (en) 2003-11-12
SK285278B6 (sk) 2006-10-05
TR199900473T2 (xx) 1999-06-21
PL201758B1 (pl) 2009-05-29
EA199900257A1 (ru) 1999-08-26
ES2252586T3 (es) 2006-05-16
PL331801A1 (en) 1999-08-02
IS4982A (is) 1999-02-19
SK284899B6 (sk) 2006-02-02
JP2008056693A (ja) 2008-03-13
AP9901497A0 (en) 1999-06-30
CZ298175B6 (cs) 2007-07-11
WO1998009951A3 (en) 1998-07-09
ES2210573T3 (es) 2004-07-01
CZ71699A3 (cs) 1999-06-16
AU766155B2 (en) 2003-10-09
AU1473602A (en) 2002-03-14
PT927165E (pt) 2004-04-30
JP4149000B2 (ja) 2008-09-10
CN1305854C (zh) 2007-03-21
AP1322A (en) 2004-11-04
AU4331797A (en) 1998-03-26
EP1361216B1 (en) 2005-11-16
DE69734689T2 (de) 2006-06-08
HUP0000028A2 (hu) 2000-05-28
NO313287B1 (no) 2002-09-09
IS2030B (is) 2005-08-15
CA2264756A1 (en) 1998-03-12
DE69734689D1 (de) 2005-12-22
PL198408B1 (pl) 2008-06-30
EA002051B1 (ru) 2001-12-24
WO1998009951A2 (en) 1998-03-12
DK1361216T3 (da) 2006-01-23
EE9900109A (et) 1999-12-15
JP2008088178A (ja) 2008-04-17
KR100563289B1 (ko) 2006-03-22
UA67727C2 (uk) 2004-07-15
JP2001500495A (ja) 2001-01-16
EP0927165A2 (en) 1999-07-07
EP0927165B1 (en) 2003-11-19
NZ334909A (en) 2000-06-23

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