IL128229A0 - Polypeptides having a single covalently bound n-terminal water-soluble polymer - Google Patents

Polypeptides having a single covalently bound n-terminal water-soluble polymer

Info

Publication number
IL128229A0
IL128229A0 IL12822997A IL12822997A IL128229A0 IL 128229 A0 IL128229 A0 IL 128229A0 IL 12822997 A IL12822997 A IL 12822997A IL 12822997 A IL12822997 A IL 12822997A IL 128229 A0 IL128229 A0 IL 128229A0
Authority
IL
Israel
Prior art keywords
soluble polymer
covalently bound
polypeptides
terminal water
single covalently
Prior art date
Application number
IL12822997A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of IL128229A0 publication Critical patent/IL128229A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
IL12822997A 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer IL128229A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2305096P 1996-08-02 1996-08-02
PCT/US1997/013756 WO1998005363A2 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer

Publications (1)

Publication Number Publication Date
IL128229A0 true IL128229A0 (en) 1999-11-30

Family

ID=21812842

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12822997A IL128229A0 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer
IL128229A IL128229A (en) 1996-08-02 1999-01-25 Peptide or protein covalently linked to PFG or its progeny through their N-terminus, method of preparation and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL128229A IL128229A (en) 1996-08-02 1999-01-25 Peptide or protein covalently linked to PFG or its progeny through their N-terminus, method of preparation and pharmaceutical preparations containing them

Country Status (19)

Country Link
US (1) US6077939A (pt)
EP (2) EP1731174A3 (pt)
JP (1) JP4410852B2 (pt)
KR (1) KR20000029673A (pt)
CN (1) CN100471521C (pt)
AT (1) ATE341344T1 (pt)
AU (1) AU3908597A (pt)
BR (1) BR9711009A (pt)
CA (1) CA2262994A1 (pt)
DE (1) DE69736780T2 (pt)
DK (1) DK0964702T3 (pt)
ES (1) ES2273373T3 (pt)
IL (2) IL128229A0 (pt)
NO (1) NO990465L (pt)
NZ (1) NZ333993A (pt)
PT (1) PT964702E (pt)
RU (1) RU2199347C2 (pt)
SI (1) SI0964702T1 (pt)
WO (1) WO1998005363A2 (pt)

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CA2262994A1 (en) 1998-02-12
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