DK2054074T3 - Modificeret erythropoietin - Google Patents

Modificeret erythropoietin

Info

Publication number
DK2054074T3
DK2054074T3 DK07812992.1T DK07812992T DK2054074T3 DK 2054074 T3 DK2054074 T3 DK 2054074T3 DK 07812992 T DK07812992 T DK 07812992T DK 2054074 T3 DK2054074 T3 DK 2054074T3
Authority
DK
Denmark
Prior art keywords
modified erythropoietin
erythropoietin
modified
Prior art date
Application number
DK07812992.1T
Other languages
English (en)
Inventor
Abraham Abuchowski
Lihysyng Stanford Lee
Original Assignee
Prolong Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolong Pharmaceuticals Llc filed Critical Prolong Pharmaceuticals Llc
Application granted granted Critical
Publication of DK2054074T3 publication Critical patent/DK2054074T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DK07812992.1T 2006-08-04 2007-07-16 Modificeret erythropoietin DK2054074T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83542906P 2006-08-04 2006-08-04
PCT/US2007/073629 WO2008019214A1 (en) 2006-08-04 2007-07-16 Modified erythropoietin

Publications (1)

Publication Number Publication Date
DK2054074T3 true DK2054074T3 (da) 2014-11-03

Family

ID=39033318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07812992.1T DK2054074T3 (da) 2006-08-04 2007-07-16 Modificeret erythropoietin

Country Status (14)

Country Link
US (1) US8765924B2 (da)
EP (1) EP2054074B8 (da)
JP (3) JP5723528B2 (da)
KR (2) KR101304081B1 (da)
CN (2) CN101534847A (da)
CA (1) CA2659990C (da)
DK (1) DK2054074T3 (da)
ES (1) ES2529234T3 (da)
HK (1) HK1131542A1 (da)
IL (2) IL196866A (da)
PL (1) PL2054074T3 (da)
PT (1) PT2054074E (da)
SI (1) SI2054074T1 (da)
WO (1) WO2008019214A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2529234T3 (es) * 2006-08-04 2015-02-18 Prolong Pharmaceuticals, LLC Eritropoyetina modificada
EP2446034A4 (en) * 2009-06-22 2013-11-27 Ipca Lab Ltd NOVEL POLYNUCLEOTIDE MOLECULES FOR IMPROVED GENE EXPRESSION
JP5809057B2 (ja) * 2009-09-15 2015-11-10 株式会社カネカ 水溶性長鎖分子を付加した修飾エリスロポエチン
CN103044539B (zh) * 2010-04-09 2014-10-22 苏州元基生物技术有限公司 重组促红细胞生成素及制备方法
EP2681327B1 (en) * 2011-03-04 2018-11-21 Intrexon Corporation Vectors conditionally expressing protein
CU20140003A7 (es) * 2014-01-08 2015-08-27 Ct De Inmunología Molecular Biofarmacuba Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
KR102268647B1 (ko) * 2017-06-12 2021-06-23 한국코러스 주식회사 안정성이 향상된 에리스로포이에틴 조성물 및 이의 제조방법

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US4677195A (en) 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
DE3785086T2 (de) 1986-06-04 1993-07-08 Agency Ind Science Techn Zubereitung fuer zellkultur und ihre verwendung.
EP0318487B1 (en) 1986-08-04 1993-10-13 The University Of New South Wales Serum free tissue culture medium containing polymeric cell-protective agent
US4954437A (en) 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
EP0343635B1 (en) 1988-05-25 1994-08-24 Teijin Limited Process for continuously culturing adherent animal cells
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
DK0747485T3 (da) * 1989-11-06 1999-08-16 Cell Genesys Inc Fremstilling af proteiner ved anvendelse af homolog rekombination
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
DE4115722A1 (de) 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen
US5968502A (en) * 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
WO1994028024A1 (en) 1993-06-01 1994-12-08 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
WO1996006815A1 (en) 1994-08-31 1996-03-07 Prodevco (N.Z.) Limited Improvements in or relating to a composter
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
IL118201A (en) 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
DE19535571A1 (de) 1995-09-14 1997-03-20 Boehringer Mannheim Gmbh Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US7074397B1 (en) * 1996-01-08 2006-07-11 Genentech, Inc. Method for enhancing proliferation or differentiation of a cell using ob protein
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
KR20000029673A (ko) 1996-08-02 2000-05-25 오르토-맥네일 파마슈티칼, 인코퍼레이티드 단일의공유결합된ｎ-말단수용성폴리머를갖는폴리펩티드
EP0885613A1 (de) 1997-06-21 1998-12-23 Roche Diagnostics GmbH Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin
DE19734293A1 (de) 1997-08-08 1999-02-11 Boehringer Mannheim Gmbh Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
CZ299516B6 (cs) * 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
PE20010288A1 (es) * 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
US6586398B1 (en) * 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
ATE291436T2 (de) * 2000-05-15 2005-04-15 Hoffmann La Roche Flüssige arzneizubereitung enthaltend ein erythropoietin derivat
WO2002032957A1 (fr) * 2000-10-16 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Erythropoietine modifiee par peg
CA2431964C (en) * 2000-12-20 2013-09-10 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
DE60144439D1 (de) 2000-12-20 2011-05-26 Hoffmann La Roche Konjugate von erythropoietin (epo) mit polyethylenglykol (peg)
US6930086B2 (en) * 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
AU2002351746A1 (en) 2001-12-21 2003-07-15 Maxygen Aps Erythropoietin conjugates
US20060239961A1 (en) * 2002-02-15 2006-10-26 Nektar Therapeutics Al, Corporation Hydrolytically degradable alkylene oxide based polymers
US7605231B2 (en) * 2002-04-26 2009-10-20 Yasuhiko Tabata Gelatin derivatives and high-molecular micelle comprising the derivatives
WO2004009627A1 (en) 2002-07-19 2004-01-29 Cangene Corporation Pegylated erythropoietic compounds
MXPA05006688A (es) 2002-12-19 2006-02-22 Nektar Therapeutics Al Corp Conjugados de polimero con una variante de cianovirina.
MXPA05007165A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Reactivos polimericos que comprnden una cetona o un grupo funcional relacionado.
US7610156B2 (en) * 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
EP2599502B1 (en) 2003-04-11 2017-03-01 Antriabio, Inc. Method for preparation of site-specific protein conjugates
EA011351B1 (ru) 2003-05-23 2009-02-27 Нектар Терапеутикс Ал, Корпорейшн Полимерные реагенты, способы их получения, а также содержащие их конъюгаты и фармацевтические препараты
JP2007537986A (ja) * 2003-05-30 2007-12-27 セントカー・インコーポレーテツド トランスグルタミナーゼを用いる新規なエリトロポエチン複合体の形成
KR101131411B1 (ko) 2003-07-22 2012-07-05 넥타르 테라퓨틱스 중합체 알코올로부터 관능화된 중합체의 제조 방법
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
MXPA06010505A (es) 2004-03-15 2006-12-19 Nektar Therapeutics Al Corp Composiciones y conjugados, basados en polimeros, de inhibidores de ingreso de vih.
MXPA06015234A (es) 2004-06-30 2007-11-22 Nektar Therapeutics Al Corp Conjugados de fraccion polimero-factor ix.
CA2573262C (en) 2004-07-16 2015-02-10 Nektar Therapeutics Al, Corporation Conjugates of a gm-csf moiety and a polymer
EP1848461A2 (en) 2005-02-16 2007-10-31 Nektar Therapeutics Al, Corporation Conjugates of an epo moiety and a polymer
US8273339B2 (en) 2005-04-12 2012-09-25 Nektar Therapeutics Polymer-based compositions and conjugates of antimicrobial agents
CN101257926A (zh) 2005-08-04 2008-09-03 尼克塔治疗亚拉巴马公司 G-csf部分与聚合物的轭合物
US20070092486A1 (en) * 2005-10-21 2007-04-26 Avigenics, Inc. Glycolated and glycosylated poultry derived therapeutic proteins
ES2529234T3 (es) * 2006-08-04 2015-02-18 Prolong Pharmaceuticals, LLC Eritropoyetina modificada
TW201138831A (en) 2009-09-30 2011-11-16 Prolong Pharmaceuticals Inc Modified granulocyte colony stimulating factor (G-CSF)

Also Published As

Publication number Publication date
PL2054074T3 (pl) 2015-03-31
IL196866A (en) 2016-08-31
EP2054074B1 (en) 2014-10-01
EP2054074A4 (en) 2009-12-23
EP2054074B8 (en) 2014-11-12
CA2659990A1 (en) 2008-02-14
JP5723528B2 (ja) 2015-05-27
IL232923A0 (en) 2014-07-31
JP5961730B2 (ja) 2016-08-02
HK1131542A1 (en) 2010-01-29
SI2054074T1 (sl) 2014-12-31
JP2009545608A (ja) 2009-12-24
KR20120105494A (ko) 2012-09-25
WO2008019214A1 (en) 2008-02-14
US20100184655A1 (en) 2010-07-22
IL232923A (en) 2016-08-31
JP5802644B2 (ja) 2015-10-28
ES2529234T3 (es) 2015-02-18
JP2015231996A (ja) 2015-12-24
EP2054074A1 (en) 2009-05-06
KR101304081B1 (ko) 2013-09-05
CN105820231A (zh) 2016-08-03
PT2054074E (pt) 2014-11-07
US8765924B2 (en) 2014-07-01
CN101534847A (zh) 2009-09-16
IL196866A0 (en) 2011-08-01
JP2013079258A (ja) 2013-05-02
CA2659990C (en) 2016-03-22
KR20090046923A (ko) 2009-05-11

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