MXPA05006688A - Conjugados de polimero con una variante de cianovirina. - Google Patents

Conjugados de polimero con una variante de cianovirina.

Info

Publication number
MXPA05006688A
MXPA05006688A MXPA05006688A MXPA05006688A MXPA05006688A MX PA05006688 A MXPA05006688 A MX PA05006688A MX PA05006688 A MXPA05006688 A MX PA05006688A MX PA05006688 A MXPA05006688 A MX PA05006688A MX PA05006688 A MXPA05006688 A MX PA05006688A
Authority
MX
Mexico
Prior art keywords
cyanovirin
polymer conjugates
conjugates
variant
cyanovirin variant
Prior art date
Application number
MXPA05006688A
Other languages
English (en)
Inventor
Michael R Boyd
Original Assignee
Nektar Therapeutics Al Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics Al Corp filed Critical Nektar Therapeutics Al Corp
Publication of MXPA05006688A publication Critical patent/MXPA05006688A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Abstract

La presente invencion proporciona variantes de cianovirina-N y polimeros solubles en agua, en particular conjugados PEGilados de los mismos. La cianovirina-N de la invencion esta particularmente adaptada para fijacion covalente selectiva puntual de uno o mas polimeros solubles en agua, para proporcionar conjugados polimericos de variantes de cianovirina-N que exhiben actividad anti-viral.
MXPA05006688A 2002-12-19 2003-12-18 Conjugados de polimero con una variante de cianovirina. MXPA05006688A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43595002P 2002-12-19 2002-12-19
US46173103P 2003-04-09 2003-04-09
PCT/US2003/040585 WO2004056852A2 (en) 2002-12-19 2003-12-18 Cyanovirin variant-polymer conjugates

Publications (1)

Publication Number Publication Date
MXPA05006688A true MXPA05006688A (es) 2006-02-22

Family

ID=32685420

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006688A MXPA05006688A (es) 2002-12-19 2003-12-18 Conjugados de polimero con una variante de cianovirina.

Country Status (10)

Country Link
US (2) US7267941B2 (es)
EP (1) EP1620129B1 (es)
JP (2) JP2006517400A (es)
KR (1) KR101145990B1 (es)
AT (1) ATE425767T1 (es)
AU (1) AU2003301122B2 (es)
CA (1) CA2507904C (es)
DE (1) DE60326774D1 (es)
MX (1) MXPA05006688A (es)
WO (1) WO2004056852A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE425767T1 (de) * 2002-12-19 2009-04-15 Nektar Therapeutics Al Corp Konjugate von cyanovirin-varianten und einem polyalkylenoxid
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
WO2007037245A1 (ja) * 2005-09-29 2007-04-05 Shionogi & Co., Ltd. 血管新生抑制作用を有するポリペプチド
DK2054074T3 (da) 2006-08-04 2014-11-03 Prolong Pharmaceuticals Llc Modificeret erythropoietin
US20100240578A1 (en) * 2006-08-18 2010-09-23 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Anti-h5n1 influenza activity of the antiviral protein cyanovirin
US8546547B2 (en) 2006-09-15 2013-10-01 Creabilis Therapeutics S.P.A. Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1
CN101143894A (zh) * 2007-06-22 2008-03-19 中国药科大学 高效抑制血管生成多肽及其物理化学修饰方法和应用
KR20100109938A (ko) 2007-12-27 2010-10-11 백스터 인터내셔널 인코포레이티드 생리학적으로 수용가능한 중합체 분자를 특이적으로 검출하기 위한 방법 및 조성물
EP2304033B1 (en) * 2008-06-30 2016-09-07 ESBATech, an Alcon Biomedical Research Unit LLC Functionalized polypeptides
CA2732508C (en) 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
SI2349342T1 (sl) 2008-10-17 2018-10-30 Baxalta GmbH Modificirani krvni faktorji, ki obsegajo nizko stopnjo v vodi topnega polimera
EP2431741B1 (en) 2008-10-21 2013-08-21 Baxter International Inc Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation)
CN102612559B (zh) * 2009-08-28 2015-06-10 一般财团法人化学及血清疗法研究所 源自流感m2的修饰的肽疫苗
CN101638435B (zh) * 2009-09-04 2011-11-16 暨南大学 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
KR102071731B1 (ko) * 2011-12-19 2020-01-30 젠자임 코포레이션 갑상선 자극 호르몬 조성물
WO2019108656A1 (en) 2017-11-28 2019-06-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Microbicidal composition
SG11202005952TA (en) * 2017-12-29 2020-07-29 Hoffmann La Roche Process for providing pegylated protein composition
ES2905105T3 (es) 2017-12-29 2022-04-07 Hoffmann La Roche Procedimiento para proporcionar una composición de proteína PEGilada
US20200323993A1 (en) * 2017-12-29 2020-10-15 Hoffmann-La Roche Inc. Process for providing pegylated protein composition
CN116854785A (zh) * 2023-05-16 2023-10-10 青岛双元泰和药业有限公司 位点特异性修饰和标记的抗病毒肽氰病毒素n

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US6780847B2 (en) 1995-04-27 2004-08-24 The United States Of America As Represented By The Department Of Health And Human Services Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins
JP2005530484A (ja) 2002-02-07 2005-10-13 デルタ バイオテクノロジー リミテッド アルブミン融合抗血管形成ペプチド
ATE425767T1 (de) * 2002-12-19 2009-04-15 Nektar Therapeutics Al Corp Konjugate von cyanovirin-varianten und einem polyalkylenoxid

Also Published As

Publication number Publication date
AU2003301122B2 (en) 2009-11-26
JP2006517400A (ja) 2006-07-27
US20080015151A1 (en) 2008-01-17
US20040258706A1 (en) 2004-12-23
KR101145990B1 (ko) 2012-08-23
WO2004056852A3 (en) 2004-10-07
WO2004056852A2 (en) 2004-07-08
KR20050084433A (ko) 2005-08-26
JP4903891B2 (ja) 2012-03-28
CA2507904C (en) 2014-12-02
US7267941B2 (en) 2007-09-11
EP1620129A2 (en) 2006-02-01
JP2011050382A (ja) 2011-03-17
AU2003301122A1 (en) 2004-07-14
US7547509B2 (en) 2009-06-16
DE60326774D1 (de) 2009-04-30
EP1620129B1 (en) 2009-03-18
CA2507904A1 (en) 2004-07-08
ATE425767T1 (de) 2009-04-15

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