ATE425767T1 - Konjugate von cyanovirin-varianten und einem polyalkylenoxid - Google Patents
Konjugate von cyanovirin-varianten und einem polyalkylenoxidInfo
- Publication number
- ATE425767T1 ATE425767T1 AT03813787T AT03813787T ATE425767T1 AT E425767 T1 ATE425767 T1 AT E425767T1 AT 03813787 T AT03813787 T AT 03813787T AT 03813787 T AT03813787 T AT 03813787T AT E425767 T1 ATE425767 T1 AT E425767T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanovirin
- conjugates
- variants
- polyalkylene oxide
- water
- Prior art date
Links
- 229920000233 poly(alkylene oxides) Polymers 0.000 title 1
- 108060002021 cyanovirin N Proteins 0.000 abstract 3
- 229920003169 water-soluble polymer Polymers 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyethers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43595002P | 2002-12-19 | 2002-12-19 | |
| US46173103P | 2003-04-09 | 2003-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425767T1 true ATE425767T1 (de) | 2009-04-15 |
Family
ID=32685420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03813787T ATE425767T1 (de) | 2002-12-19 | 2003-12-18 | Konjugate von cyanovirin-varianten und einem polyalkylenoxid |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7267941B2 (de) |
| EP (1) | EP1620129B1 (de) |
| JP (2) | JP2006517400A (de) |
| KR (1) | KR101145990B1 (de) |
| AT (1) | ATE425767T1 (de) |
| AU (1) | AU2003301122B2 (de) |
| CA (1) | CA2507904C (de) |
| DE (1) | DE60326774D1 (de) |
| MX (1) | MXPA05006688A (de) |
| WO (1) | WO2004056852A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05006688A (es) * | 2002-12-19 | 2006-02-22 | Nektar Therapeutics Al Corp | Conjugados de polimero con una variante de cianovirina. |
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| WO2007037245A1 (ja) * | 2005-09-29 | 2007-04-05 | Shionogi & Co., Ltd. | 血管新生抑制作用を有するポリペプチド |
| WO2008019214A1 (en) | 2006-08-04 | 2008-02-14 | Prolong Pharmaceuticals, Inc. | Modified erythropoietin |
| EP2051730B1 (de) * | 2006-08-18 | 2011-11-02 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Anti-h5n1-influenza-aktivität des antiviralen proteins cyanovirin |
| MX2009002820A (es) | 2006-09-15 | 2009-06-04 | Creabilis Therapeutics Spa | Conjugados polimericos de box-a de hmgb1 y variantes de box-a de hmgb1. |
| CN101143894A (zh) * | 2007-06-22 | 2008-03-19 | 中国药科大学 | 高效抑制血管生成多肽及其物理化学修饰方法和应用 |
| KR20170072365A (ko) | 2007-12-27 | 2017-06-26 | 백스터 인터내셔널 인코포레이티드 | 생리학적으로 수용가능한 중합체 분자를 특이적으로 검출하기 위한 방법 및 조성물 |
| KR101678925B1 (ko) | 2008-06-30 | 2016-11-24 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 기능화 폴리펩티드 |
| JP5588983B2 (ja) | 2008-08-11 | 2014-09-10 | ウェルズ ファーゴ バンク ナショナル アソシエイション | マルチアームポリマーアルカノエートコンジュゲート |
| KR101929641B1 (ko) | 2008-10-17 | 2018-12-14 | 박스알타 인코퍼레이티드 | 낮은 수준의 수용성 중합체를 포함하는 개질된 혈액 인자 |
| CA2740904C (en) | 2008-10-21 | 2019-01-15 | Baxter International Inc. | Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation) |
| WO2011024748A1 (ja) * | 2009-08-28 | 2011-03-03 | 一般財団法人化学及血清療法研究所 | インフルエンザm2由来の改変ペプチドワクチン |
| CN101638435B (zh) * | 2009-09-04 | 2011-11-16 | 暨南大学 | 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用 |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| CN104220097B (zh) * | 2011-12-19 | 2019-08-09 | 建新公司 | 促甲状腺激素组合物 |
| WO2019108656A1 (en) | 2017-11-28 | 2019-06-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microbicidal composition |
| EP3731872B1 (de) | 2017-12-29 | 2021-11-24 | F. Hoffmann-La Roche AG | Verfahren zur bereitstellung monopegylierten proteinen |
| EP3731873B1 (de) * | 2017-12-29 | 2022-01-26 | F. Hoffmann-La Roche AG | Verfahren zur bereitstellung monopegylierter proteine |
| EP3731871B1 (de) * | 2017-12-29 | 2023-10-04 | F. Hoffmann-La Roche AG | Verfahren zur bereitstellung pegylierter proteinen |
| CN116854785A (zh) * | 2023-05-16 | 2023-10-10 | 青岛双元泰和药业有限公司 | 位点特异性修饰和标记的抗病毒肽氰病毒素n |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US6780847B2 (en) * | 1995-04-27 | 2004-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
| JP2005516607A (ja) | 2002-02-07 | 2005-06-09 | デルタ バイオテクノロジー リミテッド | Ｈｉｖ阻害タンパク質 |
| MXPA05006688A (es) * | 2002-12-19 | 2006-02-22 | Nektar Therapeutics Al Corp | Conjugados de polimero con una variante de cianovirina. |
-
2003
- 2003-12-18 MX MXPA05006688A patent/MXPA05006688A/es active IP Right Grant
- 2003-12-18 WO PCT/US2003/040585 patent/WO2004056852A2/en active Application Filing
- 2003-12-18 AU AU2003301122A patent/AU2003301122B2/en not_active Expired
- 2003-12-18 JP JP2005502650A patent/JP2006517400A/ja active Pending
- 2003-12-18 DE DE60326774T patent/DE60326774D1/de not_active Expired - Lifetime
- 2003-12-18 CA CA2507904A patent/CA2507904C/en not_active Expired - Lifetime
- 2003-12-18 KR KR1020057011500A patent/KR101145990B1/ko active IP Right Grant
- 2003-12-18 US US10/742,465 patent/US7267941B2/en active Active
- 2003-12-18 AT AT03813787T patent/ATE425767T1/de not_active IP Right Cessation
- 2003-12-18 EP EP03813787A patent/EP1620129B1/de not_active Expired - Lifetime
-
2007
- 2007-08-02 US US11/832,925 patent/US7547509B2/en not_active Expired - Lifetime
-
2010
- 2010-09-27 JP JP2010216141A patent/JP4903891B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60326774D1 (de) | 2009-04-30 |
| US20040258706A1 (en) | 2004-12-23 |
| AU2003301122A1 (en) | 2004-07-14 |
| US7547509B2 (en) | 2009-06-16 |
| CA2507904C (en) | 2014-12-02 |
| JP2011050382A (ja) | 2011-03-17 |
| MXPA05006688A (es) | 2006-02-22 |
| KR20050084433A (ko) | 2005-08-26 |
| EP1620129B1 (de) | 2009-03-18 |
| JP2006517400A (ja) | 2006-07-27 |
| JP4903891B2 (ja) | 2012-03-28 |
| US7267941B2 (en) | 2007-09-11 |
| AU2003301122B2 (en) | 2009-11-26 |
| WO2004056852A3 (en) | 2004-10-07 |
| KR101145990B1 (ko) | 2012-08-23 |
| EP1620129A2 (de) | 2006-02-01 |
| US20080015151A1 (en) | 2008-01-17 |
| WO2004056852A2 (en) | 2004-07-08 |
| CA2507904A1 (en) | 2004-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |