ATE422880T1 - Heterofunktionelle copolymere von glycerol und polyethylenglykol, ihre konjugate und zusammensetzungen - Google Patents
Heterofunktionelle copolymere von glycerol und polyethylenglykol, ihre konjugate und zusammensetzungenInfo
- Publication number
- ATE422880T1 ATE422880T1 AT04809612T AT04809612T ATE422880T1 AT E422880 T1 ATE422880 T1 AT E422880T1 AT 04809612 T AT04809612 T AT 04809612T AT 04809612 T AT04809612 T AT 04809612T AT E422880 T1 ATE422880 T1 AT E422880T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- glycerol
- polyethylene glycol
- compositions
- heterofunctional
- Prior art date
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title abstract 6
- 229920001577 copolymer Polymers 0.000 title abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 2
- 239000012867 bioactive agent Substances 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/08—Saturated oxiranes
- C08G65/10—Saturated oxiranes characterised by the catalysts used
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49780203P | 2003-08-26 | 2003-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE422880T1 true ATE422880T1 (de) | 2009-03-15 |
Family
ID=34465064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04809612T ATE422880T1 (de) | 2003-08-26 | 2004-08-25 | Heterofunktionelle copolymere von glycerol und polyethylenglykol, ihre konjugate und zusammensetzungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7196145B2 (de) |
| EP (1) | EP1663171B9 (de) |
| JP (1) | JP2007503514A (de) |
| AT (1) | ATE422880T1 (de) |
| DE (1) | DE602004019546D1 (de) |
| ES (1) | ES2321841T3 (de) |
| WO (1) | WO2005037911A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105152A2 (en) | 2004-05-05 | 2005-11-10 | Atugen Ag | Lipids, lipid complexes and use thereof |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| DK1842557T3 (da) | 2004-12-22 | 2013-12-02 | Nitto Denko Corp | Lægemiddelbærer og lægemiddelbærerkit til inhibition af fibrose |
| CN101287497B (zh) | 2004-12-27 | 2013-03-06 | 赛伦斯治疗公司 | 涂层脂质复合体和它们的用途 |
| EP1878766B1 (de) * | 2005-05-02 | 2020-01-01 | The University of Tokyo | Polymervesikel vom typ elektrostatische bindung |
| WO2006130978A1 (en) | 2005-06-06 | 2006-12-14 | The University Of British Columbia | Polymer-based serum albumin substitute |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| CN101490253A (zh) * | 2006-07-21 | 2009-07-22 | 赛伦斯治疗公司 | 用于抑制蛋白激酶3表达的方法 |
| EP2086591A4 (de) * | 2006-11-14 | 2011-06-22 | Univ Pennsylvania | Effiziente nukleare abgabe von antisense-oligonucleotiden |
| JP5515224B2 (ja) * | 2007-02-28 | 2014-06-11 | 日油株式会社 | 多分岐鎖ポリオキシアルキレン誘導体 |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US8506993B2 (en) * | 2007-08-14 | 2013-08-13 | University Of Houston | Compositions and methods for making and using multifunctional polymerized liposomes |
| EP2207570A2 (de) * | 2007-09-14 | 2010-07-21 | Nitto Denko Corporation | Arzneimittelträger |
| WO2010053597A2 (en) * | 2008-11-06 | 2010-05-14 | University Of Washington/////////////////////-+ | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| EP2398519A2 (de) * | 2009-02-21 | 2011-12-28 | Sofradim Production | Verbindungen und mit solvophoben linkern aktivierte medizinische vorrichtungen |
| JP5502349B2 (ja) * | 2009-03-13 | 2014-05-28 | 出光興産株式会社 | 水系潤滑剤 |
| WO2011043061A1 (ja) * | 2009-10-05 | 2011-04-14 | キヤノン株式会社 | 光音響イメージング用造影剤、及び、それを用いた光音響イメージング方法 |
| US8359883B2 (en) * | 2009-11-13 | 2013-01-29 | Hasmukh Dholakiya | Gemstone setting |
| DE102009059104A1 (de) | 2009-12-18 | 2011-06-22 | Johannes-Gutenberg-Universität Mainz, 55122 | Funktionelle verzweigte Polyether Copolymere sowie Verfahren zu ihrer Herstellung |
| BR112012021991A2 (pt) | 2010-03-01 | 2020-09-01 | The University Of British Columbia | policlicerol hiperramificado uso de um poliglicerol hipermanificado, método de adiministração de uma força biologicamente ativa a um tecido biológico, composição farmacêutica e método de síntese de um poliglicerol hiperrramificado. |
| JP5949037B2 (ja) | 2011-03-30 | 2016-07-06 | 日油株式会社 | 末端に複数の水酸基を有するポリオキシエチレン誘導体 |
| KR101483786B1 (ko) * | 2011-05-27 | 2015-01-21 | 한국과학기술원 | 가지형 폴리에틸렌글리콜을 이용한 초자성나노입자의 용매 치환 방법 및 그 제조물 |
| US9919059B2 (en) * | 2012-12-10 | 2018-03-20 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
| CA2969806A1 (en) * | 2014-12-18 | 2016-06-23 | Universite de Bordeaux | Polymer particles and biomaterials comprising the same |
| US10927250B2 (en) | 2015-01-28 | 2021-02-23 | Administrators Of The Tulane Educational Fund | Nanoparticle polymer grafted dispersants and unimolecular micelles and methods of use |
| KR101607849B1 (ko) | 2015-11-10 | 2016-03-31 | 영남대학교 산학협력단 | 생분해성 고분자 필름 및 그 제조방법 |
| JP7019201B2 (ja) * | 2016-08-02 | 2022-02-15 | キュリアールエックス インコーポレーテッド | リポソームの調製方法 |
| DE102016119102A1 (de) * | 2016-10-07 | 2018-04-12 | Forschungszentrum Jülich GmbH | Translokation von synthetischen Polymeren durch Lipidmembrane |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JP2593032B2 (ja) * | 1992-02-07 | 1997-03-19 | 新技術事業団 | 両末端ヘテロ官能性ポリエーテル並びに該ポリエーテルを製造する方法及び重合開始剤 |
| WO1993017715A1 (en) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| JP3465307B2 (ja) * | 1993-08-05 | 2003-11-10 | 日本油脂株式会社 | ポリアルキレンオキシド誘導体および製造方法 |
| CA2269758C (en) | 1996-10-22 | 2008-01-08 | Hermes Biosciences, Inc. | Liposome compositions comprising ionizable compounds in stable precipitated form and methods for their preparation |
| ZA9811379B (en) * | 1997-12-12 | 1999-08-27 | Macromed Inc | Hetero-functionalized star-shaped poly(ethylene glycols) for protein modification. |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| DE69907243T2 (de) | 1998-09-16 | 2004-02-19 | Alza Corp., Mountain View | In liposomen eingeschlossene topoisomerase inhibitoren |
| CA2355727A1 (en) * | 1998-12-22 | 2000-06-29 | Bayer Aktiengesellschaft | Method for producing highly branched glycidol-based polyols |
| US6765082B2 (en) * | 1998-12-22 | 2004-07-20 | Bayer Aktiengesellschaft | Method for producing highly-branched glycidol-based polyols |
| US7009033B2 (en) | 2001-07-02 | 2006-03-07 | Polymer Source Inc. | Heterofunctional polyethylene glycol and polyethylene oxide, process for their manufacture |
-
2004
- 2004-08-25 AT AT04809612T patent/ATE422880T1/de not_active IP Right Cessation
- 2004-08-25 ES ES04809612T patent/ES2321841T3/es active Active
- 2004-08-25 JP JP2006524807A patent/JP2007503514A/ja active Pending
- 2004-08-25 WO PCT/US2004/027527 patent/WO2005037911A2/en active Application Filing
- 2004-08-25 DE DE602004019546T patent/DE602004019546D1/de active Active
- 2004-08-25 EP EP04809612A patent/EP1663171B9/de active Active
- 2004-08-25 US US10/926,215 patent/US7196145B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1663171B9 (de) | 2009-08-19 |
| EP1663171A2 (de) | 2006-06-07 |
| US20050048650A1 (en) | 2005-03-03 |
| DE602004019546D1 (de) | 2009-04-02 |
| EP1663171A4 (de) | 2006-10-18 |
| US7196145B2 (en) | 2007-03-27 |
| EP1663171B1 (de) | 2009-02-18 |
| WO2005037911A3 (en) | 2006-03-30 |
| JP2007503514A (ja) | 2007-02-22 |
| ES2321841T3 (es) | 2009-06-12 |
| WO2005037911A2 (en) | 2005-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |