HK1131542A1 - Modified erythropoietin - Google Patents

Modified erythropoietin

Info

Publication number
HK1131542A1
HK1131542A1 HK09109876.1A HK09109876A HK1131542A1 HK 1131542 A1 HK1131542 A1 HK 1131542A1 HK 09109876 A HK09109876 A HK 09109876A HK 1131542 A1 HK1131542 A1 HK 1131542A1
Authority
HK
Hong Kong
Prior art keywords
modified erythropoietin
erythropoietin
modified
Prior art date
Application number
HK09109876.1A
Other languages
English (en)
Chinese (zh)
Inventor
Abraham Abuchowski
Lihysyng Stanford Lee
Original Assignee
Prolong Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolong Pharmaceuticals Llc filed Critical Prolong Pharmaceuticals Llc
Publication of HK1131542A1 publication Critical patent/HK1131542A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
HK09109876.1A 2006-08-04 2009-10-26 Modified erythropoietin HK1131542A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83542906P 2006-08-04 2006-08-04
PCT/US2007/073629 WO2008019214A1 (en) 2006-08-04 2007-07-16 Modified erythropoietin

Publications (1)

Publication Number Publication Date
HK1131542A1 true HK1131542A1 (en) 2010-01-29

Family

ID=39033318

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09109876.1A HK1131542A1 (en) 2006-08-04 2009-10-26 Modified erythropoietin

Country Status (14)

Country Link
US (1) US8765924B2 (xx)
EP (1) EP2054074B8 (xx)
JP (3) JP5723528B2 (xx)
KR (2) KR20090046923A (xx)
CN (2) CN101534847A (xx)
CA (1) CA2659990C (xx)
DK (1) DK2054074T3 (xx)
ES (1) ES2529234T3 (xx)
HK (1) HK1131542A1 (xx)
IL (2) IL196866A (xx)
PL (1) PL2054074T3 (xx)
PT (1) PT2054074E (xx)
SI (1) SI2054074T1 (xx)
WO (1) WO2008019214A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765924B2 (en) * 2006-08-04 2014-07-01 Prolong Pharmaceuticals, Inc. Modified erythropoietin
WO2010150282A1 (en) * 2009-06-22 2010-12-29 Ipca Laboriatories Limited Novel polynucleotide molecules for enhanced gene expression
BR112012008341A2 (pt) * 2009-09-15 2020-08-25 Kaneka Corporation eritropoietina modificada à qual molécula de cadeia longa solúvel em água é adicionada
CN103044539B (zh) * 2010-04-09 2014-10-22 苏州元基生物技术有限公司 重组促红细胞生成素及制备方法
SG10201600912SA (en) * 2011-03-04 2016-03-30 Intrexon Corp Vectors conditionally expressing protein
CU20140003A7 (es) * 2014-01-08 2015-08-27 Ct De Inmunología Molecular Biofarmacuba Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
KR102268647B1 (ko) * 2017-06-12 2021-06-23 한국코러스 주식회사 안정성이 향상된 에리스로포이에틴 조성물 및 이의 제조방법

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US4677195A (en) 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
EP0248656B1 (en) 1986-06-04 1993-03-31 Director-General of the Agency of Industrial Science and Technology Composition for cell cultivation and use thereof
DE3787805T2 (de) 1986-08-04 1994-02-10 Univ New South Wales Kensingto Serumfreies gewebekulturmedium, das ein polymerzellenschutzmittel enthält.
US4954437A (en) 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
DE68917642T2 (de) 1988-05-25 1995-02-09 Teijin Ltd Verfahren zur kontinuierlichen Züchtung von haftenden tierischen Zellen.
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1991006666A1 (en) 1989-11-06 1991-05-16 Cell Genesys, Inc. Production of proteins using homologous recombination
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
DE4115722A1 (de) 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
AU7097094A (en) 1993-06-01 1994-12-20 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
WO1996006815A1 (en) 1994-08-31 1996-03-07 Prodevco (N.Z.) Limited Improvements in or relating to a composter
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
IL118201A (en) 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
DE19535571A1 (de) 1995-09-14 1997-03-20 Boehringer Mannheim Gmbh Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US7074397B1 (en) 1996-01-08 2006-07-11 Genentech, Inc. Method for enhancing proliferation or differentiation of a cell using ob protein
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
US6077939A (en) 1996-08-02 2000-06-20 Ortho-Mcneil Pharmaceutical, Inc. Methods and kits for making polypeptides having a single covalently bound N-terminal water-soluble polymer
EP0885613A1 (de) 1997-06-21 1998-12-23 Roche Diagnostics GmbH Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin
DE19734293A1 (de) 1997-08-08 1999-02-11 Boehringer Mannheim Gmbh Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
PE20010288A1 (es) 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
CN1309416C (zh) 2000-05-15 2007-04-11 霍夫曼-拉罗奇有限公司 新的药物组合物
DE60137525D1 (de) 2000-10-16 2009-03-12 Chugai Pharmaceutical Co Ltd Peg-modifiziertes erythropoietin
WO2002049673A2 (en) 2000-12-20 2002-06-27 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
BR0116381A (pt) 2000-12-20 2004-02-25 Hoffmann La Roche Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
WO2003055526A2 (en) 2001-12-21 2003-07-10 Maxygen Aps Erythropoietin conjugates
ATE391742T1 (de) 2002-02-15 2008-04-15 Nektar Therapeutics Al Corp Hydrolytisch abbaubare polyalkylenoxid-polymere
US7605231B2 (en) * 2002-04-26 2009-10-20 Yasuhiko Tabata Gelatin derivatives and high-molecular micelle comprising the derivatives
AU2003246486A1 (en) 2002-07-19 2004-02-09 Cangene Corporation Pegylated erythropoietic compounds
CA2507904C (en) 2002-12-19 2014-12-02 M. Elizabeth Snell Cyanovirin variant-polymer conjugates
US7208145B2 (en) 2002-12-31 2007-04-24 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
BRPI0409322B8 (pt) * 2003-04-11 2021-05-25 Antriabio Inc método para preparar um conjugado de insulina-polímero
CA2510040C (en) 2003-05-23 2012-01-03 Nektar Therapeutics Al, Corporation Polymeric reagents and polymer-biomolecule conjugates comprising carbamate linkages
US6995245B2 (en) * 2003-05-30 2006-02-07 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
EP1656410B1 (en) 2003-07-22 2010-03-10 Nektar Therapeutics Method for preparing functionalized polymers from polymer alcohols
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
CA2558583C (en) 2004-03-15 2013-07-09 Nektar Therapeutics Al, Corporation Polymer-based compositions and conjugates of hiv entry inhibitors
EP1765411B2 (en) 2004-06-30 2017-10-11 Nektar Therapeutics Polymer-factor ix moiety conjugates
JP2008506704A (ja) 2004-07-16 2008-03-06 ネクター セラピューティクス アラバマ，コーポレイション Ｇｍ−ｃｓｆ成分およびポリマーの複合体
US7714114B2 (en) * 2005-02-16 2010-05-11 Nektar Therapeutics Conjugates of an EPO moiety and a polymer
US8273339B2 (en) 2005-04-12 2012-09-25 Nektar Therapeutics Polymer-based compositions and conjugates of antimicrobial agents
MX2008001706A (es) 2005-08-04 2008-04-07 Nektar Therapeutics Al Corp Conjugados de una porcion g-csf y un polimero.
CA2622210A1 (en) * 2005-10-21 2007-04-26 Avigenics, Inc. Glycolated and glycosylated poultry derived therapeutic proteins
US8765924B2 (en) * 2006-08-04 2014-07-01 Prolong Pharmaceuticals, Inc. Modified erythropoietin
WO2011041376A1 (en) 2009-09-30 2011-04-07 Prolong Pharmaceuticals Modified granulocyte colony stimulating factor (g-csf)

Also Published As

Publication number Publication date
JP5961730B2 (ja) 2016-08-02
EP2054074A4 (en) 2009-12-23
EP2054074B1 (en) 2014-10-01
US20100184655A1 (en) 2010-07-22
KR101304081B1 (ko) 2013-09-05
JP2015231996A (ja) 2015-12-24
CA2659990A1 (en) 2008-02-14
CN101534847A (zh) 2009-09-16
IL196866A0 (en) 2011-08-01
WO2008019214A1 (en) 2008-02-14
IL196866A (en) 2016-08-31
EP2054074A1 (en) 2009-05-06
US8765924B2 (en) 2014-07-01
IL232923A0 (en) 2014-07-31
ES2529234T3 (es) 2015-02-18
EP2054074B8 (en) 2014-11-12
JP5802644B2 (ja) 2015-10-28
JP2013079258A (ja) 2013-05-02
IL232923A (en) 2016-08-31
DK2054074T3 (da) 2014-11-03
JP2009545608A (ja) 2009-12-24
JP5723528B2 (ja) 2015-05-27
PL2054074T3 (pl) 2015-03-31
CN105820231A (zh) 2016-08-03
CA2659990C (en) 2016-03-22
PT2054074E (pt) 2014-11-07
SI2054074T1 (sl) 2014-12-31
KR20120105494A (ko) 2012-09-25
KR20090046923A (ko) 2009-05-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200718