IL127916A0 - Erythromycins and process for their preparation - Google Patents

Erythromycins and process for their preparation

Info

Publication number
IL127916A0
IL127916A0 IL12791697A IL12791697A IL127916A0 IL 127916 A0 IL127916 A0 IL 127916A0 IL 12791697 A IL12791697 A IL 12791697A IL 12791697 A IL12791697 A IL 12791697A IL 127916 A0 IL127916 A0 IL 127916A0
Authority
IL
Israel
Prior art keywords
erythromycins
preparation
Prior art date
Application number
IL12791697A
Other languages
English (en)
Original Assignee
Biotica Technology Ltd And Pfi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Technology Ltd And Pfi filed Critical Biotica Technology Ltd And Pfi
Publication of IL127916A0 publication Critical patent/IL127916A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL12791697A 1996-07-05 1997-07-04 Erythromycins and process for their preparation IL127916A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en) 1996-07-05 1997-07-04 Erythromycins and process for their preparation

Publications (1)

Publication Number Publication Date
IL127916A0 true IL127916A0 (en) 1999-11-30

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12791697A IL127916A0 (en) 1996-07-05 1997-07-04 Erythromycins and process for their preparation

Country Status (28)

Country Link
EP (3) EP2182067A3 (ru)
JP (2) JP2000511063A (ru)
KR (1) KR20000023579A (ru)
CN (1) CN1179046C (ru)
AP (1) AP1029A (ru)
AT (2) ATE451455T1 (ru)
AU (2) AU731301B2 (ru)
BG (1) BG103133A (ru)
BR (1) BR9710209A (ru)
CA (2) CA2259420C (ru)
DE (2) DE69739688D1 (ru)
DK (2) DK0910633T3 (ru)
EA (1) EA001744B1 (ru)
EE (1) EE03976B1 (ru)
ES (2) ES2244001T3 (ru)
GB (1) GB2331518B (ru)
GE (1) GEP20012348B (ru)
IL (1) IL127916A0 (ru)
IS (1) IS4940A (ru)
NO (1) NO990012L (ru)
NZ (1) NZ333861A (ru)
OA (1) OA10952A (ru)
PL (1) PL331285A1 (ru)
PT (1) PT909327E (ru)
SI (1) SI0910633T1 (ru)
SK (1) SK182498A3 (ru)
TR (1) TR199900006T2 (ru)
WO (2) WO1998001571A2 (ru)

Families Citing this family (76)

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US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
JP3633629B2 (ja) 1995-07-06 2005-03-30 ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドの無細胞合成
EP0870053A4 (en) 1995-12-19 2002-09-11 Univ Minnesota METABOLIC PROCESS FOR THE MANUFACTURE OF POLYHYDROXYALCANOATE MONOMER SYNTHASES
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6117659A (en) 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
AU732909B2 (en) 1997-04-30 2001-05-03 Board Of Trustees Of The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6262340B1 (en) 1997-07-10 2001-07-17 Kosan Biosciences, Inc. Production of polyketides in plants
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US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
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JP4043191B2 (ja) 1998-11-03 2008-02-06 ファイザー・プロダクツ・インク 新規なマクロライド抗生物質
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
ID30233A (id) 1999-01-27 2001-11-15 Pfizer Prod Inc Antibiotika ketolida
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
EP1153124A2 (en) * 1999-02-09 2001-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
MXPA01010521A (es) 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
AU775637B2 (en) 1999-04-16 2004-08-12 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
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GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
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AU2001248588B2 (en) 2000-04-13 2006-02-02 Biotica Technology Limited Hybrid glycosylated products and their production and use
EP1492404B1 (en) 2002-02-19 2011-12-28 Dow AgroSciences LLC Novel spinosyn-producing polyketide synthases
ES2544624T3 (es) 2002-07-16 2015-09-02 Buck Institute For Research On Aging Producción de policétidos
DK200201957A (da) 2002-12-20 2003-01-20 Alpharma Aps 10-substituted erythromycin ketolides and methods of making
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EP2535042A1 (en) 2003-06-16 2012-12-19 ANDRX Pharmaceuticals LLC. Oral sustained-release composition comprising a macrolide
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
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GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
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WO2013172782A1 (en) * 2012-05-16 2013-11-21 Nanyang Technological University A polyketide synthase construct and its use in the preparation of polyketides
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
EP4085933A3 (en) 2016-04-12 2023-01-11 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
US11781128B2 (en) 2016-07-29 2023-10-10 Isomerase Therapeutics Limited Methods for producing hybrid polyketide synthase genes and polyketides
US20190264184A1 (en) * 2016-10-28 2019-08-29 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
AU2017350900A1 (en) 2016-10-28 2019-06-13 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
JP7100653B2 (ja) 2017-02-22 2022-07-13 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） 新規な免疫刺激マクロライド
US11059845B2 (en) 2017-02-22 2021-07-13 ISR Immune System Regulation Holding AB (publ) Immune stimulating macrolides
CA3094747A1 (en) 2018-03-23 2019-09-26 ISR Immune System Regulation Holding AB (publ) Combinations of macrolide compounds and immune checkpoint inhibitors
CN116947884A (zh) 2019-01-22 2023-10-27 艾奥维安制药公司 Mtorc调节剂及其用途
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
KR20220109407A (ko) 2019-11-04 2022-08-04 레볼루션 메디슨즈, 인크. Ras 억제제
WO2021091967A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) * 2023-11-24 2024-02-09 中国医学科学院医药生物技术研究所 一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
ATE206164T1 (de) * 1993-09-20 2001-10-15 Univ Leland Stanford Junior Rekombinante herstellung von neuen polyketiden

Also Published As

Publication number Publication date
WO1998001546A2 (en) 1998-01-15
AU3450997A (en) 1998-02-02
WO1998001571A2 (en) 1998-01-15
GB9900156D0 (en) 1999-02-24
DE69733416D1 (de) 2005-07-07
ES2337424T3 (es) 2010-04-23
PT909327E (pt) 2005-10-31
EE9900014A (et) 1999-08-16
ATE451455T1 (de) 2009-12-15
EP0910633B1 (en) 2009-12-09
EA199900087A1 (ru) 1999-08-26
AP1029A (en) 2001-12-11
JP2000516450A (ja) 2000-12-12
JP2000511063A (ja) 2000-08-29
BR9710209A (pt) 2000-01-11
EA001744B1 (ru) 2001-08-27
NO990012D0 (no) 1999-01-04
BG103133A (en) 2000-04-28
EP2182067A2 (en) 2010-05-05
OA10952A (en) 2002-02-25
TR199900006T2 (xx) 1999-04-21
CA2259420C (en) 2007-09-18
GEP20012348B (en) 2001-01-25
CN1179046C (zh) 2004-12-08
DK0910633T3 (da) 2010-03-29
CA2259420A1 (en) 1998-01-15
DK0909327T3 (da) 2005-09-26
ES2244001T3 (es) 2005-12-01
GB2331518B (en) 2001-03-14
ATE296893T1 (de) 2005-06-15
GB2331518A (en) 1999-05-26
JP4173551B2 (ja) 2008-10-29
AP9901444A0 (en) 1999-03-31
NZ333861A (en) 2000-08-25
AU731654B2 (en) 2001-04-05
EP0909327A2 (en) 1999-04-21
IS4940A (is) 1999-01-04
EE03976B1 (et) 2003-02-17
KR20000023579A (ko) 2000-04-25
AU731301B2 (en) 2001-03-29
CA2259463A1 (en) 1998-01-15
WO1998001546A3 (en) 1998-04-09
EP0909327B1 (en) 2005-06-01
EP2182067A3 (en) 2010-07-14
SI0910633T1 (sl) 2010-04-30
DE69739688D1 (de) 2010-01-21
PL331285A1 (en) 1999-07-05
SK182498A3 (en) 2000-05-16
WO1998001571A3 (en) 1998-02-19
DE69733416T2 (de) 2006-04-27
CN1229438A (zh) 1999-09-22
AU3451497A (en) 1998-02-02
EP0910633A2 (en) 1999-04-28
NO990012L (no) 1999-02-23

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