IL126638A0 - Substituted isoquinoline-3-carboxamides their preparation and their use as pharmaceuticals - Google Patents

Substituted isoquinoline-3-carboxamides their preparation and their use as pharmaceuticals

Info

Publication number
IL126638A0
IL126638A0 IL12663898A IL12663898A IL126638A0 IL 126638 A0 IL126638 A0 IL 126638A0 IL 12663898 A IL12663898 A IL 12663898A IL 12663898 A IL12663898 A IL 12663898A IL 126638 A0 IL126638 A0 IL 126638A0
Authority
IL
Israel
Prior art keywords
carboxamides
pharmaceuticals
preparation
substituted isoquinoline
isoquinoline
Prior art date
Application number
IL12663898A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussel De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh
Publication of IL126638A0 publication Critical patent/IL126638A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL12663898A 1997-10-20 1998-10-18 Substituted isoquinoline-3-carboxamides their preparation and their use as pharmaceuticals IL126638A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19746287A DE19746287A1 (de) 1997-10-20 1997-10-20 Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
IL126638A0 true IL126638A0 (en) 1999-08-17

Family

ID=7846053

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12663898A IL126638A0 (en) 1997-10-20 1998-10-18 Substituted isoquinoline-3-carboxamides their preparation and their use as pharmaceuticals

Country Status (25)

Country Link
US (1) US6093730A (fr)
EP (2) EP0911340B1 (fr)
JP (2) JP3782591B2 (fr)
KR (1) KR100618922B1 (fr)
CN (1) CN1117079C (fr)
AR (1) AR013696A1 (fr)
AT (2) ATE432940T1 (fr)
AU (1) AU755714B2 (fr)
BR (1) BR9804504B1 (fr)
CA (2) CA2250664A1 (fr)
CZ (1) CZ337298A3 (fr)
DE (3) DE19746287A1 (fr)
DK (2) DK1538160T3 (fr)
ES (2) ES2328156T3 (fr)
HK (1) HK1019605A1 (fr)
HU (1) HUP9802422A3 (fr)
ID (1) ID21115A (fr)
IL (1) IL126638A0 (fr)
NO (1) NO312365B1 (fr)
NZ (1) NZ332363A (fr)
PL (1) PL192354B1 (fr)
PT (1) PT911340E (fr)
SG (1) SG87776A1 (fr)
TR (1) TR199802106A2 (fr)
ZA (1) ZA989505B (fr)

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US8318703B2 (en) 2001-12-06 2012-11-27 Fibrogen, Inc. Methods for improving kidney function
EP2295060B1 (fr) 2001-12-06 2018-10-31 Fibrogen, Inc. Traitement de conditions ischémiques ou hypoxiques
ES2414706T3 (es) * 2001-12-06 2013-07-22 Fibrogen, Inc. Métodos para aumentar la eritropoyetina endógena
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
US20060251638A1 (en) * 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
SI1644336T1 (sl) 2003-06-06 2011-06-30 Fibrogen Inc Heteroarilne spojine, ki vsebujejo duĺ ik in njihova uporaba pri zviĺ anju endogenega eritropoetina
WO2006133391A2 (fr) * 2005-06-06 2006-12-14 Fibrogen, Inc. Methode amelioree de traitement de l'anemie
WO2006138511A2 (fr) 2005-06-15 2006-12-28 Fibrogen, Inc. Composes et procedes pour le traitement du cancer
ES2446416T3 (es) * 2005-12-09 2014-03-07 Amgen, Inc. Compuestos basados en quinolona que presentan actividad inhibidora de prolil hidroxilasa, composiciones y usos de los mismos
US7928120B2 (en) 2006-01-27 2011-04-19 Fibrogen, Inc. Cyanoisoquinoline compounds and methods of use thereof
WO2007101204A1 (fr) * 2006-02-27 2007-09-07 Alcon Research, Ltd. Méthode de traitement du glaucome
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
KR100934674B1 (ko) * 2006-03-30 2009-12-31 엘지전자 주식회사 비디오 신호를 디코딩/인코딩하기 위한 방법 및 장치
CN101460497A (zh) 2006-04-04 2009-06-17 菲布罗根有限公司 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物
EP3026044B8 (fr) 2006-06-26 2018-12-19 Akebia Therapeutics, Inc. Inhibiteurs de prolyl hydroxylase et procédés d'utilisation
AU2007334323B2 (en) 2006-12-18 2011-03-10 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
EP2097416B1 (fr) 2006-12-18 2012-09-12 Amgen, Inc Composés d'azaquinolone possédant une activité inhibitrice de prolyl hydroxylase, compositions et utilisations correspondantes
WO2008130600A2 (fr) 2007-04-18 2008-10-30 Amgen Inc. Quinolones et azaquinolones inhibant la prolyl hydroxylase
AU2008241577B2 (en) 2007-04-18 2011-04-07 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
WO2008137060A1 (fr) 2007-05-04 2008-11-13 Amgen Inc. Dérivés de la thienopyridine et de la thiazolopyridine qui inhibent l'activité prolyle hydroxylase
EP2155746A2 (fr) 2007-05-04 2010-02-24 Amgen, Inc Diazaquinolones inhibant l'activité de la prolyl hydroxylase
WO2009002533A1 (fr) * 2007-06-27 2008-12-31 The Brigham And Women's Hospital, Inc. Thérapies d'affection abdominale inflammatoire
CN101497584B (zh) * 2008-01-29 2010-12-22 首都医科大学 异喹啉-3-甲酰氨基酸苄酯及其制备和应用
RU2531354C2 (ru) 2008-04-28 2014-10-20 Янссен Фармацевтика Нв Бензоимидазолы как ингибиторы пролилгидроксилазы
EP2370422B1 (fr) 2008-11-14 2019-06-05 Fibrogen, Inc. Dérivés de thiochromène utiles en tant qu'inhibiteurs de l'hydroxylase hif
TWI485150B (zh) * 2009-07-17 2015-05-21 Japan Tobacco Inc 三唑并吡啶化合物及其作為脯胺醯基羥化酶抑制劑或紅血球生成素生產誘導劑之作用
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BR112014009910B1 (pt) 2011-10-25 2020-06-30 Janssen Pharmaceutica N.V. sal di-hidrato de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico, composição farmacêuticae pomada tópica
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AR108325A1 (es) * 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
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CN116120340B (zh) * 2021-11-15 2023-10-31 艾立康药业股份有限公司 一种吡啶并噁嗪类化合物及其制备方法、组合物和用途

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CA2085954A1 (fr) * 1991-12-24 1993-06-25 Klaus Weidmann Pyridine-n-oxydes substitues, procedes pour leur obtention, et leur emploi
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DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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Also Published As

Publication number Publication date
ATE432940T1 (de) 2009-06-15
KR100618922B1 (ko) 2007-04-25
AU8941398A (en) 1999-05-06
CA2251647A1 (fr) 1999-04-20
KR19990037182A (ko) 1999-05-25
EP0911340B1 (fr) 2005-07-06
JPH11302257A (ja) 1999-11-02
HK1019605A1 (en) 2000-02-18
ES2328156T3 (es) 2009-11-10
TR199802106A3 (tr) 1999-05-21
HU9802422D0 (en) 1998-12-28
PL329274A1 (en) 1999-04-26
NO984877L (no) 1999-04-21
NZ332363A (en) 2000-04-28
BR9804504A (pt) 2001-05-22
AU755714B2 (en) 2002-12-19
JP3782591B2 (ja) 2006-06-07
TR199802106A2 (xx) 1999-05-21
HUP9802422A2 (hu) 1999-08-30
CA2250664A1 (fr) 1999-04-20
DE59814365D1 (de) 2009-07-16
DK1538160T3 (da) 2009-10-05
SG87776A1 (en) 2002-04-16
ID21115A (id) 1999-04-22
JP2006056894A (ja) 2006-03-02
DK0911340T3 (da) 2005-11-07
JP4691419B2 (ja) 2011-06-01
DE59812907D1 (de) 2005-08-11
NO984877D0 (no) 1998-10-19
EP1538160A1 (fr) 2005-06-08
EP0911340A3 (fr) 1999-07-07
PT911340E (pt) 2005-09-30
AR013696A1 (es) 2001-01-10
EP0911340A2 (fr) 1999-04-28
NO312365B1 (no) 2002-04-29
HUP9802422A3 (en) 2002-02-28
ZA989505B (en) 1999-04-20
CN1117079C (zh) 2003-08-06
ATE299148T1 (de) 2005-07-15
CA2251647C (fr) 2011-08-30
CZ337298A3 (cs) 1999-05-12
ES2245471T3 (es) 2006-01-01
EP1538160B1 (fr) 2009-06-03
PL192354B1 (pl) 2006-10-31
US6093730A (en) 2000-07-25
BR9804504B1 (pt) 2009-01-13
CN1218802A (zh) 1999-06-09
DE19746287A1 (de) 1999-04-22

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