IL124551A - Pharmaceutical depot formulations comprising aqueous suspensions of 9-hydroxy risperidone fatty acid esters - Google Patents

Pharmaceutical depot formulations comprising aqueous suspensions of 9-hydroxy risperidone fatty acid esters

Info

Publication number
IL124551A
IL124551A IL12455197A IL12455197A IL124551A IL 124551 A IL124551 A IL 124551A IL 12455197 A IL12455197 A IL 12455197A IL 12455197 A IL12455197 A IL 12455197A IL 124551 A IL124551 A IL 124551A
Authority
IL
Israel
Prior art keywords
fatty acid
acid esters
aqueous suspensions
depot formulations
pharmaceutical depot
Prior art date
Application number
IL12455197A
Other languages
English (en)
Other versions
IL124551A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL124551(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL124551A0 publication Critical patent/IL124551A0/xx
Publication of IL124551A publication Critical patent/IL124551A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL12455197A 1996-05-20 1997-05-12 Pharmaceutical depot formulations comprising aqueous suspensions of 9-hydroxy risperidone fatty acid esters IL124551A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201429 1996-05-20
PCT/EP1997/002504 WO1997044039A1 (en) 1996-05-20 1997-05-12 Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters

Publications (2)

Publication Number Publication Date
IL124551A0 IL124551A0 (en) 1998-12-06
IL124551A true IL124551A (en) 2001-08-26

Family

ID=8224016

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12455197A IL124551A (en) 1996-05-20 1997-05-12 Pharmaceutical depot formulations comprising aqueous suspensions of 9-hydroxy risperidone fatty acid esters

Country Status (37)

Country Link
US (1) US6077843A (cs)
EP (1) EP0904081B1 (cs)
JP (1) JP3274687B2 (cs)
KR (1) KR100358373B1 (cs)
CN (1) CN1093762C (cs)
AR (1) AR007194A1 (cs)
AT (1) ATE208619T1 (cs)
AU (1) AU715572B2 (cs)
BG (1) BG62684B1 (cs)
BR (1) BR9706824B8 (cs)
CA (1) CA2236691C (cs)
CY (2) CY2270B1 (cs)
CZ (1) CZ291284B6 (cs)
DE (2) DE69708284T2 (cs)
DK (1) DK0904081T3 (cs)
EA (1) EA000536B1 (cs)
EE (1) EE03594B1 (cs)
ES (1) ES2167745T3 (cs)
FR (1) FR11C0035I2 (cs)
HR (1) HRP970276B1 (cs)
HU (2) HU224025B1 (cs)
ID (1) ID16927A (cs)
IL (1) IL124551A (cs)
LU (1) LU91842I2 (cs)
MX (1) MX9804816A (cs)
MY (1) MY126302A (cs)
NO (2) NO315931B1 (cs)
NZ (1) NZ330369A (cs)
PL (1) PL188309B1 (cs)
PT (1) PT904081E (cs)
SI (1) SI0904081T1 (cs)
SK (1) SK284013B6 (cs)
TR (1) TR199800923T2 (cs)
TW (1) TW487572B (cs)
UA (1) UA61898C2 (cs)
WO (1) WO1997044039A1 (cs)
ZA (1) ZA974331B (cs)

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US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
HRP20030154B1 (en) * 2000-08-14 2009-03-31 Teva Pharmaceutical Industries Ltd. Preparation of risperidone
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP4500679B2 (ja) * 2002-07-29 2010-07-14 アルザ・コーポレーシヨン パリペリドンを制御送達する方法および投薬形態物
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
DK1675573T4 (da) 2003-10-23 2012-08-06 Otsuka Pharma Co Ltd Steril, injicerbr aripiprazol-formulering med kontrolleret frigivelse samt fremgangsmåde
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
KR101242486B1 (ko) * 2004-01-12 2013-03-13 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 장기 전달을 위한 제형 및 그의 이용 방법
ES2245252B1 (es) * 2004-06-15 2007-03-01 Farmalider, S.A. Solucion acuosa de risperidona para administracion oral.
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US20080214808A1 (en) 2005-04-25 2008-09-04 Thomas Frederik Ernestine Spittaels Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester
PL116330U1 (en) 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
AU2007284759B2 (en) 2006-08-09 2010-10-28 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
EP2154138B1 (en) * 2007-04-19 2015-08-19 Youxin Li Novel compounds for treatment of psychotic disorders, preparation methods and uses thereof
NZ580447A (en) 2007-04-23 2011-06-30 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and uses thereof
US20090076035A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched paliperidone
PT2234617T (pt) * 2007-12-19 2021-05-18 Janssen Pharmaceutica Nv Regime de dosagem associado a ésteres de paliperidona injetáveis de longa ação
US20090209757A1 (en) * 2008-01-10 2009-08-20 Santiago Ini Processes for the preparation and purification of paliperidone palmitate
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
NZ604997A (en) 2008-09-04 2014-07-25 Astrazeneca Pharmaceuticals Lp Sustained release formulations using non-aqueous carriers
NZ624569A (en) 2009-09-28 2016-01-29 Intarcia Therapeutics Inc Rapid establishment and/or termination of substantial steady-state drug delivery
CA2742393A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv Dosing regimen associated with long-acting injectable paliperidone esters
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
TWI577377B (zh) 2010-09-16 2017-04-11 Ｖｉｉｖ醫療保健公司 醫藥組合物
KR101936968B1 (ko) 2010-10-18 2019-01-09 다이닛본 스미토모 세이야꾸 가부시끼가이샤 주사용 서방형 제제
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CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
KR20250013293A (ko) 2015-04-07 2025-01-31 잔센파마슈티카엔.브이. 장기간 작용형 주사용 팔리페리돈 에스테르에 대한 누락된 용량에 대한 투여 계획
MX2017015504A (es) 2015-06-03 2018-05-15 Intarcia Therapeutics Inc Sistemas de colocacion y remoción de implante.
MA53353A (fr) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP7286542B2 (ja) 2017-01-03 2023-06-05 インターシア セラピューティクス，インコーポレイティド Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
PT4025187T (pt) 2020-11-30 2024-02-28 Janssen Pharmaceutica Nv Regimes de administração associados a formulações injetáveis de paliperidona de libertação prolongada
PL4005555T3 (pl) 2020-11-30 2024-09-02 Janssen Pharmaceutica Nv Sposoby zapewniania ponownego zawieszenia preparatów palmitynianu paliperydonu
MX2023006366A (es) 2020-11-30 2023-08-07 Janssen Pharmaceutica Nv Regimenes de dosificacion asociados con formulaciones inyectables de paliperidona de liberacion prolongada.
TW202222317A (zh) 2020-11-30 2022-06-16 比利時商健生藥品公司 與延釋帕利哌酮可注射配製物相關之投藥方案（一）
HUP2100259A1 (hu) 2021-07-07 2023-01-28 Richter Gedeon Nyrt Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
KR20240049580A (ko) 2021-08-20 2024-04-16 얀센 파마슈티카 엔브이 서방형 팔리페리돈 주사용 제형과 관련된 투약 요법

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US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
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Also Published As

Publication number Publication date
CN1206347A (zh) 1999-01-27
MY126302A (en) 2006-09-29
KR19990067603A (ko) 1999-08-25
PL327995A1 (en) 1999-01-04
SK284013B6 (sk) 2004-08-03
BR9706824A (pt) 1999-03-23
CY2011011I1 (el) 2016-12-14
TW487572B (en) 2002-05-21
US6077843A (en) 2000-06-20
WO1997044039A1 (en) 1997-11-27
CN1093762C (zh) 2002-11-06
EA199800531A1 (ru) 1998-12-24
IL124551A0 (en) 1998-12-06
PL188309B1 (pl) 2005-01-31
AU715572B2 (en) 2000-02-03
FR11C0035I1 (cs) 2011-07-10
EP0904081A1 (en) 1999-03-31
ZA974331B (en) 1998-11-19
UA61898C2 (en) 2003-12-15
AR007194A1 (es) 1999-10-13
BG62684B1 (bg) 2000-05-31
EE03594B1 (et) 2002-02-15
CZ140198A3 (cs) 1999-04-14
AU2955997A (en) 1997-12-09
SI0904081T1 (en) 2002-04-30
EP0904081B1 (en) 2001-11-14
SK62098A3 (en) 2000-04-10
CY2270B1 (en) 2003-07-04
NO315931B1 (no) 2003-11-17
FR11C0035I2 (fr) 2013-08-16
DE69708284D1 (de) 2001-12-20
HK1017852A1 (en) 1999-12-03
HRP970276A2 (en) 1998-04-30
EE9800136A (et) 1998-10-15
JP3274687B2 (ja) 2002-04-15
NO981984D0 (no) 1998-04-30
LU91842I2 (fr) 2011-09-20
DE122011100027I1 (de) 2011-11-17
CZ291284B6 (cs) 2003-01-15
BG102443A (en) 1999-06-30
MX9804816A (es) 1998-10-31
NZ330369A (en) 2000-04-28
NO2011015I2 (no) 2013-03-11
HUS1100013I1 (hu) 2017-03-28
NO981984L (no) 1998-11-19
ID16927A (id) 1997-11-20
CA2236691C (en) 2007-01-02
ATE208619T1 (de) 2001-11-15
HRP970276B1 (en) 2002-04-30
JP2000513718A (ja) 2000-10-17
NO2011015I1 (no) 2011-09-19
BR9706824B8 (pt) 2015-02-18
ES2167745T3 (es) 2002-05-16
HUP9901319A3 (en) 1999-11-29
EA000536B1 (ru) 1999-10-28
CY2011011I2 (el) 2016-12-14
DK0904081T3 (da) 2002-02-25
PT904081E (pt) 2002-04-29
DE69708284T2 (de) 2002-07-25
HU224025B1 (hu) 2005-05-30
KR100358373B1 (ko) 2003-02-11
TR199800923T2 (xx) 1999-09-21
CA2236691A1 (en) 1997-11-27
HUP9901319A2 (hu) 1999-08-30

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