IL123910A - Anhydrate of 7-[7-(s)-amino-5-azaspiro [2.4] heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2s)-2-fluoro-cyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - Google Patents
Anhydrate of 7-[7-(s)-amino-5-azaspiro [2.4] heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2s)-2-fluoro-cyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acidInfo
- Publication number
- IL123910A IL123910A IL12391094A IL12391094A IL123910A IL 123910 A IL123910 A IL 123910A IL 12391094 A IL12391094 A IL 12391094A IL 12391094 A IL12391094 A IL 12391094A IL 123910 A IL123910 A IL 123910A
- Authority
- IL
- Israel
- Prior art keywords
- fluoro
- anhydrate
- azaspiro
- dihydroquinoline
- heptan
- Prior art date
Links
- PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 title 1
- 239000003125 aqueous solvent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- UTOSCAGAYZRDNY-YNEHKIRRSA-N 2-[(7s)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@H]1N)N(C=2N(C3=C(Cl)C=C(F)C=C3C(=O)C=2C(O)=O)[C@H]2[C@H](C2)F)CC11CC1 UTOSCAGAYZRDNY-YNEHKIRRSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22538093 | 1993-09-10 | ||
| IL11090994A IL110909A (en) | 1993-09-10 | 1994-09-09 | Preparation of the 3/2 hydrate of 7-Ú7-(s)- amino-5-azasprio Ú2,4¾ heptan-5-yl¾-8-chloro-6-fluoro-1-Ú1r,2s)-2- fluorocyclopropyl¾-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL123910A true IL123910A (en) | 1999-06-20 |
Family
ID=16828452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12391094A IL123910A (en) | 1993-09-10 | 1994-09-09 | Anhydrate of 7-[7-(s)-amino-5-azaspiro [2.4] heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2s)-2-fluoro-cyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| IL11090994A IL110909A (en) | 1993-09-10 | 1994-09-09 | Preparation of the 3/2 hydrate of 7-Ú7-(s)- amino-5-azasprio Ú2,4¾ heptan-5-yl¾-8-chloro-6-fluoro-1-Ú1r,2s)-2- fluorocyclopropyl¾-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11090994A IL110909A (en) | 1993-09-10 | 1994-09-09 | Preparation of the 3/2 hydrate of 7-Ú7-(s)- amino-5-azasprio Ú2,4¾ heptan-5-yl¾-8-chloro-6-fluoro-1-Ú1r,2s)-2- fluorocyclopropyl¾-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5693814A (cs) |
| EP (1) | EP0643058B1 (cs) |
| JP (1) | JP3793583B2 (cs) |
| KR (1) | KR100336247B1 (cs) |
| CN (1) | CN1057297C (cs) |
| AT (1) | ATE181069T1 (cs) |
| AU (1) | AU679094B2 (cs) |
| BG (1) | BG61767B1 (cs) |
| CA (1) | CA2131761C (cs) |
| CZ (3) | CZ284738B6 (cs) |
| DE (1) | DE69418953T2 (cs) |
| DK (1) | DK0643058T3 (cs) |
| ES (1) | ES2136142T3 (cs) |
| FI (1) | FI110777B (cs) |
| GE (1) | GEP19981355B (cs) |
| GR (1) | GR3031012T3 (cs) |
| HR (1) | HRP940506B1 (cs) |
| HU (1) | HU224970B1 (cs) |
| IL (2) | IL123910A (cs) |
| LV (1) | LV11322B (cs) |
| MY (1) | MY112574A (cs) |
| NO (2) | NO307419B1 (cs) |
| NZ (1) | NZ264422A (cs) |
| PL (1) | PL180163B1 (cs) |
| RU (1) | RU2126402C1 (cs) |
| SG (1) | SG50492A1 (cs) |
| SI (1) | SI9400349B (cs) |
| SK (3) | SK283190B6 (cs) |
| TW (1) | TW393481B (cs) |
| UA (1) | UA41312C2 (cs) |
| YU (1) | YU49132B (cs) |
| ZA (1) | ZA946853B (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546249A1 (de) * | 1995-12-12 | 1997-06-19 | Bayer Ag | Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| WO1999000393A1 (en) * | 1997-06-26 | 1999-01-07 | Dong Wha Pharmaceutical Industrial Co., Ltd. | Quinolone carboxylic acid derivatives |
| JP2001300293A (ja) * | 2000-04-25 | 2001-10-30 | Nipro Corp | 無機無水物または有機無水物の製造法 |
| ITMI20032259A1 (it) | 2003-11-20 | 2005-05-21 | Chemi Spa | Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione |
| CN102718746B (zh) * | 2012-06-18 | 2014-10-29 | 南京优科生物医药研究有限公司 | 西他沙星富马酸盐晶型a和其制药用途 |
| CN103539776B (zh) * | 2012-07-16 | 2016-06-08 | 深圳信立泰药业股份有限公司 | 一种西他沙星晶型及其制备方法 |
| CN106749174B (zh) * | 2016-12-06 | 2019-06-18 | 山东裕欣药业有限公司 | 一种西他沙星二水合物晶型、制备方法及其组合物片剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE203719C (cs) * | 1907-11-02 | 1908-10-20 | ||
| NO166131C (no) * | 1985-06-20 | 1991-06-05 | Daiichi Seiyaku Co | Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser. |
| MY105136A (en) * | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| CA1332605C (en) * | 1988-10-03 | 1994-10-18 | Yasuhiro Nishitani | Pyridonecarboxylic acids |
| TW208013B (cs) * | 1990-03-01 | 1993-06-21 | Daiichi Co Ltd | |
| US4994809A (en) * | 1990-03-07 | 1991-02-19 | Hughes Aircraft Company | Polystatic correlating radar |
| MY109714A (en) * | 1990-10-18 | 1997-04-30 | Daiichi Seiyaku Co | Process for preparing 8-chloroquinolone derivatives |
| CN1065206A (zh) * | 1991-04-01 | 1992-10-14 | 战永胜 | 天然中草药防治早泄、淋病双效药液制法 |
| WO1993025545A1 (en) * | 1992-06-09 | 1993-12-23 | Korea Research Institute Of Chemical Technology | Novel quinoline derivatives and processes for preparing the same |
-
1994
- 1994-09-06 ZA ZA946853A patent/ZA946853B/xx unknown
- 1994-09-08 NZ NZ264422A patent/NZ264422A/en not_active IP Right Cessation
- 1994-09-08 SK SK306-2002A patent/SK283190B6/sk unknown
- 1994-09-08 SK SK1076-94A patent/SK283188B6/sk unknown
- 1994-09-08 HR HR940506A patent/HRP940506B1/xx not_active IP Right Cessation
- 1994-09-08 NO NO943313A patent/NO307419B1/no unknown
- 1994-09-08 CZ CZ98215A patent/CZ284738B6/cs not_active IP Right Cessation
- 1994-09-08 SK SK305-2002A patent/SK283189B6/sk unknown
- 1994-09-08 UA UA94095787A patent/UA41312C2/uk unknown
- 1994-09-08 CZ CZ942176A patent/CZ284837B6/cs not_active IP Right Cessation
- 1994-09-08 CZ CZ98214A patent/CZ284737B6/cs not_active IP Right Cessation
- 1994-09-09 HU HU9402597A patent/HU224970B1/hu unknown
- 1994-09-09 DE DE69418953T patent/DE69418953T2/de not_active Expired - Fee Related
- 1994-09-09 LV LVP-94-173A patent/LV11322B/en unknown
- 1994-09-09 DK DK94114235T patent/DK0643058T3/da active
- 1994-09-09 IL IL12391094A patent/IL123910A/xx not_active IP Right Cessation
- 1994-09-09 YU YU53694A patent/YU49132B/sh unknown
- 1994-09-09 KR KR1019940022682A patent/KR100336247B1/ko not_active Expired - Fee Related
- 1994-09-09 AT AT94114235T patent/ATE181069T1/de not_active IP Right Cessation
- 1994-09-09 AU AU72862/94A patent/AU679094B2/en not_active Ceased
- 1994-09-09 ES ES94114235T patent/ES2136142T3/es not_active Expired - Lifetime
- 1994-09-09 BG BG99035A patent/BG61767B1/bg unknown
- 1994-09-09 CA CA002131761A patent/CA2131761C/en not_active Expired - Fee Related
- 1994-09-09 EP EP94114235A patent/EP0643058B1/en not_active Expired - Lifetime
- 1994-09-09 GE GEAP19942175A patent/GEP19981355B/en unknown
- 1994-09-09 FI FI944174A patent/FI110777B/fi not_active IP Right Cessation
- 1994-09-09 SG SG1996002767A patent/SG50492A1/en unknown
- 1994-09-09 JP JP21539594A patent/JP3793583B2/ja not_active Expired - Lifetime
- 1994-09-09 PL PL94304989A patent/PL180163B1/pl not_active IP Right Cessation
- 1994-09-09 RU RU94032286A patent/RU2126402C1/ru not_active IP Right Cessation
- 1994-09-09 TW TW083108331A patent/TW393481B/zh not_active IP Right Cessation
- 1994-09-09 MY MYPI94002376A patent/MY112574A/en unknown
- 1994-09-09 SI SI9400349A patent/SI9400349B/sl not_active IP Right Cessation
- 1994-09-09 IL IL11090994A patent/IL110909A/en not_active IP Right Cessation
- 1994-09-10 CN CN94116197A patent/CN1057297C/zh not_active Expired - Fee Related
- 1994-09-12 US US08/303,812 patent/US5693814A/en not_active Expired - Fee Related
-
1999
- 1999-05-25 NO NO992513A patent/NO307753B1/no unknown
- 1999-08-18 GR GR990402090T patent/GR3031012T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU9301361D0 (en) | Method for producing 4-aryl-piperazines and 4-aryl-piperidines | |
| EP0422485A3 (en) | Quinolone carboxylic acid derivatives, process for their preparation and their use | |
| HUT72347A (en) | Method for recovering carboxylic acids from aqueous solutions | |
| IL123910A (en) | Anhydrate of 7-[7-(s)-amino-5-azaspiro [2.4] heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2s)-2-fluoro-cyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | |
| PL264565A1 (en) | Method of obtaining 6,7-substituted 1-cyclopropylo-1,4-dihydro-4-oxo-1,8-naphtirydino-3-carboxylic acids | |
| HUT75640A (en) | Novel quinolone carboxylic acid derivatives | |
| EP0502384A3 (en) | Process for the recovery of adipic acid | |
| IL129231A0 (en) | Process for preparing 2-azadihydroxybicyclo (2.2.1) heptane compounds and the l-tartaric acid salts of the compound | |
| AU4272793A (en) | Novel quinolone carboxylic acid derivatives and process for preparing the same | |
| EP0247591A3 (en) | Method for treating air-cooling system's aqueous medium | |
| HUT43571A (en) | Process for preparing quinolone carboxylic acid derivatives | |
| EP0820998A3 (en) | Novel coumarin quinolone carboxylic acids and processes for the preparation thereof | |
| GR3023711T3 (en) | Method of preparation of 3-beta-aminocholanic acid derivatives. | |
| GB9018360D0 (en) | Process for the preparation of quinoline carboxylic acid derivatives | |
| PL310621A1 (en) | Method of obtaining condensed carbapeneme derivatives | |
| PL293808A1 (en) | Method of obtaining 4.4'-dinitrostilbene disulfonic-2,2' acid and/or its salts | |
| HUP9900937A3 (en) | Novel 1(2h) quinoline carboxylic acid derivatives, method for preparing same, and use thereof for synthesising substances having antibiotic properties | |
| CS233189A1 (en) | Method of unsweetened condensed milk stabilization | |
| BG52045B2 (en) | Method for the production of 1-ethyl-6-fluor-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinol ine-3-carboxylic acid methanesulphonatehydrate | |
| HU9201613D0 (en) | Method for s-methyl-sulfonium chloride derivatives of alpha-amino-omega-(alkyl-mercapto)-carboxylic acids | |
| ES8604566A1 (es) | Procedimiento para la obtencion del acido 1-etil-6-fluor- 1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilico | |
| CS660489A1 (en) | Method of organic nitro-compounds' carbonylation reduction | |
| IL106471A0 (en) | Recovery of carboxylic acid from organic solution that contains an amine and an extraction enhancer | |
| IL106701A0 (en) | Recovery of carboxylic acid from organic solution that contains an amine and an extraction enhancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |