IL123898A - The history of compressed tropane, their preparation and the pharmaceutical preparations containing them - Google Patents

The history of compressed tropane, their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL123898A
IL123898A IL12389896A IL12389896A IL123898A IL 123898 A IL123898 A IL 123898A IL 12389896 A IL12389896 A IL 12389896A IL 12389896 A IL12389896 A IL 12389896A IL 123898 A IL123898 A IL 123898A
Authority
IL
Israel
Prior art keywords
azatricyclo
dichlorophenyl
decan
oxime
alkyl
Prior art date
Application number
IL12389896A
Other languages
English (en)
Hebrew (he)
Other versions
IL123898A0 (en
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of IL123898A0 publication Critical patent/IL123898A0/xx
Publication of IL123898A publication Critical patent/IL123898A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Exhaust Gas After Treatment (AREA)
IL12389896A 1995-11-02 1996-11-04 The history of compressed tropane, their preparation and the pharmaceutical preparations containing them IL123898A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK122395 1995-11-02
DK14696 1996-02-13
PCT/EP1996/004793 WO1997016451A1 (fr) 1995-11-02 1996-11-04 Derives tropane condenses en tant qu'inhibiteurs de recaptage des neurotransmetteurs

Publications (2)

Publication Number Publication Date
IL123898A0 IL123898A0 (en) 1998-10-30
IL123898A true IL123898A (en) 2001-08-08

Family

ID=26063395

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12389896A IL123898A (en) 1995-11-02 1996-11-04 The history of compressed tropane, their preparation and the pharmaceutical preparations containing them

Country Status (25)

Country Link
US (1) US5998405A (fr)
EP (1) EP0858461B1 (fr)
JP (1) JP3157839B2 (fr)
KR (1) KR100277482B1 (fr)
CN (1) CN1060775C (fr)
AT (1) ATE224392T1 (fr)
AU (1) AU702720B2 (fr)
BR (1) BR9611300A (fr)
CA (1) CA2236707C (fr)
CZ (1) CZ285571B6 (fr)
DE (1) DE69623799T2 (fr)
DK (1) DK0858461T3 (fr)
EE (1) EE03566B1 (fr)
HK (1) HK1016984A1 (fr)
HU (1) HUP9802534A3 (fr)
IL (1) IL123898A (fr)
IS (1) IS4708A (fr)
NO (1) NO309569B1 (fr)
NZ (1) NZ321970A (fr)
PL (1) PL184843B1 (fr)
RU (1) RU2162469C2 (fr)
SK (1) SK282944B6 (fr)
TR (1) TR199800780T2 (fr)
UA (1) UA47442C2 (fr)
WO (1) WO1997016451A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US6706880B2 (en) 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US6150376A (en) * 1998-08-05 2000-11-21 Georgetown University Bi- and tri-cyclic aza compounds and their uses
JP2002523416A (ja) * 1998-08-18 2002-07-30 ユセベ，ソシエテ アノニム ムスカリン性アゴニストとアンタゴニスト
WO2001023385A2 (fr) * 1999-09-27 2001-04-05 Georgetown University Nouveaux analogues de tropane
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
WO2002002559A1 (fr) * 2000-07-04 2002-01-10 Neurosearch A/S Isomeres steriques de derives de tropane condenses et leur utilisation comme inhibiteurs du recaptage du recepteur des neurotransmetteurs de la monoamine
US7160899B2 (en) 2001-04-09 2007-01-09 Neurosearch A/S Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
WO2002094827A1 (fr) * 2001-05-23 2002-11-28 Neurosearch A/S Derives de tropane condenses et utilisation de ceux-ci comme inhibiteurs de recaptage de neurotransmetteur monoamine
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
AU2002365288A1 (en) * 2001-11-30 2003-06-10 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
AU2004212165B2 (en) 2003-02-12 2010-02-18 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
DK1594868T3 (da) 2003-02-12 2010-03-15 Neurosearch As 8-aza-bicyclo[3.2.1]octanderivater og anvendelse deraf som monoamin-neurotransmitter-genoptagelsesinhibitorer
US20090137625A1 (en) 2005-04-08 2009-05-28 Dan Peters Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
JP2008546826A (ja) * 2005-06-28 2008-12-25 ノイロサーチ アクティーゼルスカブ 新規な３，９−ジアザ−スピロ［５．５］ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
US8093388B2 (en) 2005-06-28 2012-01-10 Neurosearch A/S 3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
EP2430020B1 (fr) 2009-05-15 2013-10-09 Aniona ApS Dérivés de chromén-2-one et leur utilisation comme inhibiteurs de re-captage de neurotransmetteurs monoamines
US8846661B2 (en) * 2009-06-19 2014-09-30 Abbvie Inc. Diazahomoadamantane derivatives and methods of use thereof
US20120220604A1 (en) 2009-09-21 2012-08-30 Neurosearch A/S Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (fr) 2010-03-25 2011-09-29 Neurosearch A/S Dérivés de chromén-2-one et leur utilisation à titre d'inhibiteurs de recaptage des neurotransmetteurs monoaminés
WO2012000881A1 (fr) 2010-07-02 2012-01-05 Neurosearch A/S Dérivés de chromén-2-one et leur utilisation comme inhibiteurs de la résorption de neurotransmetteurs monoamine
JP6052524B1 (ja) * 2015-07-30 2016-12-27 秋夫 湯田 持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
TW202409027A (zh) 2022-07-08 2024-03-01 丹麥商創始人製藥股份有限公司 用於女性性功能障礙的治療之化合物
WO2024089247A1 (fr) 2022-10-28 2024-05-02 Initiator Pharma A/S Composé pour le traitement de la douleur

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
EP0756596B1 (fr) * 1994-04-19 2002-08-21 Neurosearch A/S Derives de tropane-2-aldoxime en tant qu'inhibiteurs de recaptage des neurotransmetteurs

Also Published As

Publication number Publication date
EP0858461B1 (fr) 2002-09-18
DK0858461T3 (da) 2003-01-27
CZ113898A3 (cs) 1998-07-15
NO981609D0 (no) 1998-04-07
HUP9802534A2 (hu) 1999-04-28
DE69623799D1 (de) 2002-10-24
MX9803554A (es) 1998-09-30
SK282944B6 (sk) 2003-01-09
IS4708A (is) 1998-03-31
ATE224392T1 (de) 2002-10-15
EP0858461A1 (fr) 1998-08-19
EE9800100A (et) 1998-10-15
US5998405A (en) 1999-12-07
UA47442C2 (uk) 2002-07-15
EE03566B1 (et) 2001-12-17
RU2162469C2 (ru) 2001-01-27
BR9611300A (pt) 1999-06-15
NZ321970A (en) 2000-02-28
DE69623799T2 (de) 2003-01-30
TR199800780T2 (xx) 1998-07-21
HK1016984A1 (en) 1999-11-12
CN1060775C (zh) 2001-01-17
KR100277482B1 (ko) 2001-01-15
CA2236707A1 (fr) 1997-05-09
KR19990064111A (ko) 1999-07-26
NO309569B1 (no) 2001-02-19
HUP9802534A3 (en) 1999-06-28
CN1201461A (zh) 1998-12-09
IL123898A0 (en) 1998-10-30
SK42298A3 (en) 1998-10-07
PL326448A1 (en) 1998-09-28
JP3157839B2 (ja) 2001-04-16
WO1997016451A1 (fr) 1997-05-09
JPH11514638A (ja) 1999-12-14
PL184843B1 (pl) 2002-12-31
AU7563196A (en) 1997-05-22
NO981609L (no) 1998-06-26
CZ285571B6 (cs) 1999-09-15
AU702720B2 (en) 1999-03-04
CA2236707C (fr) 2002-08-06

Similar Documents

Publication Publication Date Title
CA2236707C (fr) Derives tropane condenses en tant qu'inhibiteurs de recaptage des neurotransmetteurs
US6395748B2 (en) Tropane-derivatives, their preparation and use
CA2233541C (fr) Derives de 8-azabicyclo(3.2.1)oct-2-ene, leur preparation et leur utilisation
JP2009518357A (ja) 新規なジアザ二環式アリール誘導体及びそれらの医学的使用
EP0981515B1 (fr) Derives de la piperidine utilises comme inhibiteurs du recaptage des neurotransmetteurs
JP2005536522A (ja) ジアザビシクロノナン及び−デカン誘導体並びにこれをオピオイドレセプターリガンドとして使用する方法
MXPA98003554A (en) Frozen tropan derivatives, its preparation and

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees