IL122818A0 - Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof - Google Patents

Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof

Info

Publication number
IL122818A0
IL122818A0 IL12281897A IL12281897A IL122818A0 IL 122818 A0 IL122818 A0 IL 122818A0 IL 12281897 A IL12281897 A IL 12281897A IL 12281897 A IL12281897 A IL 12281897A IL 122818 A0 IL122818 A0 IL 122818A0
Authority
IL
Israel
Prior art keywords
soluble receptor
ligand protein
protein analogs
chimeric interleukin
interleukin
Prior art date
Application number
IL12281897A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26323470&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL122818(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL12128497A external-priority patent/IL121284A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12281897A priority Critical patent/IL122818A0/xx
Priority to PCT/IL1998/000321 priority patent/WO1999002552A2/en
Priority to EEP200000012A priority patent/EE05519B1/xx
Priority to HU0002426A priority patent/HU225855B1/hu
Priority to EP98931006A priority patent/EP0991661B1/en
Priority to DE69836217T priority patent/DE69836217T2/de
Priority to SK6-2000A priority patent/SK287039B6/sk
Priority to KR10-2000-7000080A priority patent/KR100505172B1/ko
Priority to CZ20000075A priority patent/CZ302488B6/cs
Priority to ES98931006T priority patent/ES2271999T3/es
Priority to JP2000502071A priority patent/JP4402288B2/ja
Priority to PL338002A priority patent/PL199212B1/pl
Priority to PT98931006T priority patent/PT991661E/pt
Priority to CA002295936A priority patent/CA2295936C/en
Priority to AT98931006T priority patent/ATE342915T1/de
Priority to EA200000109A priority patent/EA004793B1/ru
Priority to US09/462,416 priority patent/US7198781B1/en
Priority to SI9830861T priority patent/SI0991661T1/sl
Priority to IL13397298A priority patent/IL133972A0/xx
Priority to BRPI9812096-4A priority patent/BR9812096B1/pt
Priority to NZ502139A priority patent/NZ502139A/en
Priority to DK98931006T priority patent/DK0991661T3/da
Priority to AU81271/98A priority patent/AU758161B2/en
Priority to CNB988089416A priority patent/CN1185348C/zh
Priority to ARP980103377A priority patent/AR013201A1/es
Publication of IL122818A0 publication Critical patent/IL122818A0/xx
Priority to NO20000086A priority patent/NO327397B1/no
Priority to IL133972A priority patent/IL133972A/en
Priority to BG104070A priority patent/BG64680B1/bg
Priority to HK01102418A priority patent/HK1031895A1/xx
Priority to CY20061101873T priority patent/CY1105895T1/el
Priority to US11/688,640 priority patent/US7374912B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL12281897A 1997-07-10 1997-12-30 Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof IL122818A0 (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
IL12281897A IL122818A0 (en) 1997-07-10 1997-12-30 Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
AU81271/98A AU758161B2 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
CNB988089416A CN1185348C (zh) 1997-07-10 1998-07-09 嵌合白细胞介素－6可溶性受体/配体蛋白质及其应用
CA002295936A CA2295936C (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
US09/462,416 US7198781B1 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand proteins
HU0002426A HU225855B1 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
EP98931006A EP0991661B1 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
DE69836217T DE69836217T2 (de) 1997-07-10 1998-07-09 Chimäres lösliches interleukin-6 rezeptor/ligand protein, analoge und verwendungen
SK6-2000A SK287039B6 (sk) 1997-07-10 1998-07-09 Chimerický glykozylovaný proteín - sIL-6R/IL-6 a jeho analógy, DNA sekvencia, transformované cicavčie bunky obsahujúce DNA vektor, spôsob výroby chimerického proteínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
KR10-2000-7000080A KR100505172B1 (ko) 1997-07-10 1998-07-09 키메라 인터루킨-6 용해성 수용체/리간드 단백질, 이의유사체 및 용도
CZ20000075A CZ302488B6 (cs) 1997-07-10 1998-07-09 Chimérový glykosylovaný rozpustný protein (sIL-6R/IL-6)
ES98931006T ES2271999T3 (es) 1997-07-10 1998-07-09 Proteina quimerica de receptor soluble de interleucina-6/ligando, sus analogos y sus usos.
JP2000502071A JP4402288B2 (ja) 1997-07-10 1998-07-09 キメラのインターロイキン−６可溶性受容体／リガンドタンパク質、その類似体およびその使用
PL338002A PL199212B1 (pl) 1997-07-10 1998-07-09 Chimerowe glikozylowane białko rozpuszczalny receptor interleukiny-6 - interleukina-6 i jego biologicznie aktywne analogi, ich zastosowanie i sposób wytwarzania, kodująca je sekwencja DNA, wektor DNA, transformowane komórki oraz kompozycja farmaceutyczna
PT98931006T PT991661E (pt) 1997-07-10 1998-07-09 Proteina quimerica do reflector soluvel da interleucina 6/ligando, seus analogos e suas utilizações
PCT/IL1998/000321 WO1999002552A2 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
AT98931006T ATE342915T1 (de) 1997-07-10 1998-07-09 Chimäres lösliches interleukin-6 rezeptor/ligand protein, analoge und verwendungen
EA200000109A EA004793B1 (ru) 1997-07-10 1998-07-09 Химерный белок растворимого рецептора интерлейкина-6/лиганда, его аналоги и способы применения
EEP200000012A EE05519B1 (et) 1997-07-10 1998-07-09 im„„rne glkosleeritud lahustuva interleukiin 6retseptori/interleukiin 6 valk ja selle bioloogiliselt aktiivsed analoogid nende valmistamismeetodja kasutamine DNA j„rjestus DNA vektor transformeeritud imetajarakud ja farmatseutiline komposits
SI9830861T SI0991661T1 (sl) 1997-07-10 1998-07-09 Himericen interlevkin-6 topen receptor/ligand protein, njegovi analogi in njegove uporabe
IL13397298A IL133972A0 (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
BRPI9812096-4A BR9812096B1 (pt) 1997-07-10 1998-07-09 proteìna interleucina-6 (il-6) receptor de interleucina-6 (sil-6r) solúvel glicosilada quimérica (sil-6r/il-6) e seus análogos biologicamente ativos, seu processo para preparação e uso, bem como seqüência de dna, vetor de dna e composição farmacêutica.
NZ502139A NZ502139A (en) 1997-07-10 1998-07-09 Chimeric interleukin-6 soluble receptor/interleukin-6 fusion protein (sIL-6R/IL-6) to treat malignant melanoma cells
DK98931006T DK0991661T3 (da) 1997-07-10 1998-07-09 Kimært interleukin-6-oplösning receptor/ligand-protein, analoger dertil og anvendelser deraf
ARP980103377A AR013201A1 (es) 1997-07-10 1998-07-10 Proteina interleuquina-6 receptor interleuquina-6 quimerica soluble, analogos de la misma, una secuencia de adn, un vector de adn, celulas de mamifero transformadas incapaz de generar un animal, un metodo para producir una proteina quimerica, la utilizacion de dicha proteina para la preparacion de u
NO20000086A NO327397B1 (no) 1997-07-10 2000-01-07 Kimaert sIL-6R/IL-6-protein, DNA, vektor, celle, fremgangsmate for fremstilling samt ulike anvendelser av nevnte protein
IL133972A IL133972A (en) 1997-07-10 2000-01-10 A fusion protein between the soluble receptor and il-6 and the ligand, its analogs and their uses
BG104070A BG64680B1 (bg) 1997-07-10 2000-01-10 Химерен протеин на интерлевкин-6 разтворим рецептор/ лиганд, негови аналози и тяхното използване
HK01102418A HK1031895A1 (en) 1997-07-10 2001-04-04 Chimeric interleukin-6 soluble receptor/ligand protein and uses thereof.
CY20061101873T CY1105895T1 (el) 1997-07-10 2006-12-29 Χιμαιρικη πρωτεϊνη διαλυτου υποδοχεα/συνδετη ιντepλευκινης-6, αναλογα και αυτης και χρησεις αυτης
US11/688,640 US7374912B2 (en) 1997-07-10 2007-03-20 Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12128497A IL121284A0 (en) 1997-07-10 1997-07-10 Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
IL12281897A IL122818A0 (en) 1997-07-10 1997-12-30 Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof

Publications (1)

Publication Number Publication Date
IL122818A0 true IL122818A0 (en) 1998-08-16

Family

ID=26323470

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12281897A IL122818A0 (en) 1997-07-10 1997-12-30 Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
IL133972A IL133972A (en) 1997-07-10 2000-01-10 A fusion protein between the soluble receptor and il-6 and the ligand, its analogs and their uses

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL133972A IL133972A (en) 1997-07-10 2000-01-10 A fusion protein between the soluble receptor and il-6 and the ligand, its analogs and their uses

Country Status (27)

Country Link
US (2) US7198781B1 (pt)
EP (1) EP0991661B1 (pt)
JP (1) JP4402288B2 (pt)
KR (1) KR100505172B1 (pt)
CN (1) CN1185348C (pt)
AR (1) AR013201A1 (pt)
AT (1) ATE342915T1 (pt)
AU (1) AU758161B2 (pt)
BG (1) BG64680B1 (pt)
BR (1) BR9812096B1 (pt)
CA (1) CA2295936C (pt)
CY (1) CY1105895T1 (pt)
CZ (1) CZ302488B6 (pt)
DE (1) DE69836217T2 (pt)
DK (1) DK0991661T3 (pt)
EA (1) EA004793B1 (pt)
EE (1) EE05519B1 (pt)
ES (1) ES2271999T3 (pt)
HK (1) HK1031895A1 (pt)
HU (1) HU225855B1 (pt)
IL (2) IL122818A0 (pt)
NO (1) NO327397B1 (pt)
NZ (1) NZ502139A (pt)
PL (1) PL199212B1 (pt)
PT (1) PT991661E (pt)
SK (1) SK287039B6 (pt)
WO (1) WO1999002552A2 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
US5919763A (en) * 1998-06-01 1999-07-06 Hadasit Medical Research Services And Development Company Ltd. IL-6/SIL-6R complex for promotion of liver functions
WO2000001731A1 (fr) * 1998-07-06 2000-01-13 Tosoh Corporation Proteine fusionnee avec liaison directe du recepteur il-6 a il-6
US20040170604A1 (en) 1998-07-06 2004-09-02 Tosoh Corporation IL-6 receptor IL-6 direct fusion protein
UA84387C2 (ru) * 1999-03-09 2008-10-27 Займодженетикс, Инк. Человеческий цитокин как лиганд зальфа рецептора и его применение
IL130586A0 (en) 1999-06-21 2000-06-01 Yeda Res & Dev IL6RIL6 chimera for the treatment of demyelinating diseases
EP1290170A2 (en) * 2000-06-16 2003-03-12 Asterion Limited Binding agents: chimeric ligand/receptor proteins
DK1317273T3 (da) * 2000-09-14 2006-09-04 Ares Trading Sa Anvendelse af IL-6R/IL-6-kimærer mod Huntingtons sygdom
DE10106827A1 (de) * 2001-02-14 2002-09-05 Stefan Rose-John Verwendung eines Konjugats aus Interleukin-6(IL-6) und seinem Rezeptor zur Induktion der zellulären Expression des Stammzellfaktors (SCF) und von Flat-3-Ligand (Flt-3L)
DE10107737A1 (de) * 2001-02-16 2002-09-05 S Rose John Christian Albrecht Verwendung eines Konjugats aus IL-6 und einem IL-6 Rezeptor zur Tumortherapie
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
GB0119015D0 (en) * 2001-08-03 2001-09-26 Univ Cardiff A fusion protein
GB2389115B (en) * 2001-12-14 2005-03-16 Asterion Ltd Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone
IL147412A0 (en) 2001-12-31 2002-08-14 Yeda Res & Dev The use of il6r/il6 chimera in nerve cell regeneration
AU2003223089A1 (en) * 2002-04-29 2003-11-17 Hadasit Medical Research Services And Development Company Ltd. Compositions and methods for treating cancer with an oncolytic viral agent
WO2004069173A2 (en) 2003-01-31 2004-08-19 The Trustees Of The University Of Pennsylvania Methods for modulating an inflammatory response
FR2850621B1 (fr) * 2003-02-04 2006-12-08 Journee Paul Connecteur reliant un bras d'essuie-glace a un balai d'essuyage, qui comporte deux languettes pour le verrouillage transversal de bras d'essuie-glace
DE10321317A1 (de) * 2003-05-13 2004-12-23 Christian-Albrechts-Universität Zu Kiel Verfahren zum Nachweis des funktionellen IL-6/ sIL-6-Rezeptor-Komplexes und Test-Kit zur Durchführung dieses Verfahrens
IL157309A0 (en) * 2003-08-07 2004-02-19 Applied Research Systems Method for the purification of a non-immunoglobulin protein
IL159558A0 (en) 2003-12-24 2004-06-01 Applied Research Systems Use of il-6 in liver injury
IL161672A0 (en) 2004-04-29 2004-09-27 Yeda Res & Dev Compositions and methods for therapy of chemotherapy-induced neuropathy
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
EP3354723B1 (en) 2005-08-29 2023-12-13 Technion Research & Development Foundation Ltd. Media for culturing stem cells
AU2012261726B2 (en) * 2005-08-29 2015-03-12 Technion Research & Development Foundation Ltd. Media for Culturing Stem Cells
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
WO2008011081A2 (en) 2006-07-19 2008-01-24 The Trustees Of The University Of Pennsylvania Wsx-1/p28 as a target for anti-inflammatory responses
EP2733203B1 (en) 2006-08-02 2018-10-10 Technion Research & Development Foundation Ltd. Methods of expanding embryonic stem cells in a suspension culture
US20090098529A1 (en) * 2006-10-16 2009-04-16 Nanhai Chen Methods for attenuating virus strains for diagnostic and therapeutic uses
JP5213075B2 (ja) 2007-06-15 2013-06-19 ジェネラックス・コーポレイション 腫瘍の画像化および／または処置のための微生物
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CN101827857A (zh) * 2007-08-03 2010-09-08 埃斯特瑞恩有限公司 粒细胞集落刺激因子
EP2310508A1 (en) * 2008-07-02 2011-04-20 Emergent Product Development Seattle, LLC Tgf-b antagonist multi-target binding proteins
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