IL117798A - Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them - Google Patents

Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Info

Publication number
IL117798A
IL117798A IL11779896A IL11779896A IL117798A IL 117798 A IL117798 A IL 117798A IL 11779896 A IL11779896 A IL 11779896A IL 11779896 A IL11779896 A IL 11779896A IL 117798 A IL117798 A IL 117798A
Authority
IL
Israel
Prior art keywords
alkyl
formula
group
substituted
compound
Prior art date
Application number
IL11779896A
Other languages
English (en)
Hebrew (he)
Other versions
IL117798A0 (en
Original Assignee
Schering Plough Corp
Kenilworth And Pharmacopeia In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Corp, Kenilworth And Pharmacopeia In filed Critical Schering Plough Corp
Publication of IL117798A0 publication Critical patent/IL117798A0/xx
Publication of IL117798A publication Critical patent/IL117798A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11779896A 1995-04-07 1996-04-02 Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them IL117798A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41832395A 1995-04-07 1995-04-07

Publications (2)

Publication Number Publication Date
IL117798A0 IL117798A0 (en) 1996-08-04
IL117798A true IL117798A (en) 2001-11-25

Family

ID=23657636

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11779896A IL117798A (en) 1995-04-07 1996-04-02 Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Country Status (20)

Country Link
EP (1) EP0819121B1 (de)
JP (1) JP3038017B2 (de)
KR (1) KR100329877B1 (de)
AR (1) AR003116A1 (de)
AT (1) ATE363472T1 (de)
AU (1) AU719990B2 (de)
BR (1) BR9604787A (de)
CA (1) CA2217499C (de)
CZ (1) CZ316597A3 (de)
DE (1) DE69637105T2 (de)
ES (1) ES2288302T3 (de)
HU (1) HUP9800456A3 (de)
IL (1) IL117798A (de)
MX (1) MX9707665A (de)
NO (1) NO314082B1 (de)
NZ (1) NZ306665A (de)
PL (1) PL322689A1 (de)
SK (1) SK135597A3 (de)
TW (1) TW462968B (de)
WO (1) WO1996031478A1 (de)

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CA2217499C (en) 2004-03-30
ES2288302T3 (es) 2008-01-01
NZ306665A (en) 2000-01-28
PL322689A1 (en) 1998-02-16
JP3038017B2 (ja) 2000-05-08
NO314082B1 (no) 2003-01-27
KR100329877B1 (ko) 2002-08-28
CZ316597A3 (cs) 1998-03-18
DE69637105T2 (de) 2008-04-24
CA2217499A1 (en) 1996-10-10
WO1996031478A1 (en) 1996-10-10
TW462968B (en) 2001-11-11
BR9604787A (pt) 1998-07-07
IL117798A0 (en) 1996-08-04
EP0819121A1 (de) 1998-01-21
AU5527996A (en) 1996-10-23
MX9707665A (es) 1997-11-29
EP0819121B1 (de) 2007-05-30
AR003116A1 (es) 1998-07-08
NO974610L (no) 1997-12-08
HUP9800456A3 (en) 2000-04-28
DE69637105D1 (de) 2007-07-12
JPH10511981A (ja) 1998-11-17
AU719990B2 (en) 2000-05-18
ATE363472T1 (de) 2007-06-15
HUP9800456A2 (hu) 1999-06-28
NO974610D0 (no) 1997-10-06
SK135597A3 (en) 1998-07-08

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