IL116696A - Production of enzymatically active recombinant carboxypeptidase b - Google Patents

Production of enzymatically active recombinant carboxypeptidase b

Info

Publication number
IL116696A
IL116696A IL11669696A IL11669696A IL116696A IL 116696 A IL116696 A IL 116696A IL 11669696 A IL11669696 A IL 11669696A IL 11669696 A IL11669696 A IL 11669696A IL 116696 A IL116696 A IL 116696A
Authority
IL
Israel
Prior art keywords
procpb
enzymatically active
production
active recombinant
active cpb
Prior art date
Application number
IL11669696A
Other languages
English (en)
Other versions
IL116696A0 (en
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of IL116696A0 publication Critical patent/IL116696A0/xx
Publication of IL116696A publication Critical patent/IL116696A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11669696A 1995-01-25 1996-01-08 Production of enzymatically active recombinant carboxypeptidase b IL116696A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25

Publications (2)

Publication Number Publication Date
IL116696A0 IL116696A0 (en) 1996-05-14
IL116696A true IL116696A (en) 1999-08-17

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11669696A IL116696A (en) 1995-01-25 1996-01-08 Production of enzymatically active recombinant carboxypeptidase b

Country Status (21)

Country Link
US (1) US5948668A (cs)
EP (1) EP0871718B1 (cs)
JP (1) JP4250716B2 (cs)
KR (1) KR100566136B1 (cs)
CN (1) CN1144874C (cs)
AT (1) ATE358717T1 (cs)
AU (1) AU698889B2 (cs)
BR (1) BR9606795A (cs)
CA (1) CA2210242C (cs)
CZ (1) CZ292541B6 (cs)
DE (1) DE69637011T2 (cs)
DK (1) DK0871718T3 (cs)
ES (1) ES2284167T3 (cs)
HU (1) HU225673B1 (cs)
IL (1) IL116696A (cs)
MX (1) MX9705279A (cs)
NZ (1) NZ302874A (cs)
PL (1) PL183228B1 (cs)
PT (1) PT871718E (cs)
WO (1) WO1996023064A1 (cs)
ZA (1) ZA96515B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ43098A3 (cs) 1995-08-16 1998-05-13 Zeneca Limited Konjugáty obsahující mutovanou formu enzymu karboxypeptidázy B, způsob jejich přípravy a jejich použití
EP1588716B1 (en) 1998-08-06 2011-02-16 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
US6441153B1 (en) 1999-09-29 2002-08-27 Lexicon Genetics Incorporated Human carboxypeptidases and polynucleotides encoding the same
CA2382725A1 (en) * 1999-09-17 2001-03-22 Genzyme Transgenics Corporation Transgenically produced fusion proteins
EP1632575B1 (en) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Human carboxypeptidases and polynucleotides encoding the same
AU2001229253A1 (en) * 2000-01-12 2001-07-24 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
ATE455849T1 (de) * 2003-12-05 2010-02-15 Hoffmann La Roche Rekombinante carboxypeptidase b und ihre aufreinigung
EP1538203B1 (en) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Recombinantly expressed carboxypeptidase B and purification thereof
WO2006035008A1 (de) * 2004-09-27 2006-04-06 Merck Biosciences Ag Rekombinante carboxypeptidase b
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
AU2006235495B2 (en) 2005-04-11 2012-04-12 Horizon Therapeutics Usa, Inc. Variant forms of urate oxidase and use thereof
SG161248A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc A variant form of urate oxidase and use thereof
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
KR101288027B1 (ko) 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
US9285363B2 (en) 2009-05-11 2016-03-15 Imiplex Llc Method of protein nanostructure fabrication
EP2446260B1 (en) 2009-06-25 2018-12-26 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
WO2020160322A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple)
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK124483B (da) * 1967-12-04 1972-10-23 Bayer Ag Fremgangsmåde til rensning af carboxypeptidase B.
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
BR9408061A (pt) * 1993-11-16 1996-12-24 Lilly Co Eli Sequência de dna codificando carboxipeptidase b pancreática de suiínos

Also Published As

Publication number Publication date
HU225673B1 (en) 2007-06-28
JPH11503002A (ja) 1999-03-23
PL321499A1 (en) 1997-12-08
CN1177377A (zh) 1998-03-25
DE69637011D1 (de) 2007-05-16
NZ302874A (en) 1998-11-25
HK1014986A1 (en) 1999-10-08
AU4903496A (en) 1996-08-14
PT871718E (pt) 2007-06-26
MX9705279A (es) 1998-06-30
DE69637011T2 (de) 2007-12-13
EP0871718A4 (en) 2000-06-07
ATE358717T1 (de) 2007-04-15
KR100566136B1 (ko) 2006-11-10
CA2210242A1 (en) 1996-08-01
US5948668A (en) 1999-09-07
CZ292541B6 (cs) 2003-10-15
CA2210242C (en) 2010-04-27
EP0871718B1 (en) 2007-04-04
BR9606795A (pt) 1997-12-30
ES2284167T3 (es) 2007-11-01
IL116696A0 (en) 1996-05-14
CN1144874C (zh) 2004-04-07
HUP9800091A2 (hu) 1998-05-28
EP0871718A1 (en) 1998-10-21
AU698889B2 (en) 1998-11-12
WO1996023064A1 (en) 1996-08-01
CZ225897A3 (cs) 1998-10-14
ZA96515B (en) 1996-08-15
PL183228B1 (pl) 2002-06-28
KR19980701652A (ko) 1998-06-25
JP4250716B2 (ja) 2009-04-08
HUP9800091A3 (en) 2004-03-29
DK0871718T3 (da) 2007-07-02

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
EXP Patent expired