IL116385A - Sulphonamides their manufacture and pharmaceutical compositions containing them - Google Patents

Sulphonamides their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL116385A
IL116385A IL11638595A IL11638595A IL116385A IL 116385 A IL116385 A IL 116385A IL 11638595 A IL11638595 A IL 11638595A IL 11638595 A IL11638595 A IL 11638595A IL 116385 A IL116385 A IL 116385A
Authority
IL
Israel
Prior art keywords
pct
pharmaceutical compositions
compositions containing
sulphonamides
manufacture
Prior art date
Application number
IL11638595A
Other languages
English (en)
Other versions
IL116385A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL116385A0 publication Critical patent/IL116385A0/xx
Publication of IL116385A publication Critical patent/IL116385A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69Benzenesulfonamido-pyrimidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Bipolar Transistors (AREA)
  • Steroid Compounds (AREA)
  • Surgical Instruments (AREA)
  • Lubricants (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11638595A 1994-12-20 1995-12-14 Sulphonamides their manufacture and pharmaceutical compositions containing them IL116385A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH383794 1994-12-20
CH241995 1995-08-24

Publications (2)

Publication Number Publication Date
IL116385A0 IL116385A0 (en) 1996-03-31
IL116385A true IL116385A (en) 2000-07-16

Family

ID=25690401

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11638595A IL116385A (en) 1994-12-20 1995-12-14 Sulphonamides their manufacture and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US6004965A (ja)
EP (1) EP0799209B1 (ja)
JP (1) JP2989014B2 (ja)
KR (1) KR100445085B1 (ja)
CN (1) CN1098254C (ja)
AT (1) ATE246681T1 (ja)
AU (1) AU701767B2 (ja)
BR (1) BR9510104A (ja)
CA (1) CA2208018C (ja)
CY (1) CY2495B1 (ja)
CZ (1) CZ287916B6 (ja)
DE (1) DE69531457T2 (ja)
DK (1) DK0799209T3 (ja)
ES (1) ES2203649T3 (ja)
FI (1) FI120397B (ja)
HK (1) HK1001973A1 (ja)
HU (1) HU228619B1 (ja)
IL (1) IL116385A (ja)
MA (1) MA23744A1 (ja)
MY (1) MY131126A (ja)
NO (1) NO316645B1 (ja)
NZ (1) NZ297797A (ja)
PT (1) PT799209E (ja)
SA (1) SA95160421B1 (ja)
TW (1) TW313568B (ja)
WO (1) WO1996019459A1 (ja)

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JP4771563B2 (ja) 1996-12-06 2011-09-14 アムジエン・インコーポレーテツド Il−1媒介疾患を処置するためにil−1インヒビターを使用する組合せ療法
ATE267808T1 (de) * 1997-08-19 2004-06-15 Hoffmann La Roche Verfahren zur herstellung von 2,5- disubstituierten pyridinen
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
ATE311382T1 (de) * 1998-08-10 2005-12-15 Verfahren zur herstellung von 2-carbamoyl- pyridinen
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1158985B1 (en) * 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
RU2319693C9 (ru) 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
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US6417360B1 (en) * 1999-03-03 2002-07-09 Hoffmann-La Roche Inc. Heterocyclic sulfonamides
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ATE380180T1 (de) * 1999-09-03 2007-12-15 Actelion Pharmaceuticals Ltd Bis-sulfonamiden
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WO2001081338A1 (en) * 2000-04-25 2001-11-01 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
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EP1345920B1 (en) 2000-12-18 2006-04-12 Actelion Pharmaceuticals Ltd. Novel sulfamides and their use as endothelin receptor antagonists
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2002083650A1 (en) * 2001-04-11 2002-10-24 Actelion Pharmaceuticals Ltd Novel sulfonylamino-pyrimidines
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
ATE529406T1 (de) 2002-02-11 2011-11-15 Bayer Healthcare Llc Aryl-harnstoffe als kinase inhibitoren
US20040002451A1 (en) 2002-06-20 2004-01-01 Bruce Kerwin Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
ES2320649T3 (es) 2002-12-02 2009-05-27 Actelion Pharmaceuticals Ltd. Pirimidin-sulfamidas y su uso como antagonistas de receptores de endotelina.
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KR101503937B1 (ko) 2006-12-08 2015-03-18 렉시컨 파마슈티컬스 인코퍼레이티드 Angptl3 에 대한 단일클론 항체
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KR20210072041A (ko) 2018-10-03 2021-06-16 훈츠만 어드밴스트 머티리얼스(스위처랜드) 게엠베하 신규한 피리딘 및 피리미딘 치환된 트리아진 uv 흡수제
TW202233597A (zh) 2020-11-05 2022-09-01 瑞士商愛杜西亞製藥有限公司 克拉生坦(clazosentan)二鈉鹽之安定結晶水合物
TW202329952A (zh) 2021-12-17 2023-08-01 瑞士商愛杜西亞製藥有限公司 克拉生坦(clazosentan)二鈉鹽之製備方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270116B (ja) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (ja) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
MX9704587A (es) 1998-07-31
HU228619B1 (en) 2013-04-29
US6004965A (en) 1999-12-21
CZ187497A3 (en) 1997-10-15
NO972538L (no) 1997-06-04
CA2208018A1 (en) 1996-06-27
TW313568B (ja) 1997-08-21
CA2208018C (en) 2007-03-27
WO1996019459A1 (en) 1996-06-27
CN1098254C (zh) 2003-01-08
CZ287916B6 (cs) 2001-03-14
FI972628A0 (fi) 1997-06-18
MA23744A1 (fr) 1996-07-01
NO316645B1 (no) 2004-03-22
CY2495B1 (en) 2005-09-02
FI972628A (fi) 1997-06-18
HK1001973A1 (en) 1998-07-24
FI120397B (fi) 2009-10-15
DE69531457D1 (en) 2003-09-11
KR100445085B1 (ko) 2004-10-14
MY131126A (en) 2007-07-31
DK0799209T3 (da) 2003-11-24
IL116385A0 (en) 1996-03-31
CN1170407A (zh) 1998-01-14
AU701767B2 (en) 1999-02-04
NZ297797A (en) 1999-10-28
BR9510104A (pt) 1997-11-25
JP2989014B2 (ja) 1999-12-13
SA95160421B1 (ar) 2006-05-01
ATE246681T1 (de) 2003-08-15
PT799209E (pt) 2003-12-31
AU4304196A (en) 1996-07-10
DE69531457T2 (de) 2004-06-24
JPH10509182A (ja) 1998-09-08
EP0799209B1 (en) 2003-08-06
NO972538D0 (no) 1997-06-04
EP0799209A1 (en) 1997-10-08
ES2203649T3 (es) 2004-04-16
HUT77884A (hu) 1998-09-28

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